Sökresultat - "MT: Oligonucleotides: Therapies and Applications"

Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca2+ and Mg2+ in the formulation.

Miller, Rachael, Paquette, Joseph, Barker, Alexandra, Sapp, Ellen, McHugh, Nicholas, Bramato, Brianna, Yamada, Nozomi, Alterman, Julia, Echeveria, Dimas, Yamada, Ken, Watts, Jonathan, Anaclet, Christelle, DiFiglia, Marian, Khvorova, Anastasia, Aronin, Neil

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A4GALT-targeting siRNA lipid nanoparticles ameliorate Fabry disease phenotype: Greater efficacy in endothelial cells than in podocytes

Yoo Jin Shin, Hanbi Lee, Xianying Fang, Sheng Cui, Sun Woo Lim, Kang In Lee, Jae Young Lee, Hong Lim Kim, Yuna Oh, Can Li, Chul Woo Yang, Gayeon You, Hyeondo Lee, Hyejung Mok, Byung Ha Chung

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Antibody and aptamer-based therapies for osteoarthritis: Application of antibodies and promise of aptamers

Huaizhi Chen, Zijian Ye, Jasmijn V. Korpershoek, Laura B. Creemers, Harrie Weinans, Jaqueline Lourdes Rios

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Anti-gene oligonucleotides targeting Friedreich’s ataxia expanded GAA⋅TTC repeats increase Frataxin expression

Negin Mozafari, Salomé Milagres, Tea Umek, Cristina S.J. Rocha, Claudia M. Vargiu, Fiona Freyberger, Osama Saher, Marek Napierala, Jill S. Napierala, Pontus Blomberg, Per T. Jørgensen, Tanel Punga, C. I. Edvard Smith, Jesper Wengel, Rula Zain

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Removal of dsRNA byproducts using affinity chromatography

Nathaniel E. Clark, Mateusz Kozarski, Sinem Demirel Asci, Jurgen Van den Heuvel, Matt R. Schraut, Roger A. Winters, Kelley Kearns, Thomas C. Scanlon, Senne Dillen

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Design, pharmacology, and toxicology of a novel chemically modified siRNA targeting hepatic angiotensinogen

Ze-Ao Huang, Guang-Shen Ji, Shuo Yang, Yang Yang, Yu-Cheng Wu, Zhi-Kang Tian, Geng-Shen Song

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Genetic adjuvants: A paradigm shift in vaccine development and immune modulation

Karina Spunde, Ksenija Korotkaja, Irina Sominskaya, Anna Zajakina

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Inhibition of the LINE1-derived MET transcript induces apoptosis and oncoprotein knockdown in cancer cells

Umberto Miglio, Enrico Berrino, Daniele Avanzato, Ivan Molineris, Valentina Miano, Melissa Milan, Letizia Lanzetti, Eugenio Morelli, James M. Hughes, Michele De Bortoli, Anna Sapino, Tiziana Venesio

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Looking beyond the origin of SARS-CoV-2: Significant strategic aspects during the five-year journey of COVID-19 vaccine development

Chiranjib Chakraborty, Yi-Hao Lo, Manojit Bhattacharya, Arpita Das, Zhi-Hong Wen

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Splicing correction by peptide-conjugated morpholinos as a novel treatment for late-onset Pompe disease

Ryan A. Oliver, Meghan E. Ahern, Perla G. Castaneda, Tushare Jinadasa, Anirban Bardhan, Kathy Y. Morgan, Kristin Ha, Kailash Adhikari, Nino Jungels, Noa Liberman, Anindita Mitra, Christopher D. Greer, Alec M. Wright, Emily G. Thompson, Stephanie Garcia, Elena Copson, Senkara Allu, Xuyu Tan, Alex J. Callahan, Bao Zhong Cai, Vincent Guerlavais, Kevin J. Kim, Annika B. Malmberg

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Design and screening of novel endosomal escape compounds that enhance functional delivery of oligonucleotides in vitro

H. Yesid Estupiñán, Tom Baladi, Samantha Roudi, Michael J. Munson, Jeremy Bost, Oskar Gustafsson, Daniel Velásquez-Ramírez, Deepak Kumar Bhatt, Daniel Hagey, Dennis Hekman, Shalini Andersson, Samir EL Andaloussi, Anders Dahlén

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Binding of G-quadruplex DNA and serum albumins by synthetic non-proteinogenic amino acids: Implications for c-Myc-related anticancer activity and drug delivery

Hayarpi Simonyan, Rosanna Palumbo, Caterina Vicidomini, Pasqualina Liana Scognamiglio, Satenik Petrosyan, Lusine Sahakyan, Gagik Melikyan, Ashot Saghyan, Giovanni N. Roviello

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SHMT2 is essential for mammalian preimplantation embryonic development through de novo biosynthesis of nucleotide metabolites

Mingze Shi, Yingxue Huai, Tiantian Deng, Chuanxin Zhang, Jinzhu Song, Jiawei Wang, Yiwen Zhang, Zi-Jiang Chen, Han Zhao, Keliang Wu, Boyang Liu

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CAG-targeted brain-permeable therapy tested in biallelic humanized polyQ mouse models

Magdalena Surdyka, Żaneta Kalinowska-Pośka, Anna Niewiadomska-Cimicka, Ewelina Jesion, Agnieszka Fiszer, Elisabeth Singer-Mikosch, Lorraine Fievet, Lukasz Przybyl, Nicholas S. Caron, Michael R. Hayden, Huu Phuc Nguyen, Yvon Trottier, Maciej Figiel

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Physicochemical and functional assessment of messenger RNA 5′Cap-end impurities under forced degradation conditions

Hutchinson, J. ¹, Schweikart, F. ², Shannon, R. ¹, Murthy, A. ¹, Bates, S.M. ³, Leone, S. ⁴, Nissan, T. ³, Sideris, D. ¹, Lal, C. ¹, Button, J. ⁵, Rani, R. ⁵, Thom, G. ⁵, Bond, N. ¹, Örnskov, E. ^{2, ∗}, Trabulo, S. ^{1, ∗∗}

Targeting CIDEB alleviates liver steatosis and fibrosis in mouse MASH models

Lin, Yingying ^{1, 2, 3}, Fan, Fushun ^{2, 3}, Mo, Zhenxian ^{1, 2}, Huang, Ziyang ^{1, 2}, Zhou, Minhua ², Ma, Yaru ², Qian, Chuiwen ¹, Wang, Yifei ¹, Qian, Changgeng ², Liu, Xinjian ^{2, ∗}

Nanoparticle-formulated mRNA encoding engineered multivalent SIRPα-Fc fusion proteins shows robust anti-cancer activity in preclinical models

Lal, Shruti ¹, Sallets, Adrienne ¹, Bandi, Srinivasa R. ¹, Adusumilli, Gowrisudha ¹, Liu, Weiqun ¹, Low, Ray ¹, Ferry, Kimmy ¹, MacDonough, Chris ¹, ElAzzouny, Mahmoud ¹, Haabeth, Ole A.W. ¹, McKinlay, Colin J. ¹, Hsu, Pei-Ken ¹, Sharma, Anushtha ¹, Dhungel, Pragyesh ¹, Triplett, Jenna ¹, Leong, Meredith ¹, McCartney-Melstad, Evan ¹, Deutsch, Samuel ¹, Gunasekaran, Kannan ^{1, ∗}

Hyperandrogen-induced imbalance of FOXO4-AR regulatory loop contributes to ovulatory disorders in polycystic ovary syndrome

Zhou, Ruiqiong ¹, Wang, Zhaoyi ¹, Dong, Mei ¹, Wang, Songlu ¹, Li, Xiangyuan ¹, Huang, Junjiu ², Zhang, Xiqian ^{1, ∗}, Liu, Fenghua ^{1, ∗∗}

A Lyme disease mRNA vaccine targeting Borrelia burgdorferi OspA induces strong immune responses and prevents transmission in mice

Tahir, Djamel ^{1, 2, ∗}, Geolier, Virginie ¹, Bruant, Hugo ¹, Le Flèche-Matéos, Anne ¹, Mallet, Adeline ², Varloud, Marie ³, Civat, Céline ⁴, Girerd-Chambaz, Yves ⁴, Montano, Sandrine ⁴, Pion, Corinne ⁴, Ferquel, Elisabeth ¹, Pavot, Vincent ^{4, 5, ∗∗}, Choumet, Valérie ^{1, 5, ∗∗∗}

The interactions of Pu22 G-quadruplex, derived from c-MYC promoter sequence, with antitumor acridine derivatives—An NMR/MD combined study

Laskowski, Tomasz ^{1, 4, ∗}, Kosno, Michał ^{1, 3, 4}, Andrałojć, Witold ², Pakuła, Julia ¹, Stojałowski, Rafał ¹, Borzyszkowska-Bukowska, Julia ¹, Paluszkiewicz, Ewa ¹, Mazerska, Zofia ¹