Search Results - "Randomized controlled trials"

Integration of non-randomized studies with randomized controlled trials in meta-analyses of clinical studies: a meta-epidemiological study on effect estimation of interventions.

Mei F; Institute of Integrated Traditional Chinese and Western Medicine, Chinese Evidence-Based Medicine Center, Cochrane China and MAGIC China Center, West China Hospital, Sichuan University, Chengdu, China.; NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan, Chengdu, China.; Sichuan Center of Technology Innovation for Real World Data, Chengdu, China., Yao M; Institute of Integrated Traditional Chinese and Western Medicine, Chinese Evidence-Based Medicine Center, Cochrane China and MAGIC China Center, West China Hospital, Sichuan University, Chengdu, China.; NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan, Chengdu, China.; Sichuan Center of Technology Innovation for Real World Data, Chengdu, China., Wang Y; Institute of Integrated Traditional Chinese and Western Medicine, Chinese Evidence-Based Medicine Center, Cochrane China and MAGIC China Center, West China Hospital, Sichuan University, Chengdu, China.; NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan, Chengdu, China.; Sichuan Center of Technology Innovation for Real World Data, Chengdu, China., Huan J; Institute of Integrated Traditional Chinese and Western Medicine, Chinese Evidence-Based Medicine Center, Cochrane China and MAGIC China Center, West China Hospital, Sichuan University, Chengdu, China.; NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan, Chengdu, China.; Sichuan Center of Technology Innovation for Real World Data, Chengdu, China., Ma Y; Institute of Integrated Traditional Chinese and Western Medicine, Chinese Evidence-Based Medicine Center, Cochrane China and MAGIC China Center, West China Hospital, Sichuan University, Chengdu, China.; NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan, Chengdu, China.; Sichuan Center of Technology Innovation for Real World Data, Chengdu, China., Li G; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.; Center for Clinical Epidemiology and Methodology, Guangdong Second Provincial General Hospital, Guangzhou, China.; Biostatistics Unit, Research Institute at St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada., Zou K; Institute of Integrated Traditional Chinese and Western Medicine, Chinese Evidence-Based Medicine Center, Cochrane China and MAGIC China Center, West China Hospital, Sichuan University, Chengdu, China.; NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan, Chengdu, China.; Sichuan Center of Technology Innovation for Real World Data, Chengdu, China., Li L; Institute of Integrated Traditional Chinese and Western Medicine, Chinese Evidence-Based Medicine Center, Cochrane China and MAGIC China Center, West China Hospital, Sichuan University, Chengdu, China. liling@wchscu.cn.; NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan, Chengdu, China. liling@wchscu.cn.; Sichuan Center of Technology Innovation for Real World Data, Chengdu, China. liling@wchscu.cn., Sun X; Institute of Integrated Traditional Chinese and Western Medicine, Chinese Evidence-Based Medicine Center, Cochrane China and MAGIC China Center, West China Hospital, Sichuan University, Chengdu, China. sunxin@wchscu.cn.; NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan, Chengdu, China. sunxin@wchscu.cn.; Sichuan Center of Technology Innovation for Real World Data, Chengdu, China. sunxin@wchscu.cn.; Department of Epidemiology and Biostatistics, School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. sunxin@wchscu.cn.

Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't , 2024

A meta-epidemiological analysis of post-hoc comparisons and primary endpoint interpretability among randomized noncomparative trials in clinical medicine.

Sherry AD; Division of Radiation Oncology, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Msaouel P; Division of Cancer Medicine, Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Division of Pathology/Lab Medicine, Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: PMsaouel@mdanderson.org., Ludmir EB; Division of Radiation Oncology, Department of Gastrointestinal Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: ebludmir@mdanderson.org.

Journal Article , 2024

Treatment Effects in Randomized and Nonrandomized Studies of Pharmacological Interventions: A Meta-Analysis.

Salcher-Konrad M; Department of Health Policy, London School of Economics and Political Science, London, United Kingdom.; World Health Organization Collaborating Centre for Pharmaceutical Pricing and Reimbursement Policies, Pharmacoeconomics Department, Gesundheit Österreich GmbH (GÖG)/Austrian National Public Health Institute, Vienna, Austria., Nguyen M; Department of Health Policy, London School of Economics and Political Science, London, United Kingdom.; Department of Family and Community Medicine, University of California, San Francisco., Savovic J; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.; National Institute for Health and Care Research Applied Research Collaboration West, University Hospitals Bristol and Weston National Health Service Foundation Trust, Bristol, United Kingdom., Higgins JPT; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.; National Institute for Health and Care Research Applied Research Collaboration West, University Hospitals Bristol and Weston National Health Service Foundation Trust, Bristol, United Kingdom., Naci H; Department of Health Policy, London School of Economics and Political Science, London, United Kingdom.

Journal Article; Meta-Analysis , 2024

Problematic meta-analyses: Bayesian and frequentist perspectives on combining randomized controlled trials and non-randomized studies.

Moran JL; The Queen Elizabeth Hospital, Woodville, SA, 5011, Australia. john.moran@adelaide.edu.au., Linden A; Department of Medicine, School of Medicine, University of California, San Francisco, USA.

Journal Article; Research Support, Non-U.S. Gov't , 2024

Single-arm phase 3 designs: An oxymoron?

Hussein A; ECSTRRA, 1, avenue Claude Vellefaux, Paris 75010, France., Levy V; ECSTRRA, 1, avenue Claude Vellefaux, Paris 75010, France; D́epartement de Recherche Clinique, Hôpital Avicenne, Bobigny 93000, France., Chevret S; ECSTRRA, 1, avenue Claude Vellefaux, Paris 75010, France; Institut Universitaire de France, Paris 75, France. Electronic address: sylvie.chevret@u-paris.fr.

Journal Article; Review , 2024

Comprehensive care programmes for children with medical complexity.

Harvey AR; Neurodisability and Rehabilitation, Murdoch Children's Research Institute, Melbourne, Australia., Meehan E; Neurodisability and Rehabilitation, Murdoch Children's Research Institute, Melbourne, Australia., Merrick N; Department of Paediatrics, The University of Melbourne, Melbourne, Australia., D'Aprano AL; Department of Paediatrics, The University of Melbourne, Melbourne, Australia., Cox GR; Neurodevelopment and Disability, Royal Children's Hospital, Melbourne, Australia., Williams K; Department of Paediatrics, Monash University, Melbourne, Australia., Gibb SM; Neurodevelopment and Disability, Royal Children's Hospital, Melbourne, Australia., Mountford NJ; Complex Care Hub, The Royal Children's Hospital, Melbourne, Australia., Connell TG; General Medicine, The Royal Children's Hospital, Melbourne, Australia., Cohen E; Paediatrics and Health Policy, Management & Evaluation, University of Toronto, Toronto, Canada.

Journal Article; Review; Systematic Review , 2024

Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support.

Radford M; McMaster Centre for Transfusion Research, McMaster University, Hamilton, Canada.; Department of Oncology, Hamilton Health Sciences Centre, Hamilton, Canada., Estcourt LJ; Haematology/Transfusion Medicine, NHS Blood and Transplant, Oxford, UK.; Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, UK., Sirotich E; Medicine, Yale School of Medicine, New Haven, Connecticut, USA., Pitre T; Medicine, University of Toronto, Toronto, Canada., Britto J; Oncology, Hamilton Health Sciences Centre, Hamilton, Canada., Watson M; Medicine, University of Toronto, Toronto, Canada., Brunskill SJ; Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, UK.; Systematic Review Initiative, NHS Blood and Transplant, Oxford, UK., Fergusson DA; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada., Dorée C; Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, UK.; Systematic Review Initiative, NHS Blood and Transplant, Oxford, UK., Arnold DM; Division of Hematology and Thromboembolism, Department of Medicine, McMaster University, Ontario, Canada.; McMaster University, Hamilton, Canada.

Journal Article; Systematic Review; Meta-Analysis; Review , 2024

Home versus in-centre haemodialysis for people with kidney failure.

Cheetham MS; Renal Unit, Sunshine Coast University Hospital, Birtinya, Australia.; Faculty of Medicine, The University of Queensland, Herston, Australia., Ethier I; Department of Nephrology, Centre Hospitalier de l'Université de Montréal, Montréal, Canada.; Health Innovation and Evaluation Hub, Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Canada., Krishnasamy R; Renal Unit, Sunshine Coast University Hospital, Birtinya, Australia.; Faculty of Medicine, The University of Queensland, Herston, Australia.; Australasian Kidney Trials Network, Translational Research Institute, Woolloongabba, Australia., Cho Y; Faculty of Medicine, The University of Queensland, Herston, Australia.; Department of Nephrology, Princess Alexandra Hospital, Woolloongabba, Australia.; Australasian Kidney Trials Network, The University of Queensland, Brisbane, Australia., Palmer SC; Department of Medicine, University of Otago Christchurch, Christchurch, New Zealand., Johnson DW; Department of Nephrology, Princess Alexandra Hospital, Woolloongabba, Australia., Craig JC; Cochrane Kidney and Transplant, Centre for Kidney Research, The Children's Hospital at Westmead, Westmead, Australia.; College of Medicine and Public Health, Flinders University, Adelaide, Australia., Stroumza P; Medical Office, Diaverum Marseille, Marseille, France., Frantzen L; Medical Office, Diaverum Marseille, Marseille, France., Hegbrant J; Division of Nephrology, Department of Clinical Sciences, Lund University, Lund, Sweden., Strippoli GF; Cochrane Kidney and Transplant, Centre for Kidney Research, The Children's Hospital at Westmead, Westmead, Australia.; Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.

Meta-Analysis; Systematic Review; Journal Article; Review , 2024

Semiparametric Estimation of Relative Causal Effects in Randomized Controlled Trials With Noncompliance.

Liu W; KLATASDS-MOE, School of Statistics, East China Normal University, Shanghai, China., Qin J; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Liu Y; KLATASDS-MOE, School of Statistics, East China Normal University, Shanghai, China.

Journal Article , 2025

A new method for dealing with collider bias in the PWP model for recurrent events in randomized controlled trials.

Shi C; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Department of Biostatistics, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China., Wei JW; Novartis Institutes for Biomedical Research Co., Shanghai, China., Zhan ZS; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Department of Biostatistics, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China., Xu XH; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Department of Biostatistics, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China., Yan ZL; School of Biomedical Engineering, School of Information and Communication Engineering, Hainan University, Haikou, 570228, China.; Hainan Institute of Real World Data, Qionghai, 571437, China., Ou CQ; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Department of Biostatistics, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China. ouchunquan@hotmail.com.

Journal Article , 2025

Shortcomings in reporting country-level participation in multicenter randomized controlled trials involving Ireland as a collaborating partner: a metaresearch study.

Larkin J; Department of General Practice, RCSI University of Medicine and Health Sciences, Dublin, Ireland; School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin, Ireland. Electronic address: Larkinja@tcd.ie., Alanza U; Department of General Practice, RCSI University of Medicine and Health Sciences, Dublin, Ireland., Raj Nagarajan V; Department of General Practice, RCSI University of Medicine and Health Sciences, Dublin, Ireland., Collins M; Department of General Practice, RCSI University of Medicine and Health Sciences, Dublin, Ireland., Termanini S; Department of General Practice, RCSI University of Medicine and Health Sciences, Dublin, Ireland., Farrington E; School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin, Ireland., Clyne B; Department of General Practice, RCSI University of Medicine and Health Sciences, Dublin, Ireland; Department of Public Health and Epidemiology, School of Population Health, RCSI University of Medicine and Health Sciences, Dublin, Ireland., Fahey T; Department of General Practice, RCSI University of Medicine and Health Sciences, Dublin, Ireland., Moriarty F; School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin, Ireland.

Journal Article , 2025

Detecting irregularities in randomized controlled trials using machine learning.

Nelson W; Centre for Data Science and Digital Health, Hamilton Health Sciences, Hamilton, ON, Canada.; Department of Statistical Sciences, University of Toronto, Toronto, ON, Canada., Petch J; Centre for Data Science and Digital Health, Hamilton Health Sciences, Hamilton, ON, Canada.; Population Health Research Institute, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada., Ranisau J; Centre for Data Science and Digital Health, Hamilton Health Sciences, Hamilton, ON, Canada., Zhao R; Population Health Research Institute, Hamilton, ON, Canada., Balasubramanian K; Population Health Research Institute, Hamilton, ON, Canada., Bangdiwala SI; Population Health Research Institute, Hamilton, ON, Canada.; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.

Journal Article , 2025

Sample Size Assessment and Interim Analysis Strategies for Survival Trial Designs With Covariate-Adaptive Randomization.

Su PF; Department of Statistics, National Cheng Kung University, Tainan, Taiwan., Wu CC; Department of Statistics, National Cheng Kung University, Tainan, Taiwan.

Journal Article , 2025

BEAM: Bayesian Hybrid Design With Adaptive Sample Size Through Multisource Exchangeability Modeling.

Tian F; University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Liu M; Takeda Pharmaceuticals, Cambridge, Massachusetts, USA., Zhao Y; Takeda Pharmaceuticals, Cambridge, Massachusetts, USA., Lin J; Takeda Pharmaceuticals, Cambridge, Massachusetts, USA., Liu R; Takeda Pharmaceuticals, Cambridge, Massachusetts, USA.

Journal Article , 2025

A Two-Stage Method for Extending Inferences From a Collection of Trials.

Schnitzler N; Ohio Colleges of Medicine Government Resource Center, The Ohio State University, Columbus, Ohio, USA., Kaizar E; Department of Statistics, The Ohio State University, Columbus, Ohio, USA.

Journal Article , 2025

Revisiting Randomized Controlled Trials: Reassessing Their Role as the Gold Standard for Evidence-Based Treatments.

Zaur AJ; Department of Psychology, Kent State University.

Journal Article , 2025

Definitions of validity terms for use in discussions of randomized controlled trials.

Yazdani Y; Department of Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada; Centre for Studies in Family Medicine, Department of Family Medicine, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada. Electronic address: yyazdan3@uwo.ca., Taljaard M; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; School of Epidemiology & Public Health, University of Ottawa, Ottawa, Ontario, Canada., Zwarenstein M; Department of Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada; Centre for Studies in Family Medicine, Department of Family Medicine, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada; ICES, Toronto, Ontario, Canada. Electronic address: mzwarens@uwo.ca.

Journal Article; Review , 2025

Sharp Variance Estimator and Causal Bootstrap in Stratified Randomized Experiments.

Yu H; Department of Statistics and Data Science, Tsinghua University, Beijing, China., Zhu K; Department of Statistics, North Carolina State University, Raleigh, North Carolina, USA.; Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA., Liu H; Department of Statistics and Data Science, Tsinghua University, Beijing, China.

Journal Article , 2025

Reporting Compliance and Factors Influencing Timeliness of Stroke-Related Trial Results on ClinicalTrials.gov.

Cwajna M; Saba University School of Medicine, The Bottom, Saba, Dutch Caribbean, Netherlands. m.cwajna@saba.edu., Hamouda AM; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, 55905, USA. Hamouda.Abdelrahman@mayo.edu., Kendall N; The University of South Dakota Sanford School of Medicine, Vermillion, SD, 57069, USA., Ghozy S; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Radiology, Mayo Clinic, Rochester, MN, 55905, USA., Elder BD; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, 55905, USA., Kallmes DF; Department of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.

Journal Article; Observational Study , 2025

Overview of Medical, Surgical, and Rehabilitation Outcome Measures Used in Randomized Controlled Trials of Moderate to Severe Traumatic Brain Injury.

Flores-Sandoval C; From the Lawson Research Institute, London, Ontario, Canada (CF-S, EAB, HMM, SJ, RT); St. Joseph's Health Care London, Ontario, Canada (CF-S, EAB, HMM, KS, RT); and Department of Physical Medicine and Rehabilitation, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada (EAB, HMM, KS, RT)., Bateman EA, MacKenzie HM, Sequeira K, Janzen S, Teasell R

Journal Article; Systematic Review , 2025