Sökresultat - "Schneekloth JS Jr"

Chemical Evolution of Aplithianine Class of Serine/Threonine Kinase Inhibitors.

Du L; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States., Wilson BAP; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States., Moore WJ; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States., Dalilian M; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States., Shenoy SR; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States., Li N; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States., Martinez Fiesco JA; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States., Hwang JY; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States., Smith EA; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States., Wamiru A; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States., Goncharova EI; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States.; Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, United States., Alvarez de la Cruz A; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States., Pagadala K; Curia India Pvt. Ltd (Formerly Albany Molecular Research), Hyderabad Research Centre, Hyderabad, Telangana 500078, India., Piswa HK; Curia India Pvt. Ltd (Formerly Albany Molecular Research), Hyderabad Research Centre, Hyderabad, Telangana 500078, India., Patteti V; Curia India Pvt. Ltd (Formerly Albany Molecular Research), Hyderabad Research Centre, Hyderabad, Telangana 500078, India., Jampana VP; Curia India Pvt. Ltd (Formerly Albany Molecular Research), Hyderabad Research Centre, Hyderabad, Telangana 500078, India., Manepalli P; Curia India Pvt. Ltd (Formerly Albany Molecular Research), Hyderabad Research Centre, Hyderabad, Telangana 500078, India., Nimmala R; Curia India Pvt. Ltd (Formerly Albany Molecular Research), Hyderabad Research Centre, Hyderabad, Telangana 500078, India., Marri NR; Curia India Pvt. Ltd (Formerly Albany Molecular Research), Hyderabad Research Centre, Hyderabad, Telangana 500078, India., Gunuguntla M; Curia India Pvt. Ltd (Formerly Albany Molecular Research), Hyderabad Research Centre, Hyderabad, Telangana 500078, India., Reddy JJ; Curia India Pvt. Ltd (Formerly Albany Molecular Research), Hyderabad Research Centre, Hyderabad, Telangana 500078, India., Schneekloth JS Jr; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States., Zhang P; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States., O'Keefe BR; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States.; Natural Products Branch, Development Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, Maryland 21702, United States.

Journal Article , 2025

Structure-informed design of an ultrabright RNA-activated fluorophore.

Yang M; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA., Prestwood PR; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA., Passalacqua LFM; Laboratory of Nucleic Acids, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Balaratnam S; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA., Fullenkamp CR; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA., Arney JW; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA., Weeks KM; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA., Ferre-D'Amare A; Laboratory of Nucleic Acids, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Schneekloth JS Jr; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA. schneeklothjs@mail.nih.gov.

Journal Article , 2025

Harnessing Molecular Recognition for Small-Molecule-Mediated Reversible Photochemical Control Over mRNA Translation.

Parmar S; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA., Tenney L; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA., Liang X; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA., Routzahn JT 4th; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA., Sibley CD; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA., Schneekloth JS Jr; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA.

Journal Article , 2025

Use of a small molecule microarray screen to identify inhibitors of the catalytic RNA subunit of Methanobrevibacter smithii RNase P.

Sidharthan V; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.; Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA., Sibley CD; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA., Dunne-Dombrink K; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA., Yang M; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA., Zahurancik WJ; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.; Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA., Balaratnam S; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA., Wilburn DB; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA., Schneekloth JS Jr; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA., Gopalan V; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.; Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA.

Journal Article , 2025

Inferring phase transitions and critical exponents from limited observations with thermodynamic maps.

Herron L; Biophysics Program and Institute for Physical Science and Technology, University of Maryland, College Park, MD 20742.; University of Maryland Institute for Health Computing, Bethesda, MD 20852., Mondal K; Biophysics Program and Institute for Physical Science and Technology, University of Maryland, College Park, MD 20742., Schneekloth JS Jr; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702., Tiwary P; University of Maryland Institute for Health Computing, Bethesda, MD 20852.; Department of Chemistry and Biochemistry and Institute for Physical Science and Technology, University of Maryland, College Park, MD 20742.

Journal Article , 2024

Bioorthogonal Cyclopropenones for Investigating RNA Structure.

Chen S, Sibley CD; Chemical Biology Laboratory, National Cancer Institute, Frederick, Maryland 21702, United States., Latifi B, Balaratnam S; Chemical Biology Laboratory, National Cancer Institute, Frederick, Maryland 21702, United States., Dorn RS, Lupták A, Schneekloth JS Jr; Chemical Biology Laboratory, National Cancer Institute, Frederick, Maryland 21702, United States., Prescher JA

Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Letter; Research Support, N.I.H., Intramural , 2024

Insights into biofilm architecture and maturation enable improved clinical strategies for exopolysaccharide-targeting therapeutics.

Temme JS; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA., Tan Z; Department of Chemistry, Michigan State University, 578 S Shaw Lane, East Lansing, MI 48824, USA; Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI 48824, USA., Li M; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA; Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA., Yang M; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA., Wlodawer A; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA., Huang X; Department of Chemistry, Michigan State University, 578 S Shaw Lane, East Lansing, MI 48824, USA; Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI 48824, USA; Department of Biomedical Engineering, Michigan State University, East Lansing, MI 48824, USA., Schneekloth JS Jr; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA., Gildersleeve JC; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA. Electronic address: gildersj@mail.nih.gov.

Journal Article , 2024

Bioorthogonal cyclopropenones for investigating RNA structure.

Chen S; Departments of Chemistry, University of California, Irvine, California 92697, United States., Sibley CD; Chemical Biology Laboratory, National Cancer Institute, Frederick, Maryland 21702., Latifi B; Pharmaceutical Sciences, University of California, Irvine, California 92697, United States., Balaratnam S; Chemical Biology Laboratory, National Cancer Institute, Frederick, Maryland 21702., Dorn RS; Departments of Chemistry, University of California, Irvine, California 92697, United States., Lupták A; Departments of Chemistry, University of California, Irvine, California 92697, United States.; Molecular Biology & Biochemistry, University of California, Irvine, California 92697, United States.; Pharmaceutical Sciences, University of California, Irvine, California 92697, United States., Schneekloth JS Jr; Chemical Biology Laboratory, National Cancer Institute, Frederick, Maryland 21702., Prescher JA; Departments of Chemistry, University of California, Irvine, California 92697, United States.; Molecular Biology & Biochemistry, University of California, Irvine, California 92697, United States.; Pharmaceutical Sciences, University of California, Irvine, California 92697, United States.

Journal Article; Preprint , 2024

Mechanistic analysis of Riboswitch Ligand interactions provides insights into pharmacological control over gene expression.

Parmar S; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA., Bume DD; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA., Connelly CM; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA., Boer RE; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA., Prestwood PR; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA., Wang Z; Depixus SAS, Paris, France., Labuhn H; Depixus SAS, Paris, France., Sinnadurai K; Depixus SAS, Paris, France., Feri A; Depixus SAS, Paris, France., Ouellet J; Depixus SAS, Paris, France., Homan P; Center for Cancer Research Collaborative Bioinformatics Resource, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.; Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Numata T; Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan., Schneekloth JS Jr; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA. schneeklothjs@mail.nih.gov.

Journal Article , 2024

Machine learning-augmented molecular dynamics simulations (MD) reveal insights into the disconnect between affinity and activation of ZTP riboswitch ligands.

Fullenkamp CR; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD, USA., Mehdi S; Biophysics Program and Institute for Physical Science and Technology, University of Maryland, College Park 20742, USA., Jones CP; Laboratory of Nucleic Acids, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Tenney L; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD, USA., Pichling P; Laboratory of Nucleic Acids, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Prestwood PR; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD, USA., Ferré-D'Amaré AR; Laboratory of Nucleic Acids, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Tiwary P; Department of Chemistry and Biochemistry and Institute for Physical Science and Technology, University of Maryland, College Park 20742, USA.; University of Maryland Institute for Health Computing, Bethesda, Maryland 20852, USA., Schneekloth JS Jr; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD, USA.

Journal Article; Preprint , 2024

Competitive Microarray Screening Reveals Functional Ligands for the DHX15 RNA G-Quadruplex.

Prestwood PR; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States., Yang M; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States., Lewis GV; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States., Balaratnam S; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States., Yazdani K; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States., Schneekloth JS Jr; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.

Journal Article , 2024

KDM3B inhibitors disrupt the oncogenic activity of PAX3-FOXO1 in fusion-positive rhabdomyosarcoma.

Kim YY; Genetics Branch, NCI, NIH, Bethesda, MD, USA. yong.kim@nih.gov., Gryder BE; Genetics Branch, NCI, NIH, Bethesda, MD, USA.; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA., Sinniah R; Genetics Branch, NCI, NIH, Bethesda, MD, USA., Peach ML; Basic Science Program, Frederick National Laboratory for Cancer Research (FNLCR), Frederick, MD, USA., Shern JF; Pediatric Oncology Branch, NCI, NIH, Bethesda, MD, USA., Abdelmaksoud A; Collaborative Bioinformatics Resource, NCI, NIH, Bethesda, MD, USA., Pomella S; Genetics Branch, NCI, NIH, Bethesda, MD, USA.; Department of Hematology and Oncology, Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Woldemichael GM; Leidos Biomed Res Inc, FNLCR, Basic Sci Program, Frederick, MD, USA.; Molecular Targets Program, NCI, NIH, Frederick, MD, USA., Stanton BZ; Genetics Branch, NCI, NIH, Bethesda, MD, USA.; Nationwide Children's Hospital, Center for Childhood Cancer Research, Columbus, OH, USA.; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA.; Department of Biological Chemistry & Pharmacology, The Ohio State University College of Medicine, Columbus, OH, USA., Milewski D; Genetics Branch, NCI, NIH, Bethesda, MD, USA., Barchi JJ Jr; Chemical Biology Laboratory, NCI, NIH, Frederick, MD, USA., Schneekloth JS Jr; Chemical Biology Laboratory, NCI, NIH, Frederick, MD, USA., Chari R; Genome Modification Core, Laboratory Animal Sciences Program, FNLCR, Frederick, MD, USA., Kowalczyk JT; Genetics Branch, NCI, NIH, Bethesda, MD, USA., Shenoy SR; Leidos Biomed Res Inc, FNLCR, Basic Sci Program, Frederick, MD, USA.; Molecular Targets Program, NCI, NIH, Frederick, MD, USA., Evans JR; Natural Products Branch, NCI, NIH, Frederick, MD, USA., Song YK; Genetics Branch, NCI, NIH, Bethesda, MD, USA., Wang C; Genetics Branch, NCI, NIH, Bethesda, MD, USA., Wen X; Genetics Branch, NCI, NIH, Bethesda, MD, USA., Chou HC; Genetics Branch, NCI, NIH, Bethesda, MD, USA., Gangalapudi V; Genetics Branch, NCI, NIH, Bethesda, MD, USA., Esposito D; Protein Expression Laboratory, FNLCR, NIH, Frederick, MD, USA., Jones J; Protein Expression Laboratory, FNLCR, NIH, Frederick, MD, USA., Procter L; Protein Expression Laboratory, FNLCR, NIH, Frederick, MD, USA., O'Neill M; Protein Characterization Laboratory, FNLCR, NIH, Frederick, MD, USA., Jenkins LM; Laboratory of Cell Biology, NCI, NIH, Bethesda, MD, USA., Tarasova NI; Cancer Innovation Laboratory, NCI, NIH, Bethesda, MD, USA., Wei JS; Genetics Branch, NCI, NIH, Bethesda, MD, USA., McMahon JB; Molecular Targets Program, NCI, NIH, Frederick, MD, USA., O'Keefe BR; Molecular Targets Program, NCI, NIH, Frederick, MD, USA.; Natural Products Branch, NCI, NIH, Frederick, MD, USA., Hawley RG; Genetics Branch, NCI, NIH, Bethesda, MD, USA.; Department of Anatomy and Cell Biology, George Washington University, Washington, DC, USA., Khan J; Genetics Branch, NCI, NIH, Bethesda, MD, USA. khanjav@mail.nih.gov.

Journal Article , 2024

Mechanistic Analysis of Riboswitch Ligand Interactions Provides Insights into Pharmacological Control over Gene Expression.

Parmar S; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA., Bume DD; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA., Conelly C; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA., Boer R; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA., Prestwood PR; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA., Wang Z; Depixus SAS, 3-5 Impasse Reille, 75014 Paris, France., Labuhn H; Depixus SAS, 3-5 Impasse Reille, 75014 Paris, France., Sinnadurai K; Depixus SAS, 3-5 Impasse Reille, 75014 Paris, France., Feri A; Depixus SAS, 3-5 Impasse Reille, 75014 Paris, France., Ouellet J; Depixus SAS, 3-5 Impasse Reille, 75014 Paris, France., Homan P; Center for Cancer Research Collaborative Bioinformatics Resource, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.; Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA., Numata T; Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 819-0395, Japan., Schneekloth JS Jr; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA.

Journal Article; Preprint , 2024

Decoding complexity in biomolecular recognition of DNA i-motifs with microarrays.

Yazdani K; Chemical Biology Laboratory, National Cancer Institute, 1050 Boyle St., Frederick, MD 21702, USA., Seshadri S; Chemical Biology Laboratory, National Cancer Institute, 1050 Boyle St., Frederick, MD 21702, USA., Tillo D; Genome Analysis Unit, National Cancer Institute, 37 Convent Dr., Bethesda, MD 20892, USA., Yang M; Chemical Biology Laboratory, National Cancer Institute, 1050 Boyle St., Frederick, MD 21702, USA., Sibley CD; Chemical Biology Laboratory, National Cancer Institute, 1050 Boyle St., Frederick, MD 21702, USA., Vinson C; Laboratory of Metabolism, National Cancer Institute, 37 Convent Dr., Bethesda, MD 20892, USA., Schneekloth JS Jr; Chemical Biology Laboratory, National Cancer Institute, 1050 Boyle St., Frederick, MD 21702, USA.

Journal Article , 2023

RNA as an off-target for FDA-approved drugs.

Fullenkamp CR; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD, USA., Schneekloth JS Jr; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD, USA. schneeklothjs@mail.nih.gov.

Journal Article , 2023

Crystal Structure of an i-Motif from the HRAS Oncogene Promoter.

Li KS; Department Chemistry and Biochemistry, Swarthmore College, 500 College Ave, Swarthmore, PA 19081, USA., Jordan D; Department Chemistry and Biochemistry, Swarthmore College, 500 College Ave, Swarthmore, PA 19081, USA., Lin LY; Department Chemistry and Biochemistry, Swarthmore College, 500 College Ave, Swarthmore, PA 19081, USA., McCarthy SE; Department Chemistry and Biochemistry, Swarthmore College, 500 College Ave, Swarthmore, PA 19081, USA., Schneekloth JS Jr; Chemical Biology Laboratory, National Cancer Institute, National Institute of Health, Frederick, MD 21702, USA., Yatsunyk LA; Department Chemistry and Biochemistry, Swarthmore College, 500 College Ave, Swarthmore, PA 19081, USA.

Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. , 2023

Investigating the NRAS 5' UTR as a target for small molecules.

Balaratnam S; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA., Torrey ZR; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA., Calabrese DR; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA., Banco MT; Biochemistry and Biophysics Center, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA., Yazdani K; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA., Liang X; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA., Fullenkamp CR; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA., Seshadri S; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA., Holewinski RJ; Protein Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc, Frederick, MD 21702, USA., Andresson T; Protein Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc, Frederick, MD 21702, USA., Ferré-D'Amaré AR; Biochemistry and Biophysics Center, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA., Incarnato D; Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, Groningen, the Netherlands., Schneekloth JS Jr; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA. Electronic address: schneeklothjs@mail.nih.gov.

Journal Article; Research Support, N.I.H., Intramural , 2023

Discovery of Small Molecules Targeting the Frameshifting Element RNA in SARS-CoV-2 Viral Genome.

Yang M; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States., Olatunji FP; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States., Rhodes C; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States., Balaratnam S; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States., Dunne-Dombrink K; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States., Seshadri S; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States., Liang X; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States., Jones CP; Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, United States., Le Grice SFJ; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, Frederick Maryland 21702-1201, United States., Ferré-D'Amaré AR; Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, United States., Schneekloth JS Jr; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.

Journal Article , 2023

Proximity-Induced Nucleic Acid Degrader (PINAD) Approach to Targeted RNA Degradation Using Small Molecules.

Mikutis S; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K., Rebelo M; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028, Lisboa, Portugal., Yankova E; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, U.K.; Milner Therapeutics Institute, University of Cambridge, Puddicombe Way, Cambridge CB2 0AW, U.K., Gu M; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, U.K., Tang C; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028, Lisboa, Portugal., Coelho AR; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028, Lisboa, Portugal., Yang M; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States., Hazemi ME; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K., Pires de Miranda M; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028, Lisboa, Portugal., Eleftheriou M; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, U.K.; Milner Therapeutics Institute, University of Cambridge, Puddicombe Way, Cambridge CB2 0AW, U.K., Robertson M; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K., Vassiliou GS; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, U.K., Adams DJ; Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, U.K., Simas JP; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028, Lisboa, Portugal.; Católica Biomedical Research and Católica Medical School, Universidade Católica Portuguesa, 1649-023 Lisboa, Portugal., Corzana F; Departamento de Química, Centro de Investigación en Síntesis Química, Universidad de La Rioja, 26006 Logroño, Spain., Schneekloth JS Jr; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States., Tzelepis K; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, U.K.; Milner Therapeutics Institute, University of Cambridge, Puddicombe Way, Cambridge CB2 0AW, U.K., Bernardes GJL; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028, Lisboa, Portugal.

Journal Article , 2023

DECODING COMPLEXITY IN BIOMOLECULAR RECOGNITION OF DNA I-MOTIFS.

Yazdani K; Chemical Biology Laboratory, National Cancer Institute, 1050 Boyle St., Frederick, MD 21702., Seshadri S; Chemical Biology Laboratory, National Cancer Institute, 1050 Boyle St., Frederick, MD 21702., Tillo D; Genome Analysis Unit, National Cancer Institute, 37 Convent Dr., Bethesda, MD 20892., Vinson C; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, 37 Convent Dr., Bethesda MD 20892., Schneekloth JS Jr; Chemical Biology Laboratory, National Cancer Institute, 1050 Boyle St., Frederick, MD 21702.

Preprint; Journal Article , 2023