Sökresultat - "Adhesion molecule"

Serum EpCAM or PECAM Levels and Risk of Ischemic Stroke: A Two-Sample Mendelian Randomization Study.

Yikun G; Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, 430060, China., Yilin L; Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, 430060, China., Yina L; Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, 430060, China., Jin W; Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, 430060, China., Qiang C; Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, 430060, China. caiqno@whu.edu.cn., Lijuan G; Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, 430060, China. gulijuan@whu.edu.cn.

Journal Article , 2025

L1CAM ⁺ extracellular vesicles derived from the serum of adolescents with major depressive disorder induce depression-like phenotypes in adolescent mice.

Liao J; Mental Health Center, University-Town Hospital of Chongqing Medical University, NO.55, University Town Middle Road, Shapingba District, Chongqing 401331, China; Medical Sciences Research Center, University-Town Hospital of Chongqing Medical University, NO.55, University Town Middle Road, Shapingba District, Chongqing 401331, China., Liu J; Mental Health Center, University-Town Hospital of Chongqing Medical University, NO.55, University Town Middle Road, Shapingba District, Chongqing 401331, China; Medical Sciences Research Center, University-Town Hospital of Chongqing Medical University, NO.55, University Town Middle Road, Shapingba District, Chongqing 401331, China; Department of Emergency and Critical Care Medicine, University-Town Hospital of Chongqing Medical University, NO.55, University Town Middle Road, Shapingba District, Chongqing 401331, China., Zhou Y; Mental Health Center, University-Town Hospital of Chongqing Medical University, NO.55, University Town Middle Road, Shapingba District, Chongqing 401331, China; Medical Sciences Research Center, University-Town Hospital of Chongqing Medical University, NO.55, University Town Middle Road, Shapingba District, Chongqing 401331, China., Shi L; Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing 400016, China., Chen YJ; Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing 400016, China., Guo S; Mental Health Center, University-Town Hospital of Chongqing Medical University, NO.55, University Town Middle Road, Shapingba District, Chongqing 401331, China; Medical Sciences Research Center, University-Town Hospital of Chongqing Medical University, NO.55, University Town Middle Road, Shapingba District, Chongqing 401331, China., Zhang CY; Medical Sciences Research Center, University-Town Hospital of Chongqing Medical University, NO.55, University Town Middle Road, Shapingba District, Chongqing 401331, China; Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing 400016, China., Liu XY; Mental Health Center, University-Town Hospital of Chongqing Medical University, NO.55, University Town Middle Road, Shapingba District, Chongqing 401331, China; Medical Sciences Research Center, University-Town Hospital of Chongqing Medical University, NO.55, University Town Middle Road, Shapingba District, Chongqing 401331, China., Tao WQ; Mental Health Center, University-Town Hospital of Chongqing Medical University, NO.55, University Town Middle Road, Shapingba District, Chongqing 401331, China; Medical Sciences Research Center, University-Town Hospital of Chongqing Medical University, NO.55, University Town Middle Road, Shapingba District, Chongqing 401331, China., Xiang JJ; Medical Sciences Research Center, University-Town Hospital of Chongqing Medical University, NO.55, University Town Middle Road, Shapingba District, Chongqing 401331, China; Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing 400016, China., Yang-Lei; Medical Sciences Research Center, University-Town Hospital of Chongqing Medical University, NO.55, University Town Middle Road, Shapingba District, Chongqing 401331, China., Liu G; Medical Sciences Research Center, University-Town Hospital of Chongqing Medical University, NO.55, University Town Middle Road, Shapingba District, Chongqing 401331, China; Department of Emergency and Critical Care Medicine, University-Town Hospital of Chongqing Medical University, NO.55, University Town Middle Road, Shapingba District, Chongqing 401331, China., Wang W; Mental Health Center, University-Town Hospital of Chongqing Medical University, NO.55, University Town Middle Road, Shapingba District, Chongqing 401331, China; Medical Sciences Research Center, University-Town Hospital of Chongqing Medical University, NO.55, University Town Middle Road, Shapingba District, Chongqing 401331, China., Kuang L; Mental Health Center, University-Town Hospital of Chongqing Medical University, NO.55, University Town Middle Road, Shapingba District, Chongqing 401331, China; Medical Sciences Research Center, University-Town Hospital of Chongqing Medical University, NO.55, University Town Middle Road, Shapingba District, Chongqing 401331, China; Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing 400016, China. Electronic address: kuangli0308@163.com., Ran LY; Mental Health Center, University-Town Hospital of Chongqing Medical University, NO.55, University Town Middle Road, Shapingba District, Chongqing 401331, China; Medical Sciences Research Center, University-Town Hospital of Chongqing Medical University, NO.55, University Town Middle Road, Shapingba District, Chongqing 401331, China. Electronic address: ranliuyi@hospital.cqmu.edu.cn.

Journal Article , 2025

Dual-color fluorescence detection of tumor-derived extracellular vesicles using a specific and serum-stable membrane-fusion approach.

Kong H; Laboratory of Biomaterials and Translational Medicine, Center for Nanomedicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China., Chen X; Laboratory of Biomaterials and Translational Medicine, Center for Nanomedicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China., Lee W; Laboratory of Biomaterials and Translational Medicine, Center for Nanomedicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China., Xie X; State Key Laboratory of Optoelectronic Materials and Technologies, Guangdong Province Key Laboratory of Display Material and Technology, School of Electronics and Information Technology, Sun Yat-sen University, Guangzhou 510006, China. Electronic address: xiexi27@mail.sysu.edu.cn., Tao Y; Laboratory of Biomaterials and Translational Medicine, Center for Nanomedicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China; Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Sun Yat-Sen University, Guangzhou 510275, China. Electronic address: taoy28@mail.sysu.edu.cn., Li M; Laboratory of Biomaterials and Translational Medicine, Center for Nanomedicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China; Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Sun Yat-Sen University, Guangzhou 510275, China; Guangdong Provincial Key Laboratory of Liver Disease Research, Guangzhou 510630, China. Electronic address: limq567@mail.sysu.edu.cn.

Journal Article , 2025

Phosphoproteomics Reveals L1CAM-Associated Signaling Networks in High-Grade Serous Ovarian Carcinoma: Implications for Radioresistance and Tumorigenesis.

Todorov TZ; Center for Radiopharmaceutical Sciences, PSI Center for Life Sciences, 5232 Villigen PSI, Switzerland.; Ovarian Cancer Research, Department of Biomedicine, University Hospital Basel, University of Basel, 4031 Basel, Switzerland.; Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zurich, Switzerland., Coelho R; Ovarian Cancer Research, Department of Biomedicine, University Hospital Basel, University of Basel, 4031 Basel, Switzerland., Jacob F; Ovarian Cancer Research, Department of Biomedicine, University Hospital Basel, University of Basel, 4031 Basel, Switzerland., Heinzelmann-Schwarz V; Ovarian Cancer Research, Department of Biomedicine, University Hospital Basel, University of Basel, 4031 Basel, Switzerland.; Department of Gynecology and Gynecological Oncology, Hospital for Women, University Hospital Basel, 4031 Basel, Switzerland., Schibli R; Center for Radiopharmaceutical Sciences, PSI Center for Life Sciences, 5232 Villigen PSI, Switzerland.; Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zurich, Switzerland., Béhé M; Center for Radiopharmaceutical Sciences, PSI Center for Life Sciences, 5232 Villigen PSI, Switzerland., Grünberg J; Center for Radiopharmaceutical Sciences, PSI Center for Life Sciences, 5232 Villigen PSI, Switzerland., Grzmil M; Center for Radiopharmaceutical Sciences, PSI Center for Life Sciences, 5232 Villigen PSI, Switzerland.

Journal Article , 2025

NAG-1/GDF15 as a tumor suppressor in colorectal cancer: inhibition of β-catenin and NF-κB pathways via interaction with EpCAM.

Lee J; Laboratory of Signal Transduction, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, Korea., Kim I; Laboratory of Signal Transduction, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, Korea., Ryu J; Department of Otolaryngology-Head and Neck Surgery, Center for Thyroid Cancer, Research Institute and Hospital, National Cancer Center, Goyang-si, Gyeonggi-do, Korea., Eling T; Retired Scientist Emeritus, NIEHS/NIH, Research Triangle Park, NC, USA., Baek SJ; Laboratory of Signal Transduction, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, Korea. baeksj@snu.ac.kr.

Journal Article , 2025

Diagnostic performance of circulating EpCAM+ and CD45+ extracellular vesicles in platinum-sensitivity in high-grade serous ovarian cancer: a pilot study.

Tersigni C; Fondazione Policlinico Universitario A.Gemelli IRCCS, L.go A.Gemelli 8, Rome, 00168, Italy. chiara.tersigni@policlinicogemelli.it., Onori M; Università Cattolica del Sacro Cuore, L.go F.Vito 1, Rome, 00168, Italy., Buzzonetti A; Fondazione Policlinico Universitario A.Gemelli IRCCS, L.go A.Gemelli 8, Rome, 00168, Italy., Ferrante A; Fondazione Policlinico Universitario A.Gemelli IRCCS, L.go A.Gemelli 8, Rome, 00168, Italy., Fattorossi A; Fondazione Policlinico Universitario A.Gemelli IRCCS, L.go A.Gemelli 8, Rome, 00168, Italy., Battaglia A; Università Cattolica del Sacro Cuore, L.go F.Vito 1, Rome, 00168, Italy., Corrado G; Fondazione Policlinico Universitario A.Gemelli IRCCS, L.go A.Gemelli 8, Rome, 00168, Italy., Neri C; Fondazione Policlinico Universitario A.Gemelli IRCCS, L.go A.Gemelli 8, Rome, 00168, Italy., Beneduce G; Università Cattolica del Sacro Cuore, L.go F.Vito 1, Rome, 00168, Italy., Sannino F; Università Cattolica del Sacro Cuore, L.go F.Vito 1, Rome, 00168, Italy., Petrecca A; Università Cattolica del Sacro Cuore, L.go F.Vito 1, Rome, 00168, Italy., Scambia G; Fondazione Policlinico Universitario A.Gemelli IRCCS, L.go A.Gemelli 8, Rome, 00168, Italy.; Università Cattolica del Sacro Cuore, L.go F.Vito 1, Rome, 00168, Italy., Fagotti A; Fondazione Policlinico Universitario A.Gemelli IRCCS, L.go A.Gemelli 8, Rome, 00168, Italy.; Università Cattolica del Sacro Cuore, L.go F.Vito 1, Rome, 00168, Italy.

Journal Article , 2025

Soluble urine activated leukocyte cell adhesion molecule is a strong predictor of lupus nephritis.

Chu D; Equillium, La Jolla, CA, USA., Schwartz N; Department of Medicine, Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, USA., Ampudia J; Equillium, La Jolla, CA, USA., Guthridge J; Oklahoma Medical Research Foundation, Oklahoma City, OK, USA., James J; Oklahoma Medical Research Foundation, Oklahoma City, OK, USA., Buyon JP; Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, USA., Connelly S; Equillium, La Jolla, CA, USA., Fung M; Equillium, La Jolla, CA, USA., Ng CT; Equillium, La Jolla, CA, USA., Fava A; Department of Medicine, Division of Rheumatology, John Hopkins Medicine, Baltimore, MD, USA., Petri M; Department of Medicine, Division of Rheumatology, John Hopkins Medicine, Baltimore, MD, USA., Mohan C; Department of Biomedical Engineering, University of Houston, Houston, TX, USA., Putterman C; Department of Medicine, Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, USA.; Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.; Galilee Research Institute, Nahariya, Israel.

Accelerating Medicines Partnership: RA/SLE Network

Journal Article; Multicenter Study , 2025

Correlation between EpCAM expression and cervical lymph node metastasis in papillary thyroid carcinoma: a study integrating ultrasonographic features.

Zhang X; Department of Oncology, Division of Fifth Medical Center, Chinese People's Liberation Army General Hospital, Beijing, China., Li J; Department of Pathology, Division of First Medical Center, Chinese People's Liberation Army General Hospital, Beijing, China., Gao M; Department of Oncology, Division of Fifth Medical Center, Chinese People's Liberation Army General Hospital, Beijing, China., Zhang Y; Department of Ultrasound, Division of First Medical Center, Chinese People's Liberation Army General Hospital, Beijing, China. zhangyaner301@126.com.

Journal Article , 2025

Transcription factor JUNB is required for transformation of EpCAM-positive hepatocellular carcinoma (HCC) cells into CD90-positive HCC cells in vitro.

Kawakami Y; Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan., Okada H; Information-Based Medicine Development, Graduate School of Medical Sciences, Kanazawa University, Ishikawa, Japan. okada0922@staff.kanazawa-u.ac.jp., Nio K; Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan., Hayashi T; Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan., Seki A; Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan., Nakagawa H; Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan., Yamada S; Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan., Iida N; Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan., Shimakami T; Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan., Takatori H; Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan., Honda M; Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan., Kaneko S; Information-Based Medicine Development, Graduate School of Medical Sciences, Kanazawa University, Ishikawa, Japan., Yamashita T; Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan.

Journal Article , 2025

A LncRNA panel within EpCAM-specific exosomes for noninvasive early diagnosing non-small cell lung cancer.

Liu L; The Key Laboratory of Advanced Interdisciplinary Studies, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510120, China., Li D; The Key Laboratory of Advanced Interdisciplinary Studies, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510120, China., Zhuo A; The Key Laboratory of Advanced Interdisciplinary Studies, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510120, China., Lu J; The Key Laboratory of Advanced Interdisciplinary Studies, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510120, China.; Key Laboratory of Clinical Molecular Diagnosis and Research for High Incidence Diseases in Western Guangxi Universities, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533000, China.; School of Public health, Guangzhou Medical University, Guangzhou, 511436, China., Zou J; The Key Laboratory of Advanced Interdisciplinary Studies, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510120, China.; Department of Oncology, Guangzhou Chest Hospital, Guangzhou, 510095, China., Huang G; Physical Examination Center, Affiliated First People's Hospital, Guangzhou Medical university, Guangzhou, 511468, China., Hu Z; Department of Health Management Center, The Third Affiliated Hospital, Southern Medical University, Guangzhou, 510630, China., Zhang Z; The Key Laboratory of Advanced Interdisciplinary Studies, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510120, China., Deng Y; Key Laboratory of Clinical Molecular Diagnosis and Research for High Incidence Diseases in Western Guangxi Universities, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533000, China. dengyb75@163.com., Yang L; The Key Laboratory of Advanced Interdisciplinary Studies, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510120, China. leiyang@gzhmu.edu.cn.; Key Laboratory of Clinical Molecular Diagnosis and Research for High Incidence Diseases in Western Guangxi Universities, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533000, China. leiyang@gzhmu.edu.cn.; School of Public health, Guangzhou Medical University, Guangzhou, 511436, China. leiyang@gzhmu.edu.cn.

Journal Article , 2025

Depletion of Cell Adhesion Molecule L1 from Microglia and Macrophages Reduces Recovery After Spinal Cord Injury.

Theis T; Keck Center for Collaborative Neuroscience, Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08554, USA., Kumar S; Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 08844, USA., Shah P; Keck Center for Collaborative Neuroscience, Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08554, USA., Patel M; Keck Center for Collaborative Neuroscience, Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08554, USA., Tadmori I; Keck Center for Collaborative Neuroscience, Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08554, USA., Ayala C; Keck Center for Collaborative Neuroscience, Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08554, USA., Tschang M; Keck Center for Collaborative Neuroscience, Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08554, USA., Young W; Keck Center for Collaborative Neuroscience, Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08554, USA., Schachner M; Keck Center for Collaborative Neuroscience, Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08554, USA.

Journal Article , 2025

L1CAM mimetic compound duloxetine improves cognitive impairment in 5xFAD mice and protects Aβ1-42-damaged HT22 cells.

Chen H; Center for Neuroscience, Shantou University Medical College, Shantou, Guangdong, 515041, China., Fang Z; Center for Neuroscience, Shantou University Medical College, Shantou, Guangdong, 515041, China., Lin SL; Shantou Key Laboratory of Precision Diagnosis and Treatment of Women's Cancer, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China; Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, Guangdong, China; Division of Immunology, International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China. Electronic address: stanleylin@stu.edu.cn., Schachner M; Center for Neuroscience, Shantou University Medical College, Shantou, Guangdong, 515041, China; Keck Center for Collaborative Neuroscience and Department of Cell Biology and Neuroscience, Rutgers the State University of New Jersey, Piscataway, NJ, 08554, USA. Electronic address: schachner@dls.rutgers.edu.

Journal Article , 2025

Clinical and Molecular Genetic Analyses of a Girl With Isolated Nephrogenic Diabetes Insipidus due to Contiguous Gene Deletion Involving AVPR2 and L1CAM.

Saito S; Department of Pediatrics, Asahikawa Medical University, Asahikawa, Japan., Suzuki S; Department of Pediatrics, Asahikawa Medical University, Asahikawa, Japan., Izumi K; Department of Pediatrics, Asahikawa Medical University, Asahikawa, Japan., Kamiyama T; Faculty of Medicine, Asahikawa Medical University, Asahikawa, Japan., Saito K; Faculty of Medicine, Asahikawa Medical University, Asahikawa, Japan., Yamamura H; Department of Pediatrics, Asahikawa Medical University, Asahikawa, Japan., Kokumai T; Department of Pediatrics, Asahikawa Medical University, Asahikawa, Japan., Furuya A; Department of Pediatrics, Asahikawa Medical University, Asahikawa, Japan., Taketazu G; Department of Pediatrics, Asahikawa Kosei General Hospital, Asahikawa, Japan., Makita Y; Department of Genetic Counseling, Asahikawa Medical University Hospital, Asahikawa, Japan., Niida Y; Center for Clinical Genomics, Kanazawa Medical University Hospital, Uchinada, Japan.; Division of Genomic Medicine, Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical University, Uchinada, Japan., Takahashi S; Department of Pediatrics, Asahikawa Medical University, Asahikawa, Japan.

Case Reports; Journal Article , 2025

EpCAM-Targeted Erlotinib Delivery: Enhancing Nasopharyngeal Carcinoma Treatment With Polyethylene Glycol-Coated Graphene Oxide.

Yeh CF; Department of Otolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Lee SW; Institute of Materials Science and Engineering, National Central University, Taoyuan, Taiwan., Liu CH; Department of Otolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Hsu YB; Department of Otolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Lan MC; Department of Otolaryngology-Head and Neck Surgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.; School of Medicine, Tzu Chi University, Hualien, Taiwan., Lu YJ; Department of Neurosurgery, Chang Gung Memorial Hospital Linkuo Medical Center and College of Medicine, Chang Gung University, Taoyuan, Taiwan., Chen JP; Department of Chemical and Materials Engineering, Chang Gung University, Taoyuan, Taiwan.; Department of Plastic and Reconstructive Surgery and Craniofacial Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.; Research Center for Food and Cosmetic Safety, Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan.; Department of Materials Engineering, Ming Chi University of Technology, New Taipei, Taiwan., Lan MY; Department of Otolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Journal Article , 2025

A novel therapeutic strategy utilizing EpCAM aptamer-conjugated gemcitabine for targeting bladder cancer and cancer stem cells.

Liu J; Department of Urology, The Third Xiangya Hospital of Central South University, No. 138, Tongzipo Road, Changsha, 410013, Hunan, China. 602536@csu.edu.cn., Wang L; Department of Urology, The Third Xiangya Hospital of Central South University, No. 138, Tongzipo Road, Changsha, 410013, Hunan, China. 602536@csu.edu.cn., Peng Y; Chongqing Key Laboratory for Pharmaceutical Metabolism Research, College of Pharmacy, Chongqing Medical University, No. 1, Yixueyuan Road, Chongqing, 400016, China., Long S; School of Medicine, Hunan University of Chinese Medicine, Grade 2024, China., Zeng H; Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine, No. 8, Yuehua Road, Changsha 410013, China., Deng M; Department of Urology, Sun Yat-sen University Cancer Center, No. 651, Dongfeng Road East, Guangzhou, 510060, Guangdong, China.; State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, No. 651, Dongfeng Road East, Guangzhou, 510060, Guangdong, China., Xiang W; Department of Urology, The Third Xiangya Hospital of Central South University, No. 138, Tongzipo Road, Changsha, 410013, Hunan, China. 602536@csu.edu.cn., Liu B; Department of Urology, The Third Xiangya Hospital of Central South University, No. 138, Tongzipo Road, Changsha, 410013, Hunan, China. 602536@csu.edu.cn., Hu X; Department of Urology, The Third Xiangya Hospital of Central South University, No. 138, Tongzipo Road, Changsha, 410013, Hunan, China. 602536@csu.edu.cn., Liu X; Department of Oncology, The Third Xiangya Hospital of Central South University, No. 138, Tongzipo Road, Changsha, 410013, Hunan, China., Xie J; Department of Nursing, The Third Xiangya Hospital of Central South University, No. 138, Tongzipo Road, Changsha, 410013, Hunan, China., Hou W; Department of Urology, The Third Xiangya Hospital of Central South University, No. 138, Tongzipo Road, Changsha, 410013, Hunan, China. 602536@csu.edu.cn., Tang J; Department of Urology, The Third Xiangya Hospital of Central South University, No. 138, Tongzipo Road, Changsha, 410013, Hunan, China. 602536@csu.edu.cn., Liu J; Department of Urology, The Third Xiangya Hospital of Central South University, No. 138, Tongzipo Road, Changsha, 410013, Hunan, China. 602536@csu.edu.cn.

Journal Article , 2025

Bioorthogonal click chemistry and aptamer-targeting enables highly selective fluorescence labeling of exosomal glycosylated EpCAM for super resolved imaging.

Li Z; School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, PR China., Liu Y; School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, PR China., Liu F; School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, PR China., Sun G; Department of Neurosurgery, The First Medical Center, PLA General Hospital, Beijing, 100853, PR China. Electronic address: sgc3130@126.com., Zhang X; School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, PR China. Electronic address: zhangxl@bit.edu.cn., Jing J; School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, PR China. Electronic address: hellojane@bit.edu.cn.

Journal Article , 2025

Targeting MYCN upregulates L1CAM tumor antigen in MYCN-dysregulated neuroblastoma to increase CAR T cell efficacy.

Grunewald L; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Department of Pediatric Oncology and Hematology, Augustenburger Platz 1, Berlin 13353, Germany; German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany., Andersch L; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Department of Pediatric Oncology and Hematology, Augustenburger Platz 1, Berlin 13353, Germany; German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany; Freie Universität Berlin, Kaiserswerther Str. 16-18, Berlin 14195, Germany., Helmsauer K; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Department of Pediatric Oncology and Hematology, Augustenburger Platz 1, Berlin 13353, Germany; Neuroblastoma Research Group, Experimental and Clinical Research Center (ECRC) of the Charité and the Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association, Lindenberger Weg 80, Berlin 13125, Germany., Schwiebert S; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Department of Pediatric Oncology and Hematology, Augustenburger Platz 1, Berlin 13353, Germany., Klaus A; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Department of Pediatric Oncology and Hematology, Augustenburger Platz 1, Berlin 13353, Germany., Henssen AG; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Department of Pediatric Oncology and Hematology, Augustenburger Platz 1, Berlin 13353, Germany; Neuroblastoma Research Group, Experimental and Clinical Research Center (ECRC) of the Charité and the Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association, Lindenberger Weg 80, Berlin 13125, Germany., Straka T; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Department of Pediatric Oncology and Hematology, Augustenburger Platz 1, Berlin 13353, Germany., Lodrini M; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Department of Pediatric Oncology and Hematology, Augustenburger Platz 1, Berlin 13353, Germany., Wicha SG; Department of Clinical Pharmacy, Institute of Pharmacy, University of Hamburg, Bundesstrasse 45, Hamburg 20146, Germany., Fuchs S; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Department of Pediatric Oncology and Hematology, Augustenburger Platz 1, Berlin 13353, Germany; German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany; German Cancer Consortium (DKTK), Partner Site Berlin, Virchowweg 23, Berlin 10117, Germany; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Anna-Louisa-Karsch-Strasse 2, Berlin 10178, Germany., Hertwig F; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Department of Pediatric Oncology and Hematology, Augustenburger Platz 1, Berlin 13353, Germany., Westermann F; German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany., Vitali A; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Department of Pediatric Oncology and Hematology, Augustenburger Platz 1, Berlin 13353, Germany., Caramel C; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Department of Pediatric Oncology and Hematology, Augustenburger Platz 1, Berlin 13353, Germany., Büchel G; Department of Biochemistry and Molecular Biology, Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, Würzburg 97074, Germany; Mildred Scheel Early Career Center, University Hospital Würzburg, Josef-Schneider-Str. 6, Würzburg 97080, Germany., Eilers M; Department of Biochemistry and Molecular Biology, Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, Würzburg 97074, Germany., Astrahantseff K; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Department of Pediatric Oncology and Hematology, Augustenburger Platz 1, Berlin 13353, Germany., Eggert A; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Department of Pediatric Oncology and Hematology, Augustenburger Platz 1, Berlin 13353, Germany; German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany; German Cancer Consortium (DKTK), Partner Site Berlin, Virchowweg 23, Berlin 10117, Germany., Höpken UE; Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association, Robert-Rössle Str. 10, Berlin 13125, Germany., Schulte JH; Universitätsklinik für Kinder, und Jugendmedizin, Department of Pediatric Hematology and Oncology, Hoppe-Seyler-Straße 1, Tübingen 72076, Germany., Blankenstein T; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Department of Pediatric Oncology and Hematology, Augustenburger Platz 1, Berlin 13353, Germany; Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association, Robert-Rössle Str. 10, Berlin 13125, Germany., Anders K; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Department of Pediatric Oncology and Hematology, Augustenburger Platz 1, Berlin 13353, Germany., Künkele A; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Department of Pediatric Oncology and Hematology, Augustenburger Platz 1, Berlin 13353, Germany; German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany; German Cancer Consortium (DKTK), Partner Site Berlin, Virchowweg 23, Berlin 10117, Germany; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Anna-Louisa-Karsch-Strasse 2, Berlin 10178, Germany. Electronic address: Annette.kuenkele@charite.de.

Journal Article , 2025

Optimizing combination targeted immunotoxin therapy: Insights from HER2 and EpCAM expression profiles.

Obozina AS; Moscow Center for Advanced Studies, Kulakova Str. 20, 123592, Moscow, Russia., Pakhomov AA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., 117997, Moscow, Russia., Frolova AY; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., 117997, Moscow, Russia., Deyev SM; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., 117997, Moscow, Russia., Shipunova VO; Moscow Center for Advanced Studies, Kulakova Str. 20, 123592, Moscow, Russia; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., 117997, Moscow, Russia. Electronic address: viktoriya.shipunova@phystech.edu.

Journal Article; Research Support, Non-U.S. Gov't , 2025

An EpCAM/Trop2 mechanostat differentially regulates collective behaviour of human carcinoma cells.

Aslemarz A; CRBM, University of Montpellier and CNRS, Montpellier, 34293, France.; Dept. of Biology, McGill University, Montreal, QC, H3A1B1, Canada.; SGS, Mississauga, ON, L5T 1W8, Canada., Fagotto-Kaufmann M; CRBM, University of Montpellier and CNRS, Montpellier, 34293, France.; Department of Neurobiology, University of Stuttgart, 70569, Stuttgart, Germany., Ruppel A; LIPHY, UMR5588, University of Grenoble, 38400, Grenoble, France.; CRBM, University of Montpellier and CNRS, Montpellier, 34293, France., Fagotto-Kaufmann C; CRBM, University of Montpellier and CNRS, Montpellier, 34293, France., Balland M; LIPHY, UMR5588, University of Grenoble, 38400, Grenoble, France., Lasko P; Dept. of Biology, McGill University, Montreal, QC, H3A1B1, Canada., Fagotto F; CRBM, University of Montpellier and CNRS, Montpellier, 34293, France. francois.fagotto@crbm.cnrs.fr.

Journal Article , 2025

ImmunoPET imaging of EpCAM in solid tumours with nanobody tracers: a preclinical study.

Xu D; Department of Nuclear Medicine, Institute of Clinical Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China., Zhang Y; Department of Nuclear Medicine, Institute of Clinical Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China., Huang W; Department of Nuclear Medicine, Institute of Clinical Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China., Pan X; Department of Nuclear Medicine, Institute of Clinical Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China., An S; Department of Nuclear Medicine, Institute of Clinical Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China., Wang C; Department of Nuclear Medicine, Institute of Clinical Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China., Huang G; Department of Nuclear Medicine, Institute of Clinical Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China., Liu J; Department of Nuclear Medicine, Institute of Clinical Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China. ljjsh@sjtu.edu.cn., Wei W; Department of Nuclear Medicine, Institute of Clinical Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China. wwei@shsmu.edu.cn.

Journal Article , 2025