Search Results - "Beresini, Maureen"

Discovery of Potent, Selective, and Orally Available IRE1α Inhibitors Demonstrating Comparable PD Modulation to IRE1 Knockdown in a Multiple Myeloma Model

Braun, Marie-Gabrielle^aff1, Ashkenazi, Avi^aff1, Beveridge, Ramsay E.^aff2, Castanedo, Georgette^aff1, Wallweber, Heidi Ackerly^aff1, Beresini, Maureen H.^aff1, Clark, Kevin R.^aff1, De Bruyn, Tom^aff1, Fu, Liqiang^aff4, Gibbons, Paul^aff1, Jiang, Fan^aff3, Kaufman, Susan^aff1, Kan, David^aff1, Kiefer, James R.^aff1, Leclerc, Jean-Philippe^aff2, Lemire, Alexandre^aff2, Ly, Cuong^aff1, Segal, Ehud^aff1, Sims, Jessica^aff1, Wang, Weiru^aff1, Wei, Wentao^aff3, Zhao, Liang^aff2, Schwarz, Jacob B.^aff1, Rudolph, Joachim^aff1

Systematic discovery of neoepitope–HLA pairs for neoantigens shared among patients and tumor types

Gurung, Hem R., Heidersbach, Amy J., Darwish, Martine, Chan, Pamela Pui Fung, Li, Jenny, Beresini, Maureen, Zill, Oliver A., Wallace, Andrew, Tong, Ann-Jay, Hascall, Dan, Torres, Eric, Chang, Andy, Lou, Kenny ‘Hei-Wai’, Abdolazimi, Yassan, Hammer, Christian, Xavier-Magalhães, Ana, Marcu, Ana, Vaidya, Samir, Le, Daniel D., Akhmetzyanova, Ilseyar, Oh, Soyoung A., Moore, Amanda J., Uche, Uzodinma N., Laur, Melanie B., Notturno, Richard J., Ebert, Peter J. R., Blanchette, Craig^{Aff1, IDs4158702301945y_cor27}, Haley, Benjamin^{Aff1, IDs4158702301945y_cor28}, Rose, Christopher M.^{Aff1, IDs4158702301945y_cor29}

Quantifying KRAS G12C Covalent Drug Inhibitor Activity in Mouse Tumors Using Mass Spectrometry

Tran, John C.^aff1d1, Hunsaker, Thomas^aff1d2, Bell, Christina^aff2, Ma, Taylur P.^aff1d4, Chan, Emily^aff1d2, Larrocha, Pablo Saenz-Lopez^aff1d2, Homyk, Kelsey^aff1d3, Liu, Liling^aff1d5, La, Hank^aff1d5, Mao, Jialin^aff1d5, de la Cruz, Cecile C.^aff1d3, Yu, Kebing^aff1d4, Beresini, Maureen^aff1d1, Forrest, William F.^aff1d6, Xiao, Yang^aff1d2, Jang, Anne^aff2, Samus, Natalia^aff2, Stesco, Nicholas Dupuis^aff2, Mentinova, Marija^aff2, Parent, Stephane^aff2, Pottiez, Gwenael^aff2, Schirm, Michael^aff2, Purkey, Hans E.^aff1d7, Liu, Yichin^aff1d1, Merchant, Mark^aff1d2

High-Throughput Kinetic Characterization of Irreversible Covalent Inhibitors of KRASG12C by Intact Protein MS and Targeted MRM

Li, Ke Sherry^aff1, Quinn, John G.^aff1, Saabye, Matthew J.^aff2, Guerrero, Jesus F. Salcido^aff1, Nonomiya, Jim^aff1, Lian, Qihui^aff3, Phung, Wilson^aff4, Izrayelit, Yevgeniy^aff1, Walters, Benjamin T.^aff1, Gustafson, Amy^aff1, Endres, Nicholas F.^aff1, Beresini, Maureen H.^aff1, Mulvihill, Melinda M.^aff1

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Design of Organo-Peptides As Bipartite PCSK9 Antagonists

Burdick, Daniel J.^aff1d1, Skelton, Nicholas J.^aff1d1, Ultsch, Mark^aff1d2, Beresini, Maureen H.^aff1d3, Eigenbrot, Charles^aff1d2, Li, Wei^aff1d4, Zhang, Yingnan^aff1d4, Nguyen, Huy^aff1d1, Kong-Beltran, Monica^aff1d5, Quinn, John G.^aff1d3, Kirchhofer, Daniel^aff1d4

GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1‑like

Wang, Shumei^aff1, Tsui, Vickie^aff1, Crawford, Terry D.^aff1, Audia, James E.^aff2, Burdick, Daniel J.^aff1, Beresini, Maureen H.^aff1, Côté, Alexandre, Cummings, Richard^aff2, Duplessis, Martin^aff2, Flynn, E. Megan^aff1, Hewitt, Michael C.^aff2, Huang, Hon-Ren^aff2, Jayaram, Hariharan^aff2, Jiang, Ying^aff3, Joshi, Shivangi^aff2, Murray, Jeremy^aff1, Nasveschuk, Christopher G.^aff2, Pardo, Eneida^aff2, Poy, Florence^aff2, Romero, F. Anthony^aff1, Tang, Yong^aff2, Taylor, Alexander M.^aff2, Wang, Jian^aff3, Xu, Zhaowu^aff3, Zawadzke, Laura E.^aff2, Zhu, Xiaoyu^aff3, Albrecht, Brian K.^aff2, Magnuson, Steven R.^aff1, Bellon, Steve^aff2, Cochran, Andrea G.^aff1

A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors

Bronner, Sarah M.^aff1, Murray, Jeremy^aff1, Romero, F. Anthony^aff1, Lai, Kwong Wah^aff2, Tsui, Vickie^aff1, Cyr, Patrick^aff1, Beresini, Maureen H.^aff1, de leon Boenig, Gladys^aff1, Chen, Zhongguo^aff2, Choo, Edna F.^aff1, Clark, Kevin R.^aff1, Crawford, Terry D.^aff1, Jayaram, Hariharan^aff3, Kaufman, Susan^aff1, Li, Ruina^aff1, Li, Yingjie^aff2, Liao, Jiangpeng^aff2, Liang, Xiaorong^aff1, Liu, Wenfeng^aff2, Ly, Justin^aff1, Maher, Jonathan^aff1, Wai, John^aff2, Wang, Fei^aff2, Zheng, Aijun^aff2, Zhu, Xiaoyu^aff2, Magnuson, Steven^aff1

GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP)

Romero, F. Anthony^aff1, Murray, Jeremy^aff1, Lai, Kwong Wah^aff2, Tsui, Vickie^aff1, Albrecht, Brian K.^aff3, An, Le^aff1, Beresini, Maureen H.^aff1, de Leon Boenig, Gladys^aff1, Bronner, Sarah M.^aff1, Chan, Emily W.^aff1, Chen, Kevin X.^aff2, Chen, Zhongguo^aff2, Choo, Edna F.^aff1, Clagg, Kyle^aff1, Clark, Kevin^aff1, Crawford, Terry D.^aff1, Cyr, Patrick^aff1, de Almeida Nagata, Denise^aff1, Gascoigne, Karen E.^aff1, Grogan, Jane L.^aff1, Hatzivassiliou, Georgia^aff1, Huang, Wei^aff2, Hunsaker, Thomas L.^aff1, Kaufman, Susan^aff1, Koenig, Stefan G.^aff1, Li, Ruina^aff1, Li, Yingjie^aff2, Liang, Xiaorong^aff1, Liao, Jiangpeng^aff2, Liu, Wenfeng^aff2, Ly, Justin^aff1, Maher, Jonathan^aff1, Masui, Colin^aff1, Merchant, Mark^aff1, Ran, Yingqing^aff1, Taylor, Alexander M.^aff3, Wai, John^aff2, Wang, Fei^aff2, Wei, Xiaocang^aff2, Yu, Dong^aff2, Zhu, Bing-Yan^aff1, Zhu, Xiaoyu^aff2, Magnuson, Steven^aff1

Disruption of IRE1α through its kinase domain attenuates multiple myeloma

Harnoss, Jonathan M, Le Thomas, Adrien, Shemorry, Anna, Marsters, Scot A, Lawrence, David A, Lu, Min, Chen, Yung-Chia Ariel, Qing, Jing, Totpal, Klara, Kan, David, Segal, Ehud, Merchant, Mark, Reichelt, Mike, Wallweber, Heidi Ackerly, Wang, Weiru, Clark, Kevin, Kaufman, Susan, Beresini, Maureen H, Laing, Steven T, Sandoval, Wendy, Lorenzo, Maria, Wu, Jiansheng, Ly, Justin, De Bruyn, Tom, Heidersbach, Amy, Haley, Benjamin, Gogineni, Alvin, Weimer, Robby M, Lee, Dong, Braun, Marie-Gabrielle, Rudolph, Joachim, VanWyngarden, Michael J, Sherbenou, Daniel W, Gomez-Bougie, Patricia, Amiot, Martine, Acosta-Alvear, Diego, Walter, Peter, Ashkenazi, Avi

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Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K)

Castanedo, Georgette M.^aff1, Blaquiere, Nicole^aff1, Beresini, Maureen^aff1, Bravo, Brandon^aff1, Brightbill, Hans^aff1, Chen, Jacob^aff1, Cui, Hai-Feng^aff2, Eigenbrot, Charles^aff1, Everett, Christine^aff1, Feng, Jianwen^aff1, Godemann, Robert^aff3, Gogol, Emily^aff1, Hymowitz, Sarah^aff1, Johnson, Adam^aff1, Kayagaki, Nobuhiko^aff1, Kohli, Pawan Bir^aff1, Knüppel, Kathleen^aff3, Kraemer, Joachim^aff3, Krüger, Susan^aff3, Loke, Pui^aff4, McEwan, Paul^aff4, Montalbetti, Christian^aff4, Roberts, David A.^aff1, Smith, Myron^aff4, Steinbacher, Stefan^aff5, Sujatha-Bhaskar, Swathi^aff1, Takahashi, Ryan^aff1, Wang, Xiaolu^aff3, Wu, Lawren C.^aff1, Zhang, Yamin^aff2, Staben, Steven T.^aff1

Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300

Crawford, Terry D.^aff1, Romero, F. Anthony^aff1, Lai, Kwong Wah^aff2, Tsui, Vickie^aff1, Taylor, Alexander M.^aff3, de Leon Boenig, Gladys^aff1, Noland, Cameron L.^aff1, Murray, Jeremy^aff1, Ly, Justin^aff1, Choo, Edna F.^aff1, Hunsaker, Thomas L.^aff1, Chan, Emily W.^aff1, Merchant, Mark^aff1, Kharbanda, Samir^aff1, Gascoigne, Karen E.^aff1, Kaufman, Susan^aff1, Beresini, Maureen H.^aff1, Liao, Jiangpeng^aff2, Liu, Wenfeng^aff2, Chen, Kevin X.^aff2, Chen, Zhongguo^aff2, Conery, Andrew R.^aff3, Côté, Alexandre^aff3, Jayaram, Hariharan^aff3, Jiang, Ying^aff2, Kiefer, James R.^aff1, Kleinheinz, Tracy^aff1, Li, Yingjie^aff2, Maher, Jonathan^aff1, Pardo, Eneida^aff3, Poy, Florence^aff3, Spillane, Kerry L.^aff3, Wang, Fei^aff2, Wang, Jian^aff2, Wei, Xiaocang^aff2, Xu, Zhaowu^aff2, Xu, Zhongya^aff2, Yen, Ivana^aff1, Zawadzke, Laura^aff3, Zhu, Xiaoyu^aff2, Bellon, Steven^aff3, Cummings, Richard^aff3, Cochran, Andrea G.^aff1, Albrecht, Brian K.^aff3, Magnuson, Steven^aff1

Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains

Crawford, Terry D.^aff1, Tsui, Vickie^aff1, Flynn, E. Megan^aff1, Wang, Shumei^aff1, Taylor, Alexander M.^aff2, Côté, Alexandre^aff2, Audia, James E.^aff2, Beresini, Maureen H.^aff1, Burdick, Daniel J.^aff1, Cummings, Richard^aff2, Dakin, Les A.^aff2, Duplessis, Martin^aff2, Good, Andrew C.^aff2, Hewitt, Michael C.^aff2, Huang, Hon-Ren^aff2, Jayaram, Hariharan^aff2, Kiefer, James R.^aff1, Jiang, Ying^aff3, Murray, Jeremy^aff1, Nasveschuk, Christopher G.^aff2, Pardo, Eneida^aff2, Poy, Florence^aff2, Romero, F. Anthony^aff1, Tang, Yong^aff2, Wang, Jian^aff3, Xu, Zhaowu^aff3, Zawadzke, Laura E.^aff2, Zhu, Xiaoyu^aff3, Albrecht, Brian K.^aff2, Magnuson, Steven R.^aff1, Bellon, Steve^aff2, Cochran, Andrea G.^aff1

Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

Flygare, John A.^aff1d1, Beresini, Maureen^aff1d2, Budha, Nageshwar^aff1d3, Chan, Helen^aff1d4, Chan, Iris T.^aff1d5, Cheeti, Sravanthi^aff1d3, Cohen, Frederick^aff1d1, Deshayes, Kurt^aff1d6, Doerner, Karl^aff1d7, Eckhardt, S. Gail^aff2, Elliott, Linda O.^aff1d2, Feng, Bainian^aff1d1, Franklin, Matthew C.^aff1d6, Reisner, Stacy Frankovitz^aff1d2, Gazzard, Lewis^aff1d1, Halladay, Jason^aff1d4, Hymowitz, Sarah G.^aff1d8, La, Hank^aff1d4, LoRusso, Patricia^aff3, Maurer, Brigitte^aff1d8, Murray, Lesley^aff1d7, Plise, Emile^aff1d4, Quan, Clifford^aff1d6, Stephan, Jean-Philippe^aff1d2, Young, Shin G.^aff1d4, Tom, Jeffrey^aff1d6, Tsui, Vickie^aff1d1, Um, Joanne^aff1d1, Varfolomeev, Eugene^aff1d6, Vucic, Domagoj^aff1d6, Wagner, Andrew J.^aff4, Wallweber, Heidi J. A.^aff1d8, Wang, Lan^aff1d1, Ware, Joseph^aff1d3, Wen, Zhaoyang^aff1d1, Wong, Harvey^aff1d4, Wong, Jonathan M.^aff1d1, Wong, Melisa^aff1d1, Wong, Susan^aff1d4, Yu, Ron^aff1d9, Zobel, Kerry^aff1d6, Fairbrother, Wayne J.^aff1d6

Identification of BRaf-Sparing Amino-Thienopyrimidines with Potent IRE1α Inhibitory Activity

Beveridge, Ramsay E.^aff1, Wallweber, Heidi Ackerly^aff2, Ashkenazi, Avi^aff2, Beresini, Maureen^aff2, Clark, Kevin R.^aff2, Gibbons, Paul^aff2, Ghiro, Elise^aff1, Kaufman, Susan^aff2, Larivée, Alexandre^aff1, Leblanc, Melissa^aff1, Leclerc, Jean-Philippe^aff1, Lemire, Alexandre^aff1, Ly, Cuong^aff2, Rudolph, Joachim^aff2, Schwarz, Jacob B.^aff2, Srivastava, Sanjay^aff1, Wang, Weiru^aff2, Zhao, Liang^aff1, Braun, Marie-Gabrielle^aff2

Selective α4β7 Integrin Antagonists and Their Potential as Antiinflammatory Agents

Dubree, Nathan J. P., Artis, Dean R., Castanedo, Georgette, Marsters, James, Sutherlin, Daniel, Caris, Lisa, Clark, Kevin, Keating, Susan M., Beresini, Maureen H., Chiu, Henry, Fong, Sherman, Lowman, Henry B., Skelton, Nicholas J., Jackson, David Y.

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Synthesis and Screening of Linear and Cyclic Oligocarbamate Libraries. Discovery of High Affinity Ligands for GPIIb/IIIa

Cho, Charles Y., Youngquist, R. Scott, Paikoff, Sari J., Beresini, Maureen H., Hebert, Andrea R., Berleau, Lea T., Liu, Corey W., Wemmer, David E., Keough, Thomas, Schultz, Peter G.

Orally Active Fibrinogen Receptor Antagonists. 2. Amidoximes as Prodrugs of Amidines †

Weller, Thomas, Alig, Leo, Beresini, Maureen, Blackburn, Brent, Bunting, Stuart, Hadváry, Paul, Hürzeler Müller, Marianne, Knopp, Dietmar, Levet-Trafit, Bernard, Lipari, M. Terry, Modi, Nishit B., Müller, Marcel, Refino, Canio J., Schmitt, Monique, Schönholzer, Peter, Weiss, Sabine, Steiner, Beat

Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors

Chernov-Rogan, Tania, Li, Tianbo, Lu, Gang, Verschoof, Henry, Khakh, Kuldip, Jones, Steven W., Beresini, Maureen H., Liu, Chang, Ortwine, Daniel F., McKerrall, Steven J., Hackos, David H., Sutherlin, Daniel, Cohen, Charles J., Chen, Jun