Search Results - "Blood–brain barrier"

Breaking the Barrier: The Role of Proinflammatory Cytokines in BBB Dysfunction.

Gryka-Marton M; Laboratory of the Blood-Brain Barrier, Department of Biophysics, Physiology & Pathophysiology, Faculty of Health Sciences, Medical University of Warsaw, Chalubinskiego 5, 02-004 Warsaw, Poland., Grabowska AD; Laboratory of the Blood-Brain Barrier, Department of Biophysics, Physiology & Pathophysiology, Faculty of Health Sciences, Medical University of Warsaw, Chalubinskiego 5, 02-004 Warsaw, Poland., Szukiewicz D; Laboratory of the Blood-Brain Barrier, Department of Biophysics, Physiology & Pathophysiology, Faculty of Health Sciences, Medical University of Warsaw, Chalubinskiego 5, 02-004 Warsaw, Poland.

Journal Article; Review , 2025

Andrographolide attenuates PM2.5-induced blood-brain barrier damage via antioxidant and PI3K/AKT/mTOR/NRF2 pathways.

Kang K; School of Public Health, Fudan University, Shanghai 200032, China; Department of Research and Surveillance Evaluation, Shanghai Municipal Center for Health Promotion, Shanghai 200040, China., Zhang Y; Department of Nutrition and Food Hygiene, School of Public Health, Ningxia Medical University, Yinchuan 750004, China., Geng Y; Department of Research and Surveillance Evaluation, Shanghai Municipal Center for Health Promotion, Shanghai 200040, China., Wang D; Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Huangpu District, Shanghai 200025, China. Electronic address: wdpboj@126.com., Zheng P; School of Public Health, Fudan University, Shanghai 200032, China. Electronic address: zpinpin@shmu.edu.cn.

Journal Article , 2025

Regulation of blood-brain barrier integrity by brain microvascular endothelial cells in ischemic stroke: A therapeutic opportunity.

Tang Z; School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, 430070, China. Electronic address: t2980512223@163.com., Li R; Department of Biostatistics, Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY, USA., Guo X; Beijing Tiantan Hospital, Capital Medical University, Beijing, 10070, China; China National Clinical Research Center for Neurological Diseases, Beijing, 10070, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, 10070, China., Wang Z; School of Basic Medical Sciences, Guangxi Medical University, Nanning, 530021, China; Department of Pharmacology, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan, 440070, China., Wu J; School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, 430070, China; Beijing Tiantan Hospital, Capital Medical University, Beijing, 10070, China; China National Clinical Research Center for Neurological Diseases, Beijing, 10070, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, 10070, China; Department of Pharmacology, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan, 440070, China. Electronic address: biojpwu@whut.edu.cn.

Journal Article; Review , 2025

Potential role of Amyloid-β on the association between Orexin-A and blood-brain barrier leakage of globus pallidus in Alzheimer's disease and dementia with lewy bodies.

Gan J; Department of Neurology, Beijing Friendship Hospital, Capital Medical University, 95 Yong An Road, Xi Cheng District, Beijing, 100050, China., Xu Z; Center for Biomedical Imaging Research, School of Biomedical Engineering, Tsinghua University, No.30 Shuangqing Road, Haidian District, Beijing, 100084, China., Wen C; Department of Neurology, Beijing Tiantan Hospital, National Clinical Research Center for Neurological Diseases, Capital Medical University, No. 119 Nansihuan Xilu, Fengtai, Beijing, 100070, China., Wu H; Department of Neurology, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, 6 Jizhao Road, Jinnan District, Tianjin, 300350, China., Chen Z; Department of Neurology, Beijing Friendship Hospital, Capital Medical University, 95 Yong An Road, Xi Cheng District, Beijing, 100050, China., Shi Z; Department of Neurology, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, 6 Jizhao Road, Jinnan District, Tianjin, 300350, China., Lu H; Department of Radiology, Tianjin Huanhu Hospital, 6 Jizhao Road, Jinnan District, Tianjin, 300350, China., Wang Y; Center for Biomedical Imaging Research, School of Biomedical Engineering, Tsinghua University, No.30 Shuangqing Road, Haidian District, Beijing, 100084, China., Liu S; Department of Neurology, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, 6 Jizhao Road, Jinnan District, Tianjin, 300350, China. ShuaiL@tmu.edu.cn., Ji Y; Department of Neurology, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, 6 Jizhao Road, Jinnan District, Tianjin, 300350, China. jiyong@ccmu.edu.cn.

Journal Article , 2025

Kisspeptin-54 Restores Blood-Brain Barrier Integrity via GATA-4 in Ischemic Stroke.

Shan W; Department of Anesthesiology, Lishui People's Hospital, Wenzhou Medical University Lishui Hospital, Lishui, China., Lan H; Department of Anesthesiology, Lishui People's Hospital, Wenzhou Medical University Lishui Hospital, Lishui, China., Wu Y; Department of Anesthesiology, Lishui People's Hospital, Wenzhou Medical University Lishui Hospital, Lishui, China., Xu Q; Department of Anesthesiology, Lishui People's Hospital, Wenzhou Medical University Lishui Hospital, Lishui, China., You M; Department of Anesthesiology, Lishui People's Hospital, Wenzhou Medical University Lishui Hospital, Lishui, China., Ma R; Department of Anesthesiology, Lishui People's Hospital, Wenzhou Medical University Lishui Hospital, Lishui, China.

Journal Article , 2025

Progression of experimental autoimmune encephalomyelitis in mice and neutrophil-mediated blood-brain barrier dysfunction requires non-muscle myosin light chain kinase.

Beard RS Jr; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.; Department of Biological Sciences, Boise State University, Boise, ID, USA.; Biomedical Research Institute, Boise State University, Boise, ID, USA., Hoettels BA; Department of Biological Sciences, Boise State University, Boise, ID, USA.; Biomedical Research Institute, Boise State University, Boise, ID, USA., McAllister JM; Department of Biological Sciences, Boise State University, Boise, ID, USA.; Biomedical Research Institute, Boise State University, Boise, ID, USA., Meegan JE; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA., Wertz TS; Department of Biological Sciences, Boise State University, Boise, ID, USA.; Biomedical Research Institute, Boise State University, Boise, ID, USA., Self DA; Department of Biological Sciences, Boise State University, Boise, ID, USA.; Biomedical Research Institute, Boise State University, Boise, ID, USA., Hrkach DE; Department of Biological Sciences, Boise State University, Boise, ID, USA.; Biomedical Research Institute, Boise State University, Boise, ID, USA., Greiner D; Department of Biological Sciences, Boise State University, Boise, ID, USA., Chapman K; Department of Biological Sciences, Boise State University, Boise, ID, USA.; Biomedical Research Institute, Boise State University, Boise, ID, USA., Villalba N; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA., Yang X; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA., Cha BJ; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA., Jorcyk CL; Department of Biological Sciences, Boise State University, Boise, ID, USA., Oxford JT; Department of Biological Sciences, Boise State University, Boise, ID, USA.; Biomedical Research Institute, Boise State University, Boise, ID, USA., Wu MH; Department of Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL, USA., Yuan SY; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.; Department of Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

Journal Article , 2025

Pericyte-Assisted Vascular Lumen Organization in a Novel Dynamic Human Blood-Brain Barrier-on-Chip Model.

Guarino V; Department of Experimental Medicine, University of Salento, Lecce, 73100, Italy.; NANOTEC Institute of Nanotechnology, Consiglio Nazionale delle Ricerche (CNR), Lecce, 73100, Italy., Perrone E; NANOTEC Institute of Nanotechnology, Consiglio Nazionale delle Ricerche (CNR), Lecce, 73100, Italy., De Luca E; NANOTEC Institute of Nanotechnology, Consiglio Nazionale delle Ricerche (CNR), Lecce, 73100, Italy.; CBN Center for Biomolecular Nanotechnologies, Istituto Italiano di Tecnologia (IIT), Arnesano, 73010, Italy., Rainer A; Department of Engineering, Università Campus bio-Medico di Roma, Rome, 00128, Italy.; Fondazione Policlinico Universitario Campus Bio-Medico di Roma, Rome, 00128, Italy., Cesaria M; NANOTEC Institute of Nanotechnology, Consiglio Nazionale delle Ricerche (CNR), Lecce, 73100, Italy., Zizzari A; NANOTEC Institute of Nanotechnology, Consiglio Nazionale delle Ricerche (CNR), Lecce, 73100, Italy., Bianco M; NANOTEC Institute of Nanotechnology, Consiglio Nazionale delle Ricerche (CNR), Lecce, 73100, Italy., Gigli G; Department of Experimental Medicine, University of Salento, Lecce, 73100, Italy.; NANOTEC Institute of Nanotechnology, Consiglio Nazionale delle Ricerche (CNR), Lecce, 73100, Italy., Moroni L; NANOTEC Institute of Nanotechnology, Consiglio Nazionale delle Ricerche (CNR), Lecce, 73100, Italy.; MERLN Institute for Technology-Inspired Regenerative Medicine, department of complex tissue regeneration, Maastricht University, Maastricht, 6211 LK, The Netherlands., Arima V; NANOTEC Institute of Nanotechnology, Consiglio Nazionale delle Ricerche (CNR), Lecce, 73100, Italy.

Journal Article , 2025

Blood-brain barrier dysfunction in multiple system atrophy: A human postmortem study.

Gabdulkhaev R; Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan., Shimizu H; Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan., Kanazawa M; Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan., Kuroha Y; Department of Neurology, NHO Nishiniigata Chuo Hospital, Niigata, Japan., Hasegawa A; Department of Neurology, NHO Nishiniigata Chuo Hospital, Niigata, Japan., Idezuka J; Department of Neurology, Ojiya Sakura Hospital, Niigata, Japan., Tainaka K; Department of System Pathology for Neurological Disorders, Center for Bioresources, Brain Research Institute, Niigata University, Niigata, Japan., Onodera O; Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan., Kakita A; Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.

Journal Article , 2025

Δ ⁹ -tetrahydrocannabinol induces blood-brain barrier disruption: Involving the activation of CB1R and oxidative stress.

Zhang Q; NHC Key Laboratory of Drug Addiction Medicine, School of Forensic Medicine, Kunming Medical University, Kunming, China., Huang W; NHC Key Laboratory of Drug Addiction Medicine, School of Forensic Medicine, Kunming Medical University, Kunming, China., Li T; NHC Key Laboratory of Drug Addiction Medicine, School of Forensic Medicine, Kunming Medical University, Kunming, China., Wang X; NHC Key Laboratory of Drug Addiction Medicine, School of Forensic Medicine, Kunming Medical University, Kunming, China., Lai X; NHC Key Laboratory of Drug Addiction Medicine, School of Forensic Medicine, Kunming Medical University, Kunming, China., Hu W; NHC Key Laboratory of Drug Addiction Medicine, School of Forensic Medicine, Kunming Medical University, Kunming, China., Li Z; NHC Key Laboratory of Drug Addiction Medicine, School of Forensic Medicine, Kunming Medical University, Kunming, China., Zeng X; NHC Key Laboratory of Drug Addiction Medicine, School of Forensic Medicine, Kunming Medical University, Kunming, China. Electronic address: zxf2004033@163.com., Huang J; NHC Key Laboratory of Drug Addiction Medicine, School of Forensic Medicine, Kunming Medical University, Kunming, China. Electronic address: huang_jian77@163.com., Zhang R; NHC Key Laboratory of Drug Addiction Medicine, School of Forensic Medicine, Kunming Medical University, Kunming, China. Electronic address: zrlorg@126.com.

Journal Article , 2025

Alcohol diminishes barrier integrity in human stem cell-derived brain microvascular endothelial cells: Role of reactive oxygen species.

Bell KT; Indiana University School of Medicine, Terre Haute, IN, USA; Indiana State University, Terre Haute, IN, USA., Hughes JM; Indiana University School of Medicine, Terre Haute, IN, USA., Borman WA; Indiana University School of Medicine, Terre Haute, IN, USA., Stoffel RD; Indiana University School of Medicine, Terre Haute, IN, USA., Canfield SG; Indiana University School of Medicine, Terre Haute, IN, USA. Electronic address: sccanfie@iu.edu.

Journal Article , 2025

Inhibiting 15-PGDH blocks blood-brain barrier deterioration and protects mice from Alzheimer's disease and traumatic brain injury.

Koh Y; Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals, Cleveland Medical Center, Cleveland, OH 44106.; Geriatric Psychiatry, Geriatric Research Education and Clinical Center, Louis Stokes Veterans Affairs Medical Center, Cleveland, OH 44106.; Institute for Transformative Molecular Medicine, School of Medicine Case Western Reserve University, Cleveland, OH 44106.; Department of Pathology, School of Medicine Case Western Reserve University, Cleveland, OH 44106., Vázquez-Rosa E; Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals, Cleveland Medical Center, Cleveland, OH 44106.; Geriatric Psychiatry, Geriatric Research Education and Clinical Center, Louis Stokes Veterans Affairs Medical Center, Cleveland, OH 44106.; Institute for Transformative Molecular Medicine, School of Medicine Case Western Reserve University, Cleveland, OH 44106.; Department of Pathology, School of Medicine Case Western Reserve University, Cleveland, OH 44106., Gao F; Department of Genetics and Genome Sciences School of Medicine, Case Western Reserve University, Cleveland, OH 44106., Li H; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106., Chakraborty S; Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21205., Tripathi SJ; Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21205., Barker S; Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals, Cleveland Medical Center, Cleveland, OH 44106.; Geriatric Psychiatry, Geriatric Research Education and Clinical Center, Louis Stokes Veterans Affairs Medical Center, Cleveland, OH 44106.; Institute for Transformative Molecular Medicine, School of Medicine Case Western Reserve University, Cleveland, OH 44106.; Department of Pathology, School of Medicine Case Western Reserve University, Cleveland, OH 44106., Bud Z; Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals, Cleveland Medical Center, Cleveland, OH 44106.; Geriatric Psychiatry, Geriatric Research Education and Clinical Center, Louis Stokes Veterans Affairs Medical Center, Cleveland, OH 44106.; Institute for Transformative Molecular Medicine, School of Medicine Case Western Reserve University, Cleveland, OH 44106.; Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH 44106., Bangalore A; Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals, Cleveland Medical Center, Cleveland, OH 44106.; Institute for Transformative Molecular Medicine, School of Medicine Case Western Reserve University, Cleveland, OH 44106.; Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106., Kandjoze UP; Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals, Cleveland Medical Center, Cleveland, OH 44106.; Institute for Transformative Molecular Medicine, School of Medicine Case Western Reserve University, Cleveland, OH 44106.; Department of Psychology, Neuroscience Program Earlham College, Richmond, IN 47374., León-Alvarado RA; Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals, Cleveland Medical Center, Cleveland, OH 44106.; Institute for Transformative Molecular Medicine, School of Medicine Case Western Reserve University, Cleveland, OH 44106.; Department of Psychology, Neuroscience Program Earlham College, Richmond, IN 47374., Sridharan PS; Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals, Cleveland Medical Center, Cleveland, OH 44106.; Geriatric Psychiatry, Geriatric Research Education and Clinical Center, Louis Stokes Veterans Affairs Medical Center, Cleveland, OH 44106.; Institute for Transformative Molecular Medicine, School of Medicine Case Western Reserve University, Cleveland, OH 44106.; Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106., Cordova BA; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106., Yu Y; Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals, Cleveland Medical Center, Cleveland, OH 44106.; Geriatric Psychiatry, Geriatric Research Education and Clinical Center, Louis Stokes Veterans Affairs Medical Center, Cleveland, OH 44106.; Institute for Transformative Molecular Medicine, School of Medicine Case Western Reserve University, Cleveland, OH 44106.; University of Toledo College of Medicine and Life Sciences, Toledo, OH 43606., Hyung J; Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals, Cleveland Medical Center, Cleveland, OH 44106.; Institute for Transformative Molecular Medicine, School of Medicine Case Western Reserve University, Cleveland, OH 44106., Fang H; Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals, Cleveland Medical Center, Cleveland, OH 44106.; Institute for Transformative Molecular Medicine, School of Medicine Case Western Reserve University, Cleveland, OH 44106.; Hathaway Brown School, Shaker Heights, OH 44122.; Massachusetts Institute of Technology, Cambridge, MA 02139., Singh S; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106.; Center for Immunotherapy and Precision Immuno-Oncology, Lerner Research Institute Cleveland Clinic, Cleveland, OH 44195., Katabathula R; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106., LaFramboise T; Department of Genetics and Genome Sciences School of Medicine, Case Western Reserve University, Cleveland, OH 44106.; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106., Kasturi L; Department of Medicine, School of Medicine Case Western Reserve University, Cleveland, OH 44106., Lutterbaugh J; Department of Medicine, School of Medicine Case Western Reserve University, Cleveland, OH 44106., Beard L; Department of Medicine, School of Medicine Case Western Reserve University, Cleveland, OH 44106., Cordova E; Department of Medicine, School of Medicine Case Western Reserve University, Cleveland, OH 44106., Cintrón-Pérez CJ; Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals, Cleveland Medical Center, Cleveland, OH 44106.; Geriatric Psychiatry, Geriatric Research Education and Clinical Center, Louis Stokes Veterans Affairs Medical Center, Cleveland, OH 44106.; Institute for Transformative Molecular Medicine, School of Medicine Case Western Reserve University, Cleveland, OH 44106., Franke K; Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals, Cleveland Medical Center, Cleveland, OH 44106.; Geriatric Psychiatry, Geriatric Research Education and Clinical Center, Louis Stokes Veterans Affairs Medical Center, Cleveland, OH 44106.; Institute for Transformative Molecular Medicine, School of Medicine Case Western Reserve University, Cleveland, OH 44106., Fragoso MF; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106., Miller E; Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals, Cleveland Medical Center, Cleveland, OH 44106.; Geriatric Psychiatry, Geriatric Research Education and Clinical Center, Louis Stokes Veterans Affairs Medical Center, Cleveland, OH 44106.; Institute for Transformative Molecular Medicine, School of Medicine Case Western Reserve University, Cleveland, OH 44106.; Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106., Indrakumar V; Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals, Cleveland Medical Center, Cleveland, OH 44106.; Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106., Noel KL; Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals, Cleveland Medical Center, Cleveland, OH 44106.; Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106., Dhar M; Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals, Cleveland Medical Center, Cleveland, OH 44106.; Geriatric Psychiatry, Geriatric Research Education and Clinical Center, Louis Stokes Veterans Affairs Medical Center, Cleveland, OH 44106.; Institute for Transformative Molecular Medicine, School of Medicine Case Western Reserve University, Cleveland, OH 44106., Ajroud K; Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Department of Pathology, Northwestern University, Chicago, IL 60611., Zamudio C; Department of Pathology, Northwestern University, Chicago, IL 60611., Lopes FBTP; Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.; Center for Proteomics and Bioinformatics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106., Bambakidis E; Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals, Cleveland Medical Center, Cleveland, OH 44106.; Geriatric Psychiatry, Geriatric Research Education and Clinical Center, Louis Stokes Veterans Affairs Medical Center, Cleveland, OH 44106.; Institute for Transformative Molecular Medicine, School of Medicine Case Western Reserve University, Cleveland, OH 44106.; Northwestern University Weinberg College of Arts and Sciences, Chicago, IL 60208., Zhu X; Department of Pathology, School of Medicine Case Western Reserve University, Cleveland, OH 44106., Wilson B; Geriatric Psychiatry, Geriatric Research Education and Clinical Center, Louis Stokes Veterans Affairs Medical Center, Cleveland, OH 44106.; Department of Infectious Diseases and HIV Medicine, Case Western Reserve University, Cleveland, OH 44106., Flanagan ME; Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Department of Pathology, Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health San Antonio, San Antonio, TX 78229., Gefen T; Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Fujioka H; Cryo-Electron Microscopy Core Case, School of Medicine, Western Reserve University, Cleveland, OH 44016., Fink SP; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106., Desai AB; Department of Pathology, School of Medicine Case Western Reserve University, Cleveland, OH 44106.; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106., Dawson D; Department of Pathology, School of Medicine Case Western Reserve University, Cleveland, OH 44106.; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106., Williams NS; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390., Kim YK; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea., Ready JM; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390., Paul BD; Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.; Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.; The Solomon H. Snyder Department of Neuroscience, School of Medicine Johns Hopkins University, Baltimore, MD 21205.; Lieber Institute for Brain Development, Baltimore, MD 21205., Shin MK; Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals, Cleveland Medical Center, Cleveland, OH 44106.; Geriatric Psychiatry, Geriatric Research Education and Clinical Center, Louis Stokes Veterans Affairs Medical Center, Cleveland, OH 44106.; Institute for Transformative Molecular Medicine, School of Medicine Case Western Reserve University, Cleveland, OH 44106.; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Markowitz SD; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106.; Department of Medicine, School of Medicine Case Western Reserve University, Cleveland, OH 44106.; Seidman Cancer Center, University Hospitals Cleveland Medical Center, Cleveland, OH 44106., Pieper AA; Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals, Cleveland Medical Center, Cleveland, OH 44106.; Geriatric Psychiatry, Geriatric Research Education and Clinical Center, Louis Stokes Veterans Affairs Medical Center, Cleveland, OH 44106.; Institute for Transformative Molecular Medicine, School of Medicine Case Western Reserve University, Cleveland, OH 44106.; Department of Pathology, School of Medicine Case Western Reserve University, Cleveland, OH 44106.; Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.

Journal Article , 2025

Imaging a concussion and the ensuing immune response at the blood-brain barrier.

Nguyen RH; Department of Pharmacology and Physiology, University of Calgary, Calgary T2N1N4, AB, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, Calgary T2N1N4, AB, Canada., Newton M; Department of Pharmacology and Physiology, University of Calgary, Calgary T2N1N4, AB, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, Calgary T2N1N4, AB, Canada., Kratofil RM; Department of Pharmacology and Physiology, University of Calgary, Calgary T2N1N4, AB, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, Calgary T2N1N4, AB, Canada., Scott BNV; Department of Pharmacology and Physiology, University of Calgary, Calgary T2N1N4, AB, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, Calgary T2N1N4, AB, Canada., Castanheira F; Department of Pharmacology and Physiology, University of Calgary, Calgary T2N1N4, AB, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, Calgary T2N1N4, AB, Canada., Kim JS; Department of Immunology and Biological Regeneration, Weizmann Institute of Science, Rehovot 76100, Israel., Ginhoux F; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore 138648, Singapore.; Gustave Roussy Cancer Campus, Villejuif 94800, France., Jung S; Department of Immunology and Biological Regeneration, Weizmann Institute of Science, Rehovot 76100, Israel., Kubes P; Department of Pharmacology and Physiology, University of Calgary, Calgary T2N1N4, AB, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, Calgary T2N1N4, AB, Canada.

Journal Article , 2025

Endothelial TREM-1 mediates sepsis-induced blood‒brain barrier disruption and cognitive impairment via the PI3K/Akt pathway.

Su Y; State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, School of Basic Medicine Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100005, China.; Neuroscience Center, Chinese Academy of Medical Sciences, Beijing, 100005, China., Zhu W; State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, School of Basic Medicine Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100005, China.; Neuroscience Center, Chinese Academy of Medical Sciences, Beijing, 100005, China., Su T; State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, School of Basic Medicine Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100005, China.; Neuroscience Center, Chinese Academy of Medical Sciences, Beijing, 100005, China., Huang L; State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, School of Basic Medicine Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100005, China.; Neuroscience Center, Chinese Academy of Medical Sciences, Beijing, 100005, China., Qin M; Emergency Department, The State Key Laboratory of Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China., Wang Q; State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, School of Basic Medicine Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100005, China.; Neuroscience Center, Chinese Academy of Medical Sciences, Beijing, 100005, China., Xu Q; State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, School of Basic Medicine Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100005, China. xuqi@pumc.edu.cn.; Neuroscience Center, Chinese Academy of Medical Sciences, Beijing, 100005, China. xuqi@pumc.edu.cn., Li Y; Emergency Department, The State Key Laboratory of Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China. billliyi@126.com., Xiu J; State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, School of Basic Medicine Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100005, China. xiujianbo@ibms.cams.cn.; Neuroscience Center, Chinese Academy of Medical Sciences, Beijing, 100005, China. xiujianbo@ibms.cams.cn.; State Key Laboratory of Complex, Severe, and Rare Diseases, Beijing, 100005, China. xiujianbo@ibms.cams.cn.

Journal Article , 2025

Effects of M. tuberculosis and HIV-1 infection on in vitro blood-brain barrier function.

Proust A; The Francis Crick Institute, Midland Road, London, NW1 1AT, UK. alize.proust@crick.ac.uk., Wilkinson KA; The Francis Crick Institute, Midland Road, London, NW1 1AT, UK.; Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, Department of Medicine, University of Cape Town, Observatory, 7925, Republic of South Africa., Wilkinson RJ; The Francis Crick Institute, Midland Road, London, NW1 1AT, UK.; Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, Department of Medicine, University of Cape Town, Observatory, 7925, Republic of South Africa.; Department of Infectious Diseases, Imperial College London, London, W12 0NN, UK.

Journal Article , 2025

Advances in brain-targeted delivery strategies and natural product-mediated enhancement of blood-brain barrier permeability.

Liu S; State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China., Jin X; State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China., Ge Y; NMPA Key Laboratory for Bioequivalence Research of Generic Drug Evaluation, Shenzhen Institute for Drug Control, Shenzhen, 518057, China., Dong J; NMPA Key Laboratory for Bioequivalence Research of Generic Drug Evaluation, Shenzhen Institute for Drug Control, Shenzhen, 518057, China., Liu X; NMPA Key Laboratory for Bioequivalence Research of Generic Drug Evaluation, Shenzhen Institute for Drug Control, Shenzhen, 518057, China., Pei X; NMPA Key Laboratory for Bioequivalence Research of Generic Drug Evaluation, Shenzhen Institute for Drug Control, Shenzhen, 518057, China., Wang P; NMPA Key Laboratory for Bioequivalence Research of Generic Drug Evaluation, Shenzhen Institute for Drug Control, Shenzhen, 518057, China., Wang B; NMPA Key Laboratory for Bioequivalence Research of Generic Drug Evaluation, Shenzhen Institute for Drug Control, Shenzhen, 518057, China. wangbingszyj@163.com., Chang Y; State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. tcmcyx@tjutcm.edu.cn., Yu XA; NMPA Key Laboratory for Bioequivalence Research of Generic Drug Evaluation, Shenzhen Institute for Drug Control, Shenzhen, 518057, China. yuxieanalj@126.com.

Journal Article; Review , 2025

NLRP3 activation induces BBB disruption and neutrophil infiltration via CXCR2 signaling in the mouse brain.

Lee J; Department of Anatomy, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea., Cho W; Department of Anatomy, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea., Yu JW; Department of Microbiology and Immunology, Graduate School of Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Brain Korea 21 Project, Seoul, Republic of Korea., Hyun YM; Department of Anatomy, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea. ymhyun@yuhs.ac.

Journal Article , 2025

Injectable nanocomposite hydrogel for localized precision delivery of dexamethasone after traumatic brain injury: dual modulation of neuroinflammation and blood-brain barrier restoration.

Zhang B; Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China., Bai M; Department of Neurology, The First Hospital of Tsinghua University, Beijing, China., Yang M; Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China., Wang Y; Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China., Chen X; Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China., Liu B; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. liubaiyun1212@163.com., Shi G; Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. shiguangzhi@bjtth.org.

Journal Article , 2025

Aducanumab delivery via focused ultrasound-induced transient blood-brain barrier opening in vivo.

Jeong J; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.; Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (K- MEDIhub), Daegu, South Korea., Han M; Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (K- MEDIhub), Daegu, South Korea., Jeon S; Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (K- MEDIhub), Daegu, South Korea., Kim Y; Preclinical Research Center, Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDIhub), Daegu, South Korea., Choi HJ; Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (K- MEDIhub), Daegu, South Korea., Choi W; Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (K- MEDIhub), Daegu, South Korea., Kwon K; Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (K- MEDIhub), Daegu, South Korea., Choi JR; Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (K- MEDIhub), Daegu, South Korea. jongryul32@kmedihub.re.kr., Lee EH; Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (K- MEDIhub), Daegu, South Korea. ehlee@kmedihub.re.kr.

Journal Article , 2025

Breaking the fortress: a mechanistic review of meningitis-causing bacteria breaching tactics in blood brain barrier.

Quan Y; College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471000, China.; Henan Provincial Engineering Research Center for Detection and Prevention and Control of Emerging Infectious Diseases in Livestock and Poultry, Luoyang, 471003, China., Wang Y; College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471000, China.; Henan Provincial Engineering Research Center for Detection and Prevention and Control of Emerging Infectious Diseases in Livestock and Poultry, Luoyang, 471003, China., Gao S; College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471000, China.; Henan Provincial Engineering Research Center for Detection and Prevention and Control of Emerging Infectious Diseases in Livestock and Poultry, Luoyang, 471003, China., Yuan S; College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471000, China.; Henan Provincial Engineering Research Center for Detection and Prevention and Control of Emerging Infectious Diseases in Livestock and Poultry, Luoyang, 471003, China., Song S; College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471000, China.; Henan Provincial Engineering Research Center for Detection and Prevention and Control of Emerging Infectious Diseases in Livestock and Poultry, Luoyang, 471003, China., Liu B; College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471000, China. bobbyliu515@163.com.; Henan Provincial Engineering Research Center for Detection and Prevention and Control of Emerging Infectious Diseases in Livestock and Poultry, Luoyang, 471003, China. bobbyliu515@163.com., Wang Y; College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471000, China. wangyocean@163.com.; Henan Provincial Engineering Research Center for Detection and Prevention and Control of Emerging Infectious Diseases in Livestock and Poultry, Luoyang, 471003, China. wangyocean@163.com.

Journal Article; Review , 2025

Tailored Mesoporous Silica Nanoparticles and the Chick Chorioallantoic Membrane: A Promising Strategy and Model for Efficient Blood-Brain Barrier Crossing.

Lin CK; Graduate Institute of Biomedical Materials Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 110, Taiwan., Yang YS; Department of Neurosurgery, Taipei Medical University Hospital, Taipei 110, Taiwan., Liu TP; Department of Surgery, MacKay Memorial Hospital, Taipei 104, Taiwan., Lin JC; Department of Surgery, MacKay Memorial Hospital, Taipei 104, Taiwan.; MacKay Junior College of Medicine, Nursing and Management, New Taipei 252, Taiwan., Bupphathong S; Graduate Institute of Nanomedicine and Medical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 110, Taiwan., Tamanoi F; Institute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University, Kyoto 606-8501, Japan., Chen YP; Graduate Institute of Nanomedicine and Medical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 110, Taiwan.; International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 110, Taiwan.

Journal Article , 2025