Search Results - "C-MYC"

SGLT2i delays c-Myc-induced HCC progression via targeting mTOR.

Rao H; School of Basic Medical Sciences, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, People's Republic of China; Department of Medical Engineering, The First Affiliated Hospital of Army Medical University, Chongqing 400000, People's Republic of China., An X; School of Basic Medical Sciences, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, People's Republic of China., Qu X; School of Basic Medical Sciences, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, People's Republic of China., Yu J; School of Basic Medical Sciences, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, People's Republic of China; Department of Anesthesiology, People's Hospital of Yunxi County of Hubei Province, Yunxi 442600, People's Republic of China., Xie J; School of Basic Medical Sciences, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, People's Republic of China., Ke J; Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan 442000, People's Republic of China., Liu Z; Shiyan Key Laboratory of Virology, Hubei University of Medicine, Shiyan 442000, People's Republic of China., You L; Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan 442000, People's Republic of China., Qiu Z; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, People's Republic of China., Tian L; Department of Pathology, Renming Hospital, Hubei University of Medicine, Shiyan 442000, People's Republic of China., Du W; Department of Pathology, Renming Hospital, Hubei University of Medicine, Shiyan 442000, People's Republic of China., Li W; School of Basic Medical Sciences, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, People's Republic of China., Jia J; School of Basic Medical Sciences, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, People's Republic of China; Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan 442000, People's Republic of China. Electronic address: jiajie@hbmu.edu.cn., Liu D; School of Basic Medical Sciences, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, People's Republic of China; Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan 442000, People's Republic of China. Electronic address: liudanwen@hbmu.edu.cn., Li S; School of Basic Medical Sciences, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, People's Republic of China; Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan 442000, People's Republic of China. Electronic address: lishan@hbmu.edu.cn.

Journal Article; Research Support, Non-U.S. Gov't , 2025

c-Myc-dependent LAMP3 regulates the proliferation, metastasis and metabolic reprogramming of tongue squamous cell carcinoma.

Feng J; Department of Stomatology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huaian, 223300, Jiangsu, China., He W; Department of Stomatology, The People's Hospital of Suichang Country, Lishui, 323300, Zhejiang, China., Fang J; Department of Stomatology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huaian, 223300, Jiangsu, China. fangjin_0088@163.com.

Journal Article , 2025

Overexpression of c-Myc triggers p62 aggregation-mediated mitochondrial mitophagy in cabozantinib resistance of hepatocellular carcinoma.

Yang K; Department of Hepatobiliary Surgery and Liver Transplantation, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.; Key Laboratory of Surgical Critical Care and Life Support (Xi'an Jiaotong University), Ministry of Education, Xi'an, 710004, China., Zhang X; Department of Hepatobiliary Surgery and Liver Transplantation, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.; Key Laboratory of Surgical Critical Care and Life Support (Xi'an Jiaotong University), Ministry of Education, Xi'an, 710004, China., Yang K; Department of Hepatobiliary Surgery and Liver Transplantation, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.; Key Laboratory of Surgical Critical Care and Life Support (Xi'an Jiaotong University), Ministry of Education, Xi'an, 710004, China., Liu S; Key Laboratory of Surgical Critical Care and Life Support (Xi'an Jiaotong University), Ministry of Education, Xi'an, 710004, China.; Department of Surgical Intensive Care Unit, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China., Zhang J; Key Laboratory of Surgical Critical Care and Life Support (Xi'an Jiaotong University), Ministry of Education, Xi'an, 710004, China.; Department of Surgical Intensive Care Unit, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China., Fu Y; Key Laboratory of Surgical Critical Care and Life Support (Xi'an Jiaotong University), Ministry of Education, Xi'an, 710004, China., Liu T; Department of Hepatobiliary Surgery and Liver Transplantation, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.; Key Laboratory of Surgical Critical Care and Life Support (Xi'an Jiaotong University), Ministry of Education, Xi'an, 710004, China., Wu K; Department of Hepatobiliary Surgery and Liver Transplantation, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.; Key Laboratory of Surgical Critical Care and Life Support (Xi'an Jiaotong University), Ministry of Education, Xi'an, 710004, China., Li J; Department of Hepatobiliary Surgery and Liver Transplantation, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.; Key Laboratory of Surgical Critical Care and Life Support (Xi'an Jiaotong University), Ministry of Education, Xi'an, 710004, China., Liu C; Department of Hepatobiliary Surgery and Liver Transplantation, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China. liuchangfh@xjtu.edu.cn.; Key Laboratory of Surgical Critical Care and Life Support (Xi'an Jiaotong University), Ministry of Education, Xi'an, 710004, China. liuchangfh@xjtu.edu.cn., Huang Q; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Physiology and Pathophysiology, Fourth Military Medical University, Xi'an, 710032, China. huangqichao@fmmu.edu.cn., Qu K; Department of Hepatobiliary Surgery and Liver Transplantation, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China. qukai001@xjtu.edu.cn.; Key Laboratory of Surgical Critical Care and Life Support (Xi'an Jiaotong University), Ministry of Education, Xi'an, 710004, China. qukai001@xjtu.edu.cn.

Journal Article , 2025

Column Chromatography-Free Synthesis of Spirooxindole and Spiroindanone-Based Naphthalimides as Potent c-MYC G4 Stabilizers and HSA Binders for Elevating Anticancer Potential.

Jain A; Department of Chemistry and Biochemistry, Thapar Institute of Engineering and Technology, Patiala 147001, India., Paul K; Department of Chemistry and Biochemistry, Thapar Institute of Engineering and Technology, Patiala 147001, India.

Journal Article , 2025

Circaea mollis Siebold & Zucc. Induces Apoptosis in Colorectal Cancer Cells by Inhibiting c-Myc Through the Mediation of RPL5.

Park SM; College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.; Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea., Kim N; College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.; Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea., Park YR; College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.; Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea., Kim SW; College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.; Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea., Jung JH; College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.; Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea., Na YC; Metropolitan Seoul Center, Korea Basic Science Institute, Seoul 03759, Republic of Korea., Kwon D; Department of Microbiology, College of Medicine, Catholic Kwandong University, Gangneung 25601, Republic of Korea., Kim H; Department of Korean Rehabilitation Medicine, Kyung Hee University Medical Center, Seoul 02447, Republic of Korea., Jang HJ; College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.; Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.

Journal Article , 2025

Innovative evaluation of selinexor and JQ1 synergy in leukemia therapy via C-MYC inhibition.

Wang PH; Department of Hematology, Guangzhou First People's Hospital, Institute of Blood Transfusion and Hematology, Guangzhou Medical University, Guangzhou, Guangdong, 500020, China. wangph91@163.com., Hu CH; Department of Hematology, Guangzhou First People's Hospital, Institute of Blood Transfusion and Hematology, Guangzhou Medical University, Guangzhou, Guangdong, 500020, China., Fan JQ; Department of Hematology, Guangzhou First People's Hospital, Institute of Blood Transfusion and Hematology, Guangzhou Medical University, Guangzhou, Guangdong, 500020, China., He JJ; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, P. R. China., Deng TF; Department of Hematology, Guangzhou First People's Hospital, Institute of Blood Transfusion and Hematology, Guangzhou Medical University, Guangzhou, Guangdong, 500020, China., Xu YL; Department of Hematology, Guangzhou First People's Hospital, Institute of Blood Transfusion and Hematology, Guangzhou Medical University, Guangzhou, Guangdong, 500020, China., Dai YJ; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, P. R. China. daiyj@sysucc.org.cn., Wang SQ; Department of Hematology, Guangzhou First People's Hospital, Institute of Blood Transfusion and Hematology, Guangzhou Medical University, Guangzhou, Guangdong, 500020, China. eywangshq@scut.edu.cn.

Journal Article , 2025

JS-K induces ferroptosis in renal carcinoma cells by regulating the c-Myc-GSTP1 Axis.

Zhao Y; Laboratory of Urology, Affiliated Hospital of Guangdong Medical University, 57 Renmin Street South, Zhanjiang, 524001, Guangdong, China., Zhu L; Laboratory of Urology, Affiliated Hospital of Guangdong Medical University, 57 Renmin Street South, Zhanjiang, 524001, Guangdong, China., Lin X; Laboratory of Urology, Affiliated Hospital of Guangdong Medical University, 57 Renmin Street South, Zhanjiang, 524001, Guangdong, China., Li B; Laboratory of Urology, Affiliated Hospital of Guangdong Medical University, 57 Renmin Street South, Zhanjiang, 524001, Guangdong, China., Miu B; Laboratory of Urology, Affiliated Hospital of Guangdong Medical University, 57 Renmin Street South, Zhanjiang, 524001, Guangdong, China., Qiu J; Laboratory of Urology, Affiliated Hospital of Guangdong Medical University, 57 Renmin Street South, Zhanjiang, 524001, Guangdong, China., Gao S; Laboratory of Urology, Affiliated Hospital of Guangdong Medical University, 57 Renmin Street South, Zhanjiang, 524001, Guangdong, China., Liu J; Laboratory of Urology, Affiliated Hospital of Guangdong Medical University, 57 Renmin Street South, Zhanjiang, 524001, Guangdong, China. jianjunliulab@163.com.

Journal Article , 2025

Natural Product Daidzin Inhibits Glioma Development via Suppressing the LRP5-Mediated GSK-3β/c-Myc Signaling Pathway.

Pan Y; Hubei Provincial Engineering Technology Research Center for Chinese Medicine Processing, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China., Wang S; Hubei Provincial Engineering Technology Research Center for Chinese Medicine Processing, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China., Duan G; Chongqing University Three Gorges Hospital, and School of Medicine Chongqing University, Chongqing, People's Republic of China., Wu J; Hubei Provincial Engineering Technology Research Center for Chinese Medicine Processing, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China., Feng F; Hubei Provincial Engineering Technology Research Center for Chinese Medicine Processing, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.; Hubei Shizhen Laboratory, Wuhan, China., Chen L; School of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan, China., Li A; School of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan, China., Xu K; Hubei Provincial Engineering Technology Research Center for Chinese Medicine Processing, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.; Hubei Shizhen Laboratory, Wuhan, China., Wang C; Hubei Shizhen Laboratory, Wuhan, China.; School of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan, China., Fan S; Chongqing University Three Gorges Hospital, and School of Medicine Chongqing University, Chongqing, People's Republic of China.; Department of Pediatric Neurosurgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Journal Article , 2025

c-Myc knockdown restores tamoxifen sensitivity in triple-negative breast cancer by reactivating the expression of ERα: the central role of miR-152 and miR-148a.

Dong C; Department of Breast and Thyroid Surgery, the Clinical Medical Research Center of Breast and Thyroid Tumor in Xinjiang, The Affiliated Tumor Hospital of Xinjiang Medical University, No. 789 Suzhou East Street, Urumqi, 830000, Xinjiang Uygur Autonomous Region, China., Sun Y; Department of Central Operating Room, The Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang Uygur Autonomous Region, China., Xu X; Department of Breast and Thyroid Surgery, the Clinical Medical Research Center of Breast and Thyroid Tumor in Xinjiang, The Affiliated Tumor Hospital of Xinjiang Medical University, No. 789 Suzhou East Street, Urumqi, 830000, Xinjiang Uygur Autonomous Region, China., Li H; Department of Breast and Thyroid Surgery, the Clinical Medical Research Center of Breast and Thyroid Tumor in Xinjiang, The Affiliated Tumor Hospital of Xinjiang Medical University, No. 789 Suzhou East Street, Urumqi, 830000, Xinjiang Uygur Autonomous Region, China., Song X; Department of Breast and Thyroid Surgery, the Clinical Medical Research Center of Breast and Thyroid Tumor in Xinjiang, The Affiliated Tumor Hospital of Xinjiang Medical University, No. 789 Suzhou East Street, Urumqi, 830000, Xinjiang Uygur Autonomous Region, China., Wei W; Department of Breast and Thyroid Surgery, the Clinical Medical Research Center of Breast and Thyroid Tumor in Xinjiang, The Affiliated Tumor Hospital of Xinjiang Medical University, No. 789 Suzhou East Street, Urumqi, 830000, Xinjiang Uygur Autonomous Region, China., Jiao C; Department of Breast and Thyroid Surgery, the Clinical Medical Research Center of Breast and Thyroid Tumor in Xinjiang, The Affiliated Tumor Hospital of Xinjiang Medical University, No. 789 Suzhou East Street, Urumqi, 830000, Xinjiang Uygur Autonomous Region, China., Xu H; Department of Breast and Thyroid Surgery, the Clinical Medical Research Center of Breast and Thyroid Tumor in Xinjiang, The Affiliated Tumor Hospital of Xinjiang Medical University, No. 789 Suzhou East Street, Urumqi, 830000, Xinjiang Uygur Autonomous Region, China., Liu Y; Department of Breast and Thyroid Surgery, the Clinical Medical Research Center of Breast and Thyroid Tumor in Xinjiang, The Affiliated Tumor Hospital of Xinjiang Medical University, No. 789 Suzhou East Street, Urumqi, 830000, Xinjiang Uygur Autonomous Region, China., Mierzhakenmu Z; Department of Breast and Thyroid Surgery, the Clinical Medical Research Center of Breast and Thyroid Tumor in Xinjiang, The Affiliated Tumor Hospital of Xinjiang Medical University, No. 789 Suzhou East Street, Urumqi, 830000, Xinjiang Uygur Autonomous Region, China., Li L; Department of Gynecological Oncology (First Ward), The Affiliated Tumor Hospital of Xinjiang Medical University, No. 789 Suzhou East Street, Urumqi, 830000, Xinjiang Uygur Autonomous Region, China. 15699212127@163.com., Ma B; Department of Breast and Thyroid Surgery, the Clinical Medical Research Center of Breast and Thyroid Tumor in Xinjiang, The Affiliated Tumor Hospital of Xinjiang Medical University, No. 789 Suzhou East Street, Urumqi, 830000, Xinjiang Uygur Autonomous Region, China. 18099193595@163.com.

Journal Article , 2025

RNF112 Facilitates Ubiquitin-Mediated Degradation of c-Myc, Suppressing Proliferation, Migration and Lipid Synthesis in Bladder Cancer.

Xiong K; Department of Urology, Hubei Key Laboratory of Urological Diseases, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China., Chen S; Department of Urology, Hubei Key Laboratory of Urological Diseases, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China., Xu H; Department of Obstetrics and Gynecology Ultrasound, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China., Tu S; Department of Urology, Hubei Key Laboratory of Urological Diseases, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China., Weng H; Department of Urology, Hubei Key Laboratory of Urological Diseases, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.; Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China., Wang Y; Department of Urology, Sir Run Run Shaw Hospital of Zhejiang University, Hangzhou, 310016, China., Li M; Department of Urology, Hubei Key Laboratory of Urological Diseases, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China., Yu J; Department of Urology, Hubei Key Laboratory of Urological Diseases, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China., Qian K; Department of Biological Repositories, Human Genetic Resource Preservation Center of Hubei Province, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China., Ju L; Department of Biological Repositories, Human Genetic Resource Preservation Center of Hubei Province, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China., Zhang Y; Department of Biological Repositories, Human Genetic Resource Preservation Center of Hubei Province, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.; Euler Technology, ZGC Life Sciences Park, Beijing, 102206, China.; Center for Quantitative Biology, School of Life Sciences, Peking University, Beijing, 100091, China., Xiao Y; Department of Biological Repositories, Human Genetic Resource Preservation Center of Hubei Province, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.; Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, 430071, China., Wang X; Department of Urology, Hubei Key Laboratory of Urological Diseases, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.; Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Wuhan University, Wuhan, 430071, China., Wang G; Department of Urology, Hubei Key Laboratory of Urological Diseases, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.; Department of Biological Repositories, Human Genetic Resource Preservation Center of Hubei Province, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.

Journal Article , 2025

PDCD11 Stabilizes C-MYC Oncoprotein by Hindering C-MYC-SKP2 Negative Feedback Loop to Facilitate Progression of p53-Mutant Breast and Colon Malignancies.

Ding L; College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, 225009, China., Ni W; College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, 225009, China., Ma Y; Department of General Surgery, Institute of General Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, China., Xu L; College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, 225009, China., Zhang Z; College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, 225009, China., Liao K; College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, 225009, China., Li J; College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, 225009, China., Mei X; College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, 225009, China., Wang Z; College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, 225009, China., Ge H; College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, 225009, China., Li J; College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, 225009, China., Tang D; Department of General Surgery, Institute of General Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, China., Zhang X; College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, 225009, China.

Journal Article , 2025

Targeting BARD1 suppresses a Myc-dependent transcriptional program and tumor growth in pancreatic ductal adenocarcinoma.

Patel S; Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA., Jenkins E; Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA., Kusurkar RP; Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA., Lee S; Department of Pathology and Genomic Medicine, Thomas Jefferson University, Philadelphia, PA, USA., Jiang W; Department of Pathology and Genomic Medicine, Thomas Jefferson University, Philadelphia, PA, USA., Nevler A; Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA., McCoy M; Innovation Center for Biomedical Informatics & Lombardi Comprehensive Cancer Center, Washington, DC, USA., Pishvaian MJ; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Sears RC; Department of Molecular and Medical Genetics, and Brenden-Colson Center for Pancreatic Care Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA., Brody JR; Department of Surgery, and Brenden-Colson Center for Pancreatic Care Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA., Yeo CJ; Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA., Jain A; Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address: aditi.jain@jefferson.edu.

Journal Article , 2025

CircRNA-mTOR Promotes Hepatocellular Carcinoma Progression and Lenvatinib Resistance Through the PSIP1/c-Myc Axis.

Tang Y; Department of Hepatobiliary Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China.; Department of General Surgery, Qilu Hospital, Shandong University, Jinan, 250012, China., Yuan F; Department of Hepatobiliary Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China.; Department of Hepatobiliary Surgery, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510120, China., Cao M; Department of Hepatobiliary Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China., Ren Y; Department of Hepatobiliary Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China., Li Y; Department of Hepatobiliary Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China., Yang G; Department of Hepatobiliary Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China., Zhong Z; Department of Hepatobiliary Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China.; Department of Kidney Transplantation, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China., Liang H; Department of Hepatobiliary and Pancreatic Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China., Xiong Z; Department of Hepatobiliary and Pancreatic Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China., He Z; Department of Hepatobiliary Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China., Lin N; Department of Hepatobiliary Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China., Deng M; Department of Hepatobiliary Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China., Yao Z; Department of Hepatobiliary and Pancreatic Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China.

Journal Article , 2025

DCAF13 influences breast cancer chemotherapy resistance through metabolic reprogramming by regulating c-Myc expression.

Bai S; Department of Pathology, The 966th Hospital of The PLA Joint Logistic Support Force, Dandong, 118000, China., Hu Y; Department of Emergency and Intensive Care Unit, The 966th Hospital of The PLA Joint Logistic Support Force, Dandong, 118000, China., Chen N; Department of Pathology, The 966th Hospital of The PLA Joint Logistic Support Force, Dandong, 118000, China., Zhou L; Department of General Surgery, The 966th Hospital of The PLA Joint Logistic Support Force, Dandong, 118000, China., Ju W; Medical College of Liaodong University, Dandong, 118003, China., Qiao X; Department of General Surgery, The 966th Hospital of The PLA Joint Logistic Support Force, Dandong, 118000, China., Yu J; Department of General Surgery, The 966th Hospital of The PLA Joint Logistic Support Force, Dandong, 118000, China. yujianyu3614@gmail.com.

Journal Article , 2025

RBMS1 promotes the proliferation of glioma cells via regulation of the c-Myc-SSH1 axis.

Gu S; Department of Neurosurgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210006, China., Wu W; Department of Neurosurgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210006, China., Wu C; Medical School, Nantong University, Nantong, Jiangsu, 226001, China., Miao Z; Department of Neurosurgery, The Affiliated Wuxi No.2 People's Hospital, Nanjing Medical University, Wuxi, Jiangsu, 214002, China., Fan Y; Department of Neurosurgery, The Affiliated Wuxi No.2 People's Hospital, Nanjing Medical University, Wuxi, Jiangsu, 214002, China., Tian W; Department of Neurosurgery, The Affiliated Wuxi No.2 People's Hospital, Nanjing Medical University, Wuxi, Jiangsu, 214002, China; Wuxi Neurosurgical Institute, Wuxi, Jiangsu, 214002, China. Electronic address: a983314518@126.com., Wu Y; Department of Neurosurgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210006, China. Electronic address: wyztdnj@126.com.

Journal Article , 2025

N-myc downstream-regulated gene 2, co-regulated by transcription factors c-MYC and SP1, reduces cell proliferation by interacting with mTOR in GBM.

Tang T; Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China; Brain Research Innovation and Transformation Laboratory, Xuanwu Hospital Capital Medical University, Beijing, China; Department of Neurosurgery, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China., Liang H; Department of Neurosurgery, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China; Department of Neurosurgery, The First Affiliated Hospital, Guangxi Medical University, Nanning, China., Han Y; Department of Neurosurgery, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China., Cong Z; Department of Neurosurgery, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China., Wang H; Department of Neurosurgery, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China; Department of Neurosurgery, Benq Medical Center, Nanjing Medical University, Nanjing, China. Electronic address: njhdwang@hotmail.com., Wei P; Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China; Brain Research Innovation and Transformation Laboratory, Xuanwu Hospital Capital Medical University, Beijing, China. Electronic address: weipenghu2005@126.com., Zhao G; Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China; Brain Research Innovation and Transformation Laboratory, Xuanwu Hospital Capital Medical University, Beijing, China; Beijing Municipal Geriatric Medical Research Center, Beijing 100053, China. Electronic address: ggzhao@vip.sina.com.

Journal Article; Research Support, Non-U.S. Gov't , 2025

Structure-based artificial intelligence-aided design of MYC-targeting degradation drugs for cancer therapy.

Liu D; Department of Urology, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China., Jiang Y; Department of Urology, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China., Ma B; Department of Urology, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China. Electronic address: mabohan2009@sina.com., Li L; Department of Urology, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China. Electronic address: lilydr@163.com.

Journal Article , 2025

Targeting CDK7 Enhances the Antitumor Efficacy of Enzalutamide in Androgen Receptor-Positive Triple-Negative Breast Cancer by Inhibiting c-MYC-mediated Tumorigenesis.

Xie X; Section of Translational Breast Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Manai M; Section of Translational Breast Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Rampa DR; Section of Translational Breast Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Fuson JA; Section of Translational Breast Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Nakasone ES; Cancer Biology Program, University of Hawai'i Cancer Center, Honolulu, Hawai'i., Pearson T; Section of Translational Breast Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Kuntal BS; Cancer Biology Program, University of Hawai'i Cancer Center, Honolulu, Hawai'i., Tripathy D; Section of Translational Breast Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Ueno NT; Section of Translational Breast Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Lee J; Section of Translational Breast Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Journal Article , 2025

Inhibition of tumor-intrinsic NAT10 enhances antitumor immunity by triggering type I interferon response via MYC/CDK2/DNMT1 pathway.

Liu WC; Department of Hematology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, P.R. China.; Department of Clinical Laboratory, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, P.R. China., Wei YH; Department of Hematology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, P.R. China., Chen JF; Suzhou Institute of Nano-Tech and Nano-Bionics (SINANO), Chinese Academy of Sciences, Suzhou, 215123, Jiangsu, P.R. China., Xing XL; Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, P.R. China., Jia HX; Department of Hematology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, P.R. China., Yang XY; Department of Hematology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, P.R. China., Huang YJ; Department of Dermatology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, P.R. China., Liu XM; Department of Hematology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, P.R. China., Xiao K; Department of Clinical Laboratory, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, P.R. China., Guo XD; Department of Hematology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, P.R. China., Can C; Department of Hematology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, P.R. China., Zhang AM; Department of Hematology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, P.R. China., He N; Department of Hematology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, P.R. China., Zhang HL; Department of Hematology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, P.R. China., Ma DX; Department of Hematology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, P.R. China. daoxinma@sdu.edu.cn.

Journal Article , 2025

Engineered Peptide Coacervates Enable Efficient Intracellular Delivery of the MYC Inhibitor omoMYC.

Cerrato CP; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 171 65 Stockholm, Sweden., Krkoška M; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 171 65 Stockholm, Sweden.; Research Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic., Sun Y; Centre for Sustainable Materials, School of Materials Science and Engineering, Nanyang Technological University (NTU), 50 Nanyang Avenue, Singapore 637553, Singapore., Liaño-Pons J; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 171 65 Stockholm, Sweden., Neo QY; Centre for Sustainable Materials, School of Materials Science and Engineering, Nanyang Technological University (NTU), 50 Nanyang Avenue, Singapore 637553, Singapore., Vosselman T; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 171 65 Stockholm, Sweden., Alzrigat M; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 171 65 Stockholm, Sweden., Vojtěšek B; Research Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic., Lane DP; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 171 65 Stockholm, Sweden., Arsenian Henriksson M; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 171 65 Stockholm, Sweden., Miserez A; Centre for Sustainable Materials, School of Materials Science and Engineering, Nanyang Technological University (NTU), 50 Nanyang Avenue, Singapore 637553, Singapore.; School of Biological Sciences, Nanyang Technological University (NTU), 60 Nanyang Drive, Singapore 637551, Singapore., Landreh M; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 171 65 Stockholm, Sweden.; Department of Cell and Molecular Biology, Uppsala University, 751 24 Uppsala, Sweden.

Journal Article , 2025