Sökresultat - "CP: Metabolism"

Combined inhibition of de novo glutathione and nucleotide biosynthesis is synthetically lethal in glioblastoma

Udutha, Suresh, Taglang, Céline, Batsios, Georgios, Gillespie, Anne Marie, Tran, Meryssa, Hoeve, Johanna Ten, Graeber, Thomas G, Viswanath, Pavithra

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The FIRE biosensor illuminates iron regulatory protein activity and cellular iron homeostasis.

Sangokoya, Carolyn

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Insulin and leptin oscillations license food-entrained browning and metabolic flexibility

Mattar, Pamela, Reginato, Andressa, Lavados, Christian, Das, Debajyoti, Kalyani, Manu, Martinez-Lopez, Nuria, Sharma, Mridul, Skovbjerg, Grethe, Skytte, Jacob Lercke, Roostalu, Urmas, Subbarayan, Rajasekaran, Picarda, Elodie, Zang, Xingxing, Zhang, Jinghang, Guha, Chandan, Schwartz, Gary, Rajbhandari, Prashant, Singh, Rajat

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LPD-3 as a megaprotein brake for aging and insulin-mTOR signaling in C. elegans.

Pandey, Taruna, Wang, Bingying, Wang, Changnan, Zu, Jenny, Deng, Huichao, Shen, Kang, do Vale, Goncalo, McDonald, Jeffrey, Ma, Dengke

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Opioidergic signaling contributes to food-mediated suppression of AgRP neurons.

Sayar-Atasoy, Nilufer, Yavuz, Yavuz, Laule, Connor, Dong, Chunyang, Kim, Hyojin, Rysted, Jacob, Flippo, Kyle, Davis, Debbie, Aklan, Iltan, Yilmaz, Bayram, Atasoy, Deniz, Tian, Lin

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The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity

Chao Wang, Allon Wagner, Johannes Fessler, David DeTomaso, Sarah Zaghouani, Yulin Zhou, Kerry Pierce, Raymond A. Sobel, Clary Clish, Nir Yosef, Vijay K. Kuchroo

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Cholesterol metabolism regulated by CAMKK2-CREB signaling promotes castration-resistant prostate cancer

Chenchu Lin, Thomas L. Pulliam, Jenny J. Han, Jiaqian Xu, Carlos Vera Recio, Sandi R. Wilkenfeld, Yan Shi, Manoj Kushwaha, Sarah Bench, Eduardo Ruiz, Sanjanaa Senthilkumar, Jayasurya Dileep, Peter D.A. Shepherd, Nora M. Navone, Albert R. Klekers, Elizabeth M. Whitley, Michael M. Ittmann, Livia S. Eberlin, Wenyi Wang, Daniel E. Frigo

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Endosymbiont control through non-canonical immune signaling and gut metabolic remodeling

Sofie Burgmer, Fenja L. Meyer zu Altenschildesche, Akos Gyenis, Hyun Ju Lee, David Vilchez, Patrick Giavalisco, Arnaud Fichant, Mirka Uhlirova, Gilles Storelli

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Cell death and cancer: Metabolic interconnections

Destiny Dalseno, Nikolai Gajic, Lyndsey Flanagan, Stephen W.G. Tait

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Immune imprinting blunts omicron pathogenicity fluctuations and highlights the essential role of cellular immunity in SARS-CoV-2 infection

Xiaohui Wei, Hekai Yang, Jing Wu, Binbin Zhao, Yameng Mu, Na Rong, Gengxin Zhang, Wanjun Peng, Lihong Zhang, Wei Zhang, Xiaoyue Ding, Gaoying Zhang, Zhihai Chen, Jiangning Liu

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A lncRNA-mediated metabolic rewiring of cell senescence

Elena Grossi, Francesco P. Marchese, Jovanna González, Enrique Goñi, José Miguel Fernández-Justel, Alicia Amadoz, Nicolás Herranz, Leonor Puchades-Carrasco, Marta Montes, Maite Huarte

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Exploring adipose tissue-derived extracellular vesicles in inter-organ crosstalk: Implications for metabolic regulation and adipose tissue function

Soazig Le Lay, Philipp E. Scherer

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De novo serine biosynthesis is protective in mitochondrial disease

Christopher B. Jackson, Anastasiia Marmyleva, Geoffray Monteuuis, Ryan Awadhpersad, Takayuki Mito, Nicola Zamboni, Takashi Tatsuta, Amy E. Vincent, Liya Wang, Nahid A. Khan, Thomas Langer, Christopher J. Carroll, Anu Suomalainen

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The m5C methyltransferase NSUN2 promotes progression of acute myeloid leukemia by regulating serine metabolism

Songyu Li, Ya Liu, Xiang Wu, Minjia Pan, Hongxia Zhao, Yunguang Hong, Qinghua Zhang, Shushu Hu, Aorong Ouyang, Guangru Li, Minhui Wu, Shanshan Fan, Zhirong Jia, Shanchao Zhao, Guocai Wu, Xiangwei Gao, Zhigang Yang, Zhanghui Chen

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Mitochondrial GCN5L1 coordinates with YME1L and MICOS to remodel mitochondrial cristae in white adipocytes and modulate obesity

Juan Xu, Qiqi Zhang, Xinyu Yang, Qiqi Tang, Yitong Han, Jiahui Meng, Jiaqi Zhang, Xin Lu, Danni Wang, Jing Liu, Bo Shan, Xue Bai, Kai Zhang, Longhao Sun, Lingdi Wang, Lu Zhu

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Essential role of hepcidin in host resistance to disseminated candidiasis

Tanmay Arekar, Divya Katikaneni, Sadat Kasem, Dhruv Desai, Thrisha Acharya, Augustina Cole, Nazli Khodayari, Sophie Vaulont, Bernhard Hube, Elizabeta Nemeth, Alexander Drakesmith, Michail S. Lionakis, Borna Mehrad, Yogesh Scindia

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Mitochondrial Ca2+ controls pancreatic cancer growth and metastasis by regulating epithelial cell plasticity

Jillian S. Weissenrieder, Jessica Peura, Usha Paudel, Nikita Bhalerao, Natalie Weinmann, Calvin Johnson, Maximilian Wengyn, Rebecca Drager, Emma Elizabeth Furth, Karl Simin, Marcus Ruscetti, Ben Z. Stanger, Anil K. Rustgi, Jason R. Pitarresi, J. Kevin Foskett

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Heterozygous Kmt2d loss diminishes enhancers to render medulloblastoma cells vulnerable to combinatory inhibition of LSD1 and OXPHOS

Shilpa S. Dhar, Calena Brown, Ali Rizvi, Lauren Reed, Sivareddy Kotla, Constantin Zod, Janak Abraham, Jun-Ichi Abe, Veena Rajaram, Kaifu Chen, Min Gyu Lee

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Loss of neurofibromin induces inflammatory macrophage phenotypic switch and retinal neovascularization via GLUT1 activation

Yusra Zaidi, Rebekah Tritz, Nida Zaidi, Faisal Nabi, Syed Adeel H. Zaidi, Abdelhakim Morsy, Valerie Harris, Rilee Racine, Farlyn Z. Hudson, Zsuzsanna Bordan, Simone Kennard, Robert Batori, Yuqing Huo, Gabor Csanyi, Eric J. Belin de Chantemèle, Kecheng Lei, Nicholas M. Boulis, David J. Fulton, Rizwan Hasan Khan, Ruth B. Caldwell, Brian K. Stansfield

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Peroxisomes are critical for a unique metabolic demand and survival of alveolar macrophages

Mai Matsushita, Jonathan Muri, Ivan Berest, Fengqi Li, Huan Liu, Basak Corak, Nicola Zamboni, Joerg Buescher, Alaa Othman, Mauro Corrado, Jovana Cupovic, Sabine Werner, Werner Kovacs, Manfred Kopf

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