Search Results - "CYP2D6"

Clinical and pharmacogenomic predictors of survival in tamoxifen treated breast cancer female patients: a real-world study.

Al-Matrafi AR; Population Health and Genomics, School of Medicine, University of Dundee, Dundee, UK.; Department of Pharmacology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Bedair KF; Population Health and Genomics, School of Medicine, University of Dundee, Dundee, UK., Srinivasan S; Population Health and Genomics, School of Medicine, University of Dundee, Dundee, UK., Palmer C; Population Health and Genomics, School of Medicine, University of Dundee, Dundee, UK., Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.; Usher Institute, University of Edinburgh, Edinburgh Bioquarter, 5-7 Little France Road, Edinburgh, EH16 4UX, UK., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK., Pearson ER; Population Health and Genomics, School of Medicine, University of Dundee, Dundee, UK., Petty RD; Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK. r.petty@dundee.ac.uk.

Journal Article , 2025

Acute Effects and Pharmacokinetics of LSD after Paroxetine or Placebo Pre-Administration in a Randomized, Double-Blind, Cross-Over Phase I Trial.

Becker AM; Clinical Pharmacology and Toxicology, Department of Biomedicine, Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Humbert-Droz M; Clinical Pharmacology and Toxicology, Department of Biomedicine, Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Mueller L; Clinical Pharmacology and Toxicology, Department of Biomedicine, Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Jelušić A; Clinical Pharmacology and Toxicology, Department of Biomedicine, Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Tolev A; Clinical Pharmacology and Toxicology, Department of Biomedicine, Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Straumann I; Clinical Pharmacology and Toxicology, Department of Biomedicine, Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Avedisian I; Clinical Pharmacology and Toxicology, Department of Biomedicine, Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Erne L; Clinical Pharmacology and Toxicology, Department of Biomedicine, Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Thomann J; Clinical Pharmacology and Toxicology, Department of Biomedicine, Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Luethi D; Clinical Pharmacology and Toxicology, Department of Biomedicine, Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Grünblatt E; Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.; Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland., Meyer Zu Schwabedissen H; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Liechti ME; Clinical Pharmacology and Toxicology, Department of Biomedicine, Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.

Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I , 2025

Human CYP2D6 varies across the estrous cycle in brains of transgenic mice altering drug response.

Miksys S; Department of Pharmacology & Toxicology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. Electronic address: s.miksys@utoronto.ca., McDonald C; Department of Pharmacology & Toxicology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada. Electronic address: claire.mcdonald@mail.utoronto.ca., Baghai Wadji F; Department of Pharmacology & Toxicology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada. Electronic address: f.baghaiwadji@utoronto.ca., Gonzalez FJ; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: gonzalef@mail.nih.gov., Tyndale RF; Department of Pharmacology & Toxicology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. Electronic address: r.tyndale@utoronto.ca.

Journal Article , 2024

Inactivation of CYP2D6 by Berberrubine and the Chemical Mechanism.

Rao J; School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, P. R. China.; Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, P. R. China.; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, P. R. China., Wang T; School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, P. R. China.; Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, P. R. China.; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, P. R. China., Yu L; School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, P. R. China., Wang K; School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, P. R. China.; Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, P. R. China., Qiu F; School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, P. R. China.; Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, P. R. China.; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, P. R. China.

Journal Article; Research Support, Non-U.S. Gov't , 2024

Prolonged post-operative hydrocodone usage due to psychotropic drug interaction.

Whitt AG; Department of Pathology and Laboratory Medicine, 5170 University of Louisville , Louisville, KY, USA., Karimi VF; Department of Pathology and Laboratory Medicine, 5170 University of Louisville , Louisville, KY, USA., Gaskins JT; Department of Bioinformatics and Biostatistics, School of Medicine, 5170 University of Louisville , Louisville, KY, USA., Renfrow RE; Department of Pathology and Laboratory Medicine, 5170 University of Louisville , Louisville, KY, USA., Roach AR; Division of Psychology and Neuropsychology, Frazier Rehab Institute, Louisville, KY, USA., Malkani AL; Department of Orthopedic Surgery, School of Medicine, 5170 University of Louisville , Louisville, KY, USA., Hartley B; Department of Orthopedic Surgery, School of Medicine, 5170 University of Louisville , Louisville, KY, USA., Yakkanti MR; Louisville Orthopaedic Clinic, Louisville, KY, USA., Jortani SA; Department of Pathology and Laboratory Medicine, 5170 University of Louisville , Louisville, KY, USA.

Journal Article , 2024

CYP2D6 inhibition by diphenhydramine leading to fatal hydrocodone overdose.

Whitt AG; Department of Pathology and Laboratory Medicine, 5170 University of Louisville School of Medicine , Louisville, KY, USA., Jortani SA; Department of Pathology and Laboratory Medicine, 5170 University of Louisville School of Medicine , Louisville, KY, USA.

Case Reports; Journal Article , 2024

The strong clinical interaction between bupropion and CYP2D6 is primarily mediated through bupropion metabolites and their stereoisomers: A paradigm for evaluating metabolites in drug-drug interaction risk.

Tanaudommongkon I; Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana., Rashidian A; Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana., Gufford BT; Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana., Lu JBL; Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana., Desta Z; Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address: zdesta@iu.edu.

Journal Article , 2025

Association of initiating CYP2D6-metabolized opioids with risks of adverse outcomes in older adults receiving antidepressants: A retrospective cohort study.

Wei YJ; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America., Winterstein AG; Department of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville, Florida, United States of America.; Center for Drug Evaluation and Safety, University of Florida, Gainesville, Florida, United States of America.; Department of Epidemiology, Colleges of Medicine and Public Health & Health Professions, University of Florida, Gainesville, Florida, United States of America., Schmidt S; Department of Community Health and Family Medicine, College of Medicine, University of Florida, Gainesville, Florida, United States of America., Fillingim RB; Pain Research and Intervention Center of Excellence, University of Florida, Gainesville, Florida, United States of America., Daniels MJ; Department of Statistics, College of Liberal Arts and Sciences, University of Florida, Gainesville, Florida, United States of America., DeKosky ST; Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida, United States of America., Schmidt S; Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida, United States of America.

Journal Article , 2025

A Comprehensive CYP2D6 Drug-Drug-Gene Interaction Network for Application in Precision Dosing and Drug Development.

Rüdesheim S; Clinical Pharmacy, Saarland University, Saarbrücken, Germany.; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany., Loer HLH; Clinical Pharmacy, Saarland University, Saarbrücken, Germany., Feick D; Clinical Pharmacy, Saarland University, Saarbrücken, Germany.; Drug Metabolism and Pharmacokinetics, Sanofi R&D, Frankfurt am Main, Germany., Marok FZ; Clinical Pharmacy, Saarland University, Saarbrücken, Germany., Fuhr LM; Clinical Pharmacy, Saarland University, Saarbrücken, Germany., Selzer D; Clinical Pharmacy, Saarland University, Saarbrücken, Germany., Teutonico D; Translational Medicine & Early Development, Sanofi R&D, Vitry-sur-Seine, France., Schneider ARP; Bayer AG, Pharmaceuticals, Research & Development, Model-Informed Drug Development, Leverkusen, Germany., Solodenko J; Bayer AG, Pharmaceuticals, Research & Development, Model-Informed Drug Development, Leverkusen, Germany., Frechen S; Bayer AG, Pharmaceuticals, Research & Development, Model-Informed Drug Development, Leverkusen, Germany., van der Lee M; Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, The Netherlands., Moes DJAR; Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, The Netherlands., Swen JJ; Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, The Netherlands., Schwab M; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.; Departments of Clinical Pharmacology, Pharmacy and Biochemistry, University of Tübingen, Tübingen, Germany.; Cluster of Excellence iFIT (EXC2180) 'Image-guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany., Lehr T; Clinical Pharmacy, Saarland University, Saarbrücken, Germany.

Journal Article , 2025

Solanidine-derived CYP2D6 phenotyping elucidates phenoconversion in multimedicated geriatric patients.

Sarömba JA; Institute of Clinical Pharmacology, University Hospital RWTH Aachen, Aachen, North Rhine-Westphalia, Germany., Müller JP; Institute of Clinical Pharmacology, University Hospital RWTH Aachen, Aachen, North Rhine-Westphalia, Germany., Tupiec J; Institute of Clinical Pharmacology, University Hospital RWTH Aachen, Aachen, North Rhine-Westphalia, Germany., Roeth A; Department of General, Visceral, Pediatric and Transplantation Surgery, University Hospital RWTH Aachen, Aachen, North Rhine-Westphalia, Germany., Kurt B; Department of Internal Medicine I - Cardiology, University Hospital RWTH Aachen, Aachen, North Rhine-Westphalia, Germany., Kahles F; Department of Internal Medicine I - Cardiology, University Hospital RWTH Aachen, Aachen, North Rhine-Westphalia, Germany., Laurentius T; Department of Geriatric Medicine, University Hospital RWTH Aachen, Aachen, North Rhine-Westphalia, Germany.; Department of Geriatrics, Carl von Ossietzky University of Oldenburg, Oldenburg, Lower Saxony, Germany., Bollheimer C; Department of Geriatric Medicine, University Hospital RWTH Aachen, Aachen, North Rhine-Westphalia, Germany., Stingl JC; Institute of Clinical Pharmacology, University Hospital RWTH Aachen, Aachen, North Rhine-Westphalia, Germany., Just KS; Institute of Clinical Pharmacology, University Hospital RWTH Aachen, Aachen, North Rhine-Westphalia, Germany.

Journal Article; Observational Study , 2025

Sex and age effects on prevalence of CYP2C19 and CYP2D6 Phenoconversion risk over time in patients with psychosis.

De Brabander EY; Mental Health and Neuroscience Research Institute, Department of Psychiatry and Neuropsychology, Maastricht University Medical Centre, Maastricht, the Netherlands. Electronic address: Emma.debrabander@maastrichtuniversity.nl., Leibold NK; Mental Health and Neuroscience Research Institute, Department of Psychiatry and Neuropsychology, Maastricht University Medical Centre, Maastricht, the Netherlands., van Amelsvoort T; Mental Health and Neuroscience Research Institute, Department of Psychiatry and Neuropsychology, Maastricht University Medical Centre, Maastricht, the Netherlands., van Westrhenen R; Outpatient Clinic Pharmacogenetics, Parnassia Groep BV, Amsterdam, the Netherlands; Institute of Psychiatry, Psychology & Neurosciences, King's College London, London, United Kingdom; St. John's National Academy of Health Sciences, Bangalore, India.

GROUP Investigators

Journal Article , 2025

Association Between CYP2D6 Genotypes and Serum Concentrations of Mirtazapine and Mianserin.

Hole K; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.; Department of Life Sciences and Health, Oslo Metropolitan University, Oslo, Norway., Molden E; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.; Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, Oslo, Norway.

Journal Article , 2025

Effect of metoprolol exposure following myocardial infarction on future cardiovascular events: a Mendelian randomization study.

Bruun LD; Department of Pharmacology, Oslo University Hospital, Ullevål, PO BOX4956, Nydalen, Oslo, N-0424, Norway. linabruun@yahoo.no., Andersen GØ; Department of Cardiology, Oslo University Hospital, Ullevål, Oslo, Norway., Kringen MK; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.; Department of Health Sciences, Oslo Metropolitan University, Oslo, Norway., Myhre PL; Division of Medicine, Akershus University Hospital, Lørenskog, Norway.; K.G. Jebsen Center of Cardiac Biomarkers, Institute for Clinical Medicine, University of Oslo, Oslo, Norway., Halvorsen S; Department of Cardiology, Oslo University Hospital, Ullevål, Oslo, Norway.; Institute for Clinical Medicine, University of Oslo, Oslo, Norway., Hansen CH; Department of Cardiology, Oslo University Hospital, Ullevål, Oslo, Norway., Molden E; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.; Department of Pharmacy, University of Oslo, Oslo, Norway., Øie E; Institute for Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Internal Medicine, Diakonhjemmet Hospital, Oslo, Norway.

Journal Article , 2025

Evaluation of stabilizing additives to protect activities of cytochrome P450 enzymes for in vitro drug testing and pharmacogenetic studies: Focus on CYP2D6.

Yamoune S; Institute of Clinical Pharmacology, University Hospital of RWTH Aachen, Aachen, Germany. Electronic address: syamoune@ukaachen.de., Koch H; Department of Epileptology, Neurology, RWTH Aachen University Hospital, Aachen, Germany., Delev D; Department of Neurosurgery, RWTH Aachen University Hospital, Aachen, Germany., Weber Y; Department of Epileptology, Neurology, RWTH Aachen University Hospital, Aachen, Germany., Stingl JC; Institute of Clinical Pharmacology, University Hospital of RWTH Aachen, Aachen, Germany.

Journal Article; Research Support, Non-U.S. Gov't , 2025

Mechanism-Based Inactivation of CYP2D6 by Phellopterin and Related Drug-Drug Interaction with Metoprolol.

Cheng Z; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang, Guizhou 550004, P. R. China.; School of Pharmacy, Guizhou Medical University, Guiyang, Guizhou 550004, P. R. China., He Y; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang, Guizhou 550004, P. R. China.; School of Pharmacy, Guizhou Medical University, Guiyang, Guizhou 550004, P. R. China., Chen Y; Department of Pain, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, China.; School of Anesthesiology, Guizhou Medical University, Guiyang, Guizhou 550004, China.; School of Basic Medicine, Guizhou Medical University, Guiyang, Guizhou 550004, China., Zhao G; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China., Liu Y; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang, Guizhou 550004, P. R. China.; School of Basic Medicine, Guizhou Medical University, Guiyang, Guizhou 550004, China., Zhang J; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang, Guizhou 550004, P. R. China.; School of Pharmacy, Guizhou Medical University, Guiyang, Guizhou 550004, P. R. China., Li X; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang, Guizhou 550004, P. R. China.; School of Pharmacy, Guizhou Medical University, Guiyang, Guizhou 550004, P. R. China., Ran G; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang, Guizhou 550004, P. R. China.; School of Pharmacy, Guizhou Medical University, Guiyang, Guizhou 550004, P. R. China., Zhang Q; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang, Guizhou 550004, P. R. China.; School of Pharmacy, Guizhou Medical University, Guiyang, Guizhou 550004, P. R. China., Peng Y; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China., Li W; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang, Guizhou 550004, P. R. China.; School of Pharmacy, Guizhou Medical University, Guiyang, Guizhou 550004, P. R. China., Zheng J; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang, Guizhou 550004, P. R. China.; School of Pharmacy, Guizhou Medical University, Guiyang, Guizhou 550004, P. R. China.; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China.

Journal Article , 2024

Proof of principle concept for the analysis and functional prediction of rare genetic variants in the CYP2C19 and CYP2D6 genes.

Johansson I; Department of Physiology and Pharmacology, Karolinska Institutet, 171 77, Stockholm, Sweden., Lu Y; Department of Physiology and Pharmacology, Karolinska Institutet, 171 77, Stockholm, Sweden., Zhou Y; Department of Physiology and Pharmacology, Karolinska Institutet, 171 77, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden., Krebs K; Estonian Genome Centre, Institute of Genomics, University of Tartu, Riia 23B, 51010, Tartu, Estonia., Akcan M; Department of Physiology and Pharmacology, Karolinska Institutet, 171 77, Stockholm, Sweden., Milani L; Estonian Genome Centre, Institute of Genomics, University of Tartu, Riia 23B, 51010, Tartu, Estonia., Ingelman-Sundberg M; Department of Physiology and Pharmacology, Karolinska Institutet, 171 77, Stockholm, Sweden. magnus.ingelman-sundberg@ki.se.

Journal Article , 2025

Impact of CYP2D6, MAOA, and UGT2B7 genetic variants on recurrence of Plasmodium Vivax in the Brazilian Amazon.

da Silva GS; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, AM, 69040-000, Brazil.; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, AM, 69040-000, Brazil., Fontenelle FA; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, AM, 69040-000, Brazil., Carvalho AO; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, AM, 69040-000, Brazil.; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, AM, 69040-000, Brazil., Macêdo MM; Programa de Pós-Graduação em Ciências Aplicadas a Hematologia, Universidade do Estado do Amazonas, Manaus, AM, 69040-000, Brazil., Morais MC; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, AM, 69040-000, Brazil., Abreu Netto RL; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, AM, 69040-000, Brazil.; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, AM, 69040-000, Brazil., Mwangi VI; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, AM, 69040-000, Brazil.; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, AM, 69040-000, Brazil., Alecrim MGC; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, AM, 69040-000, Brazil.; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, AM, 69040-000, Brazil., Lacerda MVG; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, AM, 69040-000, Brazil.; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, AM, 69040-000, Brazil.; Instituto Leônidas & Maria Deane, Fundação Oswaldo Cruz, Manaus, AM, 69040-000, Brazil., Rodrigues-Soares F; Departamento de Patologia, Genética e Evolução, Instituto de Ciências Biológicas e Naturais, Universidade Federal do Triângulo Mineiro, Uberaba, MG, 35025-250, Brazil., de Almeida ACG; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, AM, 69040-000, Brazil.; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, AM, 69040-000, Brazil.; Programa de Pós-Graduação em Ciências Aplicadas a Hematologia, Universidade do Estado do Amazonas, Manaus, AM, 69040-000, Brazil., de Melo GC; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, AM, 69040-000, Brazil. cardosogisely@gmail.com.; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, AM, 69040-000, Brazil. cardosogisely@gmail.com.; Programa de Pós-Graduação em Ciências Aplicadas a Hematologia, Universidade do Estado do Amazonas, Manaus, AM, 69040-000, Brazil. cardosogisely@gmail.com.; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Avenida Pedro Teixeira, N° 25, Dom Pedro, Manaus, Amazonas, 69040-000, Brazil. cardosogisely@gmail.com.

Journal Article , 2025

Phenoconversion of CYP3A4, CYP2C19 and CYP2D6 in Pediatrics, Adolescents and Young Adults With Lymphoma: Rationale and Design of the PEGASUS Study.

Conyers R; Cancer Therapies Group, Murdoch Children's Research Institute, Parkville, Australia.; Department of Paediatrics, The University of Melbourne, Parkville, Australia.; Children's Cancer Centre, The Royal Children's Hospital, Parkville, Australia., Stenta T; Cancer Therapies Group, Murdoch Children's Research Institute, Parkville, Australia., Somogyi AA; School of Biomedicine, University of Adelaide, Adelaide, Australia., Kirkpatrick C; Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Australia., Halman A; Cancer Therapies Group, Murdoch Children's Research Institute, Parkville, Australia., Wang S; Cancer Therapies Group, Murdoch Children's Research Institute, Parkville, Australia.; Department of Paediatrics, The University of Melbourne, Parkville, Australia.; Department of Pharmacy, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Moore C; Cancer Therapies Group, Murdoch Children's Research Institute, Parkville, Australia.; Department of Paediatrics, The University of Melbourne, Parkville, Australia., Khatri D; Cancer Therapies Group, Murdoch Children's Research Institute, Parkville, Australia., Williams E; Cancer Therapies Group, Murdoch Children's Research Institute, Parkville, Australia., Dyas R; Cancer Therapies Group, Murdoch Children's Research Institute, Parkville, Australia., Spelman T; Department of Health Services Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia., Elliott DA; Cancer Therapies Group, Murdoch Children's Research Institute, Parkville, Australia.; Department of Paediatrics, The University of Melbourne, Parkville, Australia.; The Novo Nordisk Foundation Centre for Stem Cell Medicine, ReNEW, Parkville, Australia., Gwee A; Department of Paediatrics, The University of Melbourne, Parkville, Australia.; Infectious Disease Department, The Royal Children's Hospital, Parkville, Australia.; Antimicrobials Group, Murdoch Children's Research Institute, Parkville, Australia., Alexander M; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.

Journal Article; Clinical Trial Protocol , 2025

Drug-Drug Interaction Studies of Esmethadone (REL-1017) Involving CYP3A4- and CYP2D6-Mediated Metabolism.

Ferri N; Department of Medicine-DIMED, University of Padua, 35122, Padua, Italy. nicola.ferri@unipd.it.; Veneto Institute of Molecular Medicine, Via Giuseppe Orus 2, 35129, Padua, Italy. nicola.ferri@unipd.it., De Martin S; Department of Pharmaceutical and Pharmacological Sciences, University of Padua, 35122, Padua, Italy., Stuart J; Relmada Therapeutics, Coral Gables, FL, 33134, USA., Traversa S; Relmada Therapeutics, Coral Gables, FL, 33134, USA., Folli F; Department of Health Sciences, University of Milan, 20122, Milan, Italy., Pappagallo M; Relmada Therapeutics, Coral Gables, FL, 33134, USA., O'Gorman C; Relmada Therapeutics, Coral Gables, FL, 33134, USA., Guidetti C; Child and Adolescent Neuropsychiatry Unit, Department of Neuroscience, Bambino Pediatric Hospital, IRCCS, Rome, Italy., Mattarei A; Department of Pharmaceutical and Pharmacological Sciences, University of Padua, 35122, Padua, Italy., Inturrisi CE; Relmada Therapeutics, Coral Gables, FL, 33134, USA., Manfredi PL; Relmada Therapeutics, Coral Gables, FL, 33134, USA.

Journal Article; Clinical Trial, Phase I , 2024

Genetic Variability of CYP4F2, CYP2D6, CYP2E1, and ACE in the Chinese Yi Population.

Guo J; Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), School of Life Sciences, Ministry of Education, Northwest University, #229 North TaiBai Road, Xi'an, Shaanxi, 710069, China.; College of Life Science, Northwest University, Xi'an, 710127, China.; Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, 710069, China., Zhou W; Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), School of Life Sciences, Ministry of Education, Northwest University, #229 North TaiBai Road, Xi'an, Shaanxi, 710069, China.; College of Life Science, Northwest University, Xi'an, 710127, China.; Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, 710069, China., Ma X; Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), School of Life Sciences, Ministry of Education, Northwest University, #229 North TaiBai Road, Xi'an, Shaanxi, 710069, China.; College of Life Science, Northwest University, Xi'an, 710127, China.; Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, 710069, China., Li Y; Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), School of Life Sciences, Ministry of Education, Northwest University, #229 North TaiBai Road, Xi'an, Shaanxi, 710069, China.; College of Life Science, Northwest University, Xi'an, 710127, China.; Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, 710069, China., Zhang H; Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), School of Life Sciences, Ministry of Education, Northwest University, #229 North TaiBai Road, Xi'an, Shaanxi, 710069, China.; College of Life Science, Northwest University, Xi'an, 710127, China.; Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, 710069, China., Wei J; Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), School of Life Sciences, Ministry of Education, Northwest University, #229 North TaiBai Road, Xi'an, Shaanxi, 710069, China.; College of Life Science, Northwest University, Xi'an, 710127, China.; Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, 710069, China., Du S; Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), School of Life Sciences, Ministry of Education, Northwest University, #229 North TaiBai Road, Xi'an, Shaanxi, 710069, China. 786209865@qq.comm.; College of Life Science, Northwest University, Xi'an, 710127, China. 786209865@qq.comm.; Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, 710069, China. 786209865@qq.comm., Jin T; Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), School of Life Sciences, Ministry of Education, Northwest University, #229 North TaiBai Road, Xi'an, Shaanxi, 710069, China. jintb@nwu.edu.cn.; College of Life Science, Northwest University, Xi'an, 710127, China. jintb@nwu.edu.cn.; Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, 710069, China. jintb@nwu.edu.cn.

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