Search Results - "Cancer associated fibroblasts"

Single-cell transcriptomic analysis identifies tissue-specific fibroblasts as the main modulators of myeloid cells in peritoneal metastasis of different origin.

Gerakopoulos V; Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, 1090, Vienna, Austria., Ramos C; Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, 1090, Vienna, Austria., Müller C; Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, 1090, Vienna, Austria., Walterskirchen N; Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, 1090, Vienna, Austria., Vintila S; Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, 1090, Vienna, Austria., Zotter C; Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, 1090, Vienna, Austria., Ilg M; Cancer Immunology and Immune Modulation, Boehringer Ingelheim RCV GmBH & Co KG., Dr. Boehringer Gasse 5-11, 1120, Vienna, Austria., Pap A; Cancer Immunology and Immune Modulation, Boehringer Ingelheim RCV GmBH & Co KG., Dr. Boehringer Gasse 5-11, 1120, Vienna, Austria., Riss S; Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, 1090, Vienna, Austria., Bergmann M; Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, 1090, Vienna, Austria., Unger LW; Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, 1090, Vienna, Austria; Dept. of Colorectal Surgery, Oxford University Hospitals, Old Rd, Headington, Oxford, OX3 7LE, United Kingdom., Vogt AB; Cancer Immunology and Immune Modulation, Boehringer Ingelheim RCV GmBH & Co KG., Dr. Boehringer Gasse 5-11, 1120, Vienna, Austria., Oehler R; Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, 1090, Vienna, Austria. Electronic address: rudolf.oehler@meduniwien.ac.at., Lukowski SW; Cancer Immunology and Immune Modulation, Boehringer Ingelheim RCV GmBH & Co KG., Dr. Boehringer Gasse 5-11, 1120, Vienna, Austria.

Journal Article , 2025

Cancer-associated fibroblasts promote growth and dissemination of esophageal squamous cell carcinoma cells by secreting WNT family member 5A.

Yao L; Department of Cardiothoracic Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510620, Guangdong, China., Zhou C; Department of Cardiothoracic Surgery, The Fourth Affiliated Hospital Zhejiang University School of Medicine, Yiwu, 322000, Zhejiang, China., Liu L; Department of Cardiothoracic Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510620, Guangdong, China., He J; Department of Cardiothoracic Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510620, Guangdong, China., Wang Y; Department of Thoracic Surgery, Huashan Hospital, Fudan University, Shanghai, 200433, China., Wang A; Department of Thoracic Surgery, Huashan Hospital, Fudan University, Shanghai, 200433, China. wangantxwd@163.com.

Journal Article , 2025

Invasive phenotypes of triple-negative breast cancer-associated fibroblasts are mechanosensitive, AhR-dependent and correlate with disease state.

Brewer G; Rosalind & Morris Goodman Cancer Institute, McGill University, 1160 Avenues des Pins, Montréal, QC, Canada; Department of Biochemistry, McGill University, 3649 Promenade Sir-William-Osler, Montréal, QC, Canada., Savage P; Rosalind & Morris Goodman Cancer Institute, McGill University, 1160 Avenues des Pins, Montréal, QC, Canada; Department of Experimental Medicine, McGill University, 1001 Decarie Boulevard, Montréal, QC, Canada., Fortier AM; Rosalind & Morris Goodman Cancer Institute, McGill University, 1160 Avenues des Pins, Montréal, QC, Canada., Zhao H; Rosalind & Morris Goodman Cancer Institute, McGill University, 1160 Avenues des Pins, Montréal, QC, Canada., Pacis A; Rosalind & Morris Goodman Cancer Institute, McGill University, 1160 Avenues des Pins, Montréal, QC, Canada., Wang YC; Department of Human Genetics, McGill University, 3640 University, Montreal, QC; Genome Innovation Centre, 740 Dr Penfield Ave, Montreal, QC., Zuo D; Rosalind & Morris Goodman Cancer Institute, McGill University, 1160 Avenues des Pins, Montréal, QC, Canada., de Nobrega M; Rosalind & Morris Goodman Cancer Institute, McGill University, 1160 Avenues des Pins, Montréal, QC, Canada; Department of Genetics and Molecular Biology, State University of Londrina, Londrina, PR, Brazil., Pedersen A; Rosalind & Morris Goodman Cancer Institute, McGill University, 1160 Avenues des Pins, Montréal, QC, Canada; Department of Experimental Medicine, McGill University, 1001 Decarie Boulevard, Montréal, QC, Canada., Cassel de Camps C; Department of Biomedical Engineering, McGill University, 3775 rue University, Montréal, QC, Canada., Souleimanova M; Rosalind & Morris Goodman Cancer Institute, McGill University, 1160 Avenues des Pins, Montréal, QC, Canada., Ramos VM; Rosalind & Morris Goodman Cancer Institute, McGill University, 1160 Avenues des Pins, Montréal, QC, Canada., Ragoussis J; Department of Human Genetics, McGill University, 3640 University, Montreal, QC; Genome Innovation Centre, 740 Dr Penfield Ave, Montreal, QC., Park M; Rosalind & Morris Goodman Cancer Institute, McGill University, 1160 Avenues des Pins, Montréal, QC, Canada; Department of Biochemistry, McGill University, 3649 Promenade Sir-William-Osler, Montréal, QC, Canada; Department of Experimental Medicine, McGill University, 1001 Decarie Boulevard, Montréal, QC, Canada; Department of Oncology, McGill University, 5100 de Maisonneuve Blvd. West, Montréal, QC, Canada. Electronic address: morag.park@mcgill.ca., Moraes C; Rosalind & Morris Goodman Cancer Institute, McGill University, 1160 Avenues des Pins, Montréal, QC, Canada; Department of Biomedical Engineering, McGill University, 3775 rue University, Montréal, QC, Canada; Department of Chemical Engineering, McGill University, 3610 rue University, Montréal, QC, Canada. Electronic address: chris.moraes@mcgill.ca.

Journal Article; Research Support, Non-U.S. Gov't , 2025

The dynamic interplay between melanoma cells and CAFs: Implications drug resistance and immune evasion and possible therapeutics.

Hsu CY; Thunderbird School of Global Management, Arizona State University, Tempe Campus, Phoenix, AZ, 85004, USA. Electronic address: chouyihs@asu.edu., Saleh RO; Department of Medical Laboratories Techniques, College of Health and Medical Techniques, University of Al Maarif, Al Anbar, 31001, Iraq. Electronic address: Salehraed1979@gmail.com., Mohammed JS; Medical Analysis Department, Faculty of Applied Science, Tishk International University, Erbil, Iraq., Mansuri N; Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia., Rekha MM; Department of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, India., Kundlas M; Centre for Research Impact & Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, 140401, Punjab, India., Anand A; Department of Biomedical, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, India., Sahoo S; Department of General Medicine, IMS and SUM Hospital, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, 751003, India., Zwamel AH; Department of Medical Analysis, Medical Laboratory Technique College, The Islamic University, Najaf, Iraq; Department of medical analysis, Medical laboratory technique college, the Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq; Department of medical analysis, Medical laboratory technique college, the Islamic University of Babylon, Babylon, Iraq., Hulail HM; Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq.

Journal Article; Review , 2025

Development and validation of a cancer-associated fibroblast gene signature-based model for predicting immunotherapy response in colon cancer.

Zou D; The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China., Xin X; Ganzhou People's Hospital, Ganzhou, China., Xu H; The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China., Xu Y; The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China., Xu T; The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China. xutianwen53@163.com.

Journal Article , 2025

PAI-1-driven SFRP2 ^high cancer-associated fibroblasts hijack the abscopal effect of radioimmunotherapy.

Zhang YP; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China., Guo ZQ; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China., Cai XT; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China., Rong ZX; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China., Fang Y; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China., Chen JQ; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China., Zhuang KM; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China., Ruan MJ; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China., Ma SC; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China., Lin LY; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China., Han DD; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China., Li YS; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510515, Guangdong, China., Wang YY; Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China., Wang J; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China., Cao CH; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China., Tang XR; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China., Xie QK; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China., Chen Y; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China., Lin Y; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China., Tan JL; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China., Yu ZH; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China., Wu ZN; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China., Wei W; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Department of Oncology, Xiangyang Central Hospital, Hubei University of Arts and Science, Xiangyang, Hubei 441000, China., Zheng DY; Department of Oncology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde Foshan), Shunde 528333, China., Zeng YJ; Institute of Cancer Stem Cell, Dalian Medical University, Dalian 116044, China., Ruan YC; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China., Xu ZP; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China., Gu JZ; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China., Xiao LS; Big Data Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Hepatology Unit and Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China., Liu L; Big Data Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Department of Health Management Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China., Guan J; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Electronic address: guanjian5461@163.com., Bai X; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Electronic address: baixue1990@i.smu.edu.cn., Wu DH; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Electronic address: 18602062748@163.com., Dong ZY; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Electronic address: dongzy1317@foxmail.com.

Journal Article , 2025

Qingre Huayu Jianpi decoction suppresses colorectal tumorigenesis by inhibiting cancer stem cells and cancer-associated fibroblasts.

Guirong C; Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. Electronic address: 1033700153@qq.com., Lili H; Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. Electronic address: 2374009048@qq.com., Guifang D; Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. Electronic address: dgf1834362898@163.com., Weiqi L; The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. Electronic address: 18530042@qq.com., Xiongbo G; Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China. Electronic address: drguoxiongbo@163.com., Fan X; Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. Electronic address: 809774838@qq.com., Zhenyu N; Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. Electronic address: 20211110932@stu.gzucm.edu.cn., Jinbin S; Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. Electronic address: sjbjbtm@163.com., Gang C; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 117004, China. Electronic address: chengang1152001@163.com., Lina Z; The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. Electronic address: 642824121@qq.com., Wenfeng G; Artemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 501405, China. Electronic address: guowenfeng@gzucm.edu.cn., Qun D; Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. Electronic address: duqun@gzucm.edu.cn., Yanwu L; Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. Electronic address: liyanwu@gzucm.edu.cn.

Journal Article , 2025

Tie2 activity in cancer associated myofibroblasts serves as novel target against reprogramming of cancer cells to embryonic-like cell state and associated poor prognosis in oral carcinoma patients.

Mitra P; BRIC National Institute of Biomedical Genomics (BRIC-NIBMG), Kalyani, WB, 741251, India.; Regional Centre for Biotechnology, Faridabad, India., Saha U; BRIC National Institute of Biomedical Genomics (BRIC-NIBMG), Kalyani, WB, 741251, India.; Regional Centre for Biotechnology, Faridabad, India., Stephen KJ; BRIC National Institute of Biomedical Genomics (BRIC-NIBMG), Kalyani, WB, 741251, India., Prasad P; BRIC National Institute of Biomedical Genomics (BRIC-NIBMG), Kalyani, WB, 741251, India., Jena S; BRIC National Institute of Biomedical Genomics (BRIC-NIBMG), Kalyani, WB, 741251, India.; Regional Centre for Biotechnology, Faridabad, India., Patel AK; BRIC National Institute of Biomedical Genomics (BRIC-NIBMG), Kalyani, WB, 741251, India.; Umea University, Umea, Sweden., Bv H; Indian Institute of Science, Bengaluru, India., Mondal SK; All India Institute of Medical Sciences, Kalyani, India., Kurkalang S; BRIC National Institute of Biomedical Genomics (BRIC-NIBMG), Kalyani, WB, 741251, India.; Comprehensive Cancer Center, University of Chicago Medicine, Chicago, IL, USA., Roy S; BRIC National Institute of Biomedical Genomics (BRIC-NIBMG), Kalyani, WB, 741251, India.; Regional Centre for Biotechnology, Faridabad, India., Ghosh A; BRIC National Institute of Biomedical Genomics (BRIC-NIBMG), Kalyani, WB, 741251, India.; Regional Centre for Biotechnology, Faridabad, India., Roy SS; BRIC National Institute of Biomedical Genomics (BRIC-NIBMG), Kalyani, WB, 741251, India., Das Sarma J; Indian Institute of Science Education and Research, Kolkata, India., Biswas NK; BRIC National Institute of Biomedical Genomics (BRIC-NIBMG), Kalyani, WB, 741251, India.; Regional Centre for Biotechnology, Faridabad, India., Acharya M; BRIC National Institute of Biomedical Genomics (BRIC-NIBMG), Kalyani, WB, 741251, India.; Regional Centre for Biotechnology, Faridabad, India., Sharan R; Tata Medical Center, Kolkata, India., Arun P; Tata Medical Center, Kolkata, India., Jolly MK; Indian Institute of Science, Bengaluru, India., Maitra A; BRIC National Institute of Biomedical Genomics (BRIC-NIBMG), Kalyani, WB, 741251, India.; Regional Centre for Biotechnology, Faridabad, India., Singh S; BRIC National Institute of Biomedical Genomics (BRIC-NIBMG), Kalyani, WB, 741251, India. ss5@nibmg.ac.in.; Regional Centre for Biotechnology, Faridabad, India. ss5@nibmg.ac.in.

Journal Article , 2025

Melatonin attenuates Helicobacter pylori-mediated cholangiocarcinoma-associated fibroblast activation via modulating integrin/FAK signaling pathway.

Klungsaeng S; Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, 40002, Thailand., Hongsrichan N; Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, 40002, Thailand., Chaidee A; Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, 40002, Thailand., Intuyod K; Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, 40002, Thailand., Pinlaor P; Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand.; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, 40002, Thailand., Roytrakul S; Functional Proteomics Technology Laboratory, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathum Thani, Thailand., Vaeteewoottacharn K; Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, 40002, Thailand., Charoenlappanit S; Functional Proteomics Technology Laboratory, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathum Thani, Thailand., Dangtakot R; Department of Medical Technology, Faculty of Allied Health Sciences, Nakhonratchasima College, Nakhon Ratchasima, 30000, Thailand., Mahaamnad N; Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, 40002, Thailand., Pinlaor S; Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand. psomec@kku.ac.th.; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, 40002, Thailand. psomec@kku.ac.th.

Journal Article , 2025

Unlocking the crucial role of cancer-associated fibroblasts in tumor metastasis: Mechanisms and therapeutic prospects.

Liu Y; Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Institute of Pathology, Fudan University, Shanghai 200032, China., Zhang X; Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Institute of Pathology, Fudan University, Shanghai 200032, China., Gu W; Department of Diagnostic and Interventional Radiology, University of Tsukuba, Ibaraki, Japan., Su H; Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Institute of Pathology, Fudan University, Shanghai 200032, China., Wang X; Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Institute of Pathology, Fudan University, Shanghai 200032, China., Wang X; Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Institute of Pathology, Fudan University, Shanghai 200032, China., Zhang J; Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Institute of Pathology, Fudan University, Shanghai 200032, China., Xu M; Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Institute of Pathology, Fudan University, Shanghai 200032, China. Electronic address: 12111230022@fudan.edu.cn., Sheng W; Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Institute of Pathology, Fudan University, Shanghai 200032, China. Electronic address: shengweiqi2006@163.com.

Journal Article; Review , 2025

Cancer-associated Fibroblasts-derived Exosomes with HOXD11 Overexpression Promote Ovarian Cancer Cell Angiogenesis Via FN1.

Chen C; Department of Gynaecology, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan, 570311, P.R. China., Wang F; Department of Gynaecology, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan, 570311, P.R. China., Cheng C; Department of Gynaecology, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan, 570311, P.R. China., Li H; Department of Gynaecology, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan, 570311, P.R. China., Fan Y; Department of Gynaecology, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan, 570311, P.R. China., Jia L; Department of Gynaecology, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan, 570311, P.R. China. jialipingk@126.com.

Journal Article , 2025

Treatment of cancer-associated fibroblast-like cells with celecoxib enhances the anti-cancer T helper 1/Treg responses in breast cancer.

Samoudi A; Department of Medical Immunology, School of Medicine, Kerman University of Medical Sciences, Pajoohesh Sq, Kerman, 7616914111, Iran., Abolhasani-Zadeh F; Department of Surgery, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran., Afgar A; Research center for Hydatid Disease in Iran, Kerman University of Medical Sciences, Kerman, Iran., Jalilian E; Department of Medical Immunology, School of Medicine, Kerman University of Medical Sciences, Pajoohesh Sq, Kerman, 7616914111, Iran., Zeinalynezhad H; Department of Surgery, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran., Langroudi L; Department of Medical Immunology, School of Medicine, Kerman University of Medical Sciences, Pajoohesh Sq, Kerman, 7616914111, Iran. l.langroudi@kmu.ac.ir.

Journal Article , 2025

Mechanistic role of stromal cancer-associated fibroblasts in tumorigenesis and brain metastasis: Highlighting drug resistance and targeted therapy.

Akanda MR; Department of Pharmacology and Toxicology, Sylhet Agricultural University, Sylhet, Bangladesh. Electronic address: akandamr.dph@sau.ac.bd., Lubaba U; Department of Pharmacology and Toxicology, Sylhet Agricultural University, Sylhet, Bangladesh., Rahman MK; Department of Microbiology and Immunology, East Carolina University, Greenville, NC, USA; Department of Microbiology, Hajee Mohammad Danesh Science & Technology University, Dinajpur, Bangladesh., Islam A; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, Australia; Epilepsy Research Group, Australian Centre for Precision Health, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia., Akter M; Department of Chemistry, Michigan State University, East Lansing, MI, USA., Islam MS; Vascular Biology Center, Medical College of Georgia, Augusta University, GA, USA., Uddin MN; Department of Livestock Production and Management, Sylhet Agricultural University, Sylhet, Bangladesh., Park BY; Institute of Animal Transplantation, College of Veterinary Medicine, Jeonbuk National University, Iksan, Republic of Korea.

Journal Article; Review , 2025

Cancer-associated fibroblast heterogeneity in chordoma ^† .

Henry JC; Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, UK., Cameron AJM; Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, UK.

Journal Article , 2025

CDK16 ⁺ Luminal Progenitor Cell-Like Tumor Cells Interacted with POSTN ⁺ Cancer-Associated Fibroblasts Associate with Chemo-Resistance In Breast Cancer.

Ding X; Shanghai Institute of Immunology, Center for Immune-Related Diseases Research at Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.; Shanghai Jiao Tong University School of Medicine-Yale Institute for Immune Metabolism, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China., Wu Q; Department of Hepatobiliary Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, Anhui Provincial Clinical Research Center for Hepatobiliary Diseases, Hefei, 230001, China., Du Y; Shanghai Institute of Immunology, Center for Immune-Related Diseases Research at Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.; Shanghai Jiao Tong University School of Medicine-Yale Institute for Immune Metabolism, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China., Ji MM; Department of Medical Oncology, Affiliated Hospital of Hebei University, Hebei Key Laboratory of Cancer Radiotherapy and Chemotherapy, Baoding, 071000, China., Yang H; Department of Medical Oncology, Affiliated Hospital of Hebei University, Hebei Key Laboratory of Cancer Radiotherapy and Chemotherapy, Baoding, 071000, China., Hu Q; Department of Hepatobiliary Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, Anhui Provincial Clinical Research Center for Hepatobiliary Diseases, Hefei, 230001, China., Ye Y; Shanghai Institute of Immunology, Center for Immune-Related Diseases Research at Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.; Shanghai Jiao Tong University School of Medicine-Yale Institute for Immune Metabolism, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Journal Article; Research Support, Non-U.S. Gov't , 2025

Extracellular nicotinamide phosphoribosyltransferase visfatin activates JAK2-STAT3 pathway in cancer-associated fibroblasts to promote colorectal cancer metastasis.

Lei Y; Pathological Diagnosis Center, Zhoushan Hospital of Zhejiang Province, Zhejiang, China., Shu D; School of Bioscience and Technology, Chengdu Medical College, Chengdu, China., Xia J; School of Basic Medical Science, Chengdu Medical College, Chengdu, China., Zhang T; School of Bioscience and Technology, Chengdu Medical College, Chengdu, China. ztbill@cmc.edu.cn.; The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, China. ztbill@cmc.edu.cn., Wei H; School of Bioscience and Technology, Chengdu Medical College, Chengdu, China. weihe@cmc.edu.cn.; The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, China. weihe@cmc.edu.cn.

Journal Article , 2025

Single-cell sequencing unveils the transcriptomic landscape of castration-resistant prostate cancer-associated fibroblasts and their association with prognosis and immunotherapy response.

Qiu Y; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical school, Shenzhen, 518060, China.; Department of Urology, Shenzhen University General Hospital, Shenzhen University, Shenzhen, Guangdong, China.; Shenzhen Key Laboratory for Systemic Aging and Intervention (SAI), Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, School of Basic Medical Sciences, Marshall Laboratory of Biomedical Engineering, National Engineering Research Center for Biotechnology (Shenzhen), International Cancer Center, Shenzhen University, Shenzhen, Guangdong, China.; International Cancer Center, Shenzhen Key Laboratory, Hematology Institution of Shenzhen University, Shenzhen, China., Wang Y; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical school, Shenzhen, 518060, China.; Department of Urology, Shenzhen University General Hospital, Shenzhen University, Shenzhen, Guangdong, China.; Shenzhen Key Laboratory for Systemic Aging and Intervention (SAI), Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, School of Basic Medical Sciences, Marshall Laboratory of Biomedical Engineering, National Engineering Research Center for Biotechnology (Shenzhen), International Cancer Center, Shenzhen University, Shenzhen, Guangdong, China., Liu J; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical school, Shenzhen, 518060, China.; Department of Urology, Shenzhen University General Hospital, Shenzhen University, Shenzhen, Guangdong, China.; Shenzhen Key Laboratory for Systemic Aging and Intervention (SAI), Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, School of Basic Medical Sciences, Marshall Laboratory of Biomedical Engineering, National Engineering Research Center for Biotechnology (Shenzhen), International Cancer Center, Shenzhen University, Shenzhen, Guangdong, China., Sun K; Department of Radiology, the Third People's Hospital of Longgang District, Shenzhen, China.; Shenzhen Clinical Medical School, Guangzhou University of Chinese Medicine, Shenzhen, 518116, China., Liu B; Shenzhen Key Laboratory for Systemic Aging and Intervention (SAI), Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, School of Basic Medical Sciences, Marshall Laboratory of Biomedical Engineering, National Engineering Research Center for Biotechnology (Shenzhen), International Cancer Center, Shenzhen University, Shenzhen, Guangdong, China. ppliew@szu.edu.cn., Hou Q; Department of Urology, Shenzhen University General Hospital, Shenzhen University, Shenzhen, Guangdong, China. qi_hou@foxmail.com.; Shenzhen Key Laboratory for Systemic Aging and Intervention (SAI), Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, School of Basic Medical Sciences, Marshall Laboratory of Biomedical Engineering, National Engineering Research Center for Biotechnology (Shenzhen), International Cancer Center, Shenzhen University, Shenzhen, Guangdong, China. qi_hou@foxmail.com.; International Cancer Center, Shenzhen Key Laboratory, Hematology Institution of Shenzhen University, Shenzhen, China. qi_hou@foxmail.com.

Journal Article , 2025

LAMA4 ⁺ CD90 ⁺ eCAFs provide immunosuppressive microenvironment for liver cancer through induction of CD8 ⁺ T cell senescence.

Zhang J; Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Hengzhigang Road 78#, Guangzhou, 510095, China.; Innovation and Entrepreneurship Laboratory for College Students, Anhui Medical University, Hefei, 230031, China., Li Z; Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Hengzhigang Road 78#, Guangzhou, 510095, China.; Department of Genetics, School of Life Science, Anhui Medical University, Hefei, 230031, China., Zhang Q; Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Hengzhigang Road 78#, Guangzhou, 510095, China., Ma W; Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Hengzhigang Road 78#, Guangzhou, 510095, China., Fan W; Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Hengzhigang Road 78#, Guangzhou, 510095, China., Dong J; Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Hengzhigang Road 78#, Guangzhou, 510095, China., Tian J; Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Hengzhigang Road 78#, Guangzhou, 510095, China., Liao H; Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Hengzhigang Road 78#, Guangzhou, 510095, China., Guo J; Innovation and Entrepreneurship Laboratory for College Students, Anhui Medical University, Hefei, 230031, China., Cao Y; Kiang Wu Hospital, Macao SAR, Macao, China., Yin J; Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Hengzhigang Road 78#, Guangzhou, 510095, China. yinjiang20@gzhmu.edu.cn., Zheng G; Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Hengzhigang Road 78#, Guangzhou, 510095, China. zhengguopei@126.com., Li N; Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Hengzhigang Road 78#, Guangzhou, 510095, China. Linan_gz2013@163.com.

Journal Article , 2025

Resveratrol suppresses growth and VCAN expression in a Cancer-associated fibroblast-breast Cancer hybrid organoid.

Shi Y; Liaoning Laboratory of Cancer Genomics and Epigenomics, Department of Cell Biology, College of Basic Medical Sciences, Dalian Medical University, Dalian, China., Cai G; Department of Breast Surgery, The First People's Hospital of Foshan, Foshan, China., Zhang C; Liaoning Laboratory of Cancer Genomics and Epigenomics, Department of Cell Biology, College of Basic Medical Sciences, Dalian Medical University, Dalian, China; Translational Medicine Research Institute, First People's Hospital of Foshan, Foshan, China; Clinical Research Center, Translational Medicine Research Institute, First People's Hospital of Foshan, Foshan, China., Li H; Biomedical Laboratory, Guangzhou Jingke BioTech Group, Guangzhou 510005, China., Nie Y; Translational Medicine Research Institute, First People's Hospital of Foshan, Foshan, China; Clinical Research Center, Translational Medicine Research Institute, First People's Hospital of Foshan, Foshan, China., Yu S; Translational Medicine Research Institute, First People's Hospital of Foshan, Foshan, China., Zhang B; Translational Medicine Research Institute, First People's Hospital of Foshan, Foshan, China., Wu M; Liaoning Laboratory of Cancer Genomics and Epigenomics, Department of Cell Biology, College of Basic Medical Sciences, Dalian Medical University, Dalian, China., Luo W; Translational Medicine Research Institute, First People's Hospital of Foshan, Foshan, China. Electronic address: luowei_421@163.com., Liu J; Liaoning Laboratory of Cancer Genomics and Epigenomics, Department of Cell Biology, College of Basic Medical Sciences, Dalian Medical University, Dalian, China. Electronic address: jialiudl@dmu.edu.cn., Guan Z; Translational Medicine Research Institute, First People's Hospital of Foshan, Foshan, China. Electronic address: gzwjason@foxmail.com.

Journal Article , 2025

Cancer-associated fibroblasts as a potential novel liquid biopsy marker in cancer patients.

Weber F; Institute of Tumor Biology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany., Reese KL; Institute of Tumor Biology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany., Pantel K; Institute of Tumor Biology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.; European Liquid Biopsy Society (ELBS), Martinistraße 52, 20246, Hamburg, Germany., Smit DJ; Institute of Tumor Biology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany. d.smit@uke.de.

Journal Article; Review , 2025