Search Results - "Chekler, Eugene"

Antibody-Drug Conjugates of NLRP3 Agonists: How Overcoming Lysosomal Accumulation Necessitated Noncanonical Linker Attachments

Riehl, Paul S.^aff1, Zhang, Meng Yao^aff1, Dhar, Payal^aff1, Wang, Zhiying^aff2, Pan, Jie^aff2, Mansfield, Kathleen^aff1, Johnson, Walter L.^aff1, Zhang, Qian^aff1, Li, Yvonne^aff1, D’Souza, Ryan^aff2, Zhang, Jun^aff2, Olsen, Jonathan^aff2, Deshpande, Madhura^aff1, Kotapati, Srikanth^aff1, Hollingsworth, Scott A.^aff1, Verma, Isha^aff1, Li, Yi-xin^aff1, Su, Yang^aff1, Cheng, Qinqin^aff1, Yamazoe, Sayumi^aff1, Micci, Luca^aff1, Broz, Miranda^aff1, Janc, James^aff1, Chekler, Eugene P.^aff1, Lo, Julian C.^aff1

Targeted Delivery of TLR7 Agonists to the Tumor Microenvironment Enhances Tumor Immunity via Activation of Tumor-Resident Myeloid Cells

Sega, Emanuela, Kotapati, Srikanth, Poudel, Yam B., Cheng, Qinqin, Sadanala, Keerthi, Schneider, Bridget, Chekler, Eugene P., Rao, Chetana, Gangwar, Sanjeev, Sproul, Tim, Law, Deborah, Broz, Miranda, Strop, Pavel, Yamazoe, Sayumi

Optimization of a micro-scale air–liquid-interface model of human proximal airway epithelium for moderate throughput drug screening for SARS-CoV-2

Sen, Chandani, Rickabaugh, Tammy M, Jeyachandran, Arjit Vijey, Yuen, Constance, Ghannam, Maisam, Durra, Abdo, Aziz, Adam, Castillo, Kristen, Garcia, Gustavo, Purkayastha, Arunima, Han, Brandon, Boulton, Felix W, Chekler, Eugene, Garces, Robert, Wolff, Karen C, Riva, Laura, Kirkpatrick, Melanie G, Gebara-Lamb, Amal, McNamara, Case W, Betz, Ulrich AK, Arumugaswami, Vaithilingaraja, Damoiseaux, Robert, Gomperts, Brigitte N

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Trends in Neosubstrate Degradation by Cereblon-Based Molecular Glues and the Development of Novel Multiparameter Optimization Scores

Szewczyk, Suzanne M., Verma, Isha, Edwards, Jacob T., Weiss, Dahlia R., Chekler, Eugene L. P.

Structure-Based Design of Novel TLR7/8 Agonist Payloads Enabling an Immunomodulatory Conjugate Approach

Poudel, Yam B.^aff1, Lo, Julian C.^aff1, Norris, Derek J.^aff2, Cox, Matthew^aff1, He, Liqi^aff1, Johnson, Walter L.^aff1, A. M. Subbaiah, Murugaiah^aff3, Mondal, Santigopal^aff3, Thangavel, Soodamani^aff3, Subramani, Lakshumanan^aff3, Reddy, Maheswara^aff3, Jain, Suraksha^aff3, Weiss, Dahlia R.^aff1, Sivaprakasam, Prasanna^aff2, Critton, David^aff2, Mulligan, Dawn^aff2, Xie, Chunshan^aff2, Dhar, Payal^aff1, Li, Yvonne^aff1, Sega, Emanuela^aff1, Yamazoe, Sayumi^aff1, Gavai, Ashvinikumar V.^aff2, Mathur, Arvind^aff2, Zapf, Christoph W.^aff4, Chekler, Eugene P.^aff1

The New Frontier: Merging Molecular Glue Degrader and Antibody–Drug Conjugate Modalities To Overcome Strategic Challenges

Poudel, Yam B.^aff1, Thakore, Ruchita R.^aff2, Chekler, Eugene P.^aff1

Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects

Schindler, Christina E. M.^aff1, Baumann, Hannah^aff1, Blum, Andreas^aff1, Böse, Dietrich^aff1, Buchstaller, Hans-Peter^aff1, Burgdorf, Lars^aff1, Cappel, Daniel^aff2, Chekler, Eugene^aff3, Czodrowski, Paul^aff1, Dorsch, Dieter^aff1, Eguida, Merveille K. I.^aff1, Follows, Bruce^aff3, Fuchß, Thomas^aff1, Grädler, Ulrich^aff1, Gunera, Jakub^aff1, Johnson, Theresa^aff3, Jorand Lebrun, Catherine^aff3, Karra, Srinivasa^aff3, Klein, Markus^aff1, Knehans, Tim^aff1, Koetzner, Lisa^aff1, Krier, Mireille^aff1, Leiendecker, Matthias^aff1, Leuthner, Birgitta^aff1, Li, Liwei^aff3, Mochalkin, Igor^aff3, Musil, Djordje^aff1, Neagu, Constantin^aff3, Rippmann, Friedrich^aff1, Schiemann, Kai^aff1, Schulz, Robert^{aff1, aff4}, Steinbrecher, Thomas^aff2, Tanzer, Eva-Maria^aff3, Unzue Lopez, Andrea^aff1, Viacava Follis, Ariele^aff3, Wegener, Ansgar^aff1, Kuhn, Daniel^aff1

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Correction to 'The New Frontier: Merging Molecular Glue Degrader and Antibody–Drug Conjugate Modalities To Overcome Strategic Challenges'

Poudel, Yam B., Thakore, Ruchita R., Chekler, Eugene P.

Discovery of quinazoline HPK1 inhibitors with high cellular potency

Toure, Momar, Johnson, Theresa, Li, Bin, Schmidt, Ralf, Ma, Hong, Neagu, Constantin, Lopez, Andrea Unzue, Wang, Yanping, Guler, Satenig, Xiao, YuFang, Henkes, Renate, Ho, Kevin, Zhang, Susan, Chu, Chia Lin, Gundra, Uma Mahesh, Porichis, Filippos, Li, Long, Maurer, Christine Katharina, Fang, Zhizhou, Musil, Djordje, DiPoto, Maria, Friis, Emily, Jones, Reinaldo, Jones, Christopher, Cummings, James, Chekler, Eugene, Tanzer, Eva Maria, Huck, Bayard, Sherer, Brian

Structure-Based Design of Highly Selective Inhibitors of the CREB Binding Protein Bromodomain

Denny, R. Aldrin^aff1, Flick, Andrew C.^aff2, Coe, Jotham^aff2, Langille, Jonathan, Basak, Arindrajit^aff2, Liu, Shenping^aff3, Stock, Ingrid^aff4, Sahasrabudhe, Parag^aff3, Bonin, Paul^aff4, Hay, Duncan A.^{aff7, aff5}, Brennan, Paul E.^aff5, Pletcher, Mathew^aff6, Jones, Lyn H.^aff1, Chekler, Eugene L. Piatnitski^aff1

1‑(2-Hydroxy-2-methyl-3-phenoxypropanoyl)indoline-4-carbonitrile Derivatives as Potent and Tissue Selective Androgen Receptor Modulators

Chekler, Eugene L. Piatnitski, Unwalla, Rayomond, Khan, Taukeer A., Tangirala, Raghuram S., Johnson, Mark, St. Andre, Michael, Anderson, James T., Kenney, Thomas, Chiparri, Sue, McNally, Chris, Kilbourne, Edward, Thompson, Catherine, Nagpal, Sunil, Weber, Gregory, Schelling, Scott, Owens, Jane, Morris, Carl A., Powell, Dennis, Verhoest, Patrick R., Gilbert, Adam M.

Structure-Based Approach To Identify 5‑[4-Hydroxyphenyl]­pyrrole-2-carbonitrile Derivatives as Potent and Tissue Selective Androgen Receptor Modulators

Unwalla, Ray, Mousseau, James J., Fadeyi, Olugbeminiyi O., Choi, Chulho, Parris, Kevin, Hu, Baihua, Kenney, Thomas, Chippari, Susan, McNally, Christopher, Vishwanathan, Karthick, Kilbourne, Edward, Thompson, Catherine, Nagpal, Sunil, Wrobel, Jay, Yudt, Matthew, Morris, Carl A., Powell, Dennis, Gilbert, Adam M., Chekler, Eugene L. Piatnitski

Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities

Chekler, Eugene L. Piatnitski, Pellegrino, Jessica A., Lanz, Thomas A., Denny, R. Aldrin, Flick, Andrew C., Coe, Jotham, Langille, Jonathan, Basak, Arindrajit, Liu, Shenping, Stock, Ingrid A., Sahasrabudhe, Parag, Bonin, Paul D., Lee, Kevin, Pletcher, Mathew T., Jones, Lyn H.

Kiloscale Buchwald–Hartwig Amination: Optimized Coupling of Base-Sensitive 6‑Bromoisoquinoline-1-carbonitrile with (S)‑3-Amino-2-methylpropan-1-ol

Sperry, Jeffrey B.^aff1, Price Wiglesworth, Kristin E.^aff1, Edmonds, Ian^aff2, Fiore, Phillip^aff2, Boyles, David C.^aff1, Damon, David B.^aff1, Dorow, Roberta L.^aff1, Piatnitski Chekler, Eugene L.^aff3, Langille, Jonathan^aff3, Coe, Jotham W.^aff3

Electrostatic Docking of a Supramolecular Host−Guest Assembly to Cytochrome c Probed by Bidirectional Photoinduced Electron Transfer
Docking of a Supramolecular Host−Guest Assembly to Cytochrome c

Jankowska, Katarzyna I., Pagba, Cynthia V., Piatnitski Chekler, Eugene L., Deshayes, Kurt, Piotrowiak, Piotr

Discovery of Dual VEGFR-2 and Tubulin Inhibitors with in Vivo Efficacy

Chekler, Eugene L. Piatnitski^aff1, Kiselyov, Alexander S.^aff1, Ouyang, Xiaohu^aff1, Chen, Xiaoling^aff1, Pattaropong, Vatee^aff1, Wang, Ying^aff3, Tuma, M. Carolina^aff3, Doody, Jacqueline F.^aff3

Antitumor Activity of IMC-038525, a Novel Oral Tubulin

Tuma, Maria Carolina, Malikzay, Asra, Ouyang, Xiaohu, Surguladze, David, Fleming, James, Mitelman, Stan, Camara, Margarita, Finnerty, Bridget, Doody, Jacqueline, Chekler, Eugene L.P., Kussie, Paul, Tonra, James R.

Arylphthalazines as potent, and orally bioavailable inhibitors of VEGFR-2

Duncton, Matthew A.J., Piatnitski Chekler, Eugene L., Katoch-Rouse, Reeti, Sherman, Dan, Wong, Wai C., Smith, Leon M., II, Kawakami, Joel K., Kiselyov, Alexander S., Milligan, Daniel L., Balagtas, Chris, Hadari, Yaron R., Wang, Ying, Patel, Sheetal N., Rolster, Robin L., Tonra, James R., Surguladze, David, Mitelman, Stan, Kussie, Paul, Bohlen, Peter, Doody, Jacqueline F.

Target validation using chemical probes

Bunnage, Mark E^{Aff1, IDnchembio1197_cor1}, Chekler, Eugene L Piatnitski^{Aff1, IDnchembio1197_cor2}, Jones, Lyn H^{Aff1, IDnchembio1197_cor3}