Search Results - "Code, Erin"

Accelerated Discovery of Carbamate Cbl‑b Inhibitors Using Generative AI Models and Structure-Based Drug Design

Quinn, Taylor R.^aff1, Giblin, Kathryn A.^aff2, Thomson, Clare^aff2, Boerth, Jeffrey A.^aff1, Bommakanti, Gayathri^aff1, Braybrooke, Erin^aff2, Chan, Christina^aff2, Chinn, Alex J.^aff1, Code, Erin^aff5, Cui, Caifeng^aff4, Fan, Yukai^aff4, Grimster, Neil P.^aff1, Kohara, Keishi^aff2, Lamb, Michelle L.^aff1, Ma, Lina^aff4, Mfuh, Adelphe M.^aff1, Robb, Graeme R.^aff2, Robbins, Kevin J.^aff1, Schimpl, Marianne^aff3, Tang, Haoran^aff3, Ware, Jamie^aff3, Wrigley, Gail L.^aff2, Xue, Lin^aff4, Zhang, Yun^aff1, Zhu, Huimin^aff4, Hughes, Samantha J.^aff2

Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl‑b Inhibitors

Mfuh, Adelphe M.^aff1, Boerth, Jeffrey A.^aff1, Bommakanti, Gayathri^aff2, Chan, Christina^aff3, Chinn, Alex J.^aff1, Code, Erin^aff2, Fricke, Patrick J.^aff1, Giblin, Kathryn A.^aff3, Gohlke, Andrea^aff4, Hansel, Catherine^aff4, Hariparsad, Niresh^aff1, Hughes, Samantha J.^aff3, Jin, Meizhong^aff1, Kantae, Vasudev^aff4, Kavanagh, Stefan L.^aff4, Lamb, Michelle L.^aff1, Lane, Jordan^aff4, Moore, Rachel^aff4, Puri, Taranee^aff1, Quinn, Taylor R.^aff1, Reddy, Iswarya^aff2, Robb, Graeme R.^aff3, Robbins, Kevin J.^aff1, Gancedo Rodrigo, Miguel^{aff4, aff5}, Schimpl, Marianne^aff3, Singh, Baljinder^aff1, Singh, Meha^aff1, Tang, Haoran^aff4, Thomson, Clare^aff3, Walsh, Jarrod J.^aff4, Ware, Jamie^aff4, Watson, Iain D. G.^aff1, Ye, Min-Wei^aff2, Wrigley, Gail L.^aff3, Zhang, Andrew X.^aff2, Zhang, Yun^aff1, Grimster, Neil P.^aff1

Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase

Bagal, Sharan K.^aff1, Gregson, Clare^aff1, O’ Donovan, Daniel H.^aff1, Pike, Kurt G.^aff1, Bloecher, Andrew^aff2, Barton, Peter^aff1, Borodovsky, Alexandra^aff2, Code, Erin^aff2, Fillery, Shaun M.^aff1, Hsu, Jessie Hao-Ru^aff2, Kawatkar, Sameer P.^aff2, Li, Chengzhi^aff3, Longmire, David^aff1, Nai, Youfeng^aff3, Nash, Samuel C.^aff1, Pike, Andrew^aff1, Robinson, James^aff1, Read, Jon A.^aff1, Rawlins, Phillip B.^aff1, Shen, Minhui^aff2, Tang, Jia^aff3, Wang, Peng^aff3, Woods, Haley^aff2, Williamson, Beth^aff1

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Discovery of a Novel Benzodiazepine Series of Cbl‑b Inhibitors for the Enhancement of Antitumor Immunity

Boerth, Jeffrey A.^aff1, Chinn, Alex J.^aff1, Schimpl, Marianne^aff2, Bommakanti, Gayathri^aff3, Chan, Christina^aff4, Code, Erin L.^aff5, Giblin, Kathryn A.^aff6, Gohlke, Andrea^aff2, Hansel, Catherine S.^aff2, Jin, Meizhong^aff1, Kavanagh, Stefan L.^aff7, Lamb, Michelle L.^aff1, Lane, Jordan S.^aff2, Larner, Carrie J. B.^aff7, Mfuh, Adelphe M.^aff1, Moore, Rachel K.^aff8, Puri, Taranee^aff1, Quinn, Taylor R.^aff1, Ye, Minwei^aff3, Robbins, Kevin J.^aff1, Gancedo-Rodrigo, Miguel^aff2, Tang, Haoran^aff2, Walsh, Jarrod^aff8, Ware, Jamie^aff2, Wrigley, Gail L.^aff6, Reddy, Iswarya Karapa^aff3, Zhang, Yun^aff1, Grimster, Neil P.^aff1

Development of a Novel B‑Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6

McCoull, William^aff1, Cheung, Tony^aff2, Anderson, Erica^aff2, Barton, Peter^aff1, Burgess, Jonathan^aff1, Byth, Kate^aff2, Cao, Qing^aff2, Castaldi, M. Paola^aff2, Chen, Huawei^aff2, Chiarparin, Elisabetta^aff1, Carbajo, Rodrigo J.^aff1, Code, Erin^aff2, Cowan, Suzanna^aff1, Davey, Paul R.^aff1, Ferguson, Andrew D.^aff2, Fillery, Shaun^aff1, Fuller, Nathan O.^aff2, Gao, Ning^aff2, Hargreaves, David^aff1, Howard, Martin R.^aff1, Hu, Jun^aff2, Kawatkar, Aarti^aff2, Kemmitt, Paul D.^aff1, Leo, Elisabetta^aff1, Molina, Daniel M.^aff3, O’Connell, Nichole^aff2, Petteruti, Philip^aff2, Rasmusson, Timothy^aff2, Raubo, Piotr^aff1, Rawlins, Philip B.^aff1, Ricchiuto, Piero^aff1, Robb, Graeme R.^aff1, Schenone, Monica^aff4, Waring, Michael J.^aff1, Zinda, Michael^aff2, Fawell, Stephen^aff2, Wilson, David M.^aff1

Rapid Identification of Novel Allosteric PRC2 Inhibitors

Read, Jon A.^aff1, Tart, Jonathan^aff2, Rawlins, Philip B.^aff1, Gregson, Clare^aff3, Jones, Karen^aff4, Gao, Ning^aff5, Zhu, Xiahui^aff5, Tomlinson, Ron^aff6, Code, Erin^aff5, Cheung, Tony^aff7, Chen, Huawei^aff7, Kawatkar, Sameer P.^aff8, Bloecher, Andy^aff7, Bagal, Sharan^aff3, O’Donovan, Daniel H.^aff3, Robinson, James^aff9

Discovery of Pyrazolo[1,5‑a]pyrimidine B‑Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors

McCoull, William^aff1, Abrams, Roman D.^aff2, Anderson, Erica^aff3, Blades, Kevin^aff2, Barton, Peter^aff1, Box, Matthew^aff2, Burgess, Jonathan^aff2, Byth, Kate^aff3, Cao, Qing^aff3, Chuaqui, Claudio^aff3, Carbajo, Rodrigo J.^aff1, Cheung, Tony^aff3, Code, Erin^aff3, Ferguson, Andrew D.^aff3, Fillery, Shaun^aff1, Fuller, Nathan O.^aff3, Gangl, Eric^aff3, Gao, Ning^aff3, Grist, Matthew^aff2, Hargreaves, David^aff1, Howard, Martin R.^aff1, Hu, Jun^aff3, Kemmitt, Paul D.^aff1, Nelson, Jennifer E.^aff2, O’Connell, Nichole^aff3, Prince, D. Bryan^aff3, Raubo, Piotr^aff1, Rawlins, Philip B.^aff1, Robb, Graeme R.^aff1, Shi, Junjie^aff4, Waring, Michael J.^aff2, Whittaker, David^aff2, Wylot, Marta^aff1, Zhu, Xiahui^aff3

Discovery and Mechanistic Study of a Small Molecule Inhibitor for Motor Protein KIFC1

Wu, Jiaquan^aff1, Mikule, Keith^aff2, Wang, Wenxian^aff2, Su, Nancy^aff1, Petteruti, Philip^aff2, Gharahdaghi, Farzin^aff2, Code, Erin^aff1, Zhu, Xiahui^aff1, Jacques, Kelly^aff2, Lai, Zhongwu^aff2, Yang, Bin^aff2, Lamb, Michelle L.^aff2, Chuaqui, Claudio^aff2, Keen, Nicholas^aff2, Chen, Huawei^aff2

Discovery of (+)-N-(3-Aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a Kinesin Spindle Protein Inhibitor and Potential Anticancer Agent

Theoclitou, Maria-Elena^aff1, Aquila, Brian^aff2, Block, Michael H.^aff2, Brassil, Patrick J.^aff2, Castriotta, Lillian^aff2, Code, Erin^aff2, Collins, Michael P.^aff2, Davies, Audrey M.^aff2, Deegan, Tracy^aff2, Ezhuthachan, Jayachandran^aff2, Filla, Sandra^aff2, Freed, Ellen^aff2, Hu, Haiqing^aff2, Huszar, Dennis^aff2, Jayaraman, Muthusamy, Lawson, Deborah^aff2, Lewis, Paula M^aff2, Nadella, Murali V. P.^aff2, Oza, Vibha^aff2, Padmanilayam, Maniyan, Pontz, Timothy^aff2, Ronco, Lucienne^aff2, Russell, Daniel^aff2, Whitston, David^aff2, Zheng, Xiaolan^aff2

Biochemical Characterization of Human SET and MYND Domain-Containing Protein 2 Methyltransferase

Wu, Jiaquan^aff1, Cheung, Tony^aff1, Grande, Christie^aff1, Ferguson, Andrew D.^aff2, Zhu, Xiahui^aff1, Theriault, Kelly^aff1, Code, Erin^aff1, Birr, Cynthia^aff1, Keen, Nick^aff1, Chen, Huawei^aff1

Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome

Olivier, Nelson B., Altman, Roger B., Noeske, Jonas, Basarab, Gregory S., Code, Erin, Ferguson, Andrew D., Gao, Ning, Huang, Jian, Juette, Manuel F., Livchak, Stephania, Miller, Matthew D., Prince, D. Bryan, Cate, Jamie H. D., Buurman, Ed T., Blanchard, Scott C.

Correction to Discovery of Pyrazolo[1,5‑a]pyrimidine B‑Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors

McCoull, William, Abrams, Roman D., Anderson, Erica, Blades, Kevin, Barton, Peter, Box, Matthew, Burgess, Jonathan, Byth, Kate, Cao, Qing, Chuaqui, Claudio, Carbajo, Rodrigo J., Cheung, Tony, Code, Erin, Ferguson, Andrew D., Fillery, Shaun, Fuller, Nathan O., Gangl, Eric, Gao, Ning, Grist, Matthew, Hargreaves, David, Howard, Martin R., Hu, Jun, Kemmitt, Paul D., Nelson, Jennifer E., O’Connell, Nichole, Prince, D. Bryan, Raubo, Piotr, Rawlins, Philip B., Robb, Graeme R., Shi, Junjie, Waring, Michael J., Whittaker, David, Wylot, Marta, Zhu, Xiahui

Free energy perturbation in the design of EED ligands as inhibitors of polycomb repressive complex 2 (PRC2) methyltransferase

O' Donovan, Daniel H., Gregson, Clare, Packer, Martin J., Greenwood, Ryan, Pike, Kurt G., Kawatkar, Sameer, Bloecher, Andrew, Robinson, James, Read, Jon, Code, Erin, Hsu, Jessie Hao-Ru, Shen, Minhui, Woods, Haley, Barton, Peter, Fillery, Shaun, Williamson, Beth, Rawlins, Philip B., Bagal, Sharan K.

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Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases

Dakin, Les A., Block, Michael H., Chen, Huawei, Code, Erin, Dowling, James E., Feng, Xiaomei, Ferguson, Andrew D., Green, Isabelle, Hird, Alexander W., Howard, Tina, Keeton, Erika K., Lamb, Michelle L., Lyne, Paul D., Pollard, Hannah, Read, Jon, Wu, Allan J., Zhang, Tao, Zheng, Xiaolan

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Discovery of ()-N-(3-Aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a Kinesin Spindle Protein Inhibitor and Potential Anticancer Agent.

Theoclitou, Maria-Elena¹, Aquila, Brian¹, Block, Michael H.¹, Brassil, Patrick J.¹, Castriotta, Lillian¹, Code, Erin¹, Collins, Michael P.¹, Davies, Audrey M.¹, Deegan, Tracy¹, Ezhuthachan, Jayachandran¹, Filla, Sandra¹, Freed, Ellen¹, Hu, Haiqing¹, Huszar, Dennis¹, Jayaraman, Muthusamy¹, Lawson, Deborah¹, Lewis, Paula M¹, Nadella, Murali V. P.¹, Oza, Vibha¹, Padmanilayam, Maniyan¹

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