Search Results - "Crackett, Peter"

Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1

Gazzard, Lewis^aff1d1, Williams, Karen^aff2, Chen, Huifen^aff1d1, Axford, Lorraine^aff2, Blackwood, Elizabeth^aff1d2, Burton, Brenda^aff2, Chapman, Kerry^aff2, Crackett, Peter^aff2, Drobnick, Joy^aff1d1, Ellwood, Charles^aff2, Epler, Jennifer^aff1d2, Flagella, Michael^aff1d3, Gancia, Emanuela^aff2, Gill, Matthew^aff2, Goodacre, Simon^aff2, Halladay, Jason^aff1d4, Hewitt, Joanne^aff2, Hunt, Hazel^aff2, Kintz, Samuel^aff1d1, Lyssikatos, Joseph^aff1d1, Macleod, Calum^aff2, Major, Sarah^aff2, Médard, Guillaume^aff2, Narukulla, Raman^aff2, Ramiscal, Judi^aff1d2, Schmidt, Stephen^aff1d5, Seward, Eileen^aff2, Wiesmann, Christian^aff1d6, Wu, Ping^aff1d6, Yee, Sharon^aff1d2, Yen, Ivana^aff1d5, Malek, Shiva^aff1d5

Identification of C‑2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2

Zak, Mark^aff1d1, Hurley, Christopher A.^aff2, Ward, Stuart I.^aff2, Bergeron, Philippe^aff1d1, Barrett, Kathy^aff1d2, Balazs, Mercedesz^aff1d9, Blair, Wade S.^aff1d2, Bull, Richard^aff2, Chakravarty, Paroma^aff1d6, Chang, Christine^aff1d2, Crackett, Peter^aff2, Deshmukh, Gauri^aff1d3, DeVoss, Jason^aff1d9, Dragovich, Peter S.^aff1d1, Eigenbrot, Charles^aff1d8, Ellwood, Charles^aff2, Gaines, Simon^aff2, Ghilardi, Nico^aff1d4, Gibbons, Paul^aff1d1, Gradl, Stefan^aff1d1, Gribling, Peter^aff1d9, Hamman, Chris^aff1d1, Harstad, Eric^aff1d5, Hewitt, Peter^aff2, Johnson, Adam^aff1d2, Johnson, Tony^aff2, Kenny, Jane R.^aff1d3, Koehler, Michael F. T.^aff1d1, Bir Kohli, Pawan^aff1d2, Labadie, Sharada^aff1d1, Lee, Wyne P.^aff1d9, Liao, Jiangpeng^aff3, Liimatta, Marya^aff1d2, Mendonca, Rohan^aff1d1, Narukulla, Raman^aff2, Pulk, Rebecca^aff1d1, Reeve, Austin^aff2, Savage, Scott^aff1d7, Shia, Steven^aff1d8, Steffek, Micah^aff1d8, Ubhayakar, Savita^aff1d3, van Abbema, Anne^aff1d2, Aliagas, Ignacio^aff1d1, Avitabile-Woo, Barbara^aff2, Xiao, Yisong^aff3, Yang, Jing^aff3, Kulagowski, Janusz J.^aff2

Design, synthesis and characterization of a novel class of coumarin-based inhibitors of inducible nitric oxide synthase

Jackson, Sharon A., Sahni, Sukhveen, Lee, Lan, Luo, Yongyi, Nieduzak, Thaddeus R., Liang, Guyan, Chiang, Yulin, Collar, Nicola, Fink, David, He, Wei, Laoui, Abdelazize, Merrill, Jean, Boffey, Ray, Crackett, Peter, Rees, Bryan, Wong, Melanie, Guilloteau, Jean-Pierre, Mathieu, Magali, Rebello, Sam S.

Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling

Zak, Mark, Hanan, Emily J., Lupardus, Patrick, Brown, David G., Robinson, Colin, Siu, Michael, Lyssikatos, Joseph P., Romero, F. Anthony, Zhao, Guiling, Kellar, Terry, Mendonca, Rohan, Ray, Nicholas C., Goodacre, Simon C., Crackett, Peter H., McLean, Neville, Hurley, Christopher A., Yuen, Po-wai, Cheng, Yun-Xing, Liu, Xiongcai, Liimatta, Marya, Kohli, Pawan Bir, Nonomiya, Jim, Salmon, Gary, Buckley, Gerry, Lloyd, Julia, Gibbons, Paul, Ghilardi, Nico, Kenny, Jane R., Johnson, Adam

Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1

Hurley, Christopher A., Blair, Wade S., Bull, Richard J., Chang, Christine, Crackett, Peter H., Deshmukh, Gauri, Dyke, Hazel J., Fong, Rina, Ghilardi, Nico, Gibbons, Paul, Hewitt, Peter R., Johnson, Adam, Johnson, Tony, Kenny, Jane R., Kohli, Pawan Bir, Kulagowski, Janusz J., Liimatta, Marya, Lupardus, Patrick J., Maxey, Robert J., Mendonca, Rohan, Narukulla, Raman, Pulk, Rebecca, Ubhayakar, Savita, van Abbema, Anne, Ward, Stuart I., Waszkowycz, Bohdan, Zak, Mark

1 H-Pyrazolo[3,4- g]hexahydro-isoquinolines as selective glucocorticoid receptor antagonists with high functional activity

Clark, Robin D., Ray, Nicholas C., Williams, Karen, Blaney, Paul, Ward, Stuart, Crackett, Peter H., Hurley, Christopher, Dyke, Hazel J., Clark, David E., Lockey, Peter, Devos, Rene, Wong, Melanie, Porres, Soraya S., Bright, Colin P., Jenkins, Robert E., Belanoff, Joseph

2-Benzenesulfonyl-8a-benzyl-hexahydro-2H-isoquinolin-6-ones as selective glucocorticoid receptor antagonists

Clark, Robin D., Ray, Nicholas C., Blaney, Paul, Crackett, Peter H., Hurley, Christopher, Williams, Karen, Dyke, Hazel J., Clark, David E., Lockey, Peter M., Devos, Rene, Wong, Melanie, White, Anne, Belanoff, Joseph K.

Discovery and optimization of novel, non-steroidal glucocorticoid receptor modulators

Ray, Nicholas C., Clark, Robin D., Clark, David E., Williams, Karen, Hickin, H.G., Crackett, Peter H., Dyke, Hazel J., Lockey, Peter M., Wong, Melanie, Devos, René, White, Anne, Belanoff, Joseph K.

Identification and optimisation of a series of substituted 5-(1 H-pyrazol-3-yl)-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors

Price, Steve, Bordogna, Walter, Bull, Richard J., Clark, David E., Crackett, Peter H., Dyke, Hazel J., Gill, Matthew, Harris, Neil V., Gorski, Julia, Lloyd, Julia, Lockey, Peter M., Mullett, Julia, Roach, Alan G., Roussel, Fabien, White, Anne B.

Mitigation of AcetylcholineEsterase Activity in the 1,7-Diazacarbazole Series of Inhibitors ofCheckpoint Kinase 1.

Gazzard, Lewis¹, Williams, Karen¹, Chen, Huifen¹, Axford, Lorraine¹, Blackwood, Elizabeth¹, Burton, Brenda¹, Chapman, Kerry¹, Crackett, Peter¹, Drobnick, Joy¹, Ellwood, Charles¹, Epler, Jennifer¹, Flagella, Michael¹, Gancia, Emanuela¹, Gill, Matthew¹, Goodacre, Simon¹, Halladay, Jason¹, Hewitt, Joanne¹, Hunt, Hazel¹, Kintz, Samuel¹, Lyssikatos, Joseph¹

Identificationof C-2 HydroxyethylImidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable PhysicochemicalProperties and High Selectivity over JAK2.

Zak, Mark¹, Hurley, Christopher A.¹, Ward, Stuart I.¹, Bergeron, Philippe¹, Barrett, Kathy¹, Balazs, Mercedesz¹, Blair, Wade S.¹, Bull, Richard¹, Chakravarty, Paroma¹, Chang, Christine¹, Crackett, Peter¹, Deshmukh, Gauri¹, DeVoss, Jason¹, Dragovich, Peter S.¹, Eigenbrot, Charles¹, Ellwood, Charles¹, Gaines, Simon¹, Ghilardi, Nico¹, Gibbons, Paul¹, Gradl, Stefan¹

HIV Protease Inhibitor Part 1: Use of Evans’ Oxazolidinone in Intermolecular Diels-Alder Reaction en route to 3,4-Substituted Cyclohexanones.

Crackett, Peter, Demont, Emmanuel, Eatherton, Andrew, Frampton, Christopher S., Gilbert, Jenny, Kahn, Irfan, Redshaw, Sally, Watson, William

Total synthesis of analogues of the β-lactam antibiotics. Part 6. (6R*)-4(t-butoxycarbonyl)-2-methoxycarbonyl-3-oxacepham 1,1-dioxides.

Crackett, Peter H., Sayer, Paul, Stoodley, Richard J., Greengrass, Colin W.

Total synthesis of analogues of the β-lactam antibiotics. Part 5. 3-Thiacepham-4-exo-carboxylates and their 1,1,3,3-tetraoxides.

Beagley, Brian, Crackett, Peter H., Pritchard, Robin G., Stoodley, Richard J., Greengrass, Colin W.

Total synthesis of analogues of the β-lactam antibiotics. Part 2. Isopenam-3-carboxylates and their 2,2-dioxides.

Crackett, Peter H., Pant, Chandra M., Stoodley, Richard J.

β-Lactam-cleavage reactions of isopenam-3-carboxylates and their 2,2-dioxides.

Crackett, Peter H., Pant, Chandra M., Stoodley, Richard J.

Synthesis of racemic 3-thiacepham-4-carboxylates and their 1,1,3,3-tetroxides.

Crackett, Peter H., Greengrass, Colin W., Stoodley, Richard J.

A convenient synthesis of bisindolylmaleimides

Bit, Rino A., Crackett, Peter H., Harris, William, Hill, Christopher H.

Asymmetric synthesis via acetal templates. 9. Further studies of the allylation reaction. Preparation of (−)-dihydromyoporone

Johnson, William S., Crackett, Peter H., Elliott, John D., Jagodzinski, Jacek J., Lindell, Stephen D., Natarajan, S.

Synthesis of 2-(methoxycarbonyl)methyl-7-phenylacetamido-3-thiacepham-4-carboxylates

Crackett, Peter H., Greengrass, Colin V., Stoodley, Richard J.