Sökresultat - "Cresswell GD"

Heterogeneity and evolution of DNA mutation rates in microsatellite stable colorectal cancer.

Grassi E; Department of Oncology, University of Torino, 10060 Candiolo, Torino, Italy.; Candiolo Cancer Institute-FPO IRCCS, 10060 Candiolo, Torino, Italy., Vurchio V; Department of Oncology, University of Torino, 10060 Candiolo, Torino, Italy.; Candiolo Cancer Institute-FPO IRCCS, 10060 Candiolo, Torino, Italy., Cresswell GD; Centre for Evolution and Cancer, Institute of Cancer Research, London SW7 3RP, UK.; St. Anna Children's Cancer Research Institute, 1090 Vienna, Austria., Catalano I; Candiolo Cancer Institute-FPO IRCCS, 10060 Candiolo, Torino, Italy., Lupo B; Department of Oncology, University of Torino, 10060 Candiolo, Torino, Italy.; Candiolo Cancer Institute-FPO IRCCS, 10060 Candiolo, Torino, Italy., Sassi F; Candiolo Cancer Institute-FPO IRCCS, 10060 Candiolo, Torino, Italy., Galimi F; Department of Oncology, University of Torino, 10060 Candiolo, Torino, Italy.; Candiolo Cancer Institute-FPO IRCCS, 10060 Candiolo, Torino, Italy., Borgato S; Department of Oncology, University of Torino, 10060 Candiolo, Torino, Italy.; Candiolo Cancer Institute-FPO IRCCS, 10060 Candiolo, Torino, Italy., Ferri M; Department of Oncology, University of Torino, 10060 Candiolo, Torino, Italy.; Candiolo Cancer Institute-FPO IRCCS, 10060 Candiolo, Torino, Italy., Viviani M; Department of Oncology, University of Torino, 10060 Candiolo, Torino, Italy.; Candiolo Cancer Institute-FPO IRCCS, 10060 Candiolo, Torino, Italy., Pompei S; IFOM ETS-AIRC Institute of Molecular Oncology, 20139 Milano, Italy., Urgese G; Interuniversity Department of Regional and Urban Studies and Planning, Polytechnic University of Torino, 10129 Torino, Italy., Chen B; Centre for Evolution and Cancer, Institute of Cancer Research, London SW7 3RP, UK.; GMU-GIBH Joint School of Life Sciences, Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, 510580 Guangzhou, China., Zanella ER; Candiolo Cancer Institute-FPO IRCCS, 10060 Candiolo, Torino, Italy., Cottino F; Candiolo Cancer Institute-FPO IRCCS, 10060 Candiolo, Torino, Italy., Russo M; IFOM ETS-AIRC Institute of Molecular Oncology, 20139 Milano, Italy.; Department of Oncology, Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy., Mauri G; IFOM ETS-AIRC Institute of Molecular Oncology, 20139 Milano, Italy.; Department of Hematology, Oncology and Molecular Medicine, Grande Ospedale Metropolitano Niguarda, 20162 Milano, Italy., Pietrantonio F; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milano, Italy., Zampino MG; Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology IRCCS, 20141 Milano, Italy., Lazzari L; IFOM ETS-AIRC Institute of Molecular Oncology, 20139 Milano, Italy., Marsoni S; IFOM ETS-AIRC Institute of Molecular Oncology, 20139 Milano, Italy., Bardelli A; IFOM ETS-AIRC Institute of Molecular Oncology, 20139 Milano, Italy.; Department of Oncology, Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy., Lagomarsino MC; IFOM ETS-AIRC Institute of Molecular Oncology, 20139 Milano, Italy., Sottoriva A; Centre for Evolution and Cancer, Institute of Cancer Research, London SW7 3RP, UK.; Computational Biology Research Centre, Human Technopole, 20157 Milano, Italy., Trusolino L; Department of Oncology, University of Torino, 10060 Candiolo, Torino, Italy.; Candiolo Cancer Institute-FPO IRCCS, 10060 Candiolo, Torino, Italy., Bertotti A; Department of Oncology, University of Torino, 10060 Candiolo, Torino, Italy.; Candiolo Cancer Institute-FPO IRCCS, 10060 Candiolo, Torino, Italy.

Journal Article , 2025

Low-coverage whole genome sequencing of low-grade dysplasia strongly predicts advanced neoplasia risk in ulcerative colitis.

Al Bakir I; Barts Cancer Institute, Queen Mary University of London, London, UK.; Inflammatory Bowel Disease Unit, St Mark's Hospital, Harrow, UK.; Chelsea & Westminster Hospital, London, UK., Curtius K; Barts Cancer Institute, Queen Mary University of London, London, UK kcurtius@health.ucsd.edu simon.leedham@well.ox.ac.uk ailsa.hart@nhs.net trevor.graham@icr.ac.uk.; Division of Biomedical Informatics, Department of Medicine, University of California San Diego, La Jolla, California, USA.; VA San Diego Healthcare System, San Diego, California, USA.; Moores Cancer Center, Univeristy of California San Diego, La Jolla, California, USA., Cresswell GD; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; St. Anna Children's Cancer Research Institute, Vienna, Austria., Grant HE; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Nasreddin N; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Smith K; Barts Cancer Institute, Queen Mary University of London, London, UK.; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Nowinski S; Barts Cancer Institute, Queen Mary University of London, London, UK.; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Guo Q; Barts Cancer Institute, Queen Mary University of London, London, UK.; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Belnoue-Davis HL; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Fisher J; Inflammatory Bowel Disease Unit, St Mark's Hospital, Harrow, UK.; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Clarke T; Barts Cancer Institute, Queen Mary University of London, London, UK., Kimberley C; Barts Cancer Institute, Queen Mary University of London, London, UK., Mossner M; Barts Cancer Institute, Queen Mary University of London, London, UK.; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Dunne PD; Centre for Cancer Research and Cell Biology, Queens University Belfast, Belfast, UK., Loughrey MB; Cellular Pathology, Belfast Health and Social Care Trust, Belfast, UK.; Centre for Public Health and Patrick G. Johnston for Cancer Research, Queen's University Belfast, Belfast, UK., Speight A; Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK., East JE; Translational Gastroenterology Unit, Nuffield Department of Medicine, John Radcliffe Hospital, Univerity of Oxford, Oxford, UK., Wright NA; Barts Cancer Institute, Queen Mary University of London, London, UK., Rodriguez-Justo M; Department of Pathology, University College London Hospital, London, UK.; UCL Cancer Institute, University College London, London, UK., Jansen M; Department of Pathology, University College London Hospital, London, UK.; UCL Cancer Institute, University College London, London, UK., Moorghen M; Department of Histopathology, St Mark's Hospital, Harrow, UK., Baker AM; Barts Cancer Institute, Queen Mary University of London, London, UK.; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Leedham SJ; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK kcurtius@health.ucsd.edu simon.leedham@well.ox.ac.uk ailsa.hart@nhs.net trevor.graham@icr.ac.uk.; Translational Gastroenterology Unit, Nuffield Department of Medicine, John Radcliffe Hospital, Univerity of Oxford, Oxford, UK., Hart AL; Inflammatory Bowel Disease Unit, St Mark's Hospital, Harrow, UK kcurtius@health.ucsd.edu simon.leedham@well.ox.ac.uk ailsa.hart@nhs.net trevor.graham@icr.ac.uk.; Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK., Graham TA; Barts Cancer Institute, Queen Mary University of London, London, UK kcurtius@health.ucsd.edu simon.leedham@well.ox.ac.uk ailsa.hart@nhs.net trevor.graham@icr.ac.uk.; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.

Journal Article; Multicenter Study , 2025

Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States.

George SL; Paediatric Oncology Experimental Medicine Centre (POEM), The Institute of Cancer Research, London, United Kingdom.; Children and Young People's Unit, The Royal Marsden Hospital, London, United Kingdom., Lynn C; Paediatric Oncology Experimental Medicine Centre (POEM), The Institute of Cancer Research, London, United Kingdom.; Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom., Stankunaite R; Paediatric Oncology Experimental Medicine Centre (POEM), The Institute of Cancer Research, London, United Kingdom.; Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom.; Clinical Genomics, Centre for Molecular Pathology, The Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom., Hughes D; Clinical Genomics, Centre for Molecular Pathology, The Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom., Sauer CM; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom., Chalker J; Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom., Waqar Ahmed S; Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom., Oostveen M; Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom., Proszek PZ; Clinical Genomics, Centre for Molecular Pathology, The Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom., Yuan L; Clinical Genomics, Centre for Molecular Pathology, The Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom., Shaikh R; Clinical Genomics, Centre for Molecular Pathology, The Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom., Jamal S; Clinical Genomics, Centre for Molecular Pathology, The Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom., Brew A; Clinical Genomics, Centre for Molecular Pathology, The Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom., Tall J; Paediatric Oncology Experimental Medicine Centre (POEM), The Institute of Cancer Research, London, United Kingdom., Rogers T; Paediatric Oncology Experimental Medicine Centre (POEM), The Institute of Cancer Research, London, United Kingdom., Clifford SC; Wolfson Childhood Cancer Research Centre, Newcastle University, Newcastle upon Tyne, United Kingdom., Vormoor J; Princess Máxima Center and University Medical Center, Utrecht, the Netherlands., Shipley JM; Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom., Tweddle DA; Wolfson Childhood Cancer Research Centre, Newcastle University, Newcastle upon Tyne, United Kingdom., Jones C; Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom., Willis C; Royal Aberdeen Children's Hospital, Aberdeen, United Kingdom., Burke GAA; Cambridge University Hospital NHS Foundation Trust, Cambridge, United Kingdom.; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom., Vedi A; Cambridge University Hospital NHS Foundation Trust, Cambridge, United Kingdom., Howell L; Alder-Hey Children's Hospital, Liverpool, United Kingdom., Johnston R; Royal Belfast Hospital for Sick Children, Belfast, United Kingdom., Rees H; Bristol Royal Hospital for Children, Bristol, United Kingdom., Adams M; Noah's Ark Children's Hospital for Wales, Cardiff, United Kingdom., Jesudason A; Royal Hospital for Sick Children, Edinburgh, United Kingdom., Ronghe M; Royal Hospital for Children, Glasgow, United Kingdom., Elliott M; Leeds General Infirmary, Leeds, United Kingdom., Ross E; Leicester Royal Infirmary, Leicester, United Kingdom., Makin G; Royal Manchester Children's Hospital, Manchester, United Kingdom., Campbell-Hewson Q; Great North Children's Hospital, Newcastle upon Tyne, United Kingdom., Grundy RG; Queen's Medical Centre, Nottingham, United Kingdom., Turnbull J; Queen's Medical Centre, Nottingham, United Kingdom., Wilson S; John Radcliffe Hospital, Oxford, United Kingdom., Lee V; Sheffield Children's Hospital, Sheffield, United Kingdom., Gray JC; Southampton General Hospital, Southampton, United Kingdom., Stoneham S; University College London, London, United Kingdom., Gatz SA; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom.; Birmingham Children's Hospital, Birmingham, United Kingdom., Marshall LV; Paediatric Oncology Experimental Medicine Centre (POEM), The Institute of Cancer Research, London, United Kingdom.; Children and Young People's Unit, The Royal Marsden Hospital, London, United Kingdom., Angelini P; Children and Young People's Unit, The Royal Marsden Hospital, London, United Kingdom.; Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom., Anderson J; Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.; Developmental Biology and Cancer Department, UCL GOS Institute of Child Health, London, United Kingdom., Cresswell GD; Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom.; St. Anna Children's Cancer Research Institute, Vienna, Austria., Graham TA; Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom., Al-Lazikani B; Department of Genomic Medicine and the Therapeutics Discovery Division, MD Anderson Cancer Center, Houston, Texas., Cortés-Ciriano I; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom., Kearns P; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom., Hutchinson JC; Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom., Hargrave D; Developmental Biology and Cancer Department, UCL GOS Institute of Child Health, London, United Kingdom.; Haematology and Oncology Department, Great Ormond Street Hospital, London, United Kingdom., Jacques TS; Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.; Developmental Biology and Cancer Department, UCL GOS Institute of Child Health, London, United Kingdom., Hubank M; Clinical Genomics, Centre for Molecular Pathology, The Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom., Sottoriva A; Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom.; Computational Biology Research Centre, Human Technopole, Milan, Italy., Chesler L; Paediatric Oncology Experimental Medicine Centre (POEM), The Institute of Cancer Research, London, United Kingdom.; Children and Young People's Unit, The Royal Marsden Hospital, London, United Kingdom.

Journal Article , 2025

Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer.

Fernandez-Mateos J; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Cresswell GD; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; St. Anna Children's Cancer Research Institute, Vienna, Austria., Trahearn N; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Webb K; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; The Royal Marsden NHS Foundation Trust, London, UK., Sakr C; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Lampis A; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Stuttle C; The Royal Marsden NHS Foundation Trust, London, UK.; Oncogenetics Team, The Institute of Cancer Research, London, UK., Corbishley CM; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK.; St. George's Hospital Healthcare NHS Trust, London, UK., Stavrinides V; Division of Surgery and Interventional Science, UCL, London, UK., Zapata L; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Spiteri I; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Heide T; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Computational Biology Research Centre, Human Technopole, Milan, Italy., Gallagher L; Molecular Pathology Section, The Institute of Cancer Research, London, UK.; Clinical Genomics, The Royal Marsden NHS Foundation, London, UK., James C; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Computational Biology Research Centre, Human Technopole, Milan, Italy., Ramazzotti D; University of Milano Bicocca, Milan, Italy., Gao A; Bob Champion Cancer Unit, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK., Kote-Jarai Z; Oncogenetics Team, The Institute of Cancer Research, London, UK., Acar A; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Department of Biological Sciences, Middle East Technical University, Ankara, Turkey., Truelove L; Bob Champion Cancer Unit, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK., Proszek P; Molecular Pathology Section, The Institute of Cancer Research, London, UK.; Clinical Genomics, The Royal Marsden NHS Foundation, London, UK., Murray J; The Royal Marsden NHS Foundation Trust, London, UK.; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK., Reid A; The Royal Marsden NHS Foundation Trust, London, UK., Wilkins A; The Royal Marsden NHS Foundation Trust, London, UK.; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK., Hubank M; Molecular Pathology Section, The Institute of Cancer Research, London, UK.; Clinical Genomics, The Royal Marsden NHS Foundation, London, UK., Eeles R; The Royal Marsden NHS Foundation Trust, London, UK.; Oncogenetics Team, The Institute of Cancer Research, London, UK., Dearnaley D; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK. david.dearnaley@icr.ac.uk.; Academic Urology Unit, The Royal Marsden NHS Foundation Trust, London, UK. david.dearnaley@icr.ac.uk., Sottoriva A; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK. andrea.sottoriva@fht.org.; Computational Biology Research Centre, Human Technopole, Milan, Italy. andrea.sottoriva@fht.org.

Journal Article , 2024

A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations.

Saldana-Guerrero IM; Centre for Stem Cell Biology, School of Biosciences, The University of Sheffield, Sheffield, UK.; Neuroscience Institute, The University of Sheffield, Sheffield, UK.; Sheffield Institute for Nucleic Acids (SInFoNiA), School of Medicine and Population Health, The University of Sheffield, Sheffield, UK., Montano-Gutierrez LF; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Boswell K; Centre for Stem Cell Biology, School of Biosciences, The University of Sheffield, Sheffield, UK.; Neuroscience Institute, The University of Sheffield, Sheffield, UK., Hafemeister C; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Poon E; Division of Clinical Studies, The Institute of Cancer Research (ICR) & Royal Marsden NHS Trust, London, UK., Shaw LE; Department of Dermatology, Medical University of Vienna, Vienna, Austria., Stavish D; Centre for Stem Cell Biology, School of Biosciences, The University of Sheffield, Sheffield, UK.; Neuroscience Institute, The University of Sheffield, Sheffield, UK., Lea RA; Centre for Stem Cell Biology, School of Biosciences, The University of Sheffield, Sheffield, UK.; Neuroscience Institute, The University of Sheffield, Sheffield, UK., Wernig-Zorc S; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Bozsaky E; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Fetahu IS; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.; Medical University of Vienna, Department of Neurology, Division of Neuropathology and Neurochemistry, Vienna, Austria., Zoescher P; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Pötschger U; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Bernkopf M; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.; Labdia Labordiagnostik GmbH, Vienna, Austria., Wenninger-Weinzierl A; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Sturtzel C; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Souilhol C; Centre for Stem Cell Biology, School of Biosciences, The University of Sheffield, Sheffield, UK.; Neuroscience Institute, The University of Sheffield, Sheffield, UK.; Biomolecular Sciences Research Centre, Department of Biosciences and Chemistry, Sheffield Hallam University, Sheffield, UK., Tarelli S; Centre for Stem Cell Biology, School of Biosciences, The University of Sheffield, Sheffield, UK.; Neuroscience Institute, The University of Sheffield, Sheffield, UK., Shoeb MR; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Bozatzi P; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Rados M; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Guarini M; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Buri MC; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Weninger W; Department of Dermatology, Medical University of Vienna, Vienna, Austria., Putz EM; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Huang M; Children's Hospital Los Angeles, Cancer and Blood Disease Institutes, and The Saban Research Institute, Los Angeles, CA, USA.; Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Ladenstein R; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Andrews PW; Centre for Stem Cell Biology, School of Biosciences, The University of Sheffield, Sheffield, UK., Barbaric I; Centre for Stem Cell Biology, School of Biosciences, The University of Sheffield, Sheffield, UK.; Neuroscience Institute, The University of Sheffield, Sheffield, UK., Cresswell GD; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Bryant HE; Sheffield Institute for Nucleic Acids (SInFoNiA), School of Medicine and Population Health, The University of Sheffield, Sheffield, UK., Distel M; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Chesler L; Division of Clinical Studies, The Institute of Cancer Research (ICR) & Royal Marsden NHS Trust, London, UK., Taschner-Mandl S; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Farlik M; Department of Dermatology, Medical University of Vienna, Vienna, Austria., Tsakiridis A; Centre for Stem Cell Biology, School of Biosciences, The University of Sheffield, Sheffield, UK. a.tsakiridis@sheffield.ac.uk.; Neuroscience Institute, The University of Sheffield, Sheffield, UK. a.tsakiridis@sheffield.ac.uk., Halbritter F; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria. florian.halbritter@ccri.at.

Journal Article; Research Support, Non-U.S. Gov't , 2024

Long-term Multimodal Recording Reveals Epigenetic Adaptation Routes in Dormant Breast Cancer Cells.

Rosano D; Department of Surgery and Cancer, Imperial College London, London, United Kingdom.; The Breast Cancer Now Toby Robins Research Center, The Institute of Cancer Research, London, United Kingdom., Sofyali E; Department of Surgery and Cancer, Imperial College London, London, United Kingdom., Dhiman H; Department of Surgery and Cancer, Imperial College London, London, United Kingdom.; The Breast Cancer Now Toby Robins Research Center, The Institute of Cancer Research, London, United Kingdom., Ghirardi C; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy., Ivanoiu D; Department of Surgery and Cancer, Imperial College London, London, United Kingdom., Heide T; Human Technopole, Milan, Italy.; Centre for Evolution and Cancer, Institute of Cancer Research, London, United Kingdom., Vingiani A; Istituto Nazionale Tumori, Milan, Italy., Bertolotti A; Istituto Nazionale Tumori, Milan, Italy., Pruneri G; Istituto Nazionale Tumori, Milan, Italy.; Department of Oncology and Haematology-Oncology, University of Milano, Milano, Italy., Canale E; Department of Surgery and Cancer, Imperial College London, London, United Kingdom., Dewhurst HF; Department of Surgery and Cancer, Imperial College London, London, United Kingdom., Saha D; Department of Surgery and Cancer, Imperial College London, London, United Kingdom., Slaven N; Department of Surgery and Cancer, Imperial College London, London, United Kingdom.; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley., Barozzi I; Department of Surgery and Cancer, Imperial College London, London, United Kingdom.; Centre for Cancer Research, Medical University of Vienna, Austria., Li T; Department of Surgery and Cancer, Imperial College London, London, United Kingdom., Zemlyanskiy G; Department of Surgery and Cancer, Imperial College London, London, United Kingdom., Phillips H; Department of Surgery and Cancer, Imperial College London, London, United Kingdom., James C; Human Technopole, Milan, Italy.; Centre for Evolution and Cancer, Institute of Cancer Research, London, United Kingdom., Győrffy B; Department of Bioinformatics, Semmelweis University, Budapest, Hungary.; RCNS Cancer Biomarker Research Group, Budapest, Hungary.; Department of Biophysics, Medical School, University of Pecs, Pecs, Hungary., Lynn C; Centre for Evolution and Cancer, Institute of Cancer Research, London, United Kingdom., Cresswell GD; Centre for Evolution and Cancer, Institute of Cancer Research, London, United Kingdom., Rehman F; Charing Cross Hospital, Imperial College NHS Trust, London, United Kingdom., Noberini R; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy., Bonaldi T; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.; Department of Oncology and Haematology-Oncology, University of Milano, Milano, Italy., Sottoriva A; Human Technopole, Milan, Italy.; Centre for Evolution and Cancer, Institute of Cancer Research, London, United Kingdom., Magnani L; Department of Surgery and Cancer, Imperial College London, London, United Kingdom.; The Breast Cancer Now Toby Robins Research Center, The Institute of Cancer Research, London, United Kingdom.

Journal Article; Research Support, Non-U.S. Gov't , 2024

Epigenome and early selection determine the tumour-immune evolutionary trajectory of colorectal cancer.

Lakatos E; Department of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Gothenburg, Sweden.; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Gunasri V; UCL Cancer Institute, University College London, London, UK.; Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Zapata L; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Househam J; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Heide T; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Computational Biology Research Centre, Human Technopole, Milan, Italy., Trahearn N; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Swinyard O; Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Cisneros L; Arizona Cancer Evolution Center, Biodesign Institute and School of Life Sciences Arizona State University, Tempe, USA., Lynn C; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Mossner M; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Kimberley C; Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Spiteri I; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Cresswell GD; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Llibre-Palomar G; Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Mitchison M; Histopathology Department, University College London Hospitals NHS Foundation Trust, London, UK., Maley CC; Arizona Cancer Evolution Center, Biodesign Institute and School of Life Sciences Arizona State University, Tempe, USA., Jansen M; UCL Cancer Institute, University College London, London, UK., Rodriguez-Justo M; UCL Cancer Institute, University College London, London, UK., Bridgewater J; UCL Cancer Institute, University College London, London, UK., Baker AM; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Sottoriva A; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Computational Biology Research Centre, Human Technopole, Milan, Italy., Graham TA; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK.

Preprint; Journal Article , 2024

The co-evolution of the genome and epigenome in colorectal cancer.

Heide T; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Computational Biology Research Centre, Human Technopole, Milan, Italy., Househam J; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Evolution and Cancer Lab, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Cresswell GD; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Spiteri I; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Lynn C; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Mossner M; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Evolution and Cancer Lab, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Kimberley C; Evolution and Cancer Lab, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Fernandez-Mateos J; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Chen B; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Zapata L; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., James C; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Barozzi I; Department of Surgery and Cancer, Imperial College London, London, UK.; Centre for Cancer Research, Medical University of Vienna, Vienna, Austria., Chkhaidze K; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Nichol D; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Gunasri V; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Evolution and Cancer Lab, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Berner A; Evolution and Cancer Lab, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Schmidt M; Evolution and Cancer Lab, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Lakatos E; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Evolution and Cancer Lab, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Baker AM; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Evolution and Cancer Lab, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Costa H; Department of Pathology, UCL Cancer Institute, University College London, London, UK., Mitchinson M; Department of Pathology, UCL Cancer Institute, University College London, London, UK., Piazza R; Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy., Jansen M; Department of Pathology, UCL Cancer Institute, University College London, London, UK., Caravagna G; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Department of Mathematics and Geosciences, University of Triest, Triest, Italy., Ramazzotti D; Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy., Shibata D; Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA., Bridgewater J; UCL Cancer Institute, University College London, London, UK., Rodriguez-Justo M; Department of Pathology, UCL Cancer Institute, University College London, London, UK., Magnani L; Department of Surgery and Cancer, Imperial College London, London, UK., Graham TA; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK. trevor.graham@icr.ac.uk.; Evolution and Cancer Lab, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK. trevor.graham@icr.ac.uk., Sottoriva A; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK. andrea.sottoriva@fht.org.; Computational Biology Research Centre, Human Technopole, Milan, Italy. andrea.sottoriva@fht.org.

Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural , 2022

Phenotypic plasticity and genetic control in colorectal cancer evolution.

Househam J; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Heide T; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Computational Biology Research Centre, Human Technopole, Milan, Italy., Cresswell GD; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Spiteri I; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Kimberley C; Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Zapata L; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Lynn C; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., James C; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Mossner M; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Fernandez-Mateos J; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Vinceti A; Computational Biology Research Centre, Human Technopole, Milan, Italy., Baker AM; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Gabbutt C; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Berner A; Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Schmidt M; Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Chen B; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Lakatos E; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Gunasri V; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Nichol D; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Costa H; UCL Cancer Institute, University College London, London, UK., Mitchinson M; Histopathology Department, University College London Hospitals NHS Foundation Trust, London, UK., Ramazzotti D; Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy., Werner B; Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Iorio F; Computational Biology Research Centre, Human Technopole, Milan, Italy., Jansen M; UCL Cancer Institute, University College London, London, UK., Caravagna G; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Department of Mathematics and Geosciences, University of Trieste, Trieste, Italy., Barnes CP; Department of Cell and Developmental Biology, University College London, London, UK., Shibata D; Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA., Bridgewater J; UCL Cancer Institute, University College London, London, UK., Rodriguez-Justo M; UCL Cancer Institute, University College London, London, UK., Magnani L; Department of Surgery and Cancer, Imperial College London, London, UK., Sottoriva A; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK. andrea.sottoriva@fht.org.; Computational Biology Research Centre, Human Technopole, Milan, Italy. andrea.sottoriva@fht.org., Graham TA; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK. trevor.graham@icr.ac.uk.; Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK. trevor.graham@icr.ac.uk.

Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural , 2022

EGFR amplification and outcome in a randomised phase III trial of chemotherapy alone or chemotherapy plus panitumumab for advanced gastro-oesophageal cancers.

Smyth EC; Department of Oncology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Medicine, Royal Marsden Hospital NHS Trust, London, UK., Vlachogiannis G; Molecular Pathology, The Institute of Cancer Research, Sutton, UK.; Centre for Evolution and Cancer, The Institute of Cancer Research, Sutton, UK., Hedayat S; Molecular Pathology, The Institute of Cancer Research, Sutton, UK.; Centre for Evolution and Cancer, The Institute of Cancer Research, Sutton, UK., Harbery A; Cancer Therapeutics, The Institute of Cancer Research, Sutton, UK., Hulkki-Wilson S; Molecular Pathology, The Institute of Cancer Research, Sutton, UK., Salati M; Molecular Pathology, The Institute of Cancer Research, Sutton, UK.; Centre for Evolution and Cancer, The Institute of Cancer Research, Sutton, UK., Kouvelakis K; Clinical Research & Development, Royal Marsden Hospital NHS Trust, London, UK., Fernandez-Mateos J; Centre for Evolution and Cancer, The Institute of Cancer Research, Sutton, UK., Cresswell GD; Centre for Evolution and Cancer, The Institute of Cancer Research, Sutton, UK., Fontana E; Molecular Pathology, The Institute of Cancer Research, Sutton, UK., Seidlitz T; Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Dresden, Germany., Peckitt C; Clinical Research & Development, Royal Marsden Hospital NHS Trust, London, UK., Hahne JC; Molecular Pathology, The Institute of Cancer Research, Sutton, UK.; Centre for Evolution and Cancer, The Institute of Cancer Research, Sutton, UK., Lampis A; Molecular Pathology, The Institute of Cancer Research, Sutton, UK.; Centre for Evolution and Cancer, The Institute of Cancer Research, Sutton, UK., Begum R; Department of Medicine, Royal Marsden Hospital NHS Trust, London, UK., Watkins D; Department of Medicine, Royal Marsden Hospital NHS Trust, London, UK., Rao S; Department of Medicine, Royal Marsden Hospital NHS Trust, London, UK., Starling N; Department of Medicine, Royal Marsden Hospital NHS Trust, London, UK., Waddell T; Department of Medicine, Royal Marsden Hospital NHS Trust, London, UK.; Department of Medical Oncology, Christie Hospital, Manchester, UK., Okines A; Department of Medicine, Royal Marsden Hospital NHS Trust, London, UK., Crosby T; Department of Clinical Oncology, Velindre Cancer Centre, Cardiff, UK., Mansoor W; Department of Medical Oncology, Christie Hospital, Manchester, UK., Wadsley J; Cancer Clinical Trials Centre, Weston Park Cancer Centre, Sheffield, UK., Middleton G; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK., Fassan M; Department of Medicine (DIMED), University of Padua, Padova, Italy., Wotherspoon A; Histopathology, Royal Marsden Hospital NHS Trust, London, UK., Braconi C; Department of Medicine, Royal Marsden Hospital NHS Trust, London, UK.; Cancer Therapeutics, The Institute of Cancer Research, Sutton, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Chau I; Department of Medicine, Royal Marsden Hospital NHS Trust, London, UK., Vivanco I; Cancer Therapeutics, The Institute of Cancer Research, Sutton, UK., Sottoriva A; Centre for Evolution and Cancer, The Institute of Cancer Research, Sutton, UK., Stange DE; Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Dresden, Germany.; German Cancer Consortium (DKTK), Partner Site Dresden, Heidelberg, Germany.; National Center for Tumor Diseases, Partner Site Dresden, Heidelberg, Germany., Cunningham D; Department of Medicine, Royal Marsden Hospital NHS Trust, London, UK., Valeri N; Department of Medicine, Royal Marsden Hospital NHS Trust, London, UK nicola.valeri@icr.ac.uk.; Molecular Pathology, The Institute of Cancer Research, Sutton, UK.; Centre for Evolution and Cancer, The Institute of Cancer Research, Sutton, UK.

Clinical Trial, Phase III; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't , 2021

Pervasive chromosomal instability and karyotype order in tumour evolution.

Watkins TBK; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Lim EL; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Petkovic M; Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Berlin, Germany., Elizalde S; Department of Mathematics, Dartmouth College, Hanover, NH, USA., Birkbak NJ; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.; Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark.; Bioinformatics Research Centre (BiRC), Aarhus University, Aarhus, Denmark., Wilson GA; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Moore DA; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Department of Cellular Pathology, University College London Hospitals, London, UK., Grönroos E; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Rowan A; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Dewhurst SM; Laboratory for Cell Biology and Genetics, Rockefeller University, New York, NY, USA., Demeulemeester J; Cancer Genomics Laboratory, The Francis Crick Institute, London, UK.; Department of Human Genetics, University of Leuven, Leuven, Belgium., Dentro SC; Cancer Genomics Laboratory, The Francis Crick Institute, London, UK.; Oxford Big Data Institute, University of Oxford, Oxford, UK.; Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, UK., Horswell S; Department of Bioinformatics and Biostatistics, The Francis Crick Institute, London, UK., Au L; Renal and Skin Units, The Royal Marsden Hospital NHS Foundation Trust, London, UK.; Cancer Dynamics Laboratory, The Francis Crick Institute, London, UK., Haase K; Cancer Genomics Laboratory, The Francis Crick Institute, London, UK., Escudero M; Department of Bioinformatics and Biostatistics, The Francis Crick Institute, London, UK., Rosenthal R; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Bill Lyons Informatics Centre, University College London Cancer Institute, London, UK., Bakir MA; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Xu H; Stanford Cancer Institute, Stanford, CA, USA., Litchfield K; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Lu WT; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Mourikis TP; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Genome Evolution Research Group, University College London Cancer Institute, University College London, London, UK., Dietzen M; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Genome Evolution Research Group, University College London Cancer Institute, University College London, London, UK., Spain L; Renal and Skin Units, The Royal Marsden Hospital NHS Foundation Trust, London, UK.; Cancer Dynamics Laboratory, The Francis Crick Institute, London, UK., Cresswell GD; Bioinformatics and Computational Biology Laboratory, The Francis Crick Institute, London, UK., Biswas D; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.; Bill Lyons Informatics Centre, University College London Cancer Institute, London, UK., Lamy P; Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark., Nordentoft I; Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark., Harbst K; Division of Oncology and Pathology, Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, Lund, Sweden.; Lund University Cancer Centre, Lund University, Lund, Sweden., Castro-Giner F; Department of Biomedicine, Cancer Metastasis Laboratory, University of Basel and University Hospital Basel, Basel, Switzerland.; Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland., Yates LR; Wellcome Trust Sanger Institute, Hinxton, UK.; Department of Clinical Oncology, Guy's and St Thomas' NHS Foundation Trust, London, UK., Caramia F; Division of Research, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia., Jaulin F; INSERM U1279, Gustave Roussy, Villejuif, France., Vicier C; Department of Medical Oncology, Institut Paoli-Calmettes, Aix-Marseille University, Marseille, France., Tomlinson IPM; Edinburgh Cancer Research Centre, IGMM, University of Edinburgh, Edinburgh, UK., Brastianos PK; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA., Cho RJ; Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA., Bastian BC; Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA.; Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA., Dyrskjøt L; Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark., Jönsson GB; Division of Oncology and Pathology, Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, Lund, Sweden.; Lund University Cancer Centre, Lund University, Lund, Sweden., Savas P; Division of Research, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia., Loi S; Division of Research, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia., Campbell PJ; Wellcome Trust Sanger Institute, Hinxton, UK., Andre F; INSERM U981, PRISM Institute, Gustave Roussy, Villejuif, France.; Department of Medical Oncology, Gustave Roussy, Villejuif, France.; Medical School, Université Paris Saclay, Kremlin Bicetre, France., Luscombe NM; Bioinformatics and Computational Biology Laboratory, The Francis Crick Institute, London, UK.; UCL Genetics Institute, Department of Genetics, Evolution & Environment, University College London, London, UK.; Okinawa Institute of Science & Technology, Okinawa, Japan., Steeghs N; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands., Tjan-Heijnen VCG; Department of Medical Oncology, School of GROW, Maastricht University Medical Center, Maastricht, The Netherlands., Szallasi Z; Danish Cancer Society Research Center, Copenhagen, Denmark.; Computational Health Informatics Program, Boston Children's Hospital, Boston, MA, USA.; 2nd Department of Pathology, SE-NAP Brain Metastasis Research Group, Semmelweis University, Budapest, Hungary., Turajlic S; Renal and Skin Units, The Royal Marsden Hospital NHS Foundation Trust, London, UK.; Cancer Dynamics Laboratory, The Francis Crick Institute, London, UK., Jamal-Hanjani M; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Department of Medical Oncology, University College London Hospitals, London, UK., Van Loo P; Cancer Genomics Laboratory, The Francis Crick Institute, London, UK., Bakhoum SF; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Schwarz RF; Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Berlin, Germany. roland.schwarz@mdc-berlin.de.; German Cancer Consortium (DKTK), partner site Berlin, Berlin, Germany. roland.schwarz@mdc-berlin.de.; German Cancer Research Center (DKFZ), Heidelberg, Germany. roland.schwarz@mdc-berlin.de., McGranahan N; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. nicholas.mcgranahan.10@ucl.ac.uk.; Cancer Genome Evolution Research Group, University College London Cancer Institute, University College London, London, UK. nicholas.mcgranahan.10@ucl.ac.uk., Swanton C; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK. charles.swanton@crick.ac.uk.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. charles.swanton@crick.ac.uk.; Department of Medical Oncology, University College London Hospitals, London, UK. charles.swanton@crick.ac.uk.

Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't , 2020

Subclonal reconstruction of tumors by using machine learning and population genetics.

Caravagna G; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Heide T; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Williams MJ; Evolution and Cancer Lab, Barts Cancer Institute, School of Medicine and Dentistry, Queen Mary University of London, London, UK., Zapata L; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Nichol D; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Chkhaidze K; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Cross W; Evolution and Cancer Lab, Barts Cancer Institute, School of Medicine and Dentistry, Queen Mary University of London, London, UK., Cresswell GD; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Werner B; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Acar A; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Chesler L; Division of Clinical Studies, The Institute of Cancer Research, London, UK., Barnes CP; Department of Cell and Developmental Biology and UCL Genetics Institute, University College London, London, UK., Sanguinetti G; School of Informatics, University of Edinburgh, Edinburgh, UK.; International School for Advanced Studies, Trieste, Italy., Graham TA; Evolution and Cancer Lab, Barts Cancer Institute, School of Medicine and Dentistry, Queen Mary University of London, London, UK. t.graham@qmul.ac.uk., Sottoriva A; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK. andrea.sottoriva@icr.ac.uk.

Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't , 2020

Exploiting evolutionary steering to induce collateral drug sensitivity in cancer.

Acar A; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Department of Biological Sciences, Middle East Technical University, Ankara, Turkey., Nichol D; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Fernandez-Mateos J; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Cresswell GD; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Barozzi I; Department of Surgery and Cancer, Imperial College London, London, UK., Hong SP; Department of Surgery and Cancer, Imperial College London, London, UK., Trahearn N; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Spiteri I; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Stubbs M; CRUK Cancer Therapeutics Unit, The Institute of Cancer Research, London, UK., Burke R; CRUK Cancer Therapeutics Unit, The Institute of Cancer Research, London, UK., Stewart A; Clinical Pharmacology-Adaptive Therapy Group, Division of Cancer Therapeutics and Clinical Studies, The Institute of Cancer Research, London, UK., Caravagna G; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Werner B; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Vlachogiannis G; Gastrointestinal Cancer Biology and Genomics Team, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Maley CC; Arizona Cancer Evolution Center, Biodesign Institute, Arizona State University, Tempe, USA., Magnani L; Department of Surgery and Cancer, Imperial College London, London, UK., Valeri N; Gastrointestinal Cancer Biology and Genomics Team, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Department of Medicine, The Royal Marsden NHS Foundation Trust, London, UK., Banerji U; CRUK Cancer Therapeutics Unit, The Institute of Cancer Research, London, UK. udai.banerji@icr.ac.uk.; Clinical Pharmacology-Adaptive Therapy Group, Division of Cancer Therapeutics and Clinical Studies, The Institute of Cancer Research, London, UK. udai.banerji@icr.ac.uk.; Drug Development Unit, The Institute of Cancer Research and The Royal Marsden Hospital NHS Foundation Trust, London, UK. udai.banerji@icr.ac.uk., Sottoriva A; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK. andrea.sottoriva@icr.ac.uk.

Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. , 2020

Mapping the breast cancer metastatic cascade onto ctDNA using genetic and epigenetic clonal tracking.

Cresswell GD; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Nichol D; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Spiteri I; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Tari H; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Glioma Lab, The Institute of Cancer Research, London, UK., Zapata L; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Heide T; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Maley CC; Arizona Cancer Evolution Center, Biodesign Institute, Arizona State University, Tempe, AZ, USA., Magnani L; Department of Surgery and Cancer, Imperial College London, London, UK., Schiavon G; Breast Unit, Royal Marsden Hospital, London, UK.; AstraZeneca, Oncology R&D, Cambridge, UK., Ashworth A; UCSF Helen Diller Family Comprehensive Cancer Center, 1450 3rd St, San Francisco, CA, 94158, USA., Barry P; Breast Unit, Royal Marsden Hospital, London, UK. peter.barry@icr.ac.uk., Sottoriva A; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK. andrea.sottoriva@icr.ac.uk.

Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. , 2020

Measuring single cell divisions in human tissues from multi-region sequencing data.

Werner B; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK. b.werner@qmul.ac.uk.; Evolutionary Dynamics Group, Centre for Cancer Genomics & Computational Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK. b.werner@qmul.ac.uk., Case J; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; University of Cambridge, Cambridge, UK., Williams MJ; Evolution and Cancer Laboratory, Centre for Cancer Genomics & Computational Biology, Barts Cancer Institute, Queen Mary University London, London, Charterhouse Square, London, EC1M 6BQ, UK.; Department of Cell and Developmental Biology, University College London, London, UK.; Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London, London, UK., Chkhaidze K; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Temko D; Evolution and Cancer Laboratory, Centre for Cancer Genomics & Computational Biology, Barts Cancer Institute, Queen Mary University London, London, Charterhouse Square, London, EC1M 6BQ, UK., Fernández-Mateos J; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Cresswell GD; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Nichol D; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Cross W; Evolution and Cancer Laboratory, Centre for Cancer Genomics & Computational Biology, Barts Cancer Institute, Queen Mary University London, London, Charterhouse Square, London, EC1M 6BQ, UK., Spiteri I; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Huang W; Group of Theoretical Biology, The State Key Laboratory of Biocontrol, School of Life Science, Sun Yat-sen University, 510060, Guangzhou, China.; School of Mathematical Sciences, Queen Mary University London, London, UK., Tomlinson IPM; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Barnes CP; Department of Cell and Developmental Biology, University College London, London, UK.; UCL Genetics Institute, University College London, London, UK., Graham TA; Evolution and Cancer Laboratory, Centre for Cancer Genomics & Computational Biology, Barts Cancer Institute, Queen Mary University London, London, Charterhouse Square, London, EC1M 6BQ, UK. t.graham@qmul.ac.uk., Sottoriva A; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK. andrea.sottoriva@icr.ac.uk.

Journal Article; Research Support, Non-U.S. Gov't , 2020

Evolutionary dynamics of residual disease in human glioblastoma.

Spiteri I; Evolutionary Genomics & Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London., Caravagna G; Evolutionary Genomics & Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London., Cresswell GD; Evolutionary Genomics & Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London., Vatsiou A; Evolutionary Genomics & Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London., Nichol D; Evolutionary Genomics & Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London., Acar A; Evolutionary Genomics & Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London., Ermini L; Evolutionary Genomics & Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London; Centre for Evolution and Cancer, The Institute of Cancer Research, London., Chkhaidze K; Evolutionary Genomics & Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London., Werner B; Evolutionary Genomics & Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London., Mair R; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Brognaro E; Department of Neurosurgery, S. Maria Della Misericordia Hospital, Rovigo, Italy., Verhaak RGW; Jackson Laboratory for Genomic Medicine, Farmington, USA., Sanguinetti G; School of Informatics, University of Edinburgh, Edinburgh, UK., Piccirillo SGM; Division of Hematology and Oncolog, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA. Electronic address: sara.piccirillo@utsouthwestern.edu., Watts C; Institute of Cancer Genome Sciences, University of Birmingham, Birmingham, UK. Electronic address: c.watts.2@bham.ac.uk., Sottoriva A; Evolutionary Genomics & Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London. Electronic address: andrea.sottoriva@icr.ac.uk.

Journal Article; Research Support, Non-U.S. Gov't , 2019

Somatic TP53 Mutations Are Detectable in Circulating Tumor DNA from Children with Anaplastic Wilms Tumors.

Treger TD; UCL Great Ormond Street Institute of Child Health, London, UK; Francis Crick Institute, London, UK. Electronic address: t.treger@ucl.ac.uk., Chagtai T; UCL Great Ormond Street Institute of Child Health, London, UK., Butcher R; Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK., Cresswell GD; Francis Crick Institute, London, UK., Al-Saadi R; UCL Great Ormond Street Institute of Child Health, London, UK., Brok J; UCL Great Ormond Street Institute of Child Health, London, UK; Department of Paediatric Haematology and Oncology, Rigshospitalet, Copenhagen University Hospital, Denmark., Williams RD; UCL Great Ormond Street Institute of Child Health, London, UK., Roberts C; Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK., Luscombe NM; Francis Crick Institute, London, UK; UCL Genetics Institute, Department of Genetics, Evolution & Environment, University College London, UK., Pritchard Jones K; UCL Great Ormond Street Institute of Child Health, London, UK; Department of Paediatric Haematology and Oncology, Great Ormond Street Hospital, London, UK., Mifsud W; UCL Great Ormond Street Institute of Child Health, London, UK; Department of Histopathology, Great Ormond Street Hospital, London, UK. Electronic address: wmifsud@sidra.org.

Journal Article , 2018

The Spatiotemporal Evolution of Lymph Node Spread in Early Breast Cancer.

Barry P; Department of Surgery, Breast Unit, Royal Marsden Hospital, London, United Kingdom., Vatsiou A; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom., Spiteri I; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom., Nichol D; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom., Cresswell GD; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom., Acar A; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom., Trahearn N; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom., Hrebien S; Breast Cancer Now Research Centre, The Institute of Cancer Research, London, United Kingdom., Garcia-Murillas I; Breast Cancer Now Research Centre, The Institute of Cancer Research, London, United Kingdom., Chkhaidze K; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom., Ermini L; Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom., Huntingford IS; Department of Pathology, Mater Dei Hospital, Msida, Malta., Cottom H; Breast Cancer Now Research Centre, The Institute of Cancer Research, London, United Kingdom., Zabaglo L; Ralph Lauren Breast Cancer Research Centre, Royal Marsden Hospital, London, United Kingdom., Koelble K; Ralph Lauren Breast Cancer Research Centre, Royal Marsden Hospital, London, United Kingdom., Khalique S; Ralph Lauren Breast Cancer Research Centre, Royal Marsden Hospital, London, United Kingdom., Rusby JE; Department of Surgery, Breast Unit, Royal Marsden Hospital, London, United Kingdom., Muscara F; Department of Surgery, Breast Unit, Royal Marsden Hospital, London, United Kingdom., Dowsett M; Ralph Lauren Breast Cancer Research Centre, Royal Marsden Hospital, London, United Kingdom., Maley CC; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom.; Biodesign Institute, Arizona State University, Tempe, Arizona., Natrajan R; Breast Cancer Now Research Centre, The Institute of Cancer Research, London, United Kingdom., Yuan Y; Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom., Schiavon G; Breast Cancer Now Research Centre, The Institute of Cancer Research, London, United Kingdom., Turner N; Breast Cancer Now Research Centre, The Institute of Cancer Research, London, United Kingdom., Sottoriva A; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom. andrea.sottoriva@icr.ac.uk.

Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't , 2018

Intra-Tumor Genetic Heterogeneity in Wilms Tumor: Clonal Evolution and Clinical Implications.

Cresswell GD; The Francis Crick Institute, London, United Kingdom., Apps JR; UCL Institute of Child Health, London, United Kingdom; Department of Paediatric Haematology and Oncology, Great Ormond Street Hospital, London, United Kingdom., Chagtai T; UCL Institute of Child Health, London, United Kingdom., Mifsud B; The Francis Crick Institute, London, United Kingdom., Bentley CC; The Francis Crick Institute, London, United Kingdom; UCL Genetics Institute, Department of Genetics, Evolution & Environment, University College London, United Kingdom., Maschietto M; UCL Institute of Child Health, London, United Kingdom., Popov SD; Divisions of Molecular Pathology and Cancer Therapeutics, Institute of Cancer Research, London, United Kingdom., Weeks ME; UCL Institute of Child Health, London, United Kingdom., Olsen ØE; Department of Radiology, Great Ormond Street Hospital, London, United Kingdom., Sebire NJ; UCL Institute of Child Health, London, United Kingdom; Department of Histopathology, Great Ormond Street Hospital, London, United Kingdom., Pritchard-Jones K; UCL Institute of Child Health, London, United Kingdom; Department of Paediatric Haematology and Oncology, Great Ormond Street Hospital, London, United Kingdom., Luscombe NM; The Francis Crick Institute, London, United Kingdom; UCL Genetics Institute, Department of Genetics, Evolution & Environment, University College London, United Kingdom; Okinawa Institute of Science & Technology, Okinawa, Japan., Williams RD; UCL Institute of Child Health, London, United Kingdom., Mifsud W; UCL Institute of Child Health, London, United Kingdom; Department of Histopathology, Great Ormond Street Hospital, London, United Kingdom. Electronic address: w.mifsud@ucl.ac.uk.

Journal Article , 2016