Search Results - "Flygare, John A."

Discovery and Evaluation of TLR-Targeted Immune Agonists

Chernyak, Natalia^aff1, Bhagwat, Bhagyashree^aff2, Naravula, Saraswathi^aff2, Chen, Ying^aff3, Solban, Nicolas^aff4, Zhang, Fan^aff2, Kofman, Esther^aff2, Raoufi, Fahimeh^aff2, Dang, Xibei^aff3, Bao, Jianming^aff1, Tomazela, Daniela^aff2, Baily, Marc^aff2, Geierstanger, Bernhard^aff2, Flygare, John A.^aff1, Han, Jin-Hwan^aff5, Willingham, Aarron^aff2, Seganish, W. Michael^aff1

Design and Optimization of Selectivity-Tunable Toll-like Receptor 7/8 Agonists as Novel Antibody–Drug Conjugate Payloads

Patel, Akash M.^aff1, Willingham, Aarron^aff2, Cheng, Alan C.^aff3, Tomazela, Daniela^aff2, Bowman, Eddie^aff4, Kofman, Esther^aff2, Zhang, Fan^aff2, Bao, Jianming^aff5, Sanzone, Jillian R.^aff5, Choy, Jonathan W.^aff4, Flygare, John A.^aff1, Han, Jin-Hwan^aff4, Pradhan, Komal^aff4, Kieffer, Madeleine^aff1, Chernyak, Natalia^aff1, Akbari, Peyman^aff4, Liu, Ping^aff5, Mehmood, Rimsha^aff3, Naravula, Saraswathi^aff2, Hollingsworth, Scott A.^aff3, Bhagwat, Bhagyashree^aff2, Lang, Simon B.^aff1, Seganish, W. Michael^aff1

Modification of Cysteine-Substituted Antibodies Using Enzymatic Oxidative Coupling Reactions

Cao, Wendy^aff1, Maza, Johnathan C.^aff1, Chernyak, Natalia^aff2, Flygare, John A.^aff2, Krska, Shane W.^aff3, Toste, F. Dean^aff1, Francis, Matthew B.^aff1

In vivo bioluminescence imaging of labile iron in xenograft models and liver using FeAL-1, an iron-activatable form of D-luciferin.

Gonciarz, Ryan, Jiang, Honglin, Tram, Linh, Hugelshofer, Cedric, Ekpenyong, Oscar, Knemeyer, Ian, Aron, Allegra, Chang, Christopher, Flygare, John, Collisson, Eric, Renslo, Adam

application/pdf

Combinatorial Chemistry in Steroid Receptor Drug Discovery

Flygare, John A.^Aff2, Sutherlin, Daniel P.^Aff2, David Brown, S.^Aff3

Lieberman, Benjamin A.^Aff1, Walker, John M.

This result is not displayed to guests.
Login for full access.

Discovery of Peptidomimetic Antibody–Drug Conjugate Linkers with Enhanced Protease Specificity

Wei, BinQing^aff1, Gunzner-Toste, Janet^aff1, Yao, Hui^aff2, Wang, Tao^aff2, Wang, Jing^aff2, Xu, Zijin^aff2, Chen, Jinhua^aff2, Wai, John^aff2, Nonomiya, Jim^aff1, Tsai, Siao Ping^aff1, Chuh, Josefa^aff1, Kozak, Katherine R.^aff1, Liu, Yichin^aff1, Yu, Shang-Fan^aff1, Lau, Jeff^aff1, Li, Guangmin^aff1, Phillips, Gail D.^aff1, Leipold, Doug^aff1, Kamath, Amrita^aff1, Su, Dian^aff1, Xu, Keyang^aff1, Eigenbrot, Charles^aff1, Steinbacher, Stefan^aff3, Ohri, Rachana^aff1, Raab, Helga^aff1, Staben, Leanna R.^aff1, Zhao, Guiling^aff1, Flygare, John A.^aff1, Pillow, Thomas H.^aff1, Verma, Vishal^aff1, Masterson, Luke A.^aff4, Howard, Philip W.^aff4, Safina, Brian^aff1

Pyrrolobenzodiazepine Dimer Antibody–Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers

Gregson, Stephen J.^aff1, Masterson, Luke A.^aff1, Wei, Binqing^aff2, Pillow, Thomas H.^aff2, Spencer, Susan D.^aff2, Kang, Gyoung-Dong^aff1, Yu, Shang-Fan^aff2, Raab, Helga^aff2, Lau, Jeffrey^aff2, Li, Guangmin^aff2, Lewis Phillips, Gail D.^aff2, Gunzner-Toste, Janet^aff2, Safina, Brian S.^aff2, Ohri, Rachana^aff2, Darwish, Martine^aff2, Kozak, Katherine R.^aff2, dela Cruz-Chuh, Josefa^aff2, Polson, Andrew^aff2, Flygare, John A.^aff2, Howard, Philip W.^aff1

Site-Specific Trastuzumab Maytansinoid Antibody–Drug Conjugates with Improved Therapeutic Activity through Linker and Antibody Engineering

Pillow, Thomas H., Tien, Janet, Parsons-Reponte, Kathryn L., Bhakta, Sunil, Li, Hao, Staben, Leanna R., Li, Guangmin, Chuh, Josefa, Fourie-O’Donohue, Aimee, Darwish, Martine, Yip, Victor, Liu, Luna, Leipold, Douglas D., Su, Dian, Wu, Elmer, Spencer, Susan D., Shen, Ben-Quan, Xu, Keyang, Kozak, Katherine R., Raab, Helga, Vandlen, Richard, Lewis Phillips, Gail D., Scheller, Richard H., Polakis, Paul, Sliwkowski, Mark X., Flygare, John A., Junutula, Jagath R.

Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

Flygare, John A.^aff1d1, Beresini, Maureen^aff1d2, Budha, Nageshwar^aff1d3, Chan, Helen^aff1d4, Chan, Iris T.^aff1d5, Cheeti, Sravanthi^aff1d3, Cohen, Frederick^aff1d1, Deshayes, Kurt^aff1d6, Doerner, Karl^aff1d7, Eckhardt, S. Gail^aff2, Elliott, Linda O.^aff1d2, Feng, Bainian^aff1d1, Franklin, Matthew C.^aff1d6, Reisner, Stacy Frankovitz^aff1d2, Gazzard, Lewis^aff1d1, Halladay, Jason^aff1d4, Hymowitz, Sarah G.^aff1d8, La, Hank^aff1d4, LoRusso, Patricia^aff3, Maurer, Brigitte^aff1d8, Murray, Lesley^aff1d7, Plise, Emile^aff1d4, Quan, Clifford^aff1d6, Stephan, Jean-Philippe^aff1d2, Young, Shin G.^aff1d4, Tom, Jeffrey^aff1d6, Tsui, Vickie^aff1d1, Um, Joanne^aff1d1, Varfolomeev, Eugene^aff1d6, Vucic, Domagoj^aff1d6, Wagner, Andrew J.^aff4, Wallweber, Heidi J. A.^aff1d8, Wang, Lan^aff1d1, Ware, Joseph^aff1d3, Wen, Zhaoyang^aff1d1, Wong, Harvey^aff1d4, Wong, Jonathan M.^aff1d1, Wong, Melisa^aff1d1, Wong, Susan^aff1d4, Yu, Ron^aff1d9, Zobel, Kerry^aff1d6, Fairbrother, Wayne J.^aff1d6

Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity

Sleebs, Brad E.^{aff1, aff2}, Czabotar, Peter E.^{aff1, aff2}, Fairbrother, Wayne J.^aff3, Fairlie, W. Douglas^{aff1, aff2}, Flygare, John A.^aff3, Huang, David C. S.^{aff1, aff2}, Kersten, Wilhelmus J. A.^{aff1, aff2}, Koehler, Michael F. T.^aff3, Lessene, Guillaume^{aff1, aff2}, Lowes, Kym^{aff1, aff2}, Parisot, John P.^{aff1, aff2}, Smith, Brian J.^{aff1, aff2}, Smith, Morey L.^aff4, Souers, Andrew J.^aff4, Street, Ian P.^{aff1, aff2}, Yang, Hong^{aff1, aff2}, Baell, Jonathan B.^{aff1, aff2}

Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) ‡

Franklin, Matthew C., Kadkhodayan, Saloumeh, Ackerly, Heidi, Alexandru, Daniela, Distefano, Mark D., Elliott, Linda O., Flygare, John A., Mausisa, Grace, Okawa, David C., Ong, Danny, Vucic, Domagoj, Deshayes, Kurt, Fairbrother, Wayne J.

Cyclodextrin Reduces Intravenous Toxicity of a Model Compound

Mantik, Priscilla, Xie, Minli, Wong, Harvey, La, Hank, Steigerwalt, Ronald W., Devanaboyina, Uday, Ganem, Geoffrey, Shih, Danny, Flygare, John A., Fairbrother, Wayne J., Chakravarty, Paroma, Russell, David, Fernandez, Gilberto E., Narang, Ajit S.

Discovery of A‑1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL‑XL Inhibitor

Wang, Le^aff1, Doherty, George A.^aff1, Judd, Andrew S.^aff1, Tao, Zhi-Fu^aff1, Hansen, T. Matthew^aff1, Frey, Robin R.^aff1, Song, Xiaohong^aff1, Bruncko, Milan^aff1, Kunzer, Aaron R.^aff1, Wang, Xilu^aff1, Wendt, Michael D.^aff1, Flygare, John A.^aff2, Catron, Nathaniel D.^aff1, Judge, Russell A.^aff1, Park, Chang H.^aff1, Shekhar, Shashank^aff1, Phillips, Darren C.^aff1, Nimmer, Paul^aff1, Smith, Morey L.^aff1, Tahir, Stephen K.^aff1, Xiao, Yu^aff1, Xue, John^aff1, Zhang, Haichao^aff1, Le, Phuong N.^aff1, Mitten, Michael J.^aff1, Boghaert, Erwin R.^aff1, Gao, Wenqing^aff1, Kovar, Peter^aff1, Choo, Edna F.^aff2, Diaz, Dolores^aff2, Fairbrother, Wayne J.^aff2, Elmore, Steven W.^aff1, Sampath, Deepak^aff2, Leverson, Joel D.^aff1, Souers, Andrew James^aff1

Solid-Phase Synthesis of 2-Aminothiazoles

Kearney, Patrick C., Fernandez, Monica, Flygare, John A.

Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist

Wong, Harvey ^*, Gould, Stephen E., Budha, Nageshwar, Darbonne, Walter C., Kadel, Edward E., III, La, Hank, Alicke, Bruno, Halladay, Jason S., Erickson, Rebecca, Portera, Chia, Tolcher, Anthony W., Infante, Jeffery R., Mamounas, Michael, Flygare, John A., Hop, Cornelis E.C.A., Fairbrother, Wayne J.

Discovery of a Potent and Selective BCL‑XL Inhibitor with in Vivo Activity

Tao, Zhi-Fu^aff1, Hasvold, Lisa^aff1, Wang, Le^aff1, Wang, Xilu^aff1, Petros, Andrew M.^aff1, Park, Chang H.^aff1, Boghaert, Erwin R.^aff1, Catron, Nathaniel D.^aff1, Chen, Jun^aff1, Colman, Peter M.^{aff3, aff4}, Czabotar, Peter E.^{aff3, aff4}, Deshayes, Kurt^aff2, Fairbrother, Wayne J.^aff2, Flygare, John A.^aff2, Hymowitz, Sarah G.^aff2, Jin, Sha^aff1, Judge, Russell A.^aff1, Koehler, Michael F. T.^aff2, Kovar, Peter J.^aff1, Lessene, Guillaume^{aff3, aff4, aff5}, Mitten, Michael J.^aff1, Ndubaku, Chudi O.^aff2, Nimmer, Paul^aff1, Purkey, Hans E.^aff2, Oleksijew, Anatol^aff1, Phillips, Darren C.^aff1, Sleebs, Brad E.^{aff3, aff4}, Smith, Brian J.^{aff3, aff4}, Smith, Morey L.^aff1, Tahir, Stephen K.^aff1, Watson, Keith G.^{aff3, aff4}, Xiao, Yu^aff1, Xue, John^aff1, Zhang, Haichao^aff1, Zobel, Kerry^aff2, Rosenberg, Saul H.^aff1, Tse, Chris^aff1, Leverson, Joel D.^aff1, Elmore, Steven W.^aff1, Souers, Andrew J.^aff1

Discovery of INT131: A selective PPARγ modulator that enhances insulin sensitivity

Taygerly, Joshua P., McGee, Lawrence R., Rubenstein, Steven M., Houze, Jonathan B., Cushing, Timothy D., Li, Yang, Motani, Alykhan, Chen, Jin-Long, Frankmoelle, Walter, Ye, Guosen, Learned, Marc R., Jaen, Juan, Miao, Shichang, Timmermans, Pieter B., Thoolen, Martin, Kearney, Patrick, Flygare, John, Beckmann, Holger, Weiszmann, Jennifer, Lindstrom, Michelle, Walker, Nigel, Liu, Jinsong, Biermann, Donna, Wang, Zhulun, Hagiwara, Atsushi, Iida, Tetsuya, Aramaki, Hisateru, Kitao, Yuki, Shinkai, Hisashi, Furukawa, Noboru, Nishiu, Jun, Nakamura, Motonao

Structure-Guided Rescaffolding of Selective Antagonists of BCL‑XL

Koehler, Michael F. T.^aff1d1, Bergeron, Philippe^aff1d1, Choo, Edna F.^aff1d2, Lau, Kevin^aff1d1, Ndubaku, Chudi^aff1d1, Dudley, Danette^aff1d1, Gibbons, Paul^aff1d1, Sleebs, Brad E.^{aff2, aff3}, Rye, Carl S.^{aff2, aff3}, Nikolakopoulos, George^{aff2, aff3}, Bui, Chinh^{aff2, aff3}, Kulasegaram, Sanji^{aff2, aff3}, Kersten, Wilhelmus J. A.^{aff2, aff3}, Smith, Brian J.^{aff2, aff3}, Czabotar, Peter E.^{aff2, aff3}, Colman, Peter M.^{aff2, aff3}, Huang, David C. S.^{aff2, aff3}, Baell, Jonathan B.^{aff2, aff3}, Watson, Keith G.^{aff2, aff3}, Hasvold, Lisa^aff4, Tao, Zhi-Fu^aff4, Wang, Le^aff4, Souers, Andrew J.^aff4, Elmore, Steven W.^aff4, Flygare, John A.^aff1d1, Fairbrother, Wayne J.^aff1d3, Lessene, Guillaume^{aff2, aff3}

Antagonism of c-IAP and XIAP Proteins Is Required for Efficient Induction of Cell Death by Small-Molecule IAP Antagonists

Ndubaku, Chudi, Varfolomeev, Eugene, Wang, Lan, Zobel, Kerry, Lau, Kevin, Elliott, Linda O., Maurer, Brigitte, Fedorova, Anna V., Dynek, Jasmin N., Koehler, Michael, Hymowitz, Sarah G., Tsui, Vickie, Deshayes, Kurt, Fairbrother, Wayne J., Flygare, John A., Vucic, Domagoj