Sökresultat - "Fourie-O'Donohue, Aimee"

Exploration of Pyrrolobenzodiazepine (PBD)-Dimers Containing Disulfide-Based Prodrugs as Payloads for Antibody–Drug Conjugates

Pei, Zhonghua^aff1, Chen, Chunjiao^aff3, Chen, Jinhua^aff2, Cruz-Chuh, Josefa dela^aff1, Delarosa, Reginald^aff1, Deng, Yuzhong^aff1, Fourie-O’Donohue, Aimee^aff1, Figueroa, Isabel^aff1, Guo, Jun^aff1, Jin, Weiwei^aff3, Khojasteh, S. Cyrus^aff1, Kozak, Katherine R.^aff1, Latifi, Brandon^aff1, Lee, James^aff1, Li, Guangmin^aff1, Lin, Eva^aff1, Liu, Liling^aff1, Lu, Jiawei^aff3, Martin, Scott^aff1, Ng, Carl^aff1, Nguyen, Trung^aff1, Ohri, Rachana^aff1, Lewis Phillips, Gail^aff1, Pillow, Thomas H.^aff1, Rowntree, Rebecca K.^aff1, Stagg, Nicola J.^aff1, Stokoe, David^aff1, Ulufatu, Sheila^aff1, Verma, Vishal A.^aff1, Wai, John^aff2, Wang, Jing^aff2, Xu, Keyang^aff1, Xu, Zijin^aff2, Yao, Hui^aff2, Yu, Shang-Fan^aff1, Zhang, Donglu^aff1, Dragovich, Peter S.^aff1

Modulating Antibody–Drug Conjugate Payload Metabolism by Conjugation Site and Linker Modification

Su, Dian^aff1, Kozak, Katherine R.^aff1, Sadowsky, Jack^aff1, Yu, Shang-Fan^aff1, Fourie-O’Donohue, Aimee^aff1, Nelson, Christopher^aff1, Vandlen, Richard^aff1, Ohri, Rachana^aff1, Liu, Luna^aff1, Ng, Carl^aff1, He, Jintang^aff1, Davis, Helen^aff1, Lau, Jeff^aff1, Del Rosario, Geoffrey^aff1, Cosino, Ely^aff1, Cruz-Chuh, Josefa dela^aff1, Ma, Yong^aff1, Zhang, Donglu^aff1, Darwish, Martine^aff1, Cai, Wenwen^aff2, Chen, Chunjiao^aff2, Zhou, Hongxiang^aff2, Lu, Jiawei^aff2, Liu, Yichin^aff1, Kaur, Surinder^aff1, Xu, Keyang^aff1, Pillow, Thomas H.^aff1

High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers

Ohri, Rachana, Bhakta, Sunil, Fourie-O’Donohue, Aimee, dela Cruz-Chuh, Josefa, Tsai, Siao Ping, Cook, Ryan, Wei, Binqing, Ng, Carl, Wong, Athena W., Bos, Aaron B., Farahi, Farzam, Bhakta, Jiten, Pillow, Thomas H., Raab, Helga, Vandlen, Richard, Polakis, Paul, Liu, Yichin, Erickson, Hans, Junutula, Jagath R., Kozak, Katherine R.

Attachment Site Cysteine Thiol pK a Is a Key Driver for Site-Dependent Stability of THIOMAB Antibody–Drug Conjugates

Vollmar, Breanna S., Wei, Binqing, Ohri, Rachana, Zhou, Jianhui, He, Jintang, Yu, Shang-Fan, Leipold, Douglas, Cosino, Ely, Yee, Sharon, Fourie-O’Donohue, Aimee, Li, Guangmin, Phillips, Gail L., Kozak, Katherine R., Kamath, Amrita, Xu, Keyang, Lee, Genee, Lazar, Greg A., Erickson, Hans K.

Site-Specific Trastuzumab Maytansinoid Antibody–Drug Conjugates with Improved Therapeutic Activity through Linker and Antibody Engineering

Pillow, Thomas H., Tien, Janet, Parsons-Reponte, Kathryn L., Bhakta, Sunil, Li, Hao, Staben, Leanna R., Li, Guangmin, Chuh, Josefa, Fourie-O’Donohue, Aimee, Darwish, Martine, Yip, Victor, Liu, Luna, Leipold, Douglas D., Su, Dian, Wu, Elmer, Spencer, Susan D., Shen, Ben-Quan, Xu, Keyang, Kozak, Katherine R., Raab, Helga, Vandlen, Richard, Lewis Phillips, Gail D., Scheller, Richard H., Polakis, Paul, Sliwkowski, Mark X., Flygare, John A., Junutula, Jagath R.

Total Antibody Quantification for MMAE-Conjugated Antibody–Drug Conjugates: Impact of Assay Format and Reagents
Optimal quantification of MMAE-conjugated antibody-drug conjugates

Kozak, Katherine R.^aff1d1, Tsai, Siao Ping^aff1d1, Fourie-O’Donohue, Aimee^aff1d1, dela Cruz Chuh, Josefa^aff1d1, Roth, Leslie^aff1d1, Cook, Ryan^aff1d1, Chan, Elton^aff1d1, Chan, Pamela^aff1d1, Darwish, Martine^aff1d2, Ohri, Rachana^aff1d2, Raab, Helga^aff1d2, Zhang, Crystal^aff1d3, Lin, Kedan^aff1d3, Wong, Wai Lee T.^aff1d1

Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates

Zhang, Donglu ^*, Fourie-O’Donohue, Aimee, Dragovich, Peter S., Pillow, Thomas H., Sadowsky, Jack D., Kozak, Katherine R., Cass, Robert T., Liu, Liling, Deng, Yuzhong, Liu, Yichin, Hop, Cornelis E.C.A., Khojasteh, S. Cyrus ^**

Automated On-tip Affinity Capture Coupled with Mass Spectrometry to Characterize Intact Antibody-Drug Conjugates from Blood

Li, Ke Sherry, Chu, Phillip Y., Fourie-O’Donohue, Aimee, Srikumar, Neha, Kozak, Katherine R., Liu, Yichin, Tran, John C.^Aff1

Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for THIOMAB™ Drug Conjugates

Sukumaran, Siddharth, Gadkar, Kapil, Zhang, Crystal, Bhakta, Sunil, Liu, Luna, Xu, Keyang, Raab, Helga, Yu, Shang-Fan, Mai, Elaine, Fourie-O’Donohue, Aimee, Kozak, Katherine R., Ramanujan, Saroja, Junutula, Jagath R., Lin, Kedan

Denna resultat visas inte till gäster.
Logga in för full Login for full tillgång.

Denna resultat visas inte till gäster.
Logga in för full Login for full tillgång.

Denna resultat visas inte till gäster.
Logga in för full Login for full tillgång.

Denna resultat visas inte till gäster.
Logga in för full Login for full tillgång.

Modulating Antibody-Drug Conjugate Payload Metabolism by Conjugation Site and Linker Modification.

Dian Su¹ su.dian@gene.com, Kozak, Katherine R.¹, Sadowsky, Jack¹, Shang-Fan Yu¹, Fourie-O'Donohue, Aimee¹, Nelson, Christopher¹, Vandlen, Richard¹, Ohri, Rachana¹, Liu, Luna¹, Ng, Carl¹, Jintang He¹, Davis, Helen¹, Lau, Jeff¹, Del Rosario, Geoffrey¹, Cosino, Ely¹, dela Cruz-Chuh, Josefa¹, Yong Ma¹, Donglu Zhang¹, Darwish, Martine¹, Wenwen Cai²

Attachment Site Cysteine Thiol pKa Is a Key Driver for Site-Dependent Stability of THIOMAB Antibody-Drug Conjugates.

Vollmar, Breanna S.¹ vollmar.breanna@gene.com, Binqing Wei¹, Ohri, Rachana¹, Jianhui Zhou¹, Jintang He¹, Shang-Fan Yu¹, Leipold, Douglas¹, Cosino, Ely¹, Yee, Sharon¹, Fourie-O'Donohue, Aimee¹, Li, Guangmin¹, Phillips, Gail L.¹, Kozak, Katherine R.¹, Kamath, Amrita¹, Xu, Keyang¹, Lee, Genee¹, Lazar, Greg A.¹, Erickson, Hans K.¹ erickson.hans@gene.com

Denna resultat visas inte till gäster.
Logga in för full Login for full tillgång.

Site-Specific Trastuzumab Maytansinoid Antibody–DrugConjugates with Improved Therapeutic Activity through Linker and AntibodyEngineering.

Pillow, Thomas H.¹, Tien, Janet¹, Parsons-Reponte, Kathryn L.¹, Bhakta, Sunil¹, Li, Hao¹, Staben, Leanna R.¹, Li, Guangmin¹, Chuh, Josefa¹, Fourie-O’Donohue, Aimee¹, Darwish, Martine¹, Yip, Victor¹, Liu, Luna¹, Leipold, Douglas D.¹, Su, Dian¹, Wu, Elmer¹, Spencer, Susan D.¹, Shen, Ben-Quan¹, Xu, Keyang¹, Kozak, Katherine R.¹, Raab, Helga¹

Total AntibodyQuantification for MMAE-ConjugatedAntibody–Drug Conjugates:Impact of Assay Format and Reagents.

Kozak, Katherine R.¹, Tsai, Siao Ping¹, Fourie-O’Donohue, Aimee¹, dela Cruz Chuh, Josefa¹, Roth, Leslie¹, Cook, Ryan¹, Chan, Elton¹, Chan, Pamela¹, Darwish, Martine¹, Ohri, Rachana¹, Raab, Helga¹, Zhang, Crystal¹, Lin, Kedan¹, Wong, Wai LeeT.¹

Denna resultat visas inte till gäster.
Logga in för full Login for full tillgång.

Biodistribution and efficacy of an anti-TENB2 antibody-drug conjugate in a patient-derived model of prostate cancer.

Boswell CA; Genentech Research and Early Development, South San Francisco, 94080 CA, USA., Yadav DB; Genentech Research and Early Development, South San Francisco, 94080 CA, USA., Mundo EE; Genentech Research and Early Development, South San Francisco, 94080 CA, USA.; Present address: Department of Safety Assessment, Nektar Therapeutics, San Francisco, 94158 CA, USA., Yu SF; Genentech Research and Early Development, South San Francisco, 94080 CA, USA., Lacap JA; Genentech Research and Early Development, South San Francisco, 94080 CA, USA., Fourie-O'Donohue A; Genentech Research and Early Development, South San Francisco, 94080 CA, USA., Kozak KR; Genentech Research and Early Development, South San Francisco, 94080 CA, USA., Ferl GZ; Genentech Research and Early Development, South San Francisco, 94080 CA, USA., Zhang C; Genentech Research and Early Development, South San Francisco, 94080 CA, USA., Ho J; Genentech Research and Early Development, South San Francisco, 94080 CA, USA., Ulufatu S; Genentech Research and Early Development, South San Francisco, 94080 CA, USA., Khawli LA; Genentech Research and Early Development, South San Francisco, 94080 CA, USA.; Present address: Department of Pathology and Laboratory Medicine, Keck School of Medicine of USC, Los Angeles, 90033 CA, USA., Lin K; Genentech Research and Early Development, South San Francisco, 94080 CA, USA.; Present address: Clinical Development and US Operation, Innovent Biologics, South San Francisco, 94080 CA, USA.

Journal Article , 2019