Sökresultat - "High-Throughput Screening"

Rapid High-Throughput Discovery of Molecules With Antimicrobial Activity From Natural Products Enabled by a Nanoliter Matrix SlipChip.

Wang Q; State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China., Wang M; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Provincial Center for Research & Development of Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650091, China., Lyu W; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China., Li X; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China., Xu L; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China., Qin Y; State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China., Ren Y; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China., Deng Z; State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China., Tao M; State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China., Xiao W; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Provincial Center for Research & Development of Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650091, China., Shen F; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China.

Journal Article; Research Support, Non-U.S. Gov't , 2025

Biosensor-based dual-color droplet microfluidic platform for precise high-throughput screening of erythromycin hyperproducers.

Zhao L; College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China; Haihe Laboratory of Synthetic Biology, Tianjin, 300308, China., Li S; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China., Yang Y; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China., Qi L; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China., Zhu Q; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China; College of Horticulture, China Agricultural University, Beijing, 100193, China., Zhao Y; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China., Qi H; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China; School of Food Science and Biological Engineering, Tianjin Agricultural University, Tianjin, 300384, China., Liao X; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China., Zhang Y; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China. Electronic address: zhangy@tib.cas.cn., Wang M; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China. Electronic address: wangmeng@tib.cas.cn.

Journal Article , 2025

High-Throughput Drug Derivatization and Bioassay by Desorption Electrospray Ionization Mass Spectrometry.

Ghosh J; Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN, 47907, USA., Morato NM; Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN, 47907, USA., Feng Y; Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN, 47907, USA., Cooks RG; Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN, 47907, USA.

Journal Article , 2025

Engineering Yarrowia lipolytica for Enhanced Gastrodin Production via High-Throughput Screening and Transcriptomics-Guided Optimization.

Hu M; School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, China., He Y; School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, China., Ma Y; School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, China., Wu N; College of Marine and Bioengineering, Yangcheng Institute of Technology, Yancheng, China., Gan Z; School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, China., Fu J; School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, China., Yang Z; Zhejiang Key Laboratory of Bio-manufacturing of Anti-infective Drugs, Zhejiang Hisun Pharmaceutical Co., Ltd, Taizhou, China., Shi T; School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, China., Sun X; School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, China., Gu Y; School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, China., Xu P; Department of Chemical Engineering, Guangdong Technion-Israel Institute of Technology (GTIIT), Shantou, Guangdong, China.

Journal Article , 2025

Antibody oxidation and impact of formulation: A high-throughput screening approach.

Fischer P; AbbVie Deutschland GmbH & Co. KG, Drug Product Development, Knollstraße, Ludwigshafen am Rhein, Germany. Electronic address: paulina.fischer@abbvie.com., Merkel OM; Ludwig-Maximilians-Universität München, Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Munich, Germany., Siedler M; AbbVie Deutschland GmbH & Co. KG, Drug Product Development, Knollstraße, Ludwigshafen am Rhein, Germany., Meyer T; AbbVie Deutschland GmbH & Co. KG, Drug Product Development, Knollstraße, Ludwigshafen am Rhein, Germany., Nouchikian L; AbbVie Deutschland GmbH & Co. KG, Analytical Research & Development, Knollstraße, Ludwigshafen am Rhein, Germany., Huelsmeyer M; AbbVie Deutschland GmbH & Co. KG, Drug Product Development, Knollstraße, Ludwigshafen am Rhein, Germany.

Journal Article , 2025

High-throughput colorimetry immunoassay for aflatoxin B 1 detection using the synergistic regulation of click chemistry by polydopamine and metal-organic framework.

Ren L; Dalian Jinshiwan Laboratory, Dalian 116034, Liaoning, China; College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China., Hong F; Dalian Jinshiwan Laboratory, Dalian 116034, Liaoning, China; School of Food Science and Engineering, Ningxia University, Yinchuan 750021, China., Wen J; College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China., Chen Y; Dalian Jinshiwan Laboratory, Dalian 116034, Liaoning, China; College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China; State Key Laboratory of Marine Food Processing and Safety Control, Dalian Polytechnic University, Dalian 116034, Liaoning, China. Electronic address: chenyiping@mail.hzau.edu.cn.

Journal Article; Evaluation Study , 2025

LPS2336, a New TREK-1 Channel Activator Identified by High Throughput Screening.

Boyer R; Université Clermont Auvergne, Inserm, CHU Clermont-Ferrand, Neuro-Dol, 63000 Clermont-Ferrand, France., Bony R; Université Clermont Auvergne, Inserm, CHU Clermont-Ferrand, Neuro-Dol, 63000 Clermont-Ferrand, France., Maugis M; Université Clermont Auvergne, Inserm, CHU Clermont-Ferrand, Neuro-Dol, 63000 Clermont-Ferrand, France., Schopp J; Université Clermont Auvergne, Inserm, CHU Clermont-Ferrand, Neuro-Dol, 63000 Clermont-Ferrand, France., Leroux M; Université Clermont Auvergne, CNRS, Clermont Auvergne INP, ICCF, 63000 Clermont-Ferrand, France., Michelin C; Université Clermont Auvergne, CNRS, Clermont Auvergne INP, ICCF, 63000 Clermont-Ferrand, France., Gonthier L; Université Clermont Auvergne, CNRS, Clermont Auvergne INP, ICCF, 63000 Clermont-Ferrand, France., Grzeskiewicz Q; Université Clermont Auvergne, CNRS, Clermont Auvergne INP, ICCF, 63000 Clermont-Ferrand, France., Jouannet A; Université Clermont Auvergne, CNRS, Clermont Auvergne INP, ICCF, 63000 Clermont-Ferrand, France., Aissouni Y; Université Clermont Auvergne, Inserm, CHU Clermont-Ferrand, Neuro-Dol, 63000 Clermont-Ferrand, France., Didier B; Université de Strasbourg, CNRS, Laboratoire d'Innovation Thérapeutique, LIT UMR 7200, 67000 Strasbourg, France., Gulea M; Université de Strasbourg, CNRS, Laboratoire d'Innovation Thérapeutique, LIT UMR 7200, 67000 Strasbourg, France., Girard N; Université de Strasbourg, CNRS, Laboratoire d'Innovation Thérapeutique, LIT UMR 7200, 67000 Strasbourg, France., Cintrat JC; Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SCBM, 91191 Gif-sur-Yvette, France., Dumeige A; Université Clermont Auvergne, CNRS, Clermont Auvergne INP, ICCF, 63000 Clermont-Ferrand, France., Busserolles J; Université Clermont Auvergne, Inserm, CHU Clermont-Ferrand, Neuro-Dol, 63000 Clermont-Ferrand, France., Ducki S; Université Clermont Auvergne, CNRS, Clermont Auvergne INP, ICCF, 63000 Clermont-Ferrand, France., Lolignier S; Université Clermont Auvergne, Inserm, CHU Clermont-Ferrand, Neuro-Dol, 63000 Clermont-Ferrand, France.; Institut Universitaire de France (IUF), 75231 Paris, France.

Journal Article , 2025

A CRISPR-based high-throughput screening system identifies bromodomain inhibitors as transcriptional suppressors of CYP11B1.

Ito R; Department of Molecular Endocrinology, Tohoku University Graduate School of Medicine, 2-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan., Nakano T; Department of Molecular Endocrinology, Tohoku University Graduate School of Medicine, 2-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan., Sugawara A; Department of Molecular Endocrinology, Tohoku University Graduate School of Medicine, 2-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan., Yokoyama A; Department of Molecular Endocrinology, Tohoku University Graduate School of Medicine, 2-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan. Electronic address: atsushi.yokoyama.c6@tohoku.ac.jp.

Journal Article; Research Support, Non-U.S. Gov't , 2025

Development and Characterization of pFluor50, a Fluorogenic-Based Kinetic Assay System for High-Throughput Inhibition Screening and Characterization of Time-Dependent Inhibition and Inhibition Type for Six Human CYPs.

Shriwas P; Division of Medical Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA., Revnew A; Division of Medical Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA., Roo S; Division of Medical Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA., Bender A; Division of Medical Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA., Miller K; Department of Chemistry and Biochemistry, College of Arts and Sciences, The Ohio State University, Columbus, OH 43210, USA., Hadad CM; Department of Chemistry and Biochemistry, College of Arts and Sciences, The Ohio State University, Columbus, OH 43210, USA., Lane TR; Collaborations Pharmaceuticals, Raleigh, NC 27606, USA., Ekins S; Collaborations Pharmaceuticals, Raleigh, NC 27606, USA., McElroy CA; Division of Medical Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.

Journal Article , 2025

High-Throughput Chemotherapeutic Drug Screening System for Gastric Cancer (Cure-GA).

Lee J; Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea., Kim IH; Department of Precision Medicine, Medical and Bio Decision (MBD Co., Ltd), Suwon, Republic of Korea., Seol D; Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea., Lee S; Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.; Department of Surgery, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea., Yoo M; Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea., Lee TK; Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea., Yoon SH; Department of Precision Medicine, Medical and Bio Decision (MBD Co., Ltd), Suwon, Republic of Korea., Lee E; Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.; Department of Surgery, Chung-Ang University Gwangmyeong Hospital, Gwangmyeong, Republic of Korea., Hwang D; Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea., Kang SH; Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea., Park YS; Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea., Ku B; Department of Precision Medicine, Medical and Bio Decision (MBD Co., Ltd), Suwon, Republic of Korea., Jeon SY; Department of Precision Medicine, Medical and Bio Decision (MBD Co., Ltd), Suwon, Republic of Korea., Choi Y; Department of Precision Medicine, Medical and Bio Decision (MBD Co., Ltd), Suwon, Republic of Korea., Jung K; Department of Anatomy and Cell Biology / Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea., Kim JW; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea., Kim JW; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea., Ahn SH; Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea., Lee KW; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea., Kim HH; Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.; Department of Surgery, Chung-Ang University Gwangmyeong Hospital, Gwangmyeong, Republic of Korea., Oh HJ; Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. biohjoh212@gmail.com., Lee DW; Department of Biomedical Engineering, Gachon University, Seongnam, Republic of Korea. dw2010.lee@gmail.com., Suh YS; Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. ysksuh@snubh.org.; Department of Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea. ysksuh@snubh.org.

Journal Article , 2025

Lessons learned from evaluating defined chemical mixtures in a high-throughput estrogen receptor assay system.

Parham F; Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA., Eccles KM; Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA., Rider CV; Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA., Sakamuru S; National Center for Advancing Translational Sciences, Bethesda, MD 20850, USA., Xia M; National Center for Advancing Translational Sciences, Bethesda, MD 20850, USA., Huang R; National Center for Advancing Translational Sciences, Bethesda, MD 20850, USA., Tice RR; RTice Consulting, Hillsborough, NC 27278, USA., Dinse GE; DLH, LLC, Bethesda, MD 20817, USA., DeVito MJ; Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27709, USA.

Journal Article , 2025

Colorimetric determination of tyrosinase activity and high-throughput screening of inhibitors based on in-situ formation of gold nanoparticles.

Zhou G; Key Laboratory of Clean Energy Materials Chemistry of Guangdong Higher Education Institutes, , Lingnan Normal University, Zhanjiang, 524048, Guangdong, China. ghzhou@lingnan.edu.cn., Liu Z; Key Laboratory of Clean Energy Materials Chemistry of Guangdong Higher Education Institutes, , Lingnan Normal University, Zhanjiang, 524048, Guangdong, China., Huang Y; Key Laboratory of Clean Energy Materials Chemistry of Guangdong Higher Education Institutes, , Lingnan Normal University, Zhanjiang, 524048, Guangdong, China., Yang R; Key Laboratory of Clean Energy Materials Chemistry of Guangdong Higher Education Institutes, , Lingnan Normal University, Zhanjiang, 524048, Guangdong, China., Guo X; Key Laboratory of Clean Energy Materials Chemistry of Guangdong Higher Education Institutes, , Lingnan Normal University, Zhanjiang, 524048, Guangdong, China., Jia Y; Key Laboratory of Clean Energy Materials Chemistry of Guangdong Higher Education Institutes, , Lingnan Normal University, Zhanjiang, 524048, Guangdong, China. jymchemistry@163.com., Liu P; Key Laboratory of Clean Energy Materials Chemistry of Guangdong Higher Education Institutes, , Lingnan Normal University, Zhanjiang, 524048, Guangdong, China. liupeilian2010@126.com., Li Z; Key Laboratory of Clean Energy Materials Chemistry of Guangdong Higher Education Institutes, , Lingnan Normal University, Zhanjiang, 524048, Guangdong, China., Cui W; Key Laboratory of Clean Energy Materials Chemistry of Guangdong Higher Education Institutes, , Lingnan Normal University, Zhanjiang, 524048, Guangdong, China.

Journal Article , 2025

A cost- and time-efficient method for high-throughput cryoprocessing and tissue analysis using multiplexed tissue molds.

Reumann D; Institute of Molecular Biotechnology (IMBA) of the Austrian Academy of Sciences, Vienna BioCenter, Vienna, Austria; Vienna BioCenter, Doctoral School of the University of Vienna and Medical University of Vienna, Vienna, Austria. Electronic address: daniel.reumann@dpag.ox.ac.uk., Colombini M; Institute of Molecular Pathology (IMP), Vienna BioCenter, Vienna, Austria., Möseneder P; Institute of Molecular Biotechnology (IMBA) of the Austrian Academy of Sciences, Vienna BioCenter, Vienna, Austria., Piszczek A; Vienna BioCenter Core Facilities (VBCF), Vienna BioCenter, Vienna, Austria., Knoblich JA; Institute of Molecular Biotechnology (IMBA) of the Austrian Academy of Sciences, Vienna BioCenter, Vienna, Austria; Department of Neurology, Medical University of Vienna, Vienna, Austria. Electronic address: juergen.knoblich@imba.oeaw.ac.at.

Journal Article , 2025

High-Throughput Screening to Identify Novel Compounds Affecting the Genome Editing Efficiency of CRISPR System.

Chang J; Key Laboratory of Cellular Physiology, Shanxi Medical University, Ministry of Education, Taiyuan 030001, China.; Department of Physiology, Shanxi Medical University, Taiyuan 030001, China., Yang X; Key Laboratory of Cellular Physiology, Shanxi Medical University, Ministry of Education, Taiyuan 030001, China.; Department of Physiology, Shanxi Medical University, Taiyuan 030001, China., Zhang T; Biological Science Research Center, Southwest University, Chongqing 400715, China., Sun H; Biological Science Research Center, Southwest University, Chongqing 400715, China., Cheng H; Department of Preschool Education, Lvliang Teachers College, Lvliang 033001, China., Jia Z; Key Laboratory of Cellular Physiology, Shanxi Medical University, Ministry of Education, Taiyuan 030001, China.; Department of Physiology, Shanxi Medical University, Taiyuan 030001, China., Li Y; Key Laboratory of Cellular Physiology, Shanxi Medical University, Ministry of Education, Taiyuan 030001, China.; Department of Physiology, Shanxi Medical University, Taiyuan 030001, China., Ma S; Biological Science Research Center, Southwest University, Chongqing 400715, China., Sun T; Key Laboratory of Cellular Physiology, Shanxi Medical University, Ministry of Education, Taiyuan 030001, China.; Department of Physiology, Shanxi Medical University, Taiyuan 030001, China., Cao J; Key Laboratory of Cellular Physiology, Shanxi Medical University, Ministry of Education, Taiyuan 030001, China.; Department of Physiology, Shanxi Medical University, Taiyuan 030001, China.

Journal Article , 2025

Understanding, inhibiting, and engineering membrane transporters with high-throughput mutational screens.

Miller ST; Cellular and Molecular Biology Graduate Program, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI 53706, USA., Macdonald CB; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94143, USA., Raman S; DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address: sraman4@wisc.edu.

Journal Article; Review , 2025

Development of Sheep Duodenum Intestinal Organoids and Implementation of High-Throughput Screening Platform for Veterinary Applications.

Galli G; Departamento de Ciencias Biomédicas, Facultad de Veterinaria, Universidad de León, Campus de Vegazana s/n, 24007 León, Spain., Melcón-Fernández E; Departamento de Ciencias Biomédicas, Facultad de Veterinaria, Universidad de León, Campus de Vegazana s/n, 24007 León, Spain., de Garnica García MG; MicrosVeterinaria, C/Profesor Pedro Cármenes, Campus de Vegazana, 24007 León, Spain., Martínez-Fernández B; MicrosVeterinaria, C/Profesor Pedro Cármenes, Campus de Vegazana, 24007 León, Spain., Dehnavi M; Instituto de Ganadería de Montaña, CSIC-Universidad de León, Finca Marzanas s/n, Grulleros, 24346 León, Spain., Andrés S; Instituto de Ganadería de Montaña, CSIC-Universidad de León, Finca Marzanas s/n, Grulleros, 24346 León, Spain., Pérez-Pertejo Y; Departamento de Ciencias Biomédicas, Facultad de Veterinaria, Universidad de León, Campus de Vegazana s/n, 24007 León, Spain.; Instituto de Biomedicina (IBIOMED), Universidad de León, Campus de Vegazana s/n, 24007 León, Spain., Reguera RM; Departamento de Ciencias Biomédicas, Facultad de Veterinaria, Universidad de León, Campus de Vegazana s/n, 24007 León, Spain.; Instituto de Biomedicina (IBIOMED), Universidad de León, Campus de Vegazana s/n, 24007 León, Spain., García-Estrada C; Departamento de Ciencias Biomédicas, Facultad de Veterinaria, Universidad de León, Campus de Vegazana s/n, 24007 León, Spain.; Instituto de Biomedicina (IBIOMED), Universidad de León, Campus de Vegazana s/n, 24007 León, Spain., Martínez-Valladares M; Instituto de Ganadería de Montaña, CSIC-Universidad de León, Finca Marzanas s/n, Grulleros, 24346 León, Spain., Balaña-Fouce R; Departamento de Ciencias Biomédicas, Facultad de Veterinaria, Universidad de León, Campus de Vegazana s/n, 24007 León, Spain.; Instituto de Biomedicina (IBIOMED), Universidad de León, Campus de Vegazana s/n, 24007 León, Spain.

Journal Article , 2025

Efficient, Low-Cost, and High-Throughput Sodium Dodecyl Sulfate (SDS) Removal from Protein Digests Using Weak-Anion Exchange.

Cao W; Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana 46556, United States., Chu PY; Department of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, California 94080, United States., Bruening ML; Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana 46556, United States.; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States., Shi RL; Department of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, California 94080, United States., Hernandez-Barry H; Department of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, California 94080, United States., Tran JC; Department of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, California 94080, United States.

Journal Article , 2025

A high-throughput assay platform to discover small molecule activators of the phospholipase PLC-γ2 to treat Alzheimer's disease.

Carr AJ; Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Hajicek N; Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Tsai AP; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Acharya PP; Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Hardy PB; Center for Integrative Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Meyer E; Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Wyss-Coray T; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Pearce KH; Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Center for Integrative Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Sondek J; Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Zhang Q; Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Electronic address: qszhang@unc.edu.

Journal Article , 2025

Combining High-Throughput Screening and Machine Learning to Predict the Formation of Both Binary and Ternary Amorphous Solid Dispersion Formulations for Early Drug Discovery and Development.

Lu T; Institute of Applied Physics and Materials Engineering, University of Macau, Macau, 999078, China.; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, China., Wu Y; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, China., Xiong P; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, China., Zhong H; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, China., Ding Y; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, China., Li H; Institute of Applied Physics and Materials Engineering, University of Macau, Macau, 999078, China. haifengli@um.edu.mo., Ouyang D; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, China. defangouyang@um.edu.mo.; Faculty of Health Sciences, University of Macau, Macau, 999078, China. defangouyang@um.edu.mo.

Journal Article , 2025

High-throughput hit identification with acoustic ejection mass spectrometry.

Wen X; Merck & Co., Inc., Rahway, NJ, USA. Electronic address: xiujuan.wen@merck.com., McLaren DG; Merck & Co., Inc., Rahway, NJ, USA.

Journal Article; Review , 2025