Search Results - "Hymowitz, Sarah G."

Dimerization Induced by C‑Terminal 14–3–3 Binding Is Sufficient for BRAF Kinase Activation

Liau, Nicholas P.D.^aff1d1, Venkatanarayan, Avinashnarayan^aff1d2, Quinn, John G.^aff1d3, Phung, Wilson^aff1d4, Malek, Shiva^aff1d2, Hymowitz, Sarah G.^aff1d1, Sudhamsu, Jawahar^{aff1d1, aff1d2}

Structural basis for SHOC2 modulation of RAS signalling

Liau, Nicholas PD, Johnson, Matthew C, Izadi, Saeed, Gerosa, Luca, Hammel, Michal, Bruning, John M, Wendorff, Timothy J, Phung, Wilson, Hymowitz, Sarah G, Sudhamsu, Jawahar

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Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase

Blaquiere, Nicole^aff1, Castanedo, Georgette M.^aff1, Burch, Jason D.^aff1, Berezhkovskiy, Leonid M.^aff1, Brightbill, Hans^aff1, Brown, Suzanne^aff1, Chan, Connie^aff1, Chiang, Po-Chang^aff1, Crawford, James J.^aff1, Dong, Teresa^aff1, Fan, Peter^aff1, Feng, Jianwen^aff1, Ghilardi, Nico^aff1, Godemann, Robert^aff3, Gogol, Emily^aff1, Grabbe, Alice^aff3, Hole, Alison J.^aff3, Hu, Baihua^aff2, Hymowitz, Sarah G.^aff1, Alaoui Ismaili, Moulay Hicham^aff1, Le, Hoa^aff1, Lee, Patrick^aff1, Lee, Wyne^aff1, Lin, Xingyu^aff2, Liu, Ning^aff1, McEwan, Paul A.^aff3, McKenzie, Brent^aff1, Silvestre, Hernani L.^aff3, Suto, Eric^aff1, Sujatha-Bhaskar, Swathi^aff1, Wu, Guosheng^aff2, Wu, Lawren C.^aff1, Zhang, Yamin^aff2, Zhong, Zoe^aff1, Staben, Steven T.^aff1

Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

Flygare, John A.^aff1d1, Beresini, Maureen^aff1d2, Budha, Nageshwar^aff1d3, Chan, Helen^aff1d4, Chan, Iris T.^aff1d5, Cheeti, Sravanthi^aff1d3, Cohen, Frederick^aff1d1, Deshayes, Kurt^aff1d6, Doerner, Karl^aff1d7, Eckhardt, S. Gail^aff2, Elliott, Linda O.^aff1d2, Feng, Bainian^aff1d1, Franklin, Matthew C.^aff1d6, Reisner, Stacy Frankovitz^aff1d2, Gazzard, Lewis^aff1d1, Halladay, Jason^aff1d4, Hymowitz, Sarah G.^aff1d8, La, Hank^aff1d4, LoRusso, Patricia^aff3, Maurer, Brigitte^aff1d8, Murray, Lesley^aff1d7, Plise, Emile^aff1d4, Quan, Clifford^aff1d6, Stephan, Jean-Philippe^aff1d2, Young, Shin G.^aff1d4, Tom, Jeffrey^aff1d6, Tsui, Vickie^aff1d1, Um, Joanne^aff1d1, Varfolomeev, Eugene^aff1d6, Vucic, Domagoj^aff1d6, Wagner, Andrew J.^aff4, Wallweber, Heidi J. A.^aff1d8, Wang, Lan^aff1d1, Ware, Joseph^aff1d3, Wen, Zhaoyang^aff1d1, Wong, Harvey^aff1d4, Wong, Jonathan M.^aff1d1, Wong, Melisa^aff1d1, Wong, Susan^aff1d4, Yu, Ron^aff1d9, Zobel, Kerry^aff1d6, Fairbrother, Wayne J.^aff1d6

A Unique Zinc-Binding Site Revealed by a High-Resolution X-ray Structure of Homotrimeric Apo2L/TRAIL

Hymowitz, Sarah G., O'Connell, Mark P., Ultsch, Mark H., Hurst, Amy, Totpal, Klara, Ashkenazi, Avi, de Vos, Abraham M., Kelley, Robert F.

Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization

Liau, Nicholas P. D., Wendorff, Timothy J., Quinn, John G., Steffek, Micah, Phung, Wilson, Liu, Peter, Tang, Jia, Irudayanathan, Flaviyan J., Izadi, Saeed, Shaw, Andrey S., Malek, Shiva, Hymowitz, Sarah G.^{Aff1, IDs4159401903650_cor12}, Sudhamsu, Jawahar^{Aff1, IDs4159401903650_cor13}

Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activity

Huang, Christine S., Oberbeck, Nina, Hsiao, Yi-Chun, Liu, Peter, Johnson, Adam R., Dixit, Vishva M., Hymowitz, Sarah G.

Two-Amino Acid Molecular Switch in an Epithelial Morphogen That Regulates Binding to Two Distinct Receptors

Yan, Minhong, Wang, Li-Chong, Hymowitz, Sarah G., Schilbach, Sarah, Lee, James, Goddard, Audrey, de Vos, Abraham M., Gao, Wei-Qiang, Dixit, Vishva M.

Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2

Foster, Scott A., Whalen, Daniel M., Özen, Ayşegül, Wongchenko, Matthew J., Yin, JianPing, Yen, Ivana, Schaefer, Gabriele, Mayfield, John D., Chmielecki, Juliann, Stephens, Philip J., Albacker, Lee A., Yan, Yibing, Song, Kyung, Hatzivassiliou, Georgia, Eigenbrot, Charles, Yu, Christine, Shaw, Andrey S., Manning, Gerard, Skelton, Nicholas J., Hymowitz, Sarah G., Malek, Shiva

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Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling

Haling, Jacob R., Sudhamsu, Jawahar, Yen, Ivana, Sideris, Steve, Sandoval, Wendy, Phung, Wilson, Bravo, Brandon J., Giannetti, Anthony M., Peck, Ariana, Masselot, Alexandre, Morales, Tony, Smith, Darin, Brandhuber, Barbara J., Hymowitz, Sarah G., Malek, Shiva

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Structures of TNF Receptors and Their Interactions With Ligands

Hymowitz, Sarah G.^Aff4, de Vos, Abraham M.^Aff4

Teicher, Beverly A., editor, El-Deiry, Wafik S., editor^{Aff1, Aff2, Aff3}

MD, PhD
PhD

Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action

René, Olivier^aff1, Fauber, Benjamin P.^aff1, Boenig, Gladys de Leon^aff1, Burton, Brenda^aff2, Eidenschenk, Céline^aff1, Everett, Christine^aff1, Gobbi, Alberto^aff1, Hymowitz, Sarah G.^aff1, Johnson, Adam R.^aff1, Kiefer, James R.^aff1, Liimatta, Marya^aff1, Lockey, Peter^aff2, Norman, Maxine^aff2, Ouyang, Wenjun^aff1, Wallweber, Heidi A.^aff1, Wong, Harvey^aff1

Discovery of a Potent and Selective BCL‑XL Inhibitor with in Vivo Activity

Tao, Zhi-Fu^aff1, Hasvold, Lisa^aff1, Wang, Le^aff1, Wang, Xilu^aff1, Petros, Andrew M.^aff1, Park, Chang H.^aff1, Boghaert, Erwin R.^aff1, Catron, Nathaniel D.^aff1, Chen, Jun^aff1, Colman, Peter M.^{aff3, aff4}, Czabotar, Peter E.^{aff3, aff4}, Deshayes, Kurt^aff2, Fairbrother, Wayne J.^aff2, Flygare, John A.^aff2, Hymowitz, Sarah G.^aff2, Jin, Sha^aff1, Judge, Russell A.^aff1, Koehler, Michael F. T.^aff2, Kovar, Peter J.^aff1, Lessene, Guillaume^{aff3, aff4, aff5}, Mitten, Michael J.^aff1, Ndubaku, Chudi O.^aff2, Nimmer, Paul^aff1, Purkey, Hans E.^aff2, Oleksijew, Anatol^aff1, Phillips, Darren C.^aff1, Sleebs, Brad E.^{aff3, aff4}, Smith, Brian J.^{aff3, aff4}, Smith, Morey L.^aff1, Tahir, Stephen K.^aff1, Watson, Keith G.^{aff3, aff4}, Xiao, Yu^aff1, Xue, John^aff1, Zhang, Haichao^aff1, Zobel, Kerry^aff2, Rosenberg, Saul H.^aff1, Tse, Chris^aff1, Leverson, Joel D.^aff1, Elmore, Steven W.^aff1, Souers, Andrew J.^aff1

Dimerization of LTβR by LTα 1 β 2 is necessary and sufficient for signal transduction

Sudhamsu, Jawahar, Yin, JianPing, Chiang, Eugene Y., Starovasnik, Melissa A., Grogan, Jane L., Hymowitz, Sarah G.

Phosphorylation of Dishevelled by Protein Kinase RIPK4 Regulates Wnt Signaling

Huang, XiaoDong, McGann, James C., Liu, Bob Y., Hannoush, Rami N., Lill, Jennie R., Pham, Victoria, Newton, Kim, Kakunda, Michael, Liu, Jinfeng, Yu, Christine, Hymowitz, Sarah G., Hongo, Jo-Anne, Wynshaw-Boris, Anthony, Polakis, Paul, Harland, Richard M., Dixit, Vishva M.

The Crystal Structure of the Catalytic Domain of the NF-κB Inducing Kinase Reveals a Narrow but Flexible Active Site

de Leon-Boenig, Gladys, Bowman, Krista K., Feng, Jianwen A., Crawford, Terry, Everett, Christine, Franke, Yvonne, Oh, Angela, Stanley, Mark, Staben, Steven T., Starovasnik, Melissa A., Wallweber, Heidi J.A., Wu, Jiansheng, Wu, Lawren C., Johnson, Adam R., Hymowitz, Sarah G.

Engineering and Structural Characterization of a Linear Polyubiquitin-Specific Antibody

Matsumoto, Marissa L., Dong, Ken C., Yu, Christine, Phu, Lilian, Gao, Xinxin, Hannoush, Rami N., Hymowitz, Sarah G., Kirkpatrick, Donald S., Dixit, Vishva M., Kelley, Robert F.

Modulation of K11-Linkage Formation by Variable Loop Residues within UbcH5A

Bosanac, Ivan, Phu, Lilian, Pan, Borlan, Zilberleyb, Inna, Maurer, Brigitte, Dixit, Vishva M., Hymowitz, Sarah G., Kirkpatrick, Donald S.