Sökresultat - "Kiyoshi Yoshimura"

Ki-67 expression in anti-programmed cell death protein-1 antibody-bound CD8+ T cells as a predictor of clinical benefit

Toshiaki Tsurui, Masahiro Hosonuma, Aya Sasaki, Yuuki Maruyama, Yasunobu Amari, Eiji Funayama, Kohei Tajima, Hitoshi Toyoda, Junya Isobe, Yoshitaka Yamazaki, Yuta Baba, Midori Shida, Yuko Udaka, Emiko Mura, Risako Suzuki, Nana Iriguchi, Tomoyuki Ishiguro, Yuya Hirasawa, Ryotaro Ohkuma, Masahiro Shimokawa, Hirotsugu Ariizumi, Yutaro Kubota, Atsushi Horiike, Satoshi Wada, Atsuo Kuramasu, Mayumi Tsuji, Yuji Kiuchi, Takuya Tsunoda, Kiyoshi Yoshimura

electronic resource

Visa

Veillonella and Streptococcus are associated with aging of the gut microbiota and affect the efficacy of immune checkpoint inhibitors

Yuya Hirasawa, Junya Isobe, Masahiro Hosonuma, Toshiaki Tsurui, Yuta Baba, Eiji Funayama, Kohei Tajima, Masakazu Murayama, Yoichiro Narikawa, Hitoshi Toyoda, Midori Shida, Aya Sasaki, Yuuki Maruyama, Yasunobu Amari, Emiko Mura, Risako Suzuki, Nana Iriguchi, Tomoyuki Ishiguro, Ryotaro Ohkuma, Masahiro Shimokawa, Hirotsugu Ariizumi, Yutaro Kubota, Atsushi Horiike, Takehiko Sambe, Naoki Uchida, Satoshi Wada, Shinichi Kobayashi, Yuji Kiuchi, Atsuo Kuramasu, Kiyoshi Yoshimura, Takuya Tsunoda

electronic resource

Visa; Visa

MHC class I polypeptide-related sequence B shedding modulates pancreatic tumor immunity via the activation of NKG2DLow T cells

Hitoshi Toyoda, Atsuo Kuramasu, Masahiro Hosonuma, Masakazu Murayama, Yoichiro Narikawa, Junya Isobe, Yuta Baba, Kohei Tajima, Eiji Funayama, Midori Shida, Yuki Maruyama, Aya Sasaki, Yuya Hirasawa, Toshiaki Tsurui, Hirotsugu Ariizumi, Tomoyuki Ishiguro, Risako Suzuki, Sei Kobayashi, Atsushi Horiike, Noriko Hida, Takehiko Sambe, Koji Nobe, Satoshi Wada, Hitome Kobayashi, Mayumi Tsuji, Shinichi Kobayashi, Takuya Tsunoda, Yoshifumi Kudo, Yuji Kiuchi, Kiyoshi Yoshimura

electronic resource

Visa

Evaluation of patient immunocompetence for immune checkpoint inhibitor therapy using the psoas muscle index: a retrospective cohort study

Toshiaki Tsurui, Kazuyuki Hamada, Emiko Mura, Risako Suzuki, Nana Iriguchi, Tomoyuki Ishiguro, Yuya Hirasawa, Ryotaro Ohkuma, Masahiro Shimokawa, Hirotsugu Ariizumi, Yutaro Kubota, Atsushi Horiike, Satoshi Wada, Kiyoshi Yoshimura, Mayumi Tsuji, Yuji Kiuchi, Takuya Tsunoda

electronic resource

Visa; Visa

Association between the ABCC11 gene polymorphism-determined earwax properties and external auditory canal microbiota in healthy adults

Yasunobu Amari, Masahiro Hosonuma, Takuya Mizukami, Junya Isobe, Yuki Azetsu, Eiji Funayama, Yuki Maruyama, Toshiaki Tsurui, Kohei Tajima, Aya Sasaki, Yoshitaka Yamazaki, Ryota Nakano, Yutaka Sano, Atsushi Ishida, Tatsuya Nakanishi, Seiji Mochizuki, Yuri Yoshizawa, Sumito Kumagai, Sakiko Yasuhara, Kakei Ryu, Tatsunori Oguchi, Atsuo Kuramasu, Kiyoshi Yoshimura, Takehiko Sambe, Sei Kobayashi, Naoki Uchida

electronic resource

Visa

Chemotherapy combined with immune checkpoint inhibitors may overcome the detrimental effect of high neutrophil-to-lymphocyte ratio prior to treatment in esophageal cancer patients

Yuya Hirasawa, Yutaro Kubota, Emiko Mura, Risako Suzuki, Toshiaki Tsurui, Nana Iriguchi, Tomoyuki Ishiguro, Ryotaro Ohkuma, Masahiro Shimokawa, Hirotsugu Ariizumi, Atsushi Horiike, Satoshi Wada, Takeshi Yamashita, Tomotake Ariyoshi, Satoru Goto, Koji Otsuka, Masahiko Murakami, Yuji Kiuchi, Kiyoshi Yoshimura, Takuya Tsunoda

electronic resource

Visa; Visa

Isobutyric acid enhances the anti-tumour effect of anti-PD-1 antibody

Masakazu Murayama, Masahiro Hosonuma, Atsuo Kuramasu, Sei Kobayashi, Akiko Sasaki, Yuta Baba, Yoichiro Narikawa, Hitoshi Toyoda, Junya Isobe, Eiji Funayama, Kohei Tajima, Aya Sasaki, Yuki Maruyama, Yoshitaka Yamazaki, Midori Shida, Kazuyuki Hamada, Yuya Hirasawa, Toshiaki Tsurui, Hirotsugu Ariizumi, Tomoyuki Ishiguro, Risako Suzuki, Ryotaro Ohkuma, Yutaro Kubota, Atsushi Horiike, Takehiko Sambe, Mayumi Tsuji, Satoshi Wada, Shinichi Kobayashi, Toshikazu Shimane, Takuya Tsunoda, Hitome Kobayashi, Yuji Kiuchi, Kiyoshi Yoshimura

electronic resource

Visa

Intestinal and esophageal microbiota in esophageal cancer development and treatment

Yuta Baba, Kohei Tajima, Kiyoshi Yoshimura

electronic resource

Visa; Visa

Novel quantitative immunohistochemical analysis for evaluating PD-L1 expression with phosphor-integrated dots for predicting the efficacy of patients with cancer treated with immune checkpoint inhibitors

Ryotaro Ohkuma, Sakiko Miura, Satoshi Muto, Yoshitaka Toyomasu, Yuki Fujimoto, Katsuaki Ieguchi, Nobuyuki Onishi, Takashi Shimizu, Makoto Watanabe, Daisuke Takayanagi, Tsubasa Goshima, Atsushi Horiike, Kazuyuki Hamada, Hirotsugu Ariizumi, Masahiro Shimokawa, Yuya Hirasawa, Tomoyuki Ishiguro, Risako Suzuki, Nana Iriguchi, Toshiaki Tsurui, Emiko Mura, Sachiko Takenoshita, Kazuki Numajiri, Naoyuki Okabe, Kiyoshi Yoshimura, Mayumi Tsuji, Yuji Kiuchi, Toshiki Yajima, Hideyuki Ishida, Hiroyuki Suzuki, Toshiko Yamochi, Shinichi Kobayashi, Takuya Tsunoda, Satoshi Wada

electronic resource

Visa; Visa

Efficacy, safety, and biomarker analysis of nivolumab in combination with abemaciclib plus endocrine therapy in patients with HR-positive HER2-negative metastatic breast cancer: a phase II study (WJOG11418B NEWFLAME trial)

Hiroji Iwata, Kenichi Yoshimura, Norikazu Masuda, Kenjiro Aogi, Yuko Tanabe, Koji Matsumoto, Masato Takahashi, Hitomi Sakai, Junji Tsurutani, Chiyo K Imamura, Tsutomu Iwasa, Toshimi Takano, Kiyoshi Yoshimura, Jun Masuda, Manabu Futamura, Mari Hosonaga, Toru Mukohara, Sakiko Miura, Toshiko Yamochi, Hidetaka Kawabata, Hiroyuki Yasojima, Nobumoto Tomioka

electronic resource

Visa; Visa

Association between pH regulation of the tumor microenvironment and immunological state

Masahiro Hosonuma, Kiyoshi Yoshimura

electronic resource

Visa; Visa

Case Report: Combined pembrolizumab, 5-fluorouracil, and cisplatin therapy were remarkably effective in p16-positive squamous cell carcinoma of unknown primary

Risako Suzuki, Kazuyuki Hamada, Ryotaro Ohkuma, Mayumi Homma, Toshiaki Tsurui, Nana Iriguchi, Tomoyuki Ishiguro, Yuya Hirasawa, Hirotsugu Ariizumi, Yutaro Kubota, Atsushi Horiike, Kiyoshi Yoshimura, Satoshi Wada, Toshiko Yamochi, Takuya Tsunoda

electronic resource

Visa; Visa

Turicibacter and Acidaminococcus predict immune-related adverse events and efficacy of immune checkpoint inhibitor

Kazuyuki Hamada, Junya Isobe, Kouya Hattori, Masahiro Hosonuma, Yuta Baba, Masakazu Murayama, Yoichiro Narikawa, Hitoshi Toyoda, Eiji Funayama, Kohei Tajima, Midori Shida, Yuya Hirasawa, Toshiaki Tsurui, Hirotsugu Ariizumi, Tomoyuki Ishiguro, Risako Suzuki, Ryotaro Ohkuma, Yutaro Kubota, Takehiko Sambe, Mayumi Tsuji, Satoshi Wada, Yuji Kiuchi, Shinichi Kobayashi, Atsuo Kuramasu, Atsushi Horiike, Yun-Gi Kim, Takuya Tsunoda, Kiyoshi Yoshimura

electronic resource

Visa; Visa

Elevated expression of RAB3B plays important roles in chemoresistance and metastatic potential of hepatoma cells

Ryouichi Tsunedomi, Kiyoshi Yoshimura, Yuta Kimura, Mitsuo Nishiyama, Nobuyuki Fujiwara, Satoshi Matsukuma, Shinsuke Kanekiyo, Hiroto Matsui, Yoshitaro Shindo, Yusaku Watanabe, Yukio Tokumitsu, Shin Yoshida, Michihisa Iida, Nobuaki Suzuki, Shigeru Takeda, Tatsuya Ioka, Shoichi Hazama, Hiroaki Nagano

electronic resource

Visa

Emerging Immune-Monitoring System for Immune Checkpoint Inhibitors

Kazuyuki Hamada, Takuya Tsunoda, Kiyoshi Yoshimura

electronic resource

Visa; Visa

High expression of olfactomedin-4 is correlated with chemoresistance and poor prognosis in pancreatic cancer.

Ryotaro Ohkuma, Erica Yada, Shumpei Ishikawa, Daisuke Komura, Hidenobu Ishizaki, Koji Tamada, Yutaro Kubota, Kazuyuki Hamada, Hiroo Ishida, Yuya Hirasawa, Hirotsugu Ariizumi, Etsuko Satoh, Midori Shida, Makoto Watanabe, Rie Onoue, Kiyohiro Ando, Junji Tsurutani, Kiyoshi Yoshimura, Takehiko Yokobori, Tetsuro Sasada, Takeshi Aoki, Masahiko Murakami, Tomoko Norose, Nobuyuki Ohike, Masafumi Takimoto, Masahiko Izumizaki, Shinichi Kobayashi, Takuya Tsunoda, Satoshi Wada

electronic resource

Visa; Visa

Increased Plasma Soluble PD-1 Concentration Correlates with Disease Progression in Patients with Cancer Treated with Anti-PD-1 Antibodies

Ryotaro Ohkuma, Katsuaki Ieguchi, Makoto Watanabe, Daisuke Takayanagi, Tsubasa Goshima, Rie Onoue, Kazuyuki Hamada, Yutaro Kubota, Atsushi Horiike, Tomoyuki Ishiguro, Yuya Hirasawa, Hirotsugu Ariizumi, Junji Tsurutani, Kiyoshi Yoshimura, Mayumi Tsuji, Yuji Kiuchi, Shinichi Kobayashi, Takuya Tsunoda, Satoshi Wada

electronic resource

Visa; Visa

Immune Stress-induced Tumor Mutation Burden and Neoantigen Expression in 4T1 Mammary Cancer Cells: A Potential Mechanism for Long-term Survival in Patients Treated With Immune Checkpoint Inhibitors.

TOMOYUKI ISHIGURO, KAZUYUKI TAKEDA, DAISUKE TAKAYANAGI, EMIKO MURA, RISAKO SUZUKI, TOSHIAKI TSURUI, NANA IRIGUCHI, YUYA HIRASAWA, RYOTARO OHKUMA, MASAHIRO SHIMOKAWA, HIROTSUGU ARIIZUMI, YUTARO KUBOTA, ATSUSHI HORIIKE, MASAHIKO IZUMIZAKI, SATOSHI WADA, KIYOSHI YOSHIMURA, HOFFMAN, ROBERT M., TAKUYA TSUNODA

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Rare Nivolumab-associated Super Hyper Progressive Disease in Patients With Advanced Gastric Cancer.

YUTARO KUBOTA, KIYOSHI YOSHIMURA, KAZUYUKI HAMADA, YUYA HIRASAWA, MIDORI SHIDA, MAKOTO TANIGUCHI, HIROTO MATSUI, HIROTSUGU ARIIZUMI, TOMOYUKI ISHIGURO, NORIHIRO SUZUKI, RYOTARO OHKUMA, TAKEHIKO SAMBE, HIROO ISHIDA, ATSUSHI HORIIKE, SATOSHI WADA, JUNJI TSURUTANI, SANJU IWAMOTO, NAOKI UCHIDA, YUJI KIUCHI, SHINICHI KOBAYASHI