Sökresultat - "Klotho"

Association between ethylene oxide exposure and Klotho levels in US adults.

Zhang H; Department of Geriatrics, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250033, China., Zhang Z; Department of Gastroenterology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250033, China. 2016120200@mail.sdu.edu.cn.

Journal Article , 2025

Nanoparticle-mediated Klotho gene therapy prevents acute kidney injury to chronic kidney disease transition through regulating PPARα signaling in renal tubular epithelial cells.

Li H; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Guangzhou, 510080, China., Ouyang Y; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Guangzhou, 510080, China., Lv H; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Guangzhou, 510080, China., Liang H; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Guangzhou, 510080, China., Luo S; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China; Basic and Translational Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China., Zhang Y; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China; Basic and Translational Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China., Mao H; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Guangzhou, 510080, China., Chen T; Department of Chemistry, Jinan University, Guangzhou, 510632, China., Chen W; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Guangzhou, 510080, China. Electronic address: chenwei99@mail.sysu.edu.cn., Zhou Y; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China; Basic and Translational Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China. Electronic address: zhouym35@mail.sysu.edu.cn., Liu Q; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Guangzhou, 510080, China; Department of Nephrology, Jieyang People's Hospital, Jieyang, 522000, China. Electronic address: liuqhua6@mail.sysu.edu.cn.

Journal Article , 2025

Relationship of Klotho with cognition and dementia: A systematic review and meta-analysis.

Liu Y; School of Public Health, Zunyi Medical University, China; Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology, Shenzhen Center for Disease Control and Prevention, China., Huang J; The University of Hong Kong, Hong Kong, China., Xu B; School of Public Health, Zunyi Medical University, China; Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology, Shenzhen Center for Disease Control and Prevention, China. Electronic address: xubenhong0916@163.com.

Systematic Review; Journal Article; Meta-Analysis , 2025

Molecular mechanisms of neuroprotection: The interplay of Klotho, SIRT-1, Nrf2, and HO-1 in neurological health.

Rana R; Division of Neuroscience, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India; Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab 144603, India., Mukherjee R; Division of Neuroscience, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India; Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab 144603, India., Mehan S; Division of Neuroscience, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India; Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab 144603, India. Electronic address: sidharthmehan@isfcp.org., Khan Z; Division of Neuroscience, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India; Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab 144603, India., Das Gupta G; Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, India; Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab 144603, India., Narula AS; Narula Research, LLC, 107 Boulder Bluff, Chapel Hill, NC 27516, USA.

Journal Article; Review , 2025

The inflection point: α-Klotho levels and the risk of all-cause mortality.

Song J; Department of Nephrology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China., Li H; Department of Medical Records, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China., Fang X; Department of Nephrology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.

Journal Article , 2025

Uric acid mediates the association between testosterone and α-Klotho among males: results from the NHANES 2013-2016.

Guo A; Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China., Cao J; Department of Urology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021, Shandong, China., Wu C; Department of Urology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021, Shandong, China., Ding S; Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China. stding@email.sdfmu.edu.cn.; Department of Urology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021, Shandong, China. stding@email.sdfmu.edu.cn.

Journal Article , 2025

Influence of Klotho Protein Levels in Obesity and Sarcopenia: A Systematic Review.

Ariadel-Cobo DG; Institute of Biomedicine (IBIOMED), University of León, 24071 León, Spain.; Department of Endocrinology and Nutrition, Complejo Asistencial Universitario de León (CAULE), 24071 León, Spain., Estébanez B; Institute of Biomedicine (IBIOMED), University of León, 24071 León, Spain., González-Arnáiz E; Institute of Biomedicine (IBIOMED), University of León, 24071 León, Spain.; Department of Endocrinology and Nutrition, Complejo Asistencial Universitario de León (CAULE), 24071 León, Spain., García-Pérez MP; Department of Endocrinology and Nutrition, Complejo Asistencial Universitario de León (CAULE), 24071 León, Spain., Rivera-Viloria M; Institute of Biomedicine (IBIOMED), University of León, 24071 León, Spain., Pintor de la Maza B; Department of Endocrinology and Nutrition, Complejo Asistencial Universitario de León (CAULE), 24071 León, Spain., Barajas-Galindo DE; Department of Endocrinology and Nutrition, Complejo Asistencial Universitario de León (CAULE), 24071 León, Spain., García-Sastre D; Department of Endocrinology and Nutrition, Complejo Asistencial Universitario de León (CAULE), 24071 León, Spain., Ballesteros-Pomar MD; Institute of Biomedicine (IBIOMED), University of León, 24071 León, Spain.; Department of Endocrinology and Nutrition, Complejo Asistencial Universitario de León (CAULE), 24071 León, Spain., Cuevas MJ; Institute of Biomedicine (IBIOMED), University of León, 24071 León, Spain.

Journal Article; Systematic Review; Review , 2025

Association between adult body shape index and serum levels of the anti-aging protein Klotho in adults: a population-based cross-sectional study of the NHANES from 2007 to 2016.

Gong L; Department of Diabetes, Shenzhen Bao'an District Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Shenzhen, China., Xu J; Department of Endocrinology, Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, China., Zhuang Y; Department of Geriatrics, Shenzhen Bao'an District Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Shenzhen, China., Zeng L; Department of Diabetes, Shenzhen Bao'an District Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Shenzhen, China., Peng Z; Department of Diabetes, Shenzhen Bao'an District Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Shenzhen, China., Liu Y; Department of Diabetes, Shenzhen Bao'an District Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Shenzhen, China., Huang Y; Department of Diabetes, Shenzhen Bao'an District Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Shenzhen, China., Chen Y; Department of Diabetes, Shenzhen Bao'an District Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Shenzhen, China., Huang F; Department of Diabetes, Shenzhen Bao'an District Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Shenzhen, China., Piao C; Department of Endocrinology, Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, China.

Journal Article , 2025

Renoprotective effect of berberine in cisplatin-induced acute kidney injury: Role of Klotho and the AMPK/mtor/ULK1/Beclin-1 pathway.

Salah TM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, 11562, Cairo, Egypt., Rabie MA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, 11562, Cairo, Egypt. Electronic address: Mostafa.mohammed@pharma.cu.edu.eg., El Sayed NS; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, 11562, Cairo, Egypt.

Journal Article , 2025

Klotho mutation does not accelerate intervertebral disc aging in mice.

Hong J; HSS Research Institute, Hospital for Special Surgery, New York, New York, USA., Shah V; HSS Research Institute, Hospital for Special Surgery, New York, New York, USA., Krishnan R; HSS Research Institute, Hospital for Special Surgery, New York, New York, USA., Gomez-Stallons MV; Division of Molecular Cardiovascular Biology, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Poudel S; HSS Research Institute, Hospital for Special Surgery, New York, New York, USA., Yutzey KE; Division of Molecular Cardiovascular Biology, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Dahia CL; HSS Research Institute, Hospital for Special Surgery, New York, New York, USA.; Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, New York, USA.

Journal Article , 2025

Conformational landscape of soluble α-klotho revealed by cryogenic electron microscopy.

Schnicker NJ; Protein and Crystallography Facility, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA. nicholas-schnicker@uiowa.edu.; Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA. nicholas-schnicker@uiowa.edu., Xu Z; Protein and Crystallography Facility, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA., Amir M; Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA., Gakhar L; Protein and Crystallography Facility, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.; Department of Biochemistry and Molecular Biology, University of Iowa, Iowa City, IA, 52242, USA., Huang CL; Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA. chou-long-huang@uiowa.edu.

Journal Article , 2025

α-Klotho regulates mouse embryonic neural stem cell proliferation and differentiation.

Kim B; Department of Integrative Bioscience and Biotechnology, Sejong University, Seoul, 05006, Republic of Korea., Kim T; Department of Integrative Bioscience and Biotechnology, Sejong University, Seoul, 05006, Republic of Korea., Im H; Department of Integrative Bioscience and Biotechnology, Sejong University, Seoul, 05006, Republic of Korea., Shin KS; Department of Biology, Kyung Hee University, Seoul, 02447, Republic of Korea., Kang SJ; Department of Integrative Bioscience and Biotechnology, Sejong University, Seoul, 05006, Republic of Korea. Electronic address: sjkang@sejong.ac.kr.

Journal Article; Research Support, Non-U.S. Gov't , 2025

Neuroprotective effect of naringin by modulation of klotho and HMGB1- TLR4 axis in PTZ-induced kindling in mice.

Khan P; Department of Translational & Clinical Research, School of Chemical & Life Sciences, Jamia Hamdard, New Delhi, 110062, India., Saha N; Department of Translational & Clinical Research, School of Chemical & Life Sciences, Jamia Hamdard, New Delhi, 110062, India., Nidhi; Department of Translational & Clinical Research, School of Chemical & Life Sciences, Jamia Hamdard, New Delhi, 110062, India. Electronic address: nidhiagarwal@jamiahamdard.ac.in.

Journal Article , 2025

Clemastine mitigates sepsis-induced acute kidney injury in rats; the role of α-Klotho/TLR-4/MYD-88/NF-κB/ Caspase-3/ p-P38 MAPK signaling pathways.

Abdelnaser M; Department of Biochemistry, Faculty of Pharmacy, Deraya University, Minia, 61111, Egypt. Electronic address: mahmoud.abdelnaser@deraya.edu.eg., Attya ME; Department of Pathology, Faculty of Medicine, Minia University, Minia, 61519, Egypt. Electronic address: mena.ezzat@mu.edu.eg., El-Rehany MA; Department of Biochemistry, Faculty of Pharmacy, Deraya University, Minia, 61111, Egypt. Electronic address: mahmoud.elrehany@deraya.edu.eg., Fathy M; Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt. Electronic address: mostafa_fathe@minia.edu.eg.

Journal Article , 2025

Role of serum fibroblast growth factor-23 and Klotho level in COVID-19 infection-related mortality: a prospective study.

Akin D; Department of Nephrology, Pamukkale University School of Medicine, Denizli,Turkey., Aydogan BB; Department of İntensive care, Nazilli State Hospital, Aydin,Turkey., Emre N; Department of Family Medicine, Pamukkale University School of Medicine, Denizli,Turkey., Gundogdu G; Department of Physiology, Pamukkale University School of Medicine, Denizli,Turkey., Ozmen S; Camlica Hospital Department of Nephrology, Medipol University, Istanbul,Turkey., Erkek OK; Department of Physiology, Pamukkale University School of Medicine, Denizli,Turkey., Alpua M; Department of Gastroenterology, Pamukkale University School of Medicine, Denizli,Turkey.

Journal Article , 2024

Klotho enhances stability of chronic kidney disease atherosclerotic plaques by inhibiting GRK2/PLC-β-mediated endoplasmic reticulum stress in macrophages via modulation of the ROS/SHP1 pathway.

Li Z; Division of Nephrology, Affiliated Hospital of Hebei University, Baoding, China.; Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, Baoding, China., Li J; Division of Nephrology, Affiliated Hospital of Hebei University, Baoding, China.; Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, Baoding, China., Li L; Division of Nephrology, Affiliated Hospital of Hebei University, Baoding, China.; Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, Baoding, China., Wang Q; Division of Nephrology, Affiliated Hospital of Hebei University, Baoding, China.; Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, Baoding, China., Zhang Q; Division of Nephrology, Affiliated Hospital of Hebei University, Baoding, China.; Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, Baoding, China., Tian L; Division of Nephrology, Affiliated Hospital of Hebei University, Baoding, China. 19931215144@163.com.; Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, Baoding, China. 19931215144@163.com., Li C; Division of Nephrology, Affiliated Hospital of Hebei University, Baoding, China. lccinmedical@126.com.; Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, Baoding, China. lccinmedical@126.com.

Journal Article; Research Support, Non-U.S. Gov't , 2024

Correlation of the weight-adjusted waist circumference index with Klotho in the United States: differences by sex.

Yin H; Geriatric Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China., Qiu Y; Osteoarticular Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China., Guo L; Geriatric Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China., Zhu W; Geriatric Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China., Li W; Geriatric Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China., Zhou Y; Geriatric Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China., Wei W; Geriatric Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China., Liang M; Geriatric Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China. liangm@gxmu.edu.cn.; Department of Geriatric Endocrinology and Metabolism, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, 530021, Guangxi, China. liangm@gxmu.edu.cn.

Journal Article , 2024

Activity of Various Cathepsin Proteases and Enrichment of Klotho Protein in the Urine and Urinary Extracellular Vesicles After SARS-CoV-2 Infection.

Bala N; Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida College of Medicine, Gainesville, FL 32608, USA.; Department of Physiology and Aging, University of Florida College of Medicine, Gainesville, FL 32608, USA., Rafay RH; Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida College of Medicine, Gainesville, FL 32608, USA., Glover SC; Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA., Alli AA; Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida College of Medicine, Gainesville, FL 32608, USA.; Department of Physiology and Aging, University of Florida College of Medicine, Gainesville, FL 32608, USA.

Journal Article; Research Support, N.I.H., Extramural , 2024

Nonlinear relationship between serum Klotho and chronic kidney disease in US adults with metabolic syndrome.

Lin X; National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, China., Yang L; National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, China.

Journal Article , 2024

IGF-1 Signaling Modulates Oxidative Metabolism and Stress Resistance in ARPE-19 Cells Through PKM2 Function.

Ravera S; Department of Experimental Medicine, University of Genoa, Via De Toni 14, 16132 Genova, Italy.; IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genova, Italy., Puddu A; Department of Internal Medicine and Medical Specialties, University of Genova, Viale Benedetto XV 6, 16132 Genova, Italy., Bertola N; IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genova, Italy., Verzola D; Department of Internal Medicine and Medical Specialties, University of Genova, Viale Benedetto XV 6, 16132 Genova, Italy., Russo E; Department of Internal Medicine and Medical Specialties, University of Genova, Viale Benedetto XV 6, 16132 Genova, Italy.; Unit of Nephrology, Dialysis and Transplantation, IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genova, Italy., Maggi D; Department of Internal Medicine and Medical Specialties, University of Genova, Viale Benedetto XV 6, 16132 Genova, Italy., Panfoli I; Department of Pharmacy-(DIFAR), University of Genoa, Viale Benedetto XV 3, 16132 Genova, Italy.

Journal Article , 2024