Search Results - "Koyama, Hiroo"

Novel pharmacologic inhibition of lysine-specific demethylase 1 as a potential therapeutic for glioblastoma

Shinjo, Keiko^Aff1, Umehara, Takashi^Aff2, Niwa, Hideaki, Sato, Shin, Katsushima, Keisuke, Sato, Shinya, Wang, Xingxing, Murofushi, Yoshiteru, Suzuki, Miho M., Koyama, Hiroo, Kondo, Yutaka^{Aff1, Aff5, Aff6, IDs41417024008478_cor1}

Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents

Nishigaya, Yosuke^aff4, Takase, Shohei^aff3, Sumiya, Tatsunobu^aff4, Kikuzato, Ko^aff1d1, Sato, Tomohiro^aff2d1, Niwa, Hideaki^aff2d2, Sato, Shin^aff2d2, Nakata, Akiko^aff1d2, Sonoda, Takeshi^aff1d2, Hashimoto, Noriaki^aff4, Namie, Ryosuke^aff4, Honma, Teruki^aff2d1, Umehara, Takashi^aff2d2, Shirouzu, Mikako^aff2d2, Koyama, Hiroo^aff1d1, Yoshida, Minoru^{aff1d2, aff5, aff1d3}, Ito, Akihiro^{aff3, aff1d3}, Shirai, Fumiyuki^aff1d1

Asymmetric Synthesis, Structure Determination, and Biologic Evaluation of Isomers of TLAM as PFK1 Inhibitors

Kakehi, Ryo^aff1, Kobayashi, Hiroki^{aff2, aff3}, Mashiyama, Haruna^aff3, Yajima, Tatsuo^aff4, Koyama, Hiroo^aff5, Ito, Takashi K.^aff6, Yoshida, Minoru^{aff3, aff6, aff7, aff8}, Nagaoka, Yasuo^aff1, Sumiyoshi, Takaaki^aff1

Discovery of a novel class NSD2 inhibitor for multiple myeloma with t(4;14)+

Matsuoka, Sae ¹, Osada, Naoki ¹, Kubota, Hirokazu ², Kikuzato, Ko ², Koyama, Hiroo ², Sonoda, Takeshi ³, Idei, Akiko ³, Yoshida, Minoru ^{3, 4}, Kikuchi, Masaki ⁵, Umehara, Takashi ⁵, Watanabe, Chiduru ⁶, Honma, Teruki ⁶, Yasui, Hiroshi ^{7, 8}, Ikeda, Sho ⁹, Takahashi, Naoto ⁹, Nakasone, Hideki ¹, Kikuchi, Jiro ^{1, ∗}, Furukawa, Yusuke ^{1, 10, 11}

Discovery of potent substrate-type lysine methyltransferase G9a inhibitors for the treatment of sickle cell disease

Nishigaya, Yosuke ^{h, ⁎}, Takase, Shohei ^g, Sumiya, Tatsunobu ^h, Kikuzato, Ko ^a, Hiroyama, Takashi ^f, Maemoto, Yuki ^g, Aoki, Komei ^g, Sato, Tomohiro ^d, Niwa, Hideaki ^e, Sato, Shin ^e, Ihara, Kentaro ^e, Nakata, Akiko ^b, Matsuoka, Seiji ^b, Hashimoto, Noriaki ^h, Namie, Ryosuke ^h, Honma, Teruki ^d, Umehara, Takashi ^e, Shirouzu, Mikako ^e, Koyama, Hiroo ^a, Nakamura, Yukio ^f, Yoshida, Minoru ^{b, c, i}, Ito, Akihiro ^{b, c, g}, Shirai, Fumiyuki ^{a, j, ⁎⁎}

Structural Basis of Activin Receptor-Like Kinase 2 (R206H) Inhibition by Bis-heteroaryl Pyrazole-Based Inhibitors for the Treatment of Fibrodysplasia Ossificans Progressiva Identified by the Integration of Ligand-Based and Structure-Based Drug Design Approaches

Sato, Tomohiro^aff1, Sekimata, Katsuhiko^aff2, Sakai, Naoki^aff3, Watanabe, Hisami^aff3, Mishima-Tsumagari, Chiemi^aff3, Taguri, Tomonori^aff2, Matsumoto, Takehisa^aff3, Fujii, Yoshifumi^aff4, Handa, Noriko^aff4, Tanaka, Akiko^aff3, Shirouzu, Mikako^aff3, Yokoyama, Shigeyuki^aff4, Hashizume, Yoshinobu^aff5, Miyazono, Kohei^aff6, Koyama, Hiroo^aff2, Honma, Teruki^aff1

Design and Discovery of an Orally Efficacious Spiroindolinone-Based Tankyrase Inhibitor for the Treatment of Colon Cancer

Shirai, Fumiyuki^aff1d1, Mizutani, Anna^aff4, Yashiroda, Yoko^aff1d2, Tsumura, Takeshi^aff3d1, Kano, Yuko^aff3d1, Muramatsu, Yukiko^aff4, Chikada, Tsubasa^aff3d2, Yuki, Hitomi^aff2d1, Niwa, Hideaki^aff2d2, Sato, Shin^aff2d2, Washizuka, Kenichi^aff1d1, Koda, Yasuko^aff1d1, Mazaki, Yui^aff1d2, Jang, Myung-Kyu^{aff4, aff5}, Yoshida, Haruka^aff4, Nagamori, Akiko^aff4, Okue, Masayuki^aff3d5, Watanabe, Takashi^aff3d1, Kitamura, Kouichi^aff3d3, Shitara, Eiki^aff3d4, Honma, Teruki^aff2d1, Umehara, Takashi^aff2d2, Shirouzu, Mikako^aff2d2, Fukami, Takehiro^aff1d3, Seimiya, Hiroyuki^{aff4, aff5}, Yoshida, Minoru^{aff1d2, aff6}, Koyama, Hiroo^aff1d1

Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors

Shirai, Fumiyuki^aff1d1, Tsumura, Takeshi^aff4d1, Yashiroda, Yoko^aff1d3, Yuki, Hitomi^aff3d1, Niwa, Hideaki^aff3d2, Sato, Shin^aff3d2, Chikada, Tsubasa^aff4d2, Koda, Yasuko^aff1d1, Washizuka, Kenichi^aff1d1, Yoshimoto, Nobuko^aff1d1, Abe, Masako^aff1d2, Onuki, Tetsuo^aff1d2, Mazaki, Yui^aff1d3, Hirama, Chizuko^aff1d3, Fukami, Takehiro^aff2, Watanabe, Hirofumi^aff3d1, Honma, Teruki^aff3d1, Umehara, Takashi^aff3d2, Shirouzu, Mikako^aff3d2, Okue, Masayuki^aff4d5, Kano, Yuko^aff4d1, Watanabe, Takashi^aff4d1, Kitamura, Kouichi^aff4d3, Shitara, Eiki^aff4d4, Muramatsu, Yukiko^aff5, Yoshida, Haruka^aff5, Mizutani, Anna^aff5, Seimiya, Hiroyuki^aff5, Yoshida, Minoru^{aff1d2, aff1d3, aff6}, Koyama, Hiroo^aff1d1

A small molecule iCDM-34 identified by in silico screening suppresses HBV DNA through activation of aryl hydrocarbon receptor

Furutani, Yutaka^{Aff1, Aff2, Aff3, Aff4, IDs4142002301755w_cor1}, Hirano, Yoshinori^{Aff5, Aff6}, Toguchi, Mariko, Higuchi, Shoko, Qin, Xian-Yang^{Aff2, Aff7}, Yanaka, Kaori^{Aff1, Aff2, Aff4}, Sato-Shiozaki, Yumi, Takahashi, Nobuaki, Sakai, Marina, Kongpracha, Pornparn^{Aff1, Aff4}, Suzuki, Takehiro, Dohmae, Naoshi, Kukimoto-Niino, Mutsuko, Shirouzu, Mikako, Nagamori, Shushi^{Aff1, Aff4}, Suzuki, Harukazu, Kobayashi, Kaoru, Masaki, Takahiro, Koyama, Hiroo, Sekiba, Kazuma, Otsuka, Motoyuki^{Aff12, Aff13}, Koike, Kazuhiko, Kohara, Michinori, Kojima, Soichi, Kakeya, Hideaki, Matsuura, Tomokazu^{Aff1, Aff2, Aff4, Aff15}

New antimalarials identified by a cell-based phenotypic approach: Structure–activity relationships of 2,3,4,9-tetrahydro-1H-β-carboline derivatives possessing a 2-((coumarin-5-yl)oxy)alkanoyl moiety

Cho, Nobuo, Kikuzato, Ko, Futamura, Yushi, Shimizu, Takeshi, Hayase, Hiroki, Kamisaka, Kikuko, Takaya, Daisuke, Yuki, Hitomi, Honma, Teruki, Niikura, Mamoru, Kobayashi, Fumie, Watanabe, Nobumoto, Osada, Hiroyuki, Koyama, Hiroo

Design and Synthesis of Tranylcypromine-Derived LSD1 Inhibitors with Improved hERG and Microsomal Stability Profiles

Koda, Yasuko^aff1, Sato, Shin^{aff2, aff3}, Yamamoto, Hirofumi^aff1, Niwa, Hideaki^{aff2, aff3}, Watanabe, Hisami^{aff2, aff3}, Watanabe, Chiduru^aff4, Sato, Tomohiro^aff4, Nakamura, Kana^aff3, Tanaka, Akiko^aff3, Shirouzu, Mikako^aff3, Honma, Teruki^aff4, Fukami, Takehiro^aff5, Koyama, Hiroo^aff1, Umehara, Takashi^{aff2, aff3}

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Identification of small molecule inhibitors of human COQ7

Tsuganezawa, Keiko, Sekimata, Katsuhiko, Nakagawa, Yukari, Utata, Rei, Nakamura, Kana, Ogawa, Naoko, Koyama, Hiroo, Shirouzu, Mikako, Fukami, Takehiro, Kita, Kiyoshi, Tanaka, Akiko

(2R)-2-Ethylchromane-2-carboxylic Acids: Discovery of Novel PPARα/γ Dual Agonists as Antihyperglycemic and Hypolipidemic Agents

Koyama, Hiroo, Miller, Daniel J., Boueres, Julia K., Desai, Ranjit C., Jones, A. Brian, Berger, Joel P., MacNaul, Karen L., Kelly, Linda J., Doebber, Thomas W., Wu, Margaret S., Zhou, Gaochao, Wang, Pei-ran, Ippolito, Marc C., Chao, Yu-Sheng, Agrawal, Arun K., Franklin, Ronald, Heck, James V., Wright, Samuel D., Moller, David E., Sahoo, Soumya P.

BMP signaling is a therapeutic target in ovarian cancer

Fukuda, Tomohiko, Fukuda, Risa, Tanabe, Ryo, Koinuma, Daizo, Koyama, Hiroo, Hashizume, Yoshinobu, Moustakas, Aristidis, Miyazono, Kohei, Heldin, Carl-Henrik, 1952

electronic

Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen

Yuki, Hitomi, Kikuzato, Ko, Koda, Yasuko, Mikuni, Junko, Tomabechi, Yuri, Kukimoto-Niino, Mutsuko, Tanaka, Akiko, Shirai, Fumiyuki, Shirouzu, Mikako, Koyama, Hiroo, Honma, Teruki

Development of a degrader against oncogenic fusion protein FGFR3-TACC3

Shibata, Norihito, Cho, Nobuo, Koyama, Hiroo, Naito, Mikihiko

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Novel bicyclic pyrazoles as potent ALK2 (R206H) inhibitors for the treatment of fibrodysplasia ossificans progressiva

Yamamoto, Hirofumi, Sakai, Naoki, Ohte, Satoshi, Sato, Tomohiro, Sekimata, Katsuhiko, Matsumoto, Takehisa, Nakamura, Kana, Watanabe, Hisami, Mishima-Tsumagari, Chiemi, Tanaka, Akiko, Hashizume, Yoshinobu, Honma, Teruki, Katagiri, Takenobu, Miyazono, Kohei, Tomoda, Hiroshi, Shirouzu, Mikako, Koyama, Hiroo

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