Search Results - "MENDELIAN randomization"

Causal validation of the relationship between air pollution and lung cancer: A bidirectional Mendelian randomization study and meta-analysis.

Wang X; The First People's Hospital of Kunming City and Calmette Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China., Xiao G; Zhoupu Hospital, Pudong New District, Shanghai, China., Xu W; The First People's Hospital of Kunming City and Calmette Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China., Ni C; The First People's Hospital of Kunming City and Calmette Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.

Journal Article; Meta-Analysis , 2025

Unbiased causal inference with Mendelian randomization and covariate-adjusted GWAS data.

Wang P; Division of Biostatistics and Health Data Science, University of Minnesota, Minneapolis, MN, USA., Lin Z; Department of Statistics, Florida State University, Tallahassee, FL, USA., Pan W; Division of Biostatistics and Health Data Science, University of Minnesota, Minneapolis, MN, USA. Electronic address: panxx014@umn.edu.

Journal Article , 2025

Exploring the Causal Relationship Between Immune Cells and Idiopathic Pulmonary Fibrosis: A Mendelian Randomization Analysis.

Gong P; School of Basic Medical Sciences, Shanxi University of Traditional Chinese Medicine, Jinzhong, Shanxi, China.; Shouyang County People's Hospital, Shouyang, Shanxi, China., Lu Y; School of Basic Medical Sciences, Shanxi University of Traditional Chinese Medicine, Jinzhong, Shanxi, China., Chai X; School of Basic Medical Sciences, Shanxi University of Traditional Chinese Medicine, Jinzhong, Shanxi, China., Li X; School of Basic Medical Sciences, Shanxi University of Traditional Chinese Medicine, Jinzhong, Shanxi, China.

Journal Article , 2025

Investigation of brain structures and potential mechanisms associated with ADHD: Insights from Mendelian randomization and genetic analysis.

Hu X; The First Affiliated Hospital of Guangzhou University of Chinese Medicine, China; Guangdong Clinical Research Academy of Chinese Medicine, China., Lin L; The First Affiliated Hospital of Guangzhou University of Chinese Medicine, China; Guangzhou University of Chinese Medicine, China., Wu Z; The First Affiliated Hospital of Guangzhou University of Chinese Medicine, China; Guangzhou University of Chinese Medicine, China.

Journal Article , 2025

Bidirectional Mendelian randomization analysis of plasma lipidome and psychiatric disorders.

Yu L; Key Laboratory of Neurological and Psychiatric Disease Research of Yunnan Province, The Second Affiliated Hospital of Kunming Medical University, Kunming, China., Long Q; Key Laboratory of Neurological and Psychiatric Disease Research of Yunnan Province, The Second Affiliated Hospital of Kunming Medical University, Kunming, China., Zhang Y; Key Laboratory of Neurological and Psychiatric Disease Research of Yunnan Province, The Second Affiliated Hospital of Kunming Medical University, Kunming, China; Department of Psychiatry, the Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China., Liu Y; Key Laboratory of Neurological and Psychiatric Disease Research of Yunnan Province, The Second Affiliated Hospital of Kunming Medical University, Kunming, China., Guo Z; Key Laboratory of Neurological and Psychiatric Disease Research of Yunnan Province, The Second Affiliated Hospital of Kunming Medical University, Kunming, China., Cao X; Key Laboratory of Neurological and Psychiatric Disease Research of Yunnan Province, The Second Affiliated Hospital of Kunming Medical University, Kunming, China., Qin F; Key Laboratory of Neurological and Psychiatric Disease Research of Yunnan Province, The Second Affiliated Hospital of Kunming Medical University, Kunming, China., Xu Y; Key Laboratory of Neurological and Psychiatric Disease Research of Yunnan Province, The Second Affiliated Hospital of Kunming Medical University, Kunming, China., Qian Q; Key Laboratory of Neurological and Psychiatric Disease Research of Yunnan Province, The Second Affiliated Hospital of Kunming Medical University, Kunming, China., Gao B; Key Laboratory of Neurological and Psychiatric Disease Research of Yunnan Province, The Second Affiliated Hospital of Kunming Medical University, Kunming, China., Chen J; Department of Gastroenterology, the Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China., Liu J; Department of Dermatology and Venereology, the Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China., Zeng Y; Key Laboratory of Neurological and Psychiatric Disease Research of Yunnan Province, The Second Affiliated Hospital of Kunming Medical University, Kunming, China; Department of Psychiatry, the Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China. Electronic address: zengyong@kmmu.edu.cn., Teng Z; Key Laboratory of Neurological and Psychiatric Disease Research of Yunnan Province, The Second Affiliated Hospital of Kunming Medical University, Kunming, China. Electronic address: tengzhaowei@kmmu.edu.cn.

Journal Article , 2025

Causal link between gut microbiota and obsessive-compulsive disorder: A two-sample Mendelian randomization analysis.

He M; Department of Health Laboratory Technology, School of Public Health, Chongqing Medical University, Chongqing 400016, People's Republic of China; Research Center for Environment and Human Health, School of Public Health, Chongqing Medical University, Chongqing 400016, People's Republic of China., Zhang H; Department of Health Laboratory Technology, School of Public Health, Chongqing Medical University, Chongqing 400016, People's Republic of China; Research Center for Environment and Human Health, School of Public Health, Chongqing Medical University, Chongqing 400016, People's Republic of China., Luo Z; Department of Health Laboratory Technology, School of Public Health, Chongqing Medical University, Chongqing 400016, People's Republic of China; Research Center for Environment and Human Health, School of Public Health, Chongqing Medical University, Chongqing 400016, People's Republic of China., Duan X; Department of Health Laboratory Technology, School of Public Health, Chongqing Medical University, Chongqing 400016, People's Republic of China; Research Center for Environment and Human Health, School of Public Health, Chongqing Medical University, Chongqing 400016, People's Republic of China., Zhao F; Department of Health Laboratory Technology, School of Public Health, Chongqing Medical University, Chongqing 400016, People's Republic of China; Research Center for Environment and Human Health, School of Public Health, Chongqing Medical University, Chongqing 400016, People's Republic of China., Su P; Department of Occupational and Environmental Health, School of Public Health, Chongqing Medical University, Chongqing 400016, People's Republic of China; Research Center for Environment and Human Health, School of Public Health, Chongqing Medical University, Chongqing 400016, People's Republic of China., Zeng Z; Department of Occupational and Environmental Health, School of Public Health, Chongqing Medical University, Chongqing 400016, People's Republic of China; Research Center for Environment and Human Health, School of Public Health, Chongqing Medical University, Chongqing 400016, People's Republic of China., Zhou L; Department of Occupational and Environmental Health, School of Public Health, Chongqing Medical University, Chongqing 400016, People's Republic of China; Research Center for Environment and Human Health, School of Public Health, Chongqing Medical University, Chongqing 400016, People's Republic of China., Chen C; Department of Occupational and Environmental Health, School of Public Health, Chongqing Medical University, Chongqing 400016, People's Republic of China; Research Center for Environment and Human Health, School of Public Health, Chongqing Medical University, Chongqing 400016, People's Republic of China. Electronic address: chengzhichen@cqmu.edu.cn., Qiu J; Department of Health Laboratory Technology, School of Public Health, Chongqing Medical University, Chongqing 400016, People's Republic of China; Research Center for Environment and Human Health, School of Public Health, Chongqing Medical University, Chongqing 400016, People's Republic of China. Electronic address: 102335@cqmu.edu.cn.

Journal Article , 2025

Mendelian randomization combined with single-cell sequencing data analysis of chemokines and chemokine receptors and key genes and molecular mechanisms associated with epilepsy.

Zhang LM; Department of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China., Zeng T; Department of Neurology, The Pearl River Hospital Affiliated to Southern Medical University, Guangzhou, Guangdong, China., Zhang BR; Department of Emergency, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China., Zhang QJ; Department of Emergency, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China., Gao SJ; Department of Emergency, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China., Zhu YL; Department of Emergency, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China., Liu MW; Department of Emergency, Dali Bai Autonomous Prefecture People's Hospital, Dali, Yunnan, China.

Journal Article , 2025

Genetically Proxied Phosphodiesterase Type 5 (PDE5) Inhibition and Risk of Dementia: A Drug Target Mendelian Randomization Study.

Brennan SO; University of Galway, Galway, Ireland. stephen.o.brennan@universityofgalway.ie.; Mater Misericordiae University Hospital, Dublin, Ireland. stephen.o.brennan@universityofgalway.ie., Tinworth AC; Clinical Trial Service Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK. alexander.tinworth@ndph.ox.ac.uk.

Journal Article , 2025

Genetic evidence of the causal relationship between serum micronutrients and Graves' disease: A Mendelian randomization and cross-sectional observational study.

Zhang J; Department of Ophthalmology, Renmin Hospital of Wuhan University, Hubei, China., Lu Y; Department of Ophthalmology, Renmin Hospital of Wuhan University, Hubei, China., Yang H; Department of Ophthalmology, Renmin Hospital of Wuhan University, Hubei, China., Hu S; Department of Ophthalmology, Jingzhou Hospital of Traditional Chinese Medicine, Hubei Province, China., Zhou Y; Department of Ophthalmology, Renmin Hospital of Wuhan University, Hubei, China., Jiang M; Department of Ophthalmology, Renmin Hospital of Wuhan University, Hubei, China., Zhu R; Aier Eye Hospital of Wuhan University, Wuhan Aier eye hospital, Hubei Province, China., Wu L; Department of Ophthalmology, Renmin Hospital of Wuhan University, Hubei, China. Email: wl20221030@163.com.

Journal Article; Observational Study , 2025

Plasma Metabolites as Mediators Between Gut Microbiota and Parkinson's Disease: Insights from Mendelian Randomization.

Chen J; Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, 650032, P.R. China., Zhu L; Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, 650032, P.R. China., Wang F; Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, 650032, P.R. China., Zhu Y; Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, 650032, P.R. China., Chen J; Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, 650032, P.R. China., Liang C; Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, 650032, P.R. China., Liu B; Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, 650032, P.R. China., Pang A; Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, 650032, P.R. China. 879384106@qq.com., Yang X; Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, 650032, P.R. China. yxldoc11@163.com.

Journal Article , 2025

Obstructive sleep apnea and osteoporosis: A bidirectional two-sample mendelian randomization analysis.

Tu Y; Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China; Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, China. Electronic address: yitingtu666@163.com., Miao J; Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China; Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, China. Electronic address: miaojiansen1@163.com., Wu Q; Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China; Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, China. Electronic address: qhwu1017@163.com., Lu K; Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China; Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, China. Electronic address: lukeyu0609@163.com., Ren R; School of the Second Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, China. Electronic address: rrf18267738237@163.com., Lin C; Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China; Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, China. Electronic address: lch.1998@qq.com., Wang X; Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China; Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, China. Electronic address: xiangyangwang@wmu.edu.cn., Jin H; Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China; Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, China. Electronic address: kkjinhaiming@126.com.

Journal Article , 2025

Thyroid Dysfunction and Oral Lichen Planus: Evidence From Two-Sample Mendelian Randomization Analysis.

Xie P; College of Stomatology, North China University of Science and Technology, Tangshan, Hebei, China., Peng W; College of Stomatology, North China University of Science and Technology, Tangshan, Hebei, China. Electronic address: pengwei1968@sina.com.

Journal Article , 2025

Lipids, lipid-lowering drug target genes and pancreatic cancer: a Mendelian randomization study.

Zhan Y; School of Public Health and Institute of Wenzhou and Liangzhu Laboratory, Zhejiang University, Hangzhou, 310058, China., Zhang K; School of Public Health and Institute of Wenzhou and Liangzhu Laboratory, Zhejiang University, Hangzhou, 310058, China., Fan Y; Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China., Lin S; School of Public Health and Institute of Wenzhou and Liangzhu Laboratory, Zhejiang University, Hangzhou, 310058, China., Wu J; School of Public Health and Institute of Wenzhou and Liangzhu Laboratory, Zhejiang University, Hangzhou, 310058, China., Xu H; School of Public Health and Institute of Wenzhou and Liangzhu Laboratory, Zhejiang University, Hangzhou, 310058, China. einstein@zju.edu.cn.; Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. einstein@zju.edu.cn.

Journal Article; Meta-Analysis , 2025

Assessing the Causal Relationships Between Lipid Species and Stroke by Using Mendelian Randomization.

Wang SQ; First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450099, China., Zhang H; Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, China., Hui XS; Guang'anmen Hospital, China Academy of Chinese Medical Science, Beijing, 100053, China., Zhang Q; First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450099, China., Chen R; First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450099, China., Xie F; College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, 100039, China. xiefei0522@163.com.

Journal Article , 2025

Association between brain resting-state functional activities and obesity: A bidirectional Mendelian randomization study.

Chen Z; Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing 100010, China., Wang J; Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing 100010, China; Department of Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China., Lyu T; Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing 100010, China., Xia Q; Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing 100010, China., Liu L; Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing 100010, China. Electronic address: lululalavictor1985@126.com., Li B; Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing 100010, China. Electronic address: libin@bjzhongyi.com.

Journal Article , 2025

Exploring the genetic association between inflammatory cytokines and primary ovarian insufficiency: A Mendelian randomization study.

Wu J; Department of Pharmacy, People's Hospital of Longhua, Shenzhen City, Guangdong Province 518109, China., Fu Y; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Health Science Center, Shenzhen University, Shenzhen 518060, China., Qiu Z; Faculty of Medicine, Macau University of Science and Technology, Avenida WaiLong, Taipa, Macau 999078, China. Electronic address: qiuzhengqi2018@email.szu.edu.cn.

Journal Article , 2025

Combining Single-Cell RNA Sequencing and Mendelian Randomization to Explore Novel Drug Targets for Parkinson's Disease.

Wu X; Department of Neurosurgery, Xuanwu Hospital of the Capital Medical University, Beijing, 100053, China.; International Neuroscience Institute (China-INI), Beijing, 100053, China., Wang K; Department of Neurosurgery, Xuanwu Hospital of the Capital Medical University, Beijing, 100053, China. wkl_20080113@126.com.; International Neuroscience Institute (China-INI), Beijing, 100053, China. wkl_20080113@126.com., Li Q; Department of Neurosurgery, Xuanwu Hospital of the Capital Medical University, Beijing, 100053, China.; International Neuroscience Institute (China-INI), Beijing, 100053, China., Zhang Y; Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China., Wei P; Department of Neurosurgery, Xuanwu Hospital of the Capital Medical University, Beijing, 100053, China.; International Neuroscience Institute (China-INI), Beijing, 100053, China., Shan Y; Department of Neurosurgery, Xuanwu Hospital of the Capital Medical University, Beijing, 100053, China.; International Neuroscience Institute (China-INI), Beijing, 100053, China., Zhao G; Department of Neurosurgery, Xuanwu Hospital of the Capital Medical University, Beijing, 100053, China. ggzhao@vip.sina.com.; International Neuroscience Institute (China-INI), Beijing, 100053, China. ggzhao@vip.sina.com.; Beijing Municipal Geriatric Medical Research Center, Beijing, 100053, China. ggzhao@vip.sina.com.

Journal Article , 2025

Mendelian randomization studies of testosterone exposure: A systematic review.

Rhomberg-Kauert AM; Department of Clinical Pharmacology, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Bispebjerg Bakke 23, 2400 Copenhagen, Denmark; Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria., Tulstrup M; Department of Clinical Pharmacology, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Bispebjerg Bakke 23, 2400 Copenhagen, Denmark., Badsted C; Department of Clinical Pharmacology, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Bispebjerg Bakke 23, 2400 Copenhagen, Denmark., Horwitz H; Department of Clinical Pharmacology, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Bispebjerg Bakke 23, 2400 Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark., Heerfordt IM; Department of Clinical Pharmacology, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Bispebjerg Bakke 23, 2400 Copenhagen, Denmark; Department of Geriatric and Palliative Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Denmark. Electronic address: ida.marie.heerfordt@regionh.dk.

Journal Article; Systematic Review; Review , 2025

Identification of EPHB4 as a potential causal gene and therapeutic target for endometriosis using Mendelian randomization.

Ling S; Reproductive Medicine Center, Baise People's Hospital/Affiliated Southwest Hospital of Youjiang Medical University for Nationalities, Baise, China., Xie D; Clinical Laboratory, Baise People's Hospital/Affiliated Southwest Hospital of Youjiang Medical University for Nationalities, Baise, China., Huang L; Reproductive Medicine Center, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China., Huang S; Department of Gynecology, Baise People's Hospital/Affiliated Southwest Hospital of Youjiang Medical University for Nationalities, Baise, China., Tian C; Reproductive Medicine Center, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China., Huang L; Reproductive Medicine Center, Baise People's Hospital/Affiliated Southwest Hospital of Youjiang Medical University for Nationalities, Baise, China., Chen R; Reproductive Medicine Center, Baise People's Hospital/Affiliated Southwest Hospital of Youjiang Medical University for Nationalities, Baise, China., Qin L; Reproductive Medicine Center, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China. qinlimy@126.com., Qin X; Reproductive Medicine Center, Baise People's Hospital/Affiliated Southwest Hospital of Youjiang Medical University for Nationalities, Baise, China. qinxiaomy@163.com.

Journal Article , 2025

Identifying causal genes for prostatitis through drug-targeted Mendelian randomization.

Yan K; Department of Urology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157, Xiwu Rd., Xi'an, 710004, Shaanxi Province, China., Tao Y; Department of Urology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157, Xiwu Rd., Xi'an, 710004, Shaanxi Province, China., Chen B; Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaan'xi Province, China., Zhang D; Department of Urology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157, Xiwu Rd., Xi'an, 710004, Shaanxi Province, China., Li Z; Department of Urology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157, Xiwu Rd., Xi'an, 710004, Shaanxi Province, China., Li C; Department of Urology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157, Xiwu Rd., Xi'an, 710004, Shaanxi Province, China., Zhang P; Department of Urology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157, Xiwu Rd., Xi'an, 710004, Shaanxi Province, China. zpbill@aliyun.com.

Journal Article , 2025