Search Results - "Methotrexate"

Methotrexate carried in lipid core nanoparticles reduces microglial activation and induces neuroprotection after cortical stroke induced in rats.

Pereira ELR; Laboratory of Experimental Neuroprotection and Neuroregeneration, Institute of Collective Health, Universidade Federal do Oeste do Pará, Santarém, PA, Brazil; Neurology Unity, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Belém, PA, Brazil., Maranhão RC; Neurology Unity, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Belém, PA, Brazil. Electronic address: ramarans@usp.br., Dias MNC; Laboratório de Metabolismo e Lípides, Instituto do Coração (InCor-HCMUSP), Department of Cardiopneumology of the Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil., Dos Santos IR; Laboratório de Metabolismo e Lípides, Instituto do Coração (InCor-HCMUSP), Department of Cardiopneumology of the Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil., Dos Santos CR; Laboratory of Experimental Neuroprotection and Neuroregeneration, Institute of Collective Health, Universidade Federal do Oeste do Pará, Santarém, PA, Brazil., Hamoy M; Laboratory of Toxicology and Natural Products, Institute of Biological Sciences, Universidade Federal do Pará, Belém, PA, Brazil., Feio DCA; Laboratory of Molecular Biology, Universidade Estadual do Pará, Belém, PA, Brazil., Carvalho PO; Neurology Unity, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Belém, PA, Brazil., Bazioli JM; Neurology Unity, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Belém, PA, Brazil., Morikawa AT; Neurology Unity, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Belém, PA, Brazil., Gomes-Leal W; Laboratory of Experimental Neuroprotection and Neuroregeneration, Institute of Collective Health, Universidade Federal do Oeste do Pará, Santarém, PA, Brazil.

Journal Article , 2025

Monotropein synergizes with methotrexate to attenuate synovial inflammation in adjuvant-induced arthritis mice and fibroblast-like synoviocyte via GSK-3β.

Shen Y; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China., Bao RH; Hangzhou Fuyang Hospital of TCM Orthopedics and Traumatology, Hangzhou 311400, China., Ren QR; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China., Sun YQ; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China., Liu YL; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China., Ye XY; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China., Du JM; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China., Ye TW; Department of Orthopaedic Surgery, Changzheng Hospital, Naval Medical University, Shanghai 200003, China., Zhang QL; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China., Wu YB; College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China. Electronic address: wxsq1@163.com., Qin LP; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China. Electronic address: lpqin@zcmu.edu.cn., Zhang QY; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China. Electronic address: zqy1965@163.com.

Journal Article , 2025

Involvement of IL-6/JAK/STAT3/SOCS3, SIRT1, and Cytoglobin Signaling in Diacerein Protective Effect against Intestinal Injury Induced by Methotrexate.

Ali GF; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt., Hassanein EHM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, Egypt., Abdel-Reheim MA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.; Department of Pharmacology, College of Pharmacy, Shaqra University, Shaqra, Saudi Arabia., Arafa EA; Department of Clinical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman, United Arab Emirates.; Center of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates., Mohamed WR; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.

Journal Article , 2025

Exploring the potentials of chitosan as a promising carrier for methotrexate for beating cancer.

Amin H; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt. Electronic address: haithamamin.4522@azhar.edu.eg., Zayed G; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt; Al-Azhar Centre of Nanosciences and Applications (ACNA), Al-Azhar University, Assiut 71524, Egypt. Electronic address: gamalzayed@azhar.edu.eg., Ibrahim IM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt. Electronic address: IslamM.Ibrahim.2020@azhar.edu.eg., Hassanein EHM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt. Electronic address: emadhassanien@azhar.edu.eg.

Journal Article; Review , 2025

Longitudinal assessment of liver stiffness using ARFI technique does not support increased risk of fibrosis in rheumatoid arthritis patients on methotrexate.

Schäfer A; Diabetes Zentrum Mergentheim, Bad Mergentheim, Germany.; Medizinische Klinik und Poliklinik II, University Hospital Würzburg, Würzburg, Germany., Kovacs MS; MVZ MED|BAYERN OST, Krankenhausstraße 1, 84489, Burghausen, Germany., Eder A; MVZ MED|BAYERN OST, Krankenhausstraße 1, 84489, Burghausen, Germany., Nigg A; MVZ MED|BAYERN OST, Krankenhausstraße 1, 84489, Burghausen, Germany., Feuchtenberger M; Medizinische Klinik und Poliklinik II, University Hospital Würzburg, Würzburg, Germany. m.feuchtenberger@innklinikum.de.; MVZ MED|BAYERN OST, Krankenhausstraße 1, 84489, Burghausen, Germany. m.feuchtenberger@innklinikum.de.

Journal Article , 2025

Efficacy and safety of methotrexate in osteoarthritis: A systematic review and meta-analysis of randomized controlled trials.

Wong W; Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China; Institute of Traumatology & Orthopedics, Shanghai Academy of Traditional Chinese Medicine, Shanghai, People's Republic of China., Huang Y; Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China; Institute of Traumatology & Orthopedics, Shanghai Academy of Traditional Chinese Medicine, Shanghai, People's Republic of China., Wichienwantana N; Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China; Institute of Traumatology & Orthopedics, Shanghai Academy of Traditional Chinese Medicine, Shanghai, People's Republic of China., Sun H; Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China; Institute of Traumatology & Orthopedics, Shanghai Academy of Traditional Chinese Medicine, Shanghai, People's Republic of China., Pang J; Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China; Institute of Traumatology & Orthopedics, Shanghai Academy of Traditional Chinese Medicine, Shanghai, People's Republic of China. Electronic address: pangjian@shutcm.edu.cn., Shi Y; Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China; Institute of Traumatology & Orthopedics, Shanghai Academy of Traditional Chinese Medicine, Shanghai, People's Republic of China. Electronic address: shiying1974@126.com.

Journal Article; Systematic Review; Meta-Analysis; Review , 2025

Effects of SCT genetic polymorphisms on methotrexate concentrations and toxicities in Chinese children with acute lymphoblastic leukemia.

Li M; Department of Pediatrics, Beijing Shijitan Hospital, Capital Medical University, Beijing, China., Zhao DQ; Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.; Department of Clinical Pharmacy, College of Pharmacy, Capital Medical University, Beijing, China., Kong XY; Department of Pharmacy, Armed Police Beijing Corps Hospital, Beijing, China., Wang SM; Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.

Journal Article , 2025

Blood pressure changes during methotrexate treatment: results from a randomized placebo-controlled trial among patients with cardiovascular risk.

Cui J; Division of Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Solomon DH; Division of Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Journal Article; Randomized Controlled Trial , 2025

MTX-induced gastrointestinal reactions in RA: Prevotella enrichment, gut dysbiosis, and PI3K/Akt/Ras/AMPK pathways.

Duo R; Department of Rheumatology and Immunology, Lanzhou University Second Hospital, 82 Cuiyingmen, Chengguan District, Lanzhou, 730030, Gansu Province, China.; The Second Clinical Medical School, Lanzhou University, Lanzhou, 730030, Gansu, China., Wang Y; The Second Clinical Medical School, Lanzhou University, Lanzhou, 730030, Gansu, China., Ma Q; The Second Clinical Medical School, Lanzhou University, Lanzhou, 730030, Gansu, China., Wang X; Department of Rheumatology and Immunology, Lanzhou University Second Hospital, 82 Cuiyingmen, Chengguan District, Lanzhou, 730030, Gansu Province, China.; The Second Clinical Medical School, Lanzhou University, Lanzhou, 730030, Gansu, China., Zhang Y; Department of Rheumatology and Immunology, Lanzhou University Second Hospital, 82 Cuiyingmen, Chengguan District, Lanzhou, 730030, Gansu Province, China.; The Second Clinical Medical School, Lanzhou University, Lanzhou, 730030, Gansu, China., Shen H; Department of Rheumatology and Immunology, Lanzhou University Second Hospital, 82 Cuiyingmen, Chengguan District, Lanzhou, 730030, Gansu Province, China. shenhl@lzu.edu.cn.; The Second Clinical Medical School, Lanzhou University, Lanzhou, 730030, Gansu, China. shenhl@lzu.edu.cn.

Journal Article , 2025

Comparison of the efficacy and safety of methotrexate injection and methotrexate tablets in active RA.

Qiao L; Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Beijing, China.; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing, China.; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China., Hu J; Department of Rheumatology, Pingxiang People's Hospital, Pingxiang, China., Ou D; Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of University of South China, Hengyang, China., Liu M; Department of Rheumatology and Immunology, Jincheng General Hospital, Jincheng, China., Shi X; Department of Rheumatology and Immunology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China., Li X; Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of USTC Anhui Provincial Hospital, Hefei, China., Wu R; Department of Rheumatology and Immunology, First Affiliated Hospital of Nanchang University, Nanchang, China., Zhang L; Rheumatology and Immunology Department, Shanxi Norman Bethune Hospital, Taiyuan, China., Liu Y; Department of Rheumatology and Immunology, Liuzhou People's Hospital, Liuzhou, China., Xiao C; Department of Rheumatology and Clinical Immunology, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China., Fu Z; Rheumatology Department, First Hospital of Shanxi Medical University, Taiyuan, China., Lin J; Department of Rheumatology and Immunology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Wang R; Department of Rheumatology, Shanghai Guanghua Hospital of Integrated Traditional and Western Medicine, Shanghai, China., Zhou D; Department of Rheumatology and Immunology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China., Yu J; Rheumatology Department, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China., Jin J; Immunology Department, Yanbian University Affiliated Hospital, Yanji, China., Song S; Department of Rheumatology and Immunology, Xiling Hospital, Yichang Central People's Hospital, Yichang, China., Tang L; Department of Rheumatology and Immunology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China., Sun H; Department of Rheumatology and Immunology, Shandong First Medical University Affiliated Provincial Hospital, Jinan, China., Yin Y; Shenzhen Kangzhe Biotechnology Co., Ltd., Shenzhen, China., Zeng X; Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Beijing, China.; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing, China.; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.

Journal Article; Randomized Controlled Trial; Comparative Study , 2025

Drug-related problems experienced by rheumatoid arthritis patients during the first three months of methotrexate use: a longitudinal observational study.

Oude Lansink MAM; Department of Research, Sint Maartenskliniek, Hengstdal 3, 6574 NA, Ubbergen, Nijmegen, The Netherlands. m.oudelansink@maartenskliniek.nl.; Department of Pharmacy, Sint Maartenskliniek, Nijmegen, The Netherlands. m.oudelansink@maartenskliniek.nl.; Department of Pharmacy, Radboudumc, Nijmegen, The Netherlands. m.oudelansink@maartenskliniek.nl., Pongers SAS; Master Pharmacy, University of Utrecht, Utrecht, The Netherlands., Bekker CL; Department of Pharmacy, Radboudumc, Nijmegen, The Netherlands., Eikelboom D; Department of Research, Sint Maartenskliniek, Hengstdal 3, 6574 NA, Ubbergen, Nijmegen, The Netherlands.; Department of Pharmacy, Sint Maartenskliniek, Nijmegen, The Netherlands., Ten Cate DF; Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands., van den Bemt BJF; Department of Research, Sint Maartenskliniek, Hengstdal 3, 6574 NA, Ubbergen, Nijmegen, The Netherlands.; Department of Pharmacy, Sint Maartenskliniek, Nijmegen, The Netherlands.; Department of Pharmacy, Radboudumc, Nijmegen, The Netherlands., Huiskes VJB; Department of Pharmacy, Sint Maartenskliniek, Nijmegen, The Netherlands.; Department of Pharmacy, Radboudumc, Nijmegen, The Netherlands.

Journal Article; Observational Study , 2025

Fabrication of sodium alginate/polyvinyl alcohol@ ZnNPs with SPI scaffold for evaluation of immune-stimulating and liver-protective effects in methotrexate-treated rats.

Mohamed RS; Nutrition and Food Sciences Department, National Research Centre, Cairo, Egypt., Akl EM; Fats and Oils Department, National Research Centre, Cairo, Egypt. Electronic address: engy_akl@yahoo.com., Dacrory S; Cellulose & Paper Department, National Research Centre, Giza, Egypt. Electronic address: sdmali82@yahoo.com.

Journal Article , 2025

OpenSAFELY: The impact of COVID-19 on azathioprine, leflunomide and methotrexate monitoring, and factors associated with change in monitoring rate.

Brown AD; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, UK., Fisher L; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, UK., Curtis HJ; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, UK., Wiedemann M; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, UK., Hulme WJ; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, UK., Speed V; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, UK., Hopcroft LEM; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, UK., Cunningham C; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, UK., Costello RE; London School of Hygiene and Tropical Medicine, London, UK., Galloway JB; Centre for Rheumatic Diseases, King's College London, UK., Russell MD; Centre for Rheumatic Diseases, King's College London, UK., Bechman K; Centre for Rheumatic Diseases, King's College London, UK., Kurt Z; Northumbria University, Newcastle upon Tyne, UK., Croker R; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, UK., Wood C; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, UK., Walker AJ; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, UK., Schaffer AL; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, UK., Bacon SCJ; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, UK., Mehrkar A; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, UK., Hickman G; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, UK., Bates C; TPP, Leeds, UK., Cockburn J; TPP, Leeds, UK., Parry J; TPP, Leeds, UK., Hester F; TPP, Leeds, UK., Harper S; TPP, Leeds, UK., Goldacre B; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, UK., MacKenna B; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, UK.

OpenSAFELY Collaborative

Journal Article , 2025

Simultaneous Determination of Unbound Plasma Concentration of Methotrexate and 7-Hydroxymethotrexate in Children Patients Receiving High-Dose Methotrexate Therapy.

Dong WC; Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, 050051, People's Republic of China.; The School of Medicine, Nankai University, Tianjin, 300071, People's Republic of China., Gao SS; Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, 050051, People's Republic of China., Shi B; Department of Orthopaedics, Hebei Medical University Third Hospital, Shijiazhuang, Hebei Province, 050000, People's Republic of China., Li HR; Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, 050051, People's Republic of China., Jiang Y; School of Pharmacy, Hebei Medical University, Shijiazhuang, Hebei Province, 050017, People's Republic of China.; Hebei Key Laboratory of Forensic Medicine, Shijiazhuang, Hebei Province, 050017, People's Republic of China., Guo JL; Department of Orthopaedics, Hebei Medical University Third Hospital, Shijiazhuang, Hebei Province, 050000, People's Republic of China., Zhang ZQ; Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, 050051, People's Republic of China., Zhang YZ; The School of Medicine, Nankai University, Tianjin, 300071, People's Republic of China.; Department of Orthopaedics, Hebei Medical University Third Hospital, Shijiazhuang, Hebei Province, 050000, People's Republic of China.

Journal Article , 2025

Upadacitinib as monotherapy in patients with rheumatoid arthritis and prior inadequate response to methotrexate: results at 260 weeks from the SELECT-MONOTHERAPY randomised study.

Smolen JS; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Wien, Austria josef.smolen@meduniwien.ac.at., Emery P; Department of Rheumatology, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Biomedical Research Centre, Leeds, UK., Rigby W; Rheumatology Section, Dartmouth Health, Lebanon, New Hampshire, USA., Tanaka Y; First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health Japan, Kitakyushu, Fukuoka, Japan., Vargas JI; Quantum Research, Puerto Varas, Chile., Jain M; Flourish Research, Chicago, Illinois, USA., Kato K; AbbVie Inc, North Chicago, Illinois, USA., Carter KM; AbbVie Inc, North Chicago, Illinois, USA., Khan N; AbbVie Inc, North Chicago, Illinois, USA., Phillips C; AbbVie Inc, North Chicago, Illinois, USA., Meerwein S; AbbVie Deutschland GmbH & Co KG, Ludwigshafen, Germany., Cohen SB; Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas, USA.

Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study , 2025

Intrathecal methotrexate in progressive multiple sclerosis: a phase 1 open-label study with long-term follow-up.

Kolb H; Neuroimmunology and Multiple Sclerosis Unit, Neurology Division, Neurology Institute, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, 6423906, Tel Aviv, Israel., Shachaf Y; Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel., Fainberg K; Neuroimmunology and Multiple Sclerosis Unit, Neurology Division, Neurology Institute, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, 6423906, Tel Aviv, Israel., Golan M; Neuroimmunology and Multiple Sclerosis Unit, Neurology Division, Neurology Institute, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, 6423906, Tel Aviv, Israel., Regev K; Neuroimmunology and Multiple Sclerosis Unit, Neurology Division, Neurology Institute, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, 6423906, Tel Aviv, Israel., Vigiser I; Neuroimmunology and Multiple Sclerosis Unit, Neurology Division, Neurology Institute, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, 6423906, Tel Aviv, Israel.; Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel., Fuchs L; Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel., Gadoth A; Neurology Outpatient Hospitalization Unit, Neurology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Kestenbaum M; Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel.; Neurology Outpatient Hospitalization Unit, Neurology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Omer N; Neurology Outpatient Hospitalization Unit, Neurology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Shopin L; Neurology Outpatient Hospitalization Unit, Neurology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Ash EL; Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel.; Neurology Outpatient Hospitalization Unit, Neurology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Artzi M; Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.; Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Ben Bashat D; Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.; Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Aizenstein O; Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Department of Radiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Karni A; Neuroimmunology and Multiple Sclerosis Unit, Neurology Division, Neurology Institute, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, 6423906, Tel Aviv, Israel. arnonk@tlvmc.gov.il.; Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel. arnonk@tlvmc.gov.il.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel. arnonk@tlvmc.gov.il.

Journal Article; Clinical Trial, Phase I , 2025

Prediction of High-Dose Methotrexate Blood Concentration in Osteosarcoma Patients Using Machine Learning.

Zhao J; Department of Pharmacy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, 110042, People's Republic of China., Dai S; Department of Pharmacy, Qujing Medical College, Qujing, Yunnan, 655000, People's Republic of China., He J; Department of Pharmacy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, 110042, People's Republic of China., Liu N; Department of Pharmacy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, 110042, People's Republic of China., Zhang B; Department of Pharmacy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, 110042, People's Republic of China., Li S; Department of Pharmacy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, 110042, People's Republic of China.

Journal Article , 2025

Tofacitinib Versus Methotrexate in Treating Mucocutaneous and Musculoskeletal Lesions of Systemic Lupus Erythematosus: Real-World Results From the CSTAR Cohort XXXII.

Zhao M; Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Beijing, China.; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing, China.; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.; Department of Rheumatology, People's Hospital of Zhengzhou, Zhengzhou, China., Ma L; Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Beijing, China.; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing, China.; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China., Duan X; Department of Rheumatology, The Second Affiliated Hospital of Nanchang University, Nanchang, China., Huo Y; Department of Rheumatology, The Fifth People's Hospital of Datong, Datong, China., Liu S; Department of Rheumatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Zhao C; Department of Rheumatology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China., Wang Q; Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Beijing, China.; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing, China.; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China., Tian X; Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Beijing, China.; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing, China.; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China., Chen Y; Department of Rheumatology, People's Hospital of Zhengzhou, Zhengzhou, China., Li M; Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Beijing, China.; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing, China.; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.

Journal Article; Comparative Study , 2025

Vinpocetine Mitigates Methotrexate-Induced Liver Injury in Rats Through Modulating Intercellular Communication.

Kamel GAM; Department of Pharmacology and Toxicology, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.; Department of Pharmacology & Toxicology, College of Pharmacy, Uruk University, Baghdad, Iraq., Hussein S; Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Aljouf, Saudi Arabia.

Journal Article , 2025

Drug Delivery Platform Targeting MMP9 in Combination with Photothermal Therapy to Improve Tumor Chemosensitivity.

Fu J; Department of Nuclear Medicine, Harbin Medical University Cancer Hospital, Harbin, 150086, China.; Department of Interventional Radiology, the First Hospital of China Medical University, Shenyang, 110001, China., Song C; Department of Orthopedics, Harbin Medical University Cancer Hospital, Harbin, 150086, China., Jiang S; Department of Nuclear Medicine, Harbin Medical University Cancer Hospital, Harbin, 150086, China., Yang S; Department of Pain Medicine, The First Hospital of China Medical University, Shenyang, 110001, China., Wu Q; Institute of Cancer Prevention and Treatment, Harbin Medical University Cancer Hospital, Harbin, 150086, China., Liu X; Department of Nuclear Medicine, Harbin Medical University Cancer Hospital, Harbin, 150086, China., Hong Z; Department of Nuclear Medicine, Harbin Medical University Cancer Hospital, Harbin, 150086, China., A R; Department of Nuclear Medicine, Harbin Medical University Cancer Hospital, Harbin, 150086, China., Li B; Department of Nuclear Medicine, Harbin Medical University Cancer Hospital, Harbin, 150086, China., Qu G; Department of Orthopedics, Harbin Medical University Cancer Hospital, Harbin, 150086, China., Ma T; Department of Nuclear Medicine, Harbin Medical University Cancer Hospital, Harbin, 150086, China., Shao H; Department of Interventional Radiology, the First Hospital of China Medical University, Shenyang, 110001, China.

Journal Article , 2025