Sökresultat - "Microbial Sensitivity Tests"

Potent synergistic effect of natural product-inspired Sinomenine derivatives with fluconazole against azole-resistant Candida albicans.

Liu W; Faculty of Pharmacy, Shaanxi University of Science and Technology, Xi'an 710021, China., Du J; Faculty of Pharmacy, Shaanxi University of Science and Technology, Xi'an 710021, China., Qin Z; Faculty of Pharmacy, Shaanxi University of Science and Technology, Xi'an 710021, China., Zhao M; Faculty of Pharmacy, Shaanxi University of Science and Technology, Xi'an 710021, China., Du S; Faculty of Pharmacy, Shaanxi University of Science and Technology, Xi'an 710021, China., Xie J; Faculty of Pharmacy, Shaanxi University of Science and Technology, Xi'an 710021, China., Zhang Y; School of Pharmacy, Fourth Military Medical University, Xi'an 710027, China. Electronic address: lmlx2428@163.com., Wang M; Faculty of Pharmacy, Shaanxi University of Science and Technology, Xi'an 710021, China. Electronic address: 4977@sust.edu.cn., Wang S; School of Pharmacy, Fourth Military Medical University, Xi'an 710027, China. Electronic address: wangshengzheng001@163.com.

Journal Article , 2025

Discovery of 1,3-Disubstituted Pyrazole derivatives as Mycobacterium tuberculosis inhibitors.

Wan G; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China., Gao C; Institute of Immunology and Inflammation，Frontiers Science Center for Disease-related Molecular Network，West China Hospital, Sichuan University, Chengdu 610041, China., Zhang X; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China., Qiu H; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China., Tang Q; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China., Zeng J; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China. Electronic address: zengjumei@scu.edu.cn., Yu L; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China; Children's Medicine Key Laboratory of Sichuan Province, Chengdu 610041, China. Electronic address: yuluot@scu.edu.cn.

Journal Article , 2025

Exploration of quinoxaline triazoles as antimycobacterial agents: design, synthesis and biological evaluation.

Kumar BVS; Department of Chemistry, Birla Institute of Technology and Science, Pilani, Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Hyderabad 500078, Telangana, India., Talamadla MK; Department of Chemistry, Birla Institute of Technology and Science, Pilani, Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Hyderabad 500078, Telangana, India., Nandikolla A; Department of Chemistry, Birla Institute of Technology and Science, Pilani, Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Hyderabad 500078, Telangana, India., Khetmalis YM; Department of Chemistry, Birla Institute of Technology and Science, Pilani, Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Hyderabad 500078, Telangana, India., Shetye G; Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA., Franzblau SG; Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA., Murugesan S; Medicinal Chemistry Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Pilani 333031, Rajasthan. India., Sekhar KVGC; Department of Chemistry, Birla Institute of Technology and Science, Pilani, Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Hyderabad 500078, Telangana, India. Electronic address: kvgc@hyderabad.bits-pilani.ac.in.

Journal Article , 2025

N-alkyl substituted armeniaspirol analogs show potent antibiotic activity and have low susceptibility to resistance.

Darnowski MG; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada., Lanosky TD; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada., Spada AD; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada., Ma J; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada., Paquette AR; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada., Boddy CN; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada. Electronic address: cboddy@uottawa.ca.

Journal Article , 2025

Phenyl urea based adjuvants for β-lactam antibiotics against methicillin resistant Staphylococcus aureus.

Butman HS; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, 46556, United States., Stefaniak MA; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, 46556, United States., Walsh DJ; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, 46556, United States., Gondil VS; Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14642, United States., Young M; Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14642, United States., Crow AH; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, 46556, United States., Nemeth AM; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, 46556, United States., Melander RJ; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, 46556, United States., Dunman PM; Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14642, United States. Electronic address: paul_dunman@urmc.rochester.edu., Melander C; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, 46556, United States. Electronic address: cmelande@nd.edu.

Journal Article , 2025

A systematic review on the anti-microbial activities and structure-activity relationship (SAR) of quinoxaline derivatives.

Bellapukonda SM; Department of Chemical Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500037, India., Bandela R; Department of Chemical Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500037, India., Singampalli A; Department of Chemical Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500037, India., Srikanth D; Department of Chemical Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500037, India., Kumar P; Department of Chemical Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500037, India., Nanduri S; Department of Chemical Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500037, India., Yaddanapudi VM; Department of Chemical Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500037, India. Electronic address: yssmadhavi@gmail.com.

Journal Article; Systematic Review , 2025

The discovery of novel antimicrobial peptides against drug-resistant bacteria based on fragments fusion strategy.

Zeng C; State Key Laboratory of National Security Specially Needed Medicines, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China., Ning Z; State Key Laboratory of National Security Specially Needed Medicines, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China., Xu Y; State Key Laboratory of National Security Specially Needed Medicines, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China., Tian L; State Key Laboratory of National Security Specially Needed Medicines, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China., Jing J; State Key Laboratory of National Security Specially Needed Medicines, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China., Chen L; State Key Laboratory of National Security Specially Needed Medicines, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China., Ye W; Center of Clinical Laboratory, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China., Han J; State Key Laboratory of National Security Specially Needed Medicines, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China., Wang T; State Key Laboratory of National Security Specially Needed Medicines, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China. Electronic address: wtr1372957199@126.com., Meng Z; State Key Laboratory of National Security Specially Needed Medicines, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China. Electronic address: mengzhao900817@163.com., Meng Q; State Key Laboratory of National Security Specially Needed Medicines, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China. Electronic address: nankaimqb@sina.com.

Journal Article , 2025

Rapid discovery of pseudorabies virus inhibitors repurposed from the antimicrobial agent ciprofloxacin.

Wei L; State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR China; Hubei Jiangxia Laboratory, Wuhan, Hubei, PR China., You Y; State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR China., Hu Y; State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR China., Wang K; State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR China., Zhao H; State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR China., Cheng Y; State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR China., Zhu J; State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR China., Weng J; State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR China; Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, PR China., Ren Y; Key Laboratory of Pesticide & Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079, PR China., Chen Y; State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR China., Chen M; State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR China., Chen X; State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR China., Xing B; State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR China., Bai L; State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR China., Li H; State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR China., Chen P; State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR China., Wei Z; State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR China; Hubei Jiangxia Laboratory, Wuhan, Hubei, PR China; Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine, National & Local Joint Engineering Research Center of High-throughput Drug Screening Technology, School of life sciences, Hubei University, Wuhan, Hubei, PR China. Electronic address: weizigong@163.com.

Journal Article , 2025

Naturally inspired chimeric quinolone derivatives to reverse bacterial drug resistance.

Wen Q; Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd, Hangzhou, 310058, Zhejiang, China., He Y; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, West Donggang Road 199, Lanzhou, 730000, China., Chi J; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou, 511436, China., Wang L; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China., Ren Y; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, West Donggang Road 199, Lanzhou, 730000, China., Niu X; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China., Yang Y; Zhejiang Key Laboratory of Cell and Molecular Intelligent Design and Development, Institute of Quantitative Biology, College of Life Sciences, Zhejiang University, Hangzhou, 310058, China., Chen K; Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd, Hangzhou, 310058, Zhejiang, China., Zhu Q; Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd, Hangzhou, 310058, Zhejiang, China., Lin J; Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd, Hangzhou, 310058, Zhejiang, China., Xiang Y; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China., Xie J; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, West Donggang Road 199, Lanzhou, 730000, China., Chen W; Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd, Hangzhou, 310058, Zhejiang, China., Yu Y; Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd, Hangzhou, 310058, Zhejiang, China., Wang B; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China., Wang B; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China. Electronic address: bwang@njucm.edu.cn., Zhang Y; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China. Electronic address: yzhang207@zju.edu.cn., Lu C; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou, 511436, China. Electronic address: chaolu@jnu.edu.cn., Wang K; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, West Donggang Road 199, Lanzhou, 730000, China. Electronic address: wangkr@lzu.edu.cn., Teng P; Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd, Hangzhou, 310058, Zhejiang, China; National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, Hangzhou, 310058, China. Electronic address: pengteng@zju.edu.cn., Zhou R; Zhejiang Key Laboratory of Cell and Molecular Intelligent Design and Development, Institute of Quantitative Biology, College of Life Sciences, Zhejiang University, Hangzhou, 310058, China; Shanghai Institute for Advanced Study, Zhejiang University, Shanghai, China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China; Department of Chemistry, Columbia University, New York, NY, USA.

Journal Article , 2025

Pyrylium derivatives as outer membrane permeabilizers against MDR gram-negative bacteria via multi-target mode of action.

Duan Q; State Key Laboratory of Bioactive Substances and Function of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China., Yuan M; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China., Ma X; State Key Laboratory of Bioactive Substances and Function of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China., Zheng Y; State Key Laboratory of Bioactive Substances and Function of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China., Meng R; State Key Laboratory of Bioactive Substances and Function of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China., Shi W; State Key Laboratory of Bioactive Substances and Function of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China., Ni Y; State Key Laboratory of Bioactive Substances and Function of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China., Zhao C; State Key Laboratory of Bioactive Substances and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China., Liu Y; State Key Laboratory of Bioactive Substances and Function of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China., Yu Z; State Key Laboratory of Bioactive Substances and Function of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China., Zhu J; State Key Laboratory of Bioactive Substances and Function of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China., Shi Y; State Key Laboratory of Bioactive Substances and Function of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China., Zhu X; State Key Laboratory of Bioactive Substances and Function of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China., Li L; State Key Laboratory of Bioactive Substances and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China., Si S; State Key Laboratory of Bioactive Substances and Function of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China., Li Y; State Key Laboratory of Bioactive Substances and Function of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. Electronic address: liyan@imb.pumc.edu.cn., Li Y; State Key Laboratory of Bioactive Substances and Function of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. Electronic address: liyinghong@imb.pumc.edu.cn., Song D; State Key Laboratory of Bioactive Substances and Function of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. Electronic address: songdanqing@imb.pumc.edu.cn.

Journal Article , 2025

LPS-enriched interaction drives spectrum conversion in antimicrobial peptides: Design and optimization of AA16 derivatives for targeting gram-negative bacteria.

Xiao W; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325015, China; Zhejiang Provincial Key Laboratory for Water Environment and Marine, Biological Resources Protection, College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China., Sun R; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK., Lou J; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325015, China., Xu Y; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325015, China., Li X; Zhejiang Provincial Key Laboratory for Water Environment and Marine, Biological Resources Protection, College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China., Xin K; Zhejiang Provincial Key Laboratory for Water Environment and Marine, Biological Resources Protection, College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China., Lu W; Zhejiang Provincial Key Laboratory for Water Environment and Marine, Biological Resources Protection, College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China., Sun C; Zhejiang Provincial Key Laboratory for Water Environment and Marine, Biological Resources Protection, College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China., Chen T; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK., Gao Y; Zhejiang Provincial Key Laboratory for Water Environment and Marine, Biological Resources Protection, College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China. Electronic address: gyt@wzu.edu.cn., Wu D; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325015, China. Electronic address: wudi2017@wmu.edu.cn.

Journal Article , 2025

Synthesis and antibacterial evaluations of novel vancomycin analogues targeting bacteria membrane to combat Gram-negative infections.

Li T; School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Shuitu Technology Development Zone, No. 55 Daxuecheng South Rd., Shapingba, Chongqing, 401331, PR China., Zhang R; School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Shuitu Technology Development Zone, No. 55 Daxuecheng South Rd., Shapingba, Chongqing, 401331, PR China., Gong H; School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Shuitu Technology Development Zone, No. 55 Daxuecheng South Rd., Shapingba, Chongqing, 401331, PR China., Tang Z; Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, 266 Fangzheng Ave, Beibei, Chongqing, 400714, PR China; Chongqing Institute for Food and Drug Control, Chongqing, 401120, PR China., Li X; School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Shuitu Technology Development Zone, No. 55 Daxuecheng South Rd., Shapingba, Chongqing, 401331, PR China., Gong Z; School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Shuitu Technology Development Zone, No. 55 Daxuecheng South Rd., Shapingba, Chongqing, 401331, PR China., Challa M; School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Shuitu Technology Development Zone, No. 55 Daxuecheng South Rd., Shapingba, Chongqing, 401331, PR China., Zou C; School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Shuitu Technology Development Zone, No. 55 Daxuecheng South Rd., Shapingba, Chongqing, 401331, PR China., Zhang SL; School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Shuitu Technology Development Zone, No. 55 Daxuecheng South Rd., Shapingba, Chongqing, 401331, PR China. Electronic address: zhangsl@cqu.edu.cn., Guo J; School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Shuitu Technology Development Zone, No. 55 Daxuecheng South Rd., Shapingba, Chongqing, 401331, PR China. Electronic address: jian.guo@cqu.edu.cn., He Y; School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Shuitu Technology Development Zone, No. 55 Daxuecheng South Rd., Shapingba, Chongqing, 401331, PR China; BayRay Innovation Center, Shenzhen Bay Laboratory, Shenzhen, 518132, PR China. Electronic address: yun.he@cqu.edu.cn.

Journal Article , 2025

Exploration of membrane-active cephalosporin derivatives as potent antibacterial agents against Staphylococcus aureus biofilms and persisters.

Chen S; School of Pharmaceutical Sciences, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, PR China., Qu Y; School of Pharmaceutical Sciences, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, PR China., Li R; School of Pharmaceutical Sciences, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, PR China., Ampomah-Wireko M; School of Pharmaceutical Sciences, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, PR China., Kong H; School of Pharmaceutical Sciences, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, PR China., Li D; School of Pharmaceutical Sciences, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, PR China., Wang M; School of Pharmaceutical Sciences, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, PR China., Gao C; School of Pharmaceutical Sciences, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, PR China., Qin S; School of Pharmaceutical Sciences, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, PR China., Liu J; School of Pharmaceutical Sciences, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, PR China., Wang Z; School of Pharmaceutical Sciences, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, PR China., Zhang M; School of Pharmaceutical Sciences, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, PR China. Electronic address: chen_zhang@zzu.edu.cn., Zhang E; School of Pharmaceutical Sciences, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, PR China; Pingyuan Laboratory (Zhengzhou University), PR China. Electronic address: zhangen@zzu.edu.cn.

Journal Article , 2025

Discovery of 3-hydroxypyridin-4(1H)-ones ester of ciprofloxacin as prodrug to combat biofilm-associated Pseudomonas aeruginosa.

Wang YY; School of Medicine, Foshan University, Foshan, 528000, PR China; College of Pharmacy, Jinan University, Guangzhou, 510632, PR China., Luo BZ; School of Medicine, Foshan University, Foshan, 528000, PR China., Li CM; College of Pharmacy, Jinan University, Guangzhou, 510632, PR China., Liang JL; School of Medicine, Foshan University, Foshan, 528000, PR China., Liu Z; School of Medicine, Foshan University, Foshan, 528000, PR China., Chen WM; College of Pharmacy, Jinan University, Guangzhou, 510632, PR China. Electronic address: twmchen@jnu.edu.cn., Guo JL; School of Medicine, Foshan University, Foshan, 528000, PR China; College of Pharmacy, Jinan University, Guangzhou, 510632, PR China. Electronic address: janalguo@126.com.

Journal Article , 2025

Discovery of novel pyrimidinetrione derivatives as DprE1 inhibitors with potent antimycobacterial activities.

Liang J; Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China., Liu Y; Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China., Guan Q; Hubei Province Key Laboratory of Allergy and Immunology, Department of Immunology, Wuhan University Taikang Medical School (School of Basic Medical Sciences), Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, 430071, China., Li Y; Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China., Zheng MZ; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430071, China., Zhang XL; Hubei Province Key Laboratory of Allergy and Immunology, Department of Immunology, Wuhan University Taikang Medical School (School of Basic Medical Sciences), Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, 430071, China; Department of Allergy, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China. Electronic address: zhangxiaolian@whu.edu.cn., Chen LX; Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China. Electronic address: syzyclx@163.com., Li H; Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China; Institute of Structural Pharmacology & TCM Chemical Biology, Fujian Key Laboratory of Chinese Materia Medica, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China. Electronic address: lihua@fjtcm.edu.cn.

Journal Article , 2025

Dodecapeptides derived from human cathelicidin with potent activity against carbapenem-resistant Acinetobacter baumannii.

Jiang Y; State Key Laboratory of Trauma and Chemical Poisoning, Institute of Combined Injury of PLA, College of Preventive Medicine, Army Medical University, Chongqing, 400038, China., Zhao G; State Key Laboratory of Trauma and Chemical Poisoning, Institute of Combined Injury of PLA, College of Preventive Medicine, Army Medical University, Chongqing, 400038, China., Gong Y; State Key Laboratory of Trauma and Chemical Poisoning, Institute of Burn Research, the First Affiliated Hospital of Army Medical University, Chongqing, 400038, China., Chen Y; State Key Laboratory of Trauma and Chemical Poisoning, Institute of Combined Injury of PLA, College of Preventive Medicine, Army Medical University, Chongqing, 400038, China., Li C; State Key Laboratory of Trauma and Chemical Poisoning, Institute of Combined Injury of PLA, College of Preventive Medicine, Army Medical University, Chongqing, 400038, China., Han S; State Key Laboratory of Trauma and Chemical Poisoning, Institute of Combined Injury of PLA, College of Preventive Medicine, Army Medical University, Chongqing, 400038, China., Deng Y; Department of Clinical Hematology, College of Pharmacy and Laboratory Medicine Science, Army Medical University, Chongqing, 400038, China., Zhao J; Department of Nephrology, Xinqiao Hospital, Army Medical University, Chongqing, 400047, China., Wang J; State Key Laboratory of Trauma and Chemical Poisoning, Institute of Combined Injury of PLA, College of Preventive Medicine, Army Medical University, Chongqing, 400038, China. Electronic address: wangjunping@tmmu.edu.cn., Wang C; State Key Laboratory of Trauma and Chemical Poisoning, Institute of Combined Injury of PLA, College of Preventive Medicine, Army Medical University, Chongqing, 400038, China. Electronic address: wangcheng@tmmu.edu.cn.

Journal Article , 2025

A benzoxazolyl urea inhibits VraS and enhances antimicrobials against vancomycin intermediate-resistant Staphylococcus aureus.

Heckler EP; Department of Basic Pharmaceutical Sciences, Fred Wilson School of Pharmacy, High Point University, High Point, NC, USA., Ali L; Department of Pharmaceutical Sciences and Health Outcomes, Fisch College of Pharmacy, The University of Texas at Tyler, Tyler, TX, USA., Bhattarai S; Department of Pharmaceutical Sciences and Health Outcomes, Fisch College of Pharmacy, The University of Texas at Tyler, Tyler, TX, USA., Cagle-White B; Department of Pharmaceutical Sciences and Health Outcomes, Fisch College of Pharmacy, The University of Texas at Tyler, Tyler, TX, USA., Smith NC; Department of Basic Pharmaceutical Sciences, Fred Wilson School of Pharmacy, High Point University, High Point, NC, USA., Moore ED; Department of Pharmacy Sciences, School of Pharmacy and Health Professions, Creighton University, Omaha, NE, USA., Coover RA; Department of Basic Pharmaceutical Sciences, Fred Wilson School of Pharmacy, High Point University, High Point, NC, USA., Abdel Aziz MH; Department of Pharmaceutical Sciences and Health Outcomes, Fisch College of Pharmacy, The University of Texas at Tyler, Tyler, TX, USA. Electronic address: MAbdelaziz@UTTyler.edu., Sarkar A; Department of Basic Pharmaceutical Sciences, Fred Wilson School of Pharmacy, High Point University, High Point, NC, USA; Department of Pharmacy Sciences, School of Pharmacy and Health Professions, Creighton University, Omaha, NE, USA. Electronic address: Sarkar@Creighton.edu.

Journal Article , 2025

Designing novel nucleoside inhibitors targeting the allosteric site of PBP2a: A strategic approach to overcome resistance in MRSA.

Yao S; Department of Pharmacology, School of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China; Department of Pharmacology, School of Pharmacy, Air Force Medical University, Xi'an 710032, China., Fang C; Department of Pharmacology, School of Pharmacy, Air Force Medical University, Xi'an 710032, China., Xu B; Department of Pharmacology, School of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China; Department of Pharmacology, School of Pharmacy, Air Force Medical University, Xi'an 710032, China., Hu Y; Department of Pharmacology, School of Pharmacy, Air Force Medical University, Xi'an 710032, China., Chen Z; Department of Pharmacology, School of Pharmacy, Air Force Medical University, Xi'an 710032, China., Xue X; Department of Pharmacology, School of Pharmacy, Air Force Medical University, Xi'an 710032, China., Liu J; Department of Pharmacology, School of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China. Electronic address: liwenjie780711@163.com., Li M; Department of Pharmacology, School of Pharmacy, Air Force Medical University, Xi'an 710032, China. Electronic address: mingkai@fmmu.edu.cn., Li P; Department of Pharmacology, School of Pharmacy, Air Force Medical University, Xi'an 710032, China. Electronic address: lipengyu0213@126.com.

Journal Article , 2025

Synthesis, antibacterial and anticancer activity of azo-based and aminomethylene derivatives of cyclic β-keto sulfones.

Milokhov DS; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyiv 01033 Ukraine; Hygiene and Ecology Institute Bogomolets National Medical University, Beresteisky Avenue 34, Kyiv 03057 Ukraine., Balabushko MO; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyiv 01033 Ukraine; Enamine Ltd., Chervonotkatska Street 78, Kyiv 02094 Ukraine., Kolomiets AY; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyiv 01033 Ukraine., Rabotnikova SD; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyiv 01033 Ukraine., Virych PA; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyiv 01033 Ukraine; Kavetsky Institute for Experimental Pathology, Oncology and Radiobiology, Vasylkivska Street 45, Kyiv 03022 Ukraine., Poliudov AO; Enamine Ltd., Chervonotkatska Street 78, Kyiv 02094 Ukraine; National Technical University of Ukraine 'Igor Sikorsky Kyiv Polytechnic Institute', Beresteiskyi Avenue 37, Kyiv 03056 Ukraine., Shishkina SV; Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmanska Street 5, Kyiv 02094 Ukraine; SSI 'Institute for Single Crystals' National Academy of Science of Ukraine, Nauky Avenue 60, Kharkiv 61001 Ukraine., Volovenko YM; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyiv 01033 Ukraine., Dobrydnev AV; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyiv 01033 Ukraine; Enamine Ltd., Chervonotkatska Street 78, Kyiv 02094 Ukraine. Electronic address: alexey.pierrot@gmail.com.

Journal Article , 2025

Design, synthesis and antibacterial evaluation of oxazolidinone derivatives containing N-methylglycyl or quaternary ammonium salts.

Ampomah-Wireko M; School of Pharmaceutical Sciences, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, PR China., Qu Y; School of Pharmaceutical Sciences, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, PR China., Li D; School of Pharmaceutical Sciences, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, PR China., Wu Y; School of Pharmaceutical Sciences, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, PR China., Li R; School of Pharmaceutical Sciences, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, PR China., Li Y; School of Pharmaceutical Sciences, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, PR China., Kong H; School of Pharmaceutical Sciences, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, PR China., Li ZH; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China., Wang YN; School of Pharmaceutical Sciences, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, PR China. Electronic address: wangyn@zzu.edu.cn., Zhang E; School of Pharmaceutical Sciences, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, PR China; Pingyuan Laboratory (Zhengzhou University), PR China. Electronic address: zhangen@zzu.edu.cn.

Journal Article , 2025