Sökresultat - "Moehle MS"

Denna resultat visas inte till gäster.
Logga in för full Login for full tillgång.

Early α-synuclein aggregation decreases corticostriatal glutamate drive and synapse density.

Brzozowski CF; Department of Neurology, Killon Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294, USA; Department of Pharmacology and Therapeutics, Center for Translational Research in Neurodegeneration, and Fixel Institute, University of Florida, Gainesville, FL 32610, USA., Challa H; Department of Neurology, Killon Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Gcwensa NZ; Department of Neurology, Killon Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Hall D; Department of Pharmacology and Therapeutics, Center for Translational Research in Neurodegeneration, and Fixel Institute, University of Florida, Gainesville, FL 32610, USA., Nabert D; Department of Pharmacology and Therapeutics, Center for Translational Research in Neurodegeneration, and Fixel Institute, University of Florida, Gainesville, FL 32610, USA., Chambers N; Department of Pharmacology and Therapeutics, Center for Translational Research in Neurodegeneration, and Fixel Institute, University of Florida, Gainesville, FL 32610, USA., Gallardo I; Department of Pharmacology and Therapeutics, Center for Translational Research in Neurodegeneration, and Fixel Institute, University of Florida, Gainesville, FL 32610, USA., Millet M; Department of Pharmacology and Therapeutics, Center for Translational Research in Neurodegeneration, and Fixel Institute, University of Florida, Gainesville, FL 32610, USA., Volpicelli-Daley L; Department of Neurology, Killon Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Moehle MS; Department of Pharmacology and Therapeutics, Center for Translational Research in Neurodegeneration, and Fixel Institute, University of Florida, Gainesville, FL 32610, USA. Electronic address: mark.moehle@ufl.edu.

Journal Article , 2025

Anticholinergic drugs for parkinsonism and other movement disorders.

LeWitt PA; Departments of Neurology, Wayne State University School of Medicine and Henry Ford Hospital, 8-D 4201 St. Antoine Street, Detroit, MI, 48201, USA. aa1142@wayne.edu., Hong L; The Department of Neurology, University of South Florida, Tampa, FL, USA., Moehle MS; Department of Pharmacology and Therapeutics, Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA.

Journal Article; Review , 2024

Neuron specific quantitation of Gα olf expression and signaling in murine brain tissue.

Millett M; Department of Pharmacology & Therapeutics and Center for Translational Research in Neurodegeneration, University of Florida College of Medicine, Gainesville, FL, 32610, United States. Electronic address: michaelmillett@ufl.edu., Heuberger A; Department of Pharmacology & Therapeutics and Center for Translational Research in Neurodegeneration, University of Florida College of Medicine, Gainesville, FL, 32610, United States. Electronic address: heubergera@ufl.edu., Martin Castosa E; Department of Pharmacology & Therapeutics and Center for Translational Research in Neurodegeneration, University of Florida College of Medicine, Gainesville, FL, 32610, United States. Electronic address: emartincastosa@ufl.edu., Comite A; Department of Pharmacology & Therapeutics and Center for Translational Research in Neurodegeneration, University of Florida College of Medicine, Gainesville, FL, 32610, United States. Electronic address: allison.comite@ufl.edu., Wagner P; Department of Pharmacology & Therapeutics and Center for Translational Research in Neurodegeneration, University of Florida College of Medicine, Gainesville, FL, 32610, United States. Electronic address: wagnerpreston@ufl.edu., Hall D; Department of Pharmacology & Therapeutics and Center for Translational Research in Neurodegeneration, University of Florida College of Medicine, Gainesville, FL, 32610, United States. Electronic address: hall.dominic@ufl.edu., Gallardo I; Department of Pharmacology & Therapeutics and Center for Translational Research in Neurodegeneration, University of Florida College of Medicine, Gainesville, FL, 32610, United States. Electronic address: igallardo@ufl.edu., Chambers NE; Department of Pharmacology & Therapeutics and Center for Translational Research in Neurodegeneration, University of Florida College of Medicine, Gainesville, FL, 32610, United States. Electronic address: nicole.chambers@ufl.edu., Wagner L; Department of Pharmacology & Therapeutics and Center for Translational Research in Neurodegeneration, University of Florida College of Medicine, Gainesville, FL, 32610, United States. Electronic address: lloydwagner@ufl.edu., Reinhardt J; Department of Pharmacology & Therapeutics and Center for Translational Research in Neurodegeneration, University of Florida College of Medicine, Gainesville, FL, 32610, United States. Electronic address: jreinhardt@ufl.edu., Moehle MS; Department of Pharmacology & Therapeutics and Center for Translational Research in Neurodegeneration, University of Florida College of Medicine, Gainesville, FL, 32610, United States. Electronic address: mark.moehle@ufl.edu.

Journal Article , 2024

Conditional Knockout of Striatal Gnal Produces Dystonia-like Motor Phenotypes.

Chambers NE, Hall D, Barsoum S, Miller E, Curry T, Kaplan M, Garan S, Gallardo I, Staab R, Nabert D, Hutchinson K, Millett M, Moehle MS

Journal Article; Preprint , 2024

G α olf Regulates Biochemical Signaling in Neurons Associated with Movement Control and Initiation.

Millett M, Heuberger A, Castosa EM, Comite A, Wagner P, Hall D, Gallardo I, Chambers NE, Wagner L, Moehle MS

Preprint; Journal Article , 2024

Inhibition of LRRK2 kinase activity rescues deficits in striatal dopamine physiology in VPS35 p.D620N knock-in mice.

Bu M; Department of Neurology, University of Florida, Gainesville, FL, USA.; McKnight Brain Institute, University of Florida, Gainesville, FL, USA., Follett J; Department of Neurology, University of Florida, Gainesville, FL, USA.; McKnight Brain Institute, University of Florida, Gainesville, FL, USA., Deng I; Department of Neurology, University of Florida, Gainesville, FL, USA.; McKnight Brain Institute, University of Florida, Gainesville, FL, USA., Tatarnikov I; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada., Wall S; Department of Neurology, University of Florida, Gainesville, FL, USA.; McKnight Brain Institute, University of Florida, Gainesville, FL, USA., Guenther D; Department of Neurology, University of Florida, Gainesville, FL, USA.; McKnight Brain Institute, University of Florida, Gainesville, FL, USA., Maczis M; Department of Neurology, University of Florida, Gainesville, FL, USA.; McKnight Brain Institute, University of Florida, Gainesville, FL, USA., Wimsatt G; Department of Neurology, University of Florida, Gainesville, FL, USA.; McKnight Brain Institute, University of Florida, Gainesville, FL, USA., Milnerwood A; Department of Neurology & Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada., Moehle MS; Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, USA., Khoshbouei H; McKnight Brain Institute, University of Florida, Gainesville, FL, USA.; Department of Neuroscience, University of Florida, Gainesville, FL, USA., Farrer MJ; Department of Neurology, University of Florida, Gainesville, FL, USA. m.farrer@ufl.edu.; McKnight Brain Institute, University of Florida, Gainesville, FL, USA. m.farrer@ufl.edu.

Journal Article , 2023

Development of a Selective and High Affinity Radioligand, [ ³ H]VU6013720, for the M 4 Muscarinic Receptor.

Qi A; Department of Pharmacology and Warren Center for Neuroscience Drug Discovery (A.Q., H.E.K., N.B., A.L.R., L.P., J.W.D., J.L.E., A.M.B., C.W.L., J.M.R., C.M.N.) and Department of Chemistry (C.W.L.), Vanderbilt University, Nashville, Tennessee; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee (C.M.N); Vanderbilt Brain Institute (C.M.N.) and Vanderbilt Institute of Chemical Biology (C.W.L., C.M.N.),Vanderbilt University School of Medicine, Nashville, Tennessee; and Department of Pharmacology and Therapeutics and Center for Translational Research in Neurodegeneration (M.S.M.), University of Florida, Gainesville, Florida., Kling HE; Department of Pharmacology and Warren Center for Neuroscience Drug Discovery (A.Q., H.E.K., N.B., A.L.R., L.P., J.W.D., J.L.E., A.M.B., C.W.L., J.M.R., C.M.N.) and Department of Chemistry (C.W.L.), Vanderbilt University, Nashville, Tennessee; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee (C.M.N); Vanderbilt Brain Institute (C.M.N.) and Vanderbilt Institute of Chemical Biology (C.W.L., C.M.N.),Vanderbilt University School of Medicine, Nashville, Tennessee; and Department of Pharmacology and Therapeutics and Center for Translational Research in Neurodegeneration (M.S.M.), University of Florida, Gainesville, Florida., Billard N; Department of Pharmacology and Warren Center for Neuroscience Drug Discovery (A.Q., H.E.K., N.B., A.L.R., L.P., J.W.D., J.L.E., A.M.B., C.W.L., J.M.R., C.M.N.) and Department of Chemistry (C.W.L.), Vanderbilt University, Nashville, Tennessee; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee (C.M.N); Vanderbilt Brain Institute (C.M.N.) and Vanderbilt Institute of Chemical Biology (C.W.L., C.M.N.),Vanderbilt University School of Medicine, Nashville, Tennessee; and Department of Pharmacology and Therapeutics and Center for Translational Research in Neurodegeneration (M.S.M.), University of Florida, Gainesville, Florida., Rodriguez AL; Department of Pharmacology and Warren Center for Neuroscience Drug Discovery (A.Q., H.E.K., N.B., A.L.R., L.P., J.W.D., J.L.E., A.M.B., C.W.L., J.M.R., C.M.N.) and Department of Chemistry (C.W.L.), Vanderbilt University, Nashville, Tennessee; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee (C.M.N); Vanderbilt Brain Institute (C.M.N.) and Vanderbilt Institute of Chemical Biology (C.W.L., C.M.N.),Vanderbilt University School of Medicine, Nashville, Tennessee; and Department of Pharmacology and Therapeutics and Center for Translational Research in Neurodegeneration (M.S.M.), University of Florida, Gainesville, Florida., Peng L; Department of Pharmacology and Warren Center for Neuroscience Drug Discovery (A.Q., H.E.K., N.B., A.L.R., L.P., J.W.D., J.L.E., A.M.B., C.W.L., J.M.R., C.M.N.) and Department of Chemistry (C.W.L.), Vanderbilt University, Nashville, Tennessee; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee (C.M.N); Vanderbilt Brain Institute (C.M.N.) and Vanderbilt Institute of Chemical Biology (C.W.L., C.M.N.),Vanderbilt University School of Medicine, Nashville, Tennessee; and Department of Pharmacology and Therapeutics and Center for Translational Research in Neurodegeneration (M.S.M.), University of Florida, Gainesville, Florida., Dickerson JW; Department of Pharmacology and Warren Center for Neuroscience Drug Discovery (A.Q., H.E.K., N.B., A.L.R., L.P., J.W.D., J.L.E., A.M.B., C.W.L., J.M.R., C.M.N.) and Department of Chemistry (C.W.L.), Vanderbilt University, Nashville, Tennessee; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee (C.M.N); Vanderbilt Brain Institute (C.M.N.) and Vanderbilt Institute of Chemical Biology (C.W.L., C.M.N.),Vanderbilt University School of Medicine, Nashville, Tennessee; and Department of Pharmacology and Therapeutics and Center for Translational Research in Neurodegeneration (M.S.M.), University of Florida, Gainesville, Florida., Engers JL; Department of Pharmacology and Warren Center for Neuroscience Drug Discovery (A.Q., H.E.K., N.B., A.L.R., L.P., J.W.D., J.L.E., A.M.B., C.W.L., J.M.R., C.M.N.) and Department of Chemistry (C.W.L.), Vanderbilt University, Nashville, Tennessee; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee (C.M.N); Vanderbilt Brain Institute (C.M.N.) and Vanderbilt Institute of Chemical Biology (C.W.L., C.M.N.),Vanderbilt University School of Medicine, Nashville, Tennessee; and Department of Pharmacology and Therapeutics and Center for Translational Research in Neurodegeneration (M.S.M.), University of Florida, Gainesville, Florida., Bender AM; Department of Pharmacology and Warren Center for Neuroscience Drug Discovery (A.Q., H.E.K., N.B., A.L.R., L.P., J.W.D., J.L.E., A.M.B., C.W.L., J.M.R., C.M.N.) and Department of Chemistry (C.W.L.), Vanderbilt University, Nashville, Tennessee; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee (C.M.N); Vanderbilt Brain Institute (C.M.N.) and Vanderbilt Institute of Chemical Biology (C.W.L., C.M.N.),Vanderbilt University School of Medicine, Nashville, Tennessee; and Department of Pharmacology and Therapeutics and Center for Translational Research in Neurodegeneration (M.S.M.), University of Florida, Gainesville, Florida., Moehle MS; Department of Pharmacology and Warren Center for Neuroscience Drug Discovery (A.Q., H.E.K., N.B., A.L.R., L.P., J.W.D., J.L.E., A.M.B., C.W.L., J.M.R., C.M.N.) and Department of Chemistry (C.W.L.), Vanderbilt University, Nashville, Tennessee; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee (C.M.N); Vanderbilt Brain Institute (C.M.N.) and Vanderbilt Institute of Chemical Biology (C.W.L., C.M.N.),Vanderbilt University School of Medicine, Nashville, Tennessee; and Department of Pharmacology and Therapeutics and Center for Translational Research in Neurodegeneration (M.S.M.), University of Florida, Gainesville, Florida., Lindsley CW; Department of Pharmacology and Warren Center for Neuroscience Drug Discovery (A.Q., H.E.K., N.B., A.L.R., L.P., J.W.D., J.L.E., A.M.B., C.W.L., J.M.R., C.M.N.) and Department of Chemistry (C.W.L.), Vanderbilt University, Nashville, Tennessee; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee (C.M.N); Vanderbilt Brain Institute (C.M.N.) and Vanderbilt Institute of Chemical Biology (C.W.L., C.M.N.),Vanderbilt University School of Medicine, Nashville, Tennessee; and Department of Pharmacology and Therapeutics and Center for Translational Research in Neurodegeneration (M.S.M.), University of Florida, Gainesville, Florida., Rook JM; Department of Pharmacology and Warren Center for Neuroscience Drug Discovery (A.Q., H.E.K., N.B., A.L.R., L.P., J.W.D., J.L.E., A.M.B., C.W.L., J.M.R., C.M.N.) and Department of Chemistry (C.W.L.), Vanderbilt University, Nashville, Tennessee; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee (C.M.N); Vanderbilt Brain Institute (C.M.N.) and Vanderbilt Institute of Chemical Biology (C.W.L., C.M.N.),Vanderbilt University School of Medicine, Nashville, Tennessee; and Department of Pharmacology and Therapeutics and Center for Translational Research in Neurodegeneration (M.S.M.), University of Florida, Gainesville, Florida., Niswender CM; Department of Pharmacology and Warren Center for Neuroscience Drug Discovery (A.Q., H.E.K., N.B., A.L.R., L.P., J.W.D., J.L.E., A.M.B., C.W.L., J.M.R., C.M.N.) and Department of Chemistry (C.W.L.), Vanderbilt University, Nashville, Tennessee; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee (C.M.N); Vanderbilt Brain Institute (C.M.N.) and Vanderbilt Institute of Chemical Biology (C.W.L., C.M.N.),Vanderbilt University School of Medicine, Nashville, Tennessee; and Department of Pharmacology and Therapeutics and Center for Translational Research in Neurodegeneration (M.S.M.), University of Florida, Gainesville, Florida.

Journal Article , 2023

The muscarinic M4 acetylcholine receptor exacerbates symptoms of movement disorders.

Chambers NE; Department of Pharmacology and Therapeutics and Center for Translational Research in Neurodegeneration, University of Florida College of Medicine, Gainesville, FL 32610, U.S.A., Millett M; Department of Pharmacology and Therapeutics and Center for Translational Research in Neurodegeneration, University of Florida College of Medicine, Gainesville, FL 32610, U.S.A., Moehle MS; Department of Pharmacology and Therapeutics and Center for Translational Research in Neurodegeneration, University of Florida College of Medicine, Gainesville, FL 32610, U.S.A.

Review; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't , 2023

Cholinergic system changes in Parkinson's disease: emerging therapeutic approaches.

Bohnen NI; Department of Radiology, University of Michigan, Ann Arbor, MI, USA; Department of Neurology, University of Michigan, Ann Arbor, MI, USA; Neurology Service, Ann Arbor, MI, USA; VA Geriatric Research Education and Clinical Center, Ann Arbor, MI, USA; Ann Arbor VAMC, Ann Arbor, MI, USA. Electronic address: nbohnen@umich.edu., Yarnall AJ; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Weil RS; Dementia Research Centre, University College London, London, UK., Moro E; Division of Neurology, CHU of Grenoble, Grenoble, France; Grenoble Alpes University, and INSERM u1216, Grenoble, France., Moehle MS; Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, USA., Borghammer P; Department of Nuclear Medicine and PET, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Bedard MA; Cognitive Pharmacology Research Unit, UQAM, Montreal, QC, Canada; McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, QC, Canada; Research Centre for Studies in Aging, McGill University, Montreal, QC, Canada; Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada., Albin RL; VA Geriatric Research Education and Clinical Center, Ann Arbor, MI, USA; Department of Neurology, University of Michigan, Ann Arbor, MI, USA.

Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't , 2022

Corrigendum to "α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration" [Neurobiol. Dis., Volume 105 (2017) Article 84, 98].

Abdelmotilib H; Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, USA., Maltbie T; Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, USA., Delic V; Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, USA., Liu Z; Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, USA., Hu X; Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, USA., Fraser KB; Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, USA., Moehle MS; Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, USA., Stoyka L; Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, USA., Anabtawi N; Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, USA., Krendelchtchikova V; Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, USA., Volpicelli-Daley LA; Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, USA., West A; Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: andrew.west@duke.edu.

Published Erratum , 2021

Discovery of the First Selective M 4 Muscarinic Acetylcholine Receptor Antagonists with in Vivo Antiparkinsonian and Antidystonic Efficacy.

Moehle MS; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology & Therapeutics, Center for Translational Research in Neurodegeneration, University of Florida, Gainesville, Florida 32610, United States., Bender AM; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Dickerson JW; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Foster DJ; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Vanderbilt Kennedy Center, Vanderbilt University, Nashville, Tennessee 37232, United States., Qi A; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Cho HP; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Donsante Y; Department of Pharmacology & Chemical Biology, Emory University, Atlanta, Georgia 30322, United States., Peng W; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Bryant Z; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Stillwell KJ; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Bridges TM; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Chang S; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Watson KJ; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., O'Neill JC; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Engers JL; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Peng L; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Rodriguez AL; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Niswender CM; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Vanderbilt Kennedy Center, Vanderbilt University, Nashville, Tennessee 37232, United States., Lindsley CW; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Hess EJ; Department of Pharmacology & Chemical Biology, Emory University, Atlanta, Georgia 30322, United States., Conn PJ; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Vanderbilt Kennedy Center, Vanderbilt University, Nashville, Tennessee 37232, United States., Rook JM; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.

Journal Article , 2021

Activation of the mGlu 1 metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M 4 muscarinic receptor allosteric modulators.

Yohn SE; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, USA., Foster DJ; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Kennedy Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Covey DP; Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA., Moehle MS; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, USA., Galbraith J; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA., Garcia-Barrantes PM; Department of Chemistry, Department of Biochemistry, Vanderbilt University, Nashville, TN, USA., Cho HP; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, USA., Bubser M; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, USA., Blobaum AL; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, USA., Joffe ME; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, USA., Cheer JF; Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA., Jones CK; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Kennedy Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Lindsley CW; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, USA.; Department of Chemistry, Department of Biochemistry, Vanderbilt University, Nashville, TN, USA., Conn PJ; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA. Jeff.Conn@Vanderbilt.edu.; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, USA. Jeff.Conn@Vanderbilt.edu.; Vanderbilt Kennedy Center, Vanderbilt University School of Medicine, Nashville, TN, USA. Jeff.Conn@Vanderbilt.edu.

Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't , 2020

Roles of the M 4 acetylcholine receptor in the basal ganglia and the treatment of movement disorders.

Moehle MS; Vanderbilt Center for Neuroscience Drug Discovery and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Conn PJ; Vanderbilt Center for Neuroscience Drug Discovery and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review , 2019

Cholinergic Projections to the Substantia Nigra Pars Reticulata Inhibit Dopamine Modulation of Basal Ganglia through the M 4 Muscarinic Receptor.

Moehle MS; Vanderbilt Center for Neuroscience Drug Discovery and Department of Pharmacology, Vanderbilt University, Nashville, TN, USA., Pancani T; Vanderbilt Center for Neuroscience Drug Discovery and Department of Pharmacology, Vanderbilt University, Nashville, TN, USA., Byun N; Vanderbilt Center for Neuroscience Drug Discovery and Department of Pharmacology, Vanderbilt University, Nashville, TN, USA; Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA., Yohn SE; Vanderbilt Center for Neuroscience Drug Discovery and Department of Pharmacology, Vanderbilt University, Nashville, TN, USA., Wilson GH 3rd; Vanderbilt Center for Neuroscience Drug Discovery and Department of Pharmacology, Vanderbilt University, Nashville, TN, USA; Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA., Dickerson JW; Vanderbilt Center for Neuroscience Drug Discovery and Department of Pharmacology, Vanderbilt University, Nashville, TN, USA., Remke DH; Vanderbilt Center for Neuroscience Drug Discovery and Department of Pharmacology, Vanderbilt University, Nashville, TN, USA., Xiang Z; Vanderbilt Center for Neuroscience Drug Discovery and Department of Pharmacology, Vanderbilt University, Nashville, TN, USA., Niswender CM; Vanderbilt Center for Neuroscience Drug Discovery and Department of Pharmacology, Vanderbilt University, Nashville, TN, USA; Vanderbilt Kennedy Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Wess J; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, NIDDK, NIH, Bethesda, MD, USA., Jones CK; Vanderbilt Center for Neuroscience Drug Discovery and Department of Pharmacology, Vanderbilt University, Nashville, TN, USA., Lindsley CW; Vanderbilt Center for Neuroscience Drug Discovery and Department of Pharmacology, Vanderbilt University, Nashville, TN, USA., Rook JM; Vanderbilt Center for Neuroscience Drug Discovery and Department of Pharmacology, Vanderbilt University, Nashville, TN, USA., Conn PJ; Vanderbilt Center for Neuroscience Drug Discovery and Department of Pharmacology, Vanderbilt University, Nashville, TN, USA; Vanderbilt Kennedy Center, Vanderbilt University School of Medicine, Nashville, TN, USA. Electronic address: jeff.conn@vanderbilt.edu.

Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't , 2017

Co-Activation of Metabotropic Glutamate Receptor 3 and Beta-Adrenergic Receptors Modulates Cyclic-AMP and Long-Term Potentiation, and Disrupts Memory Reconsolidation.

Walker AG; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, USA., Sheffler DJ; Cancer Metabolism and Signaling Networks Program, Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Lewis AS; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, USA., Dickerson JW; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, USA., Foster DJ; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, USA., Senter RK; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, USA., Moehle MS; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, USA., Lv X; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, USA., Stansley BJ; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, USA., Xiang Z; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, USA., Rook JM; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, USA., Emmitte KA; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, USA.; Department of Chemistry, Vanderbilt University, Nashville, TN, USA., Lindsley CW; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, USA.; Department of Chemistry, Vanderbilt University, Nashville, TN, USA., Conn PJ; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, USA.

Journal Article , 2017

α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration.

Abdelmotilib H; Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, USA., Maltbie T; Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, USA., Delic V; Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, USA., Liu Z; Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, USA., Hu X; Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, USA., Fraser KB; Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, USA., Moehle MS; Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, USA., Stoyka L; Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, USA., Anabtawi N; Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, USA., Krendelchtchikova V; Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, USA., Volpicelli-Daley LA; Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, USA., West A; Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: abwest@uab.edu.

Journal Article , 2017

Urinary LRRK2 phosphorylation predicts parkinsonian phenotypes in G2019S LRRK2 carriers.

Fraser KB; From the Center for Neurodegeneration and Experimental Therapeutics (K.B.F., M.S.M., A.B.W.), Department of Neurology, University of Alabama at Birmingham; and Department of Neurology (R.N.A.), Columbia University, New York, NY., Moehle MS; From the Center for Neurodegeneration and Experimental Therapeutics (K.B.F., M.S.M., A.B.W.), Department of Neurology, University of Alabama at Birmingham; and Department of Neurology (R.N.A.), Columbia University, New York, NY., Alcalay RN; From the Center for Neurodegeneration and Experimental Therapeutics (K.B.F., M.S.M., A.B.W.), Department of Neurology, University of Alabama at Birmingham; and Department of Neurology (R.N.A.), Columbia University, New York, NY., West AB; From the Center for Neurodegeneration and Experimental Therapeutics (K.B.F., M.S.M., A.B.W.), Department of Neurology, University of Alabama at Birmingham; and Department of Neurology (R.N.A.), Columbia University, New York, NY. abwest@uab.edu.

LRRK2 Cohort Consortium

Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't , 2016

Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice.

Pancani T; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232;, Foster DJ; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232;, Moehle MS; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232;, Bichell TJ; Department of Neurology, Vanderbilt University, Nashville, TN 37232;, Bradley E; Department of Neurology, Vanderbilt University, Nashville, TN 37232;, Bridges TM; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232;, Klar R; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232;, Poslusney M; Lieber Institute for Brain Development, Baltimore, MD 21205., Rook JM; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232;, Daniels JS; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232;, Niswender CM; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232;, Jones CK; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232;, Wood MR; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232;, Bowman AB; Department of Neurology, Vanderbilt University, Nashville, TN 37232;, Lindsley CW; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232;, Xiang Z; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232; zixiu.xiang@vanderbilt.edu jeff.conn@vanderbilt.edu., Conn PJ; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232; zixiu.xiang@vanderbilt.edu jeff.conn@vanderbilt.edu.

Journal Article; Research Support, N.I.H., Extramural , 2015

M1 and M2 immune activation in Parkinson's Disease: Foe and ally?

Moehle MS; Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, The University of Alabama at Birmingham, Birmingham, AL, United States. Electronic address: msmoehle@gmail.com., West AB; Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, The University of Alabama at Birmingham, Birmingham, AL, United States.

Journal Article; Research Support, N.I.H., Extramural; Review , 2015