Search Results - "NPC1"

Deficiency of myeloid NPC1 exacerbates liver injury and fibrosis by impairing macrophage efferocytosis

Dongwei Guan, Pengju Huang, Xinlei Liu, Qing Li, Xiaoxun Zhang, Nan Liu, Yong Wang, Ying Wan, Jin Chai, Shiying Cai, Rui Chen, Zhijia Ye

electronic resource

View item; View item

ApoE4 requires lipidation enhancement to resolve cellular lipid and protein abnormalities following NPC1 inhibition

Erika Di Biase, Kyle J. Connolly, Ingrid Crumpton, Oliver Cooper, Penelope J. Hallett, Ole Isacson

electronic resource

View item

NPC1 promotes the progression of hepatocellular carcinoma by mediating the accumulation of neutrophils into the tumor microenvironment

Songhai Yang, Jiangming Chen, Kun Xie, Fubao Liu

electronic resource

View item

Focusing on the Abnormal Events of NPC1, NPC2, and NPC1L1 in Pan-Cancer and Further Constructing LUAD and KICH Prediction Models

Chen, Keheng^aff1, Zhang, Xin^aff2, Sun, Guangyu^aff3, Fang, Zhichao^aff3, Liao, Lusheng^aff2, Zhong, Yanping^aff2, Huang, Fengdie^aff2, Dong, Mingyou^aff1, Luo, Shihua^aff4

Purification and Characterization of Human Niemann–Pick C1 Protein

Gong, Xin^{Aff3, Aff4}, Qian, Hongwu^Aff3

Drin, Guillaume^Aff2, Walker, John M.^Aff1

The role of bile acid metabolism-related genes in prognosis assessment of hepatocellular carcinoma and identification of NPC1 as a biomarker

Maosen Xu, Yu Zhang, Yan Tie, Yiqiao Luo, Yang Wang, Ziqi Zhang

electronic resource

View item; View item

Development of a neutralization assay and bioluminescent imaging mouse model for Dehong virus (DEHV) using a pseudovirus system

Xuelian Wu, Fan Liu, Tao Li, Danfeng Li, Yanru Shen, Xiaoai Zhang, Shuo Liu, Qi Jiang, Chenyan Zhao, Jianhui Nie, Youchun Wang, Baomin Feng, Wei Liu, Weijin Huang

electronic resource

View item

Small-molecule activation of TFEB alleviates Niemann–Pick disease type C via promoting lysosomal exocytosis and biogenesis

Kaili Du, Hongyu Chen, Zhaonan Pan, Mengli Zhao, Shixue Cheng, Yu Luo, Wenhe Zhang, Dan Li

electronic resource

View item; View item

CRISPR/Cas9-Mediated Generation of Niemann–Pick C1 Knockout Cell Line

Du, Ximing^Aff4, Lukmantara, Ivan^Aff4, Yang, Hongyuan^Aff4

Gelissen, Ingrid C.^Aff2, Brown, Andrew J.^Aff3, Walker, John M.^Aff1

In silico comparative analysis of cestode and human NPC1 provides insights for ezetimibe repurposing to visceral cestodiases treatment

Kulakowski Corá, Renato^{Aff1, Aff2}, Prado Paludo, Gabriela^{Aff1, Aff2}, Andrade Paes, Jéssica^{Aff1, Aff2}, Bunselmeyer Ferreira, Henrique^{Aff1, Aff2, IDs41598024721361_cor4}

Clinical and genetic analysis of Niemann-Pick disease type C with a novel NPC1 variant

Neissi, Mostafa^{Aff1, Aff2, Aff3, IDs44162024000430_cor1}, Al-Badran, Adnan Issa, Mohammadi-Asl, Misagh, Al-Badran, Raed Abdulelah^{Aff5, IDs44162024000430_cor4}, Sheikh-Hosseini, Motahareh^{Aff3, Aff6}, Roghani, Mojdeh, Mohammadi-Asl, Javad^{Aff3, Aff7}

Novel compound heterozygous mutations of the NPC1 gene associated with Niemann-pick disease type C: a case report and review of the literature

Tao, Chaoxin, Zhao, Min, Zhang, Xiaohui, Hao, Jihong, Huo, Qiuyue, Sun, Jie, Xing, Jiangtao, Zhang, Yuna, Zhao, Jianhong^{Aff2, IDs12879024090255_cor9}, Huang, Huaipeng^{Aff1, IDs12879024090255_cor10}

Inhibition of NPC1 suppresses cell proliferation and β-catenin signaling activation of liver cancer

Cao, Dan^{Aff1, Aff2, Aff3}, Chen, Han^{Aff1, Aff2}, He, Min^{Aff1, Aff2}, Han, Ning^{Aff1, Aff2}, Tang, Hong^{Aff1, Aff2, IDs00432024060237_cor5}

Instationary metabolic flux analysis reveals that NPC1 inhibition increases glycolysis and decreases mitochondrial metabolism in brain microvascular endothelial cells

Bilal Moiz, Matthew Walls, Viviana Alpizar Vargas, Anirudh Addepalli, Callie Weber, Andrew Li, Ganesh Sriram, Alisa Morss Clyne

electronic resource

View item; View item

Niacin-induced lysosomal free cholesterol efflux via LXRα-mediated signaling pathways in macrophages retards the progression of atherosclerosis

Xu, Hao ^{a, 1}, Sun, Xueni ^{a, 1}, Peng, Miaoru ^a, Zhao, Yuanshu ^a, Li, Shuxian ^a, Li, Ping ^a, Zhang, Fan ^b, Fu, Xiaodong ^{a, ⁎}, Xu, Xiaoyang ^{a, ⁎⁎}

The multiple facets of Rab proteins modulating the cellular distribution of cholesterol from the late endosomal compartment

Nguyen, Mai Khanh Linh ^a, Pinkenburg, Céline ^a, Du, Jonathan James ^a, Bernaus-Esqué, Marc ^b, Enrich, Carlos ^{b, c}, Rentero, Carles ^{b, c}, Grewal, Thomas ^{a, ⁎}

Decoding the blueprint of receptor binding by filoviruses through large-scale binding assays and machine learning

Lasso, Gorka ^{1, 25, ∗}, Grodus, Michael ^{2, 25, 26}, Valencia, Estefania ^{1, 25, 27}, DeJesus, Veronica ^{1, 28}, Liang, Eliza ², Delwel, Isabel ^{1, 29}, Bortz, Rob H., III ^{1, 30}, Lupyan, Dmitry ³, Ehrlich, Hanna Y. ⁴, Castellanos, Adrian A. ⁵, Gazzo, Andrea ⁶, Wells, Heather L. ⁷, Wacharapluesadee, Supaporn ⁸, Tremeau-Bravard, Alexandre ⁴, Seetahal, Janine F.R. ⁹, Hughes, Tom ^{10, 11}, Lee, Jimmy ^{10, 11}, Lee, Mei-Ho ^{10, 11}, Sjodin, Anna R. ¹², Geldenhuys, Marike ¹³, Mortlock, Marinda ¹³, Navarrete-Macias, Isamara ⁷, Gilardi, Kirsten ⁴, Willig, Michael R. ^{12, 14}, Nava, Alessandra F.D. ¹⁵, Loh, Elisabeth H. ¹⁶, Asrat, Makda ⁷, Smiley-Evans, Tierra ⁴, Magesa, Walter S. ¹⁷, Zikankuba, Sijali ¹⁷, Wolking, David ⁴, Suzán, Gerardo ¹⁸, Ojeda-Flores, Rafael ¹⁸, Carrington, Christine V.F. ¹⁹, Islam, Ariful ²⁰, Epstein, Jonathan H. ¹¹, Markotter, Wanda ¹³, Johnson, Christine K. ⁴, Goldstein, Tracey ²¹, Han, Barbara A. ⁵, Mazet, Jonna A.K. ⁴, Jangra, Rohit K. ^{22, 23, 24, ∗∗}, Chandran, Kartik ^{1, 31, ∗∗∗}, Anthony, Simon J. ^{7, ∗∗∗∗}

Identification Novel Peptides Conjugated to HIV1 Tat Peptide to Inhibit Ebola Virus Entry by Targeting Niemann Pick C1 Protein

Saragih, Mutiara, Stephanie, Filia, Alkaff, Ahmad Husein, Tambunan, Usman Sumo Friend

2019 IEEE 19th International Conference on Bioinformatics and Bioengineering (BIBE)

Caveolae-Mediated Endocytosis Drives Robust siRNA Delivery of Polymeric Nanoparticles to Macrophages

Song, Yudong^aff1, Wu, Yanhua^aff2, Xu, Lu^aff1, Jiang, Ting^aff1, Tang, Cui^aff1, Yin, Chunhua^aff1

Genetic and clinical characterization of Niemann-Pick disease type C with homozygous NPC1 gene mutation: insights from whole exome sequencing and advanced neuroimaging of two familial cases

Hajira Karim, Lima Oria, Muhsin Elmas

electronic resource

View item; View item; View item