Search Results - "Nonomiya, Jim"

Covalent Library Screening by Targeted Mass Spectrometry for Rapid Binding Site Identification

Nonomiya, Jim, Li, Ke Sherry, Babin, Brett M., Mulvihill, Melinda M.

High-Throughput Kinetic Characterization of Irreversible Covalent Inhibitors of KRASG12C by Intact Protein MS and Targeted MRM

Li, Ke Sherry^aff1, Quinn, John G.^aff1, Saabye, Matthew J.^aff2, Guerrero, Jesus F. Salcido^aff1, Nonomiya, Jim^aff1, Lian, Qihui^aff3, Phung, Wilson^aff4, Izrayelit, Yevgeniy^aff1, Walters, Benjamin T.^aff1, Gustafson, Amy^aff1, Endres, Nicholas F.^aff1, Beresini, Maureen H.^aff1, Mulvihill, Melinda M.^aff1

Discovery of Peptidomimetic Antibody–Drug Conjugate Linkers with Enhanced Protease Specificity

Wei, BinQing^aff1, Gunzner-Toste, Janet^aff1, Yao, Hui^aff2, Wang, Tao^aff2, Wang, Jing^aff2, Xu, Zijin^aff2, Chen, Jinhua^aff2, Wai, John^aff2, Nonomiya, Jim^aff1, Tsai, Siao Ping^aff1, Chuh, Josefa^aff1, Kozak, Katherine R.^aff1, Liu, Yichin^aff1, Yu, Shang-Fan^aff1, Lau, Jeff^aff1, Li, Guangmin^aff1, Phillips, Gail D.^aff1, Leipold, Doug^aff1, Kamath, Amrita^aff1, Su, Dian^aff1, Xu, Keyang^aff1, Eigenbrot, Charles^aff1, Steinbacher, Stefan^aff3, Ohri, Rachana^aff1, Raab, Helga^aff1, Staben, Leanna R.^aff1, Zhao, Guiling^aff1, Flygare, John A.^aff1, Pillow, Thomas H.^aff1, Verma, Vishal^aff1, Masterson, Luke A.^aff4, Howard, Philip W.^aff4, Safina, Brian^aff1

The Rational Design of Selective Benzoxazepin Inhibitors of the α‑Isoform of Phosphoinositide 3‑Kinase Culminating in the Identification of (S)‑2-((2-(1-Isopropyl‑1H‑1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2‑d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326)

Heffron, Timothy P.^aff1, Heald, Robert A.^aff2, Ndubaku, Chudi^aff1, Wei, BinQing^aff1, Augistin, Martin^aff3, Do, Steven^aff1, Edgar, Kyle^aff1, Eigenbrot, Charles^aff1, Friedman, Lori^aff1, Gancia, Emanuela^aff2, Jackson, Philip S.^aff2, Jones, Graham^aff2, Kolesnikov, Aleksander^aff1, Lee, Leslie B.^aff1, Lesnick, John D.^aff1, Lewis, Cristina^aff1, McLean, Neville^aff2, Mörtl, Mario^aff3, Nonomiya, Jim^aff1, Pang, Jodie^aff1, Price, Steve^aff2, Prior, Wei Wei^aff1, Salphati, Laurent^aff1, Sideris, Steve^aff1, Staben, Steven T.^aff1, Steinbacher, Stefan^aff3, Tsui, Vickie^aff1, Wallin, Jeffrey^aff1, Sampath, Deepak^aff1, Olivero, Alan G.^aff1

Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity

Barreira da Silva, Rosa^{Aff1, IDs4159002201153x_cor1}, Leitao, Ricardo M., Pechuan-Jorge, Ximo, Werneke, Scott, Oeh, Jason, Javinal, Vincent, Wang, Yingyun, Phung, Wilson, Everett, Christine, Nonomiya, Jim, Arnott, David, Lu, Cheng, Hsiao, Yi-Chun, Koerber, James T., Hötzel, Isidro, Ziai, James, Modrusan, Zora, Pillow, Thomas H., Roose-Girma, Merone, Schartner, Jill M., Merchant, Mark, Rutz, Sascha, Eidenschenk, Céline, Mellman, Ira^{Aff1, IDs4159002201153x_cor24}, Albert, Matthew L.^{Aff1, Aff2, IDs4159002201153x_cor25}

Discovery of Selective 4‑Amino-pyridopyrimidine Inhibitors of MAP4K4 Using Fragment-Based Lead Identification and Optimization

Crawford, Terry D., Ndubaku, Chudi O., Chen, Huifen, Boggs, Jason W., Bravo, Brandon J., DeLaTorre, Kelly, Giannetti, Anthony M., Gould, Stephen E., Harris, Seth F., Magnuson, Steven R., McNamara, Erin, Murray, Lesley J., Nonomiya, Jim, Sambrone, Amy, Schmidt, Stephen, Smyczek, Tanya, Stanley, Mark, Vitorino, Philip, Wang, Lan, West, Kristina, Wu, Ping, Ye, Weilan

Discovery of 2‑{3-[2-(1-Isopropyl-3-methyl‑1H‑1,2–4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2‑d][1,4]oxazepin-9-yl]‑1H‑pyrazol-1-yl}-2-methylpropanamide (GDC-0032): A β‑Sparing Phosphoinositide 3‑Kinase Inhibitor with High Unbound Exposure and Robust in Vivo Antitumor Activity

Ndubaku, Chudi O.^aff1d1, Heffron, Timothy P.^aff1d1, Staben, Steven T.^aff1d1, Baumgardner, Matthew^aff1d2, Blaquiere, Nicole^aff1d1, Bradley, Erin^aff1d1, Bull, Richard^aff2, Do, Steven^aff1d1, Dotson, Jennafer^aff1d1, Dudley, Danette^aff1d1, Edgar, Kyle A.^aff1d3, Friedman, Lori S.^aff1d3, Goldsmith, Richard^aff1d1, Heald, Robert A.^aff2, Kolesnikov, Aleksandr^aff1d1, Lee, Leslie^aff1d3, Lewis, Cristina^aff1d4, Nannini, Michelle^aff1d3, Nonomiya, Jim^aff1d4, Pang, Jodie^aff1d2, Price, Steve^aff2, Prior, Wei Wei^aff1d3, Salphati, Laurent^aff1d2, Sideris, Steve^aff1d4, Wallin, Jeffery J.^aff1d3, Wang, Lan^aff1d1, Wei, BinQing^aff1d1, Sampath, Deepak^aff1d3, Olivero, Alan G.^aff1d1

Pyrimidoaminotropanes as Potent, Selective, and Efficacious Small Molecule Kinase Inhibitors of the Mammalian Target of Rapamycin (mTOR)

Estrada, Anthony A.^aff1d1, Shore, Daniel G.^aff1d1, Blackwood, Elizabeth^aff1d2, Chen, Yung-Hsiang^aff1d4, Deshmukh, Gauri^aff1d4, Ding, Xiao^aff1d4, DiPasquale, Antonio G.^aff2, Epler, Jennifer A.^aff1d2, Friedman, Lori S.^aff1d2, Koehler, Michael F. T.^aff1d1, Liu, Lichuan^aff1d4, Malek, Shiva^aff1d3, Nonomiya, Jim^aff1d3, Ortwine, Daniel F.^aff1d1, Pei, Zhonghua^aff1d1, Sideris, Steve^aff1d3, St-Jean, Frederic^aff1d1, Trinh, Lan^aff1d3, Truong, Tom^aff1d2, Lyssikatos, Joseph P.^aff1d1

Potent, Selective, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin Kinase Domain Exhibiting Single Agent Antiproliferative Activity

Koehler, Michael F. T.^aff1d1, Bergeron, Philippe^aff1d1, Blackwood, Elizabeth^aff1d2, Bowman, Krista K.^aff1d3, Chen, Yung-Hsiang^aff1d5, Deshmukh, Gauri^aff1d5, Ding, Xiao^aff1d5, Epler, Jennifer^aff1d2, Lau, Kevin^aff1d1, Lee, Leslie^aff1d2, Liu, Lichuan^aff1d5, Ly, Cuong^aff1d1, Malek, Shiva^aff1d2, Nonomiya, Jim^aff1d4, Oeh, Jason^aff1d2, Ortwine, Daniel F.^aff1d1, Sampath, Deepak^aff1d2, Sideris, Steve^aff1d4, Trinh, Lan^aff1d4, Truong, Tom^aff1d2, Wu, Jiansheng^aff1d6, Pei, Zhonghua^aff1d1, Lyssikatos, Joseph P.^aff1d1

The Design and Identification of Brain Penetrant Inhibitors of Phosphoinositide 3‑Kinase α

Heffron, Timothy P., Salphati, Laurent, Alicke, Bruno, Cheong, Jonathan, Dotson, Jennafer, Edgar, Kyle, Goldsmith, Richard, Gould, Stephen E., Lee, Leslie B., Lesnick, John D., Lewis, Cristina, Ndubaku, Chudi, Nonomiya, Jim, Olivero, Alan G., Pang, Jodie, Plise, Emile G., Sideris, Steve, Trapp, Sean, Wallin, Jeffrey, Wang, Lan, Zhang, Xiaolin

Potent and Highly Selective Benzimidazole Inhibitors of PI3-Kinase Delta

Murray, Jeremy M.^aff1, Sweeney, Zachary K.^aff1, Chan, Bryan K.^aff1, Balazs, Mercedesz^aff1, Bradley, Erin^aff1, Castanedo, Georgette^aff1, Chabot, Christine^aff1, Chantry, David^aff1, Flagella, Michael^aff1, Goldstein, David M.^aff3, Kondru, Rama^aff3, Lesnick, John^aff1, Li, Jun^aff1, Lucas, Matthew C.^aff3, Nonomiya, Jim^aff1, Pang, Jodie^aff1, Price, Stephen^aff2, Salphati, Laurent^aff1, Safina, Brian^aff1, Savy, Pascal P. A.^aff2, Seward, Eileen M.^aff2, Ultsch, Mark^aff1, Sutherlin, Daniel P.^aff1

Discovery of Novel PI3-Kinase δ Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent Inhibition

Safina, Brian S.^aff1, Baker, Stewart^aff4, Baumgardner, Matt^aff1, Blaney, Paul M.^aff2, Chan, Bryan K.^aff1, Chen, Yung-Hsiang^aff1, Cartwright, Matthew W.^aff2, Castanedo, Georgette^aff1, Chabot, Christine^aff1, Cheguillaume, Arnaud J.^aff2, Goldsmith, Paul^aff4, Goldstein, David M.^aff3, Goyal, Bindu^aff3, Hancox, Timothy^aff4, Handa, Raj K.^aff2, Iyer, Pravin S^aff3, Kaur, Jasmit^aff4, Kondru, Rama^aff3, Kenny, Jane R.^aff1, Krintel, Sussie L.^aff2, Li, Jun^aff1, Lesnick, John^aff1, Lucas, Matthew C.^aff3, Lewis, Cristina^aff1, Mukadam, Sophie^aff1, Murray, Jeremy^aff1, Nadin, Alan J.^aff2, Nonomiya, Jim^aff1, Padilla, Fernando^aff3, Palmer, Wylie S.^aff3, Pang, Jodie^aff1, Pegg, Neil^aff4, Price, Steve^aff2, Reif, Karin^aff1, Salphati, Laurent^aff1, Savy, Pascal A.^aff2, Seward, Eileen M.^aff2, Shuttleworth, Stephen^aff4, Sohal, Sukhjit^aff4, Sweeney, Zachary K.^aff1, Tay, Suzanne^aff1, Tivitmahaisoon, Parcharee^aff3, Waszkowycz, Bohdan^aff2, Wei, Binqing^aff1, Yue, Qin^aff1, Zhang, Chenghong^aff1, Sutherlin, Daniel P.^aff1

Rational Design of Phosphoinositide 3-Kinase α Inhibitors That Exhibit Selectivity over the Phosphoinositide 3-Kinase β Isoform

Heffron, Timothy P.^aff1, Wei, BinQing^aff1, Olivero, Alan^aff1, Staben, Steven T.^aff1, Tsui, Vickie^aff1, Do, Steven^aff1, Dotson, Jennafer^aff1, Folkes, Adrian J.^aff2, Goldsmith, Paul^aff2, Goldsmith, Richard^aff1, Gunzner, Janet^aff1, Lesnick, John^aff1, Lewis, Cristina^aff1, Mathieu, Simon^aff1, Nonomiya, Jim^aff1, Shuttleworth, Stephen^aff2, Sutherlin, Daniel P.^aff1, Wan, Nan Chi^aff2, Wang, Shumei^aff1, Wiesmann, Christian^aff1, Zhu, Bing-Yan^aff1

Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer

Sutherlin, Daniel P.^aff1, Bao, Linda^aff1, Berry, Megan^aff1, Castanedo, Georgette^aff1, Chuckowree, Irina^aff2, Dotson, Jenna^aff1, Folks, Adrian^aff2, Friedman, Lori^aff1, Goldsmith, Richard^aff1, Gunzner, Janet^aff1, Heffron, Timothy^aff1, Lesnick, John^aff1, Lewis, Cristina^aff1, Mathieu, Simon^aff1, Murray, Jeremy^aff1, Nonomiya, Jim^aff1, Pang, Jodie^aff1, Pegg, Niel^aff2, Prior, Wei Wei^aff1, Rouge, Lionel^aff1, Salphati, Laurent^aff1, Sampath, Deepak^aff1, Tian, Qingping^aff1, Tsui, Vickie^aff1, Wan, Nan Chi^aff2, Wang, Shumei^aff1, Wei, BinQing^aff1, Wiesmann, Christian^aff1, Wu, Ping^aff1, Zhu, Bing-Yan^aff1, Olivero, Alan^aff1

Potent, Selective, and Orally Bioavailable Inhibitors of Mammalian Target of Rapamycin (mTOR) Kinase Based on a Quaternary Substituted Dihydrofuropyrimidine

Cohen, Frederick^aff1d1, Bergeron, Philippe^aff1d1, Blackwood, Elizabeth^aff1d4, Bowman, Krista K.^aff1d5, Chen, Huifen^aff1d1, DiPasquale, Antonio G.^aff2, Epler, Jennifer A.^aff1d4, Koehler, Michael F. T.^aff1d1, Lau, Kevin^aff1d1, Lewis, Cristina^aff1d2, Liu, Lichuan^aff1d3, Ly, Cuong Q.^aff1d1, Malek, Shiva^aff1d2, Nonomiya, Jim^aff1d2, Ortwine, Daniel F.^aff1d1, Pei, Zhonghua^aff1d1, Robarge, Kirk D.^aff1d1, Sideris, Steve^aff1d2, Trinh, Lan^aff1d2, Truong, Tom^aff1d4, Wu, Jiansheng^aff1d6, Zhao, Xianrui^aff1d1, Lyssikatos, Joseph P.^aff1d1

Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer

Sutherlin, Daniel P.^aff1, Sampath, Deepak^aff1, Berry, Megan^aff1, Castanedo, Georgette^aff1, Chang, Zhigang^aff1, Chuckowree, Irina^aff2, Dotson, Jenna^aff1, Folkes, Adrian^aff2, Friedman, Lori^aff1, Goldsmith, Richard^aff1, Heffron, Tim^aff1, Lee, Leslie^aff1, Lesnick, John^aff1, Lewis, Cristina^aff1, Mathieu, Simon^aff1, Nonomiya, Jim^aff1, Olivero, Alan^aff1, Pang, Jodie^aff1, Prior, Wei Wei^aff1, Salphati, Laurent^aff1, Sideris, Steve^aff1, Tian, Qingping^aff1, Tsui, Vickie^aff1, Wan, Nan Chi^aff2, Wang, Shumei^aff1, Wiesmann, Christian^aff1, Wong, Susan^aff1, Zhu, Bing-Yan^aff1

Characterization of Antineovascularization Activity and Ocular Pharmacokinetics of Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GNE-947

Liu, Xingrong, Liang, Xiaorong, LeCouter, Jenninfer, Ubhayakar, Savita, Chen, Jacob, Cheng, Jay, Lee, Tom, Lubach, Joe, Nonomiya, Jim, Shahidi-Latham, Sheerin, Quiason, Cristine, Solon, Eric, Wright, Matthew, Hop, Cornelis E.C.A., Heffron, Timothy P. ^*

Structure of the Catalytic Domain of Human Polo-like Kinase 1 † , ‡

Kothe, Michael, Kohls, Darcy, Low, Simon, Coli, Rocco, Cheng, Alan C., Jacques, Suzanne L., Johnson, Theresa L., Lewis, Cristina, Loh, Christine, Nonomiya, Jim, Sheils, Alissa L., Verdries, Kimberly A., Wynn, Thomas A., Kuhn, Cyrille, Ding, Yuan-Hua

Structure of the Catalytic Domain of Human Protein Kinase C β II Complexed with a Bisindolylmaleimide Inhibitor ‡

Grodsky, Neil, Li, Ying, Bouzida, Djamal, Love, Robert, Jensen, Jordan, Nodes, Beverly, Nonomiya, Jim, Grant, Stephan

Design of Selective Benzoxazepin PI3Kδ Inhibitors Through Control of Dihedral Angles

Safina, Brian S.^aff1, Elliott, Richard L.^aff3, Forrest, Andrew K.^aff3, Heald, Robert A.^aff3, Murray, Jeremy M.^aff1, Nonomiya, Jim^aff1, Pang, Jodie^aff1, Salphati, Laurent^aff1, Seward, Eileen M.^aff3, Staben, Steven T.^aff1, Ultsch, Mark^aff1, Wei, Binqing^aff1, Yang, Wenqian^aff2, Sutherlin, Daniel P.^aff1