Sökresultat - "O'Donovan, Daniel"

Identification of Novel Potent NSD2-PWWP1 Ligands Using Structure-Based Design and Computational Approaches

Carlino, Luca^aff1, Astles, Peter C.^aff1, Ackroyd, Bryony^aff2, Ahmed, Afshan^aff2, Chan, Christina^aff1, Collie, Gavin W.^aff3, Dale, Ian L.^aff1, O’Donovan, Daniel H.^aff1, Fawcett, Caroline^aff4, di Fruscia, Paolo^aff1, Gohlke, Andrea^aff3, Guo, Xiaoxiao^aff3, Hao-Ru Hsu, Jessie^aff4, Kaplan, Bethany^aff4, Milbradt, Alexander G.^aff3, Northall, Sarah^aff3, Petrović, Dušan^aff5, Rivers, Emma L.^aff6, Underwood, Elizabeth^aff2, Webb, Alice^aff3

Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists

Scott, James S.^aff1, Stead, Darren^aff1, Barlaam, Bernard^aff1, Breed, Jason^aff3, Carbajo, Rodrigo J.^aff1, Chiarparin, Elisabetta^aff1, Cureton, Natalie^aff1, Davey, Paul R. J.^aff1, Fisher, David I.^aff3, Gangl, Eric T.^aff2, Grebe, Tyler^aff2, Greenwood, Ryan D.^aff1, Hande, Sudhir^aff2, Hatoum-Mokdad, Holia^aff2, Hughes, Samantha J.^aff1, Hunt, Thomas A.^aff1, Johnson, Tony^aff1, Kavanagh, Stefan L.^aff5, Klinowska, Teresa C. M.^aff1, Larner, Carrie J. B.^aff5, Lawson, Mandy^aff1, Lister, Andrew S.^aff1, Longmire, David^aff1, Marden, Stacey^aff4, McGuire, Thomas M.^aff1, McMillan, Caroline^aff1, McMurray, Lindsay^aff1, Morrow, Christopher J.^aff1, Nissink, J. Willem M.^aff1, Moss, Thomas A.^aff1, O’Donovan, Daniel H.^aff1, Polanski, Radoslaw^aff3, Stokes, Stephen^aff1, Thakur, Kumar^aff2, Trueman, Dawn^aff1, Truman, Caroline^aff3, Tucker, Michael J.^aff1, Wang, Haixia^aff2, Whalley, Nicky^aff1, Wu, Dedong^aff4, Wu, Ye^aff2, Yang, Bin^aff2, Yang, Wenzhan^aff4

Transcriptomics-based matching of drugs to diseases with deep learning

Papanikolaou, Yannis, Tuveri, Francesco, Ogura, Misa, O'Donovan, Daniel

An experimentally validated approach to automated biological evidence generation in drug discovery using knowledge graphs

Sudhahar, Saatviga^{Aff1, IDs41467024500246_cor1}, Ozer, Bugra, Chang, Jiakang, Chadwick, Wayne, O’Donovan, Daniel, Campbell, Aoife, Tulip, Emma, Thompson, Neil, Roberts, Ian

Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist

Scott, James S.^aff1, Moss, Thomas A.^aff1, Balazs, Amber^aff2, Barlaam, Bernard^aff1, Breed, Jason^aff3, Carbajo, Rodrigo J.^aff1, Chiarparin, Elisabetta^aff1, Davey, Paul R. J.^aff1, Delpuech, Oona^aff1, Fawell, Stephen^aff2, Fisher, David I.^aff3, Gagrica, Sladjana^aff1, Gangl, Eric T.^aff2, Grebe, Tyler^aff2, Greenwood, Ryan D.^aff1, Hande, Sudhir^aff2, Hatoum-Mokdad, Holia^aff2, Herlihy, Kara^aff3, Hughes, Samantha^aff1, Hunt, Thomas A.^aff1, Huynh, Hoan^aff2, Janbon, Sophie L. M.^aff5, Johnson, Tony^aff1, Kavanagh, Stefan^aff6, Klinowska, Teresa^aff1, Lawson, Mandy^aff1, Lister, Andrew S.^aff1, Marden, Stacey^aff4, McGinnity, Dermot F.^aff1, Morrow, Christopher J.^aff1, Nissink, J. Willem M.^aff1, O’Donovan, Daniel H.^aff1, Peng, Bo^aff2, Polanski, Radoslaw^aff3, Stead, Darren S.^aff1, Stokes, Stephen^aff1, Thakur, Kumar^aff2, Throner, Scott R.^aff2, Tucker, Michael J.^aff1, Varnes, Jeffrey^aff2, Wang, Haixia^aff2, Wilson, David M.^aff1, Wu, Dedong^aff4, Wu, Ye^aff2, Yang, Bin^aff2, Yang, Wenzhan^aff4

Rapid Identification of Novel Allosteric PRC2 Inhibitors

Read, Jon A.^aff1, Tart, Jonathan^aff2, Rawlins, Philip B.^aff1, Gregson, Clare^aff3, Jones, Karen^aff4, Gao, Ning^aff5, Zhu, Xiahui^aff5, Tomlinson, Ron^aff6, Code, Erin^aff5, Cheung, Tony^aff7, Chen, Huawei^aff7, Kawatkar, Sameer P.^aff8, Bloecher, Andy^aff7, Bagal, Sharan^aff3, O’Donovan, Daniel H.^aff3, Robinson, James^aff9

Drug discovery for epigenetics targets

Holdgate, Geoffrey A., Bardelle, Catherine, Lanne, Alice, Read, Jon, O'Donovan, Daniel H., Smith, James M., Selmi, Nidhal, Sheppard, Robert

An integrated science portal for collaborative compute and data intensive protein structure studies

Stokes-Rees, Ian, O'Donovan, Daniel, Doherty, Peter, Porter-Mahoney, Meghan, Sliz, Piotr

2012 IEEE 8th International Conference on E-Science (e-Science)

Pyridin-2-yl Guanidine Derivatives: Conformational Control Induced by Intramolecular Hydrogen-Bonding Interactions

Kelly, Brendan, O'Donovan, Daniel H., O'Brien, John, McCabe, Thomas, Blanco, Fernando, Rozas, Isabel

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Addressing the Reciprocal Crosstalk between the AR and the PI3K/AKT/mTOR Signaling Pathways for Prostate Cancer Treatment.

Raith, Fabio¹ (AUTHOR), O'Donovan, Daniel H.¹ (AUTHOR), Lemos, Clara² (AUTHOR), Politz, Oliver¹ (AUTHOR), Haendler, Bernard¹ (AUTHOR) bernard.haendler@bayer.com

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The kinetics of inorganic phosphate excretion in the acidotic rabbit during intravenous phosphate loading: a pseudo-ruminant model

Walsh, Patrick A.^Aff1, O’Donovan, Daniel J.

Potential errors in the determination of urinary ammonium by formol titration

Walsh, Patrick A.^{aff1_w2aab2b8c46b1b7b1aab1b4b2Aa}, O’Donovan, Daniel J.^{aff2_w2aab2b8c46b1b7b1aab1b4b3Aa}

Guanidine-based α2-adrenoceptor ligands: Towards selective antagonist activity

O'Donovan, Daniel H., Muguruza, Carolina, Callado, Luis F., Rozas, Isabel

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A novel combination treatment for fragile X syndrome predicted using computational methods.

Chadwick, Wayne, Angulo-Herrera, Ivan, Cogram, Patricia, Deacon, Robert J M, Mason, Daniel J, Brown, David, Roberts, Ian, O'Donovan, Daniel J, Tranfaglia, Michael R, Guilliams, Tim, Thompson, Neil T

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Conformational Locking upon Cooperative Assembly of Notch Transcription Complexes

Choi, Sung Hee, Wales, Thomas E., Nam, Yunsun, O'Donovan, Daniel J., Sliz, Piotr, Engen, John R., Blacklow, Stephen C.

High-Resolution Heteronuclear Multidimensional NMR of Proteins in Living Insect Cells Using a Baculovirus Protein Expression System

Hamatsu, Jumpei^aff1, O’Donovan, Daniel^aff2, Tanaka, Takashi^aff1, Shirai, Takahiro^aff1, Hourai, Yuichiro^aff1, Mikawa, Tsutomu^aff4, Ikeya, Teppei^aff1, Mishima, Masaki^aff1, Boucher, Wayne^aff2, Smith, Brian O.^aff5, Laue, Ernest D.^aff2, Shirakawa, Masahiro^aff6, Ito, Yutaka^aff1