Search Results - "Observational studies"

A Bayesian Approach to the G-Formula via Iterative Conditional Regression.

Liu R; Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA.; Center for Methods in Implementation and Prevention Science, Yale School of Public Health, New Haven, CT, USA., Hu L; Department of Biostatistics and Epidemiology, Rutgers University, New Brunswick, NJ, USA., Perry Wilson F; Clinical and Translational Research Accelerator, Yale School of Medicine, New Haven, CT, USA., Warren JL; Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA., Li F; Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA.; Center for Methods in Implementation and Prevention Science, Yale School of Public Health, New Haven, CT, USA.; Clinical and Translational Research Accelerator, Yale School of Medicine, New Haven, CT, USA.

Journal Article , 2025

How Effective Are Machine Learning and Doubly Robust Estimators in Incorporating High-Dimensional Proxies to Reduce Residual Confounding?

Karim ME; School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.; Centre for Advancing Health Outcomes, University of British Columbia, Vancouver, British Columbia, Canada., Lei Y; Department of Statistics, University of British Columbia, Vancouver, British Columbia, Canada.

Journal Article , 2025

Scoping review of registration of observational studies finds inadequate registration policies, increased registration, and a debate converging toward proregistration.

Malmsiø D; Centre for Evidence-Based Medicine Odense (CEBMO) and Cochrane Denmark, Department of Clinical Research, University of Southern Denmark, Odense, Denmark; Open Patient data Exploratory Network (OPEN), Odense University Hospital, Odense, Denmark. Electronic address: danielmalmsio@gmail.com., Norlén S; Department of Emergency Medicine at Lillebælt Hospital, Kolding, Denmark., Jespersen C; Centre for Evidence-Based Medicine Odense (CEBMO) and Cochrane Denmark, Department of Clinical Research, University of Southern Denmark, Odense, Denmark; Open Patient data Exploratory Network (OPEN), Odense University Hospital, Odense, Denmark., Neesgaard VE; Department of Neurosurgery at Rigshospitalet, Copenhagen, Denmark., Song Z; Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada., Chan AW; Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada; Department of Medicine, University of Toronto, Toronto, Ontario, Canada., Hróbjartsson A; Centre for Evidence-Based Medicine Odense (CEBMO) and Cochrane Denmark, Department of Clinical Research, University of Southern Denmark, Odense, Denmark; Open Patient data Exploratory Network (OPEN), Odense University Hospital, Odense, Denmark.

Journal Article; Scoping Review , 2025

False Discovery Rate Control for Confounder Selection Using Mirror Statistics.

Harada K; Department of Health Data Science, Tokyo Medical University, Tokyo, Japan., Taguri M; Department of Health Data Science, Tokyo Medical University, Tokyo, Japan.

Journal Article , 2025

Emulating randomized trials by observational database studies: the RCT-DUPLICATE initiative in COPD and asthma.

Suissa S; Centre for Clinical Epidemiology, Lady Davis Institute Jewish General Hospital, Montreal, Quebec, Canada.; Department of Epidemiology, Biostatistics, and of Medicine, McGill University Montreal, Quebec, Canada., Schneeweiss S; Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, 1620 Tremont St Suite 3030, Boston, MA, United States.; Department of Medicine, Harvard Medical School, Boston, MA, United States., Feldman WB; Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, 1620 Tremont St Suite 3030, Boston, MA, United States.; Department of Medicine, Harvard Medical School, Boston, MA, United States.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 15 Francis Street, Boston, MA, United States., Tesfaye H; Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, 1620 Tremont St Suite 3030, Boston, MA, United States., Wang SV; Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, 1620 Tremont St Suite 3030, Boston, MA, United States.; Department of Medicine, Harvard Medical School, Boston, MA, United States.

Journal Article , 2025

Breaking Down Bias: A Methodological Primer on Identifying, Evaluating, and Mitigating Bias in Cardiovascular Research.

Grubic N; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. Electronic address: nicholas.j.grubic@gmail.com., Johnston A; Department of Obstetrics and Gynecology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Electronic address: View item., Randhawa VK; Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada. Electronic address: View item., Humphries KH; Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Rosella LC; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, Toronto, Ontario, Canada; Institute for Better Health, Trillium Health Partners, Mississauga, Ontario, Canada. Electronic address: View item., Maximova K; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; MAP Centre for Urban Health Solutions, St Michael's Hospital, Toronto, Ontario, Canada.

Journal Article; Review , 2025

Methods in dynamic treatment regimens using observational healthcare data: A systematic review.

Liang D; Division of Pharmacoepidemiology & Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, the Netherlands., Paul AK; Alberta Machine Intelligence Institute, University of Alberta, Edmonton, AB, Canada; Department of Computing Science, University of Alberta, Edmonton, AB, Canada., Weir DL; Division of Pharmacoepidemiology & Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, the Netherlands., Deneer VHM; Division of Pharmacoepidemiology & Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, the Netherlands; Department of Clinical Pharmacy, Division Laboratories, Pharmacy and Biomedical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands., Greiner R; Alberta Machine Intelligence Institute, University of Alberta, Edmonton, AB, Canada; Department of Computing Science, University of Alberta, Edmonton, AB, Canada; Department of Psychiatry, University of Alberta, Edmonton, AB, Canada., Siebes A; Department of Information and Computing Sciences, Utrecht University, Utrecht, the Netherlands., Gardarsdottir H; Division of Pharmacoepidemiology & Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, the Netherlands; Department of Clinical Pharmacy, Division Laboratories, Pharmacy and Biomedical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Pharmaceutical Sciences, School of Health Sciences, University of Iceland, Reykjavík, Iceland. Electronic address: H.Gardarsdottir@uu.nl.

Journal Article; Systematic Review; Review , 2025

Genetic architecture of tic disorders: A systematic review of 125 observational studies.

Yang CS; Department of Pharmacy, Evidence-based Pharmacy Center, West China Second Hospital, Sichuan University, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, China., Yang N; Department of Pharmacy, Evidence-based Pharmacy Center, West China Second Hospital, Sichuan University, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, China., Hao ZL; Department of Neurology, West China Hospital, Sichuan University, China. Electronic address: zhilong1983@126.com., Yu D; Department of Children's Genetic Endocrinology and Metabolism, West China Second Hospital, Sichuan University, China., Zhang LL; Department of Pharmacy, Evidence-based Pharmacy Center, West China Second Hospital, Sichuan University, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, China. Electronic address: zhanglingli@scu.edu.cn.

Systematic Review; Journal Article; Review , 2025

Generalized framework for identifying meaningful heterogenous treatment effects in observational studies: A parametric data-adaptive G-computation approach.

Nianogo RA; Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles (UCLA), USA.; California Center for Population Research, University of California, Los Angeles (UCLA), USA., O'Neill S; Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, UK., Inoue K; Department of Social Epidemiology, Graduate School of Medicine, Kyoto University, Japan.; Hakubi Center, Kyoto University, Japan.

Journal Article , 2025

Association Does Not Mean Causation, When Observational Data Were Misinterpreted as Causal: The Observational Interpretation Fallacy.

D'Amico F; Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Marmiere M; Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Fonti M; Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Battaglia M; Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Belletti A; Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Journal Article; Review , 2025

Confounder adjustment in observational studies investigating multiple risk factors: a methodological study.

Gao Y; Department of Epidemiology and Biostatistics, Xiangya School of Public Health, Central South University, Changsha, China., Xiang L; Department of Epidemiology and Biostatistics, Xiangya School of Public Health, Central South University, Changsha, China., Yi H; Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Song J; Department of Epidemiology and Biostatistics, Xiangya School of Public Health, Central South University, Changsha, China., Sun D; Department of Epidemiology and Biostatistics, Xiangya School of Public Health, Central South University, Changsha, China., Xu B; Department of Epidemiology and Biostatistics, Xiangya School of Public Health, Central South University, Changsha, China., Zhang G; Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. 18801038718@163.com., Wu IX; Department of Epidemiology and Biostatistics, Xiangya School of Public Health, Central South University, Changsha, China. irenexywu@csu.edu.cn.; Hunan Provincial Key Laboratory of Clinical Epidemiology, Central South University, Changsha, China. irenexywu@csu.edu.cn.

Journal Article , 2025

Target Trial Emulation: Improving the Quality of Observational Studies in Inflammatory Bowel Disease Using the Principles of Randomized Trials.

Honap S; INFINY Institute, Nancy University Hospital, F-54500 Vandœuvre-lès-Nancy, France.; School of Immunology and Microbial Sciences, King's College London, London, UK.; Department of Gastroenterology, St George's University Hospitals NHS Foundation Trust, London, UK., Danese S; Department of Gastroenterology and Endoscopy, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, 20132 Milan, Italy., Peyrin-Biroulet L; INFINY Institute, Nancy University Hospital, F-54500 Vandœuvre-lès-Nancy, France.; Department of Gastroenterology, Nancy University Hospital, F-54500 Vandœuvre-lès-Nancy, France.; INSERM, NGERE, University of Lorraine, F-54000 Nancy, France.; FHU-CURE, Nancy University Hospital, F-54500 Vandœuvre-lès-Nancy, France.; Groupe Hospitalier privé Ambroise Paré - Hartmann, Paris IBD Center, 92200 Neuilly sur Seine, France.; Division of Gastroenterology and Hepatology, McGill University Health Centre, Montreal, Quebec, Canada.

Journal Article; Review , 2025

Real Effect or Bias? Good Practices for Evaluating the Robustness of Evidence From Comparative Observational Studies Through Quantitative Sensitivity Analysis for Unmeasured Confounding.

Faries D; Real-World Access and Analytics, Eli Lilly & Company, Indianapolis, USA., Gao C; Department of Statistics, North Carolina State University, Raleigh, North Carolina, USA., Zhang X; Medical Affairs Biostatistics, CSL Behring, King of Prussia, USA., Hazlett C; Departments of Statistics & Data Science and Political Science, University of California at Los Angeles, Los Angeles, USA., Stamey J; Department of Statistical Science, Baylor University, Waco, USA., Yang S; Department of Statistics, North Carolina State University, Raleigh, North Carolina, USA., Ding P; Department of Statistics, University of California Berkeley, Berkeley, USA., Shan M; Real-World Access and Analytics, Eli Lilly & Company, Indianapolis, USA., Sheffield K; Value, Economics, and Outcomes, Eli Lilly & Company, Indianapolis, USA., Dreyer N; Dreyer Strategies, USA.

Journal Article , 2025

Directed Acyclic Graph Assisted Method For Estimating Average Treatment Effect.

Sun J; Department of Bioinformatics and Biostatistics, University of Louisville School of Public Health and Information Sciences, Louisville, Kentucky, USA.; Global Statistics and Data Science, Clinical Development and Regulatory, BeiGene, Beijing, China., Duncan S; Division of Neonatal Medicine, Department of Pediatrics, University of Louisville School of Medicine, Louisville, Kentucky, USA., Pal S; Department of Analytics in the Digital Era, United Arab Emirates University, Abu Dhabi, United Arab Emirates., Kong M; Department of Bioinformatics and Biostatistics, University of Louisville School of Public Health and Information Sciences, Louisville, Kentucky, USA.; Biostatistics Core, JG Brown Cancer Center, University of Louisville, Louisville, Kentucky, USA.

Journal Article , 2025

A Simple Sensitivity Analysis Method for Unmeasured Confounders via Linear Programming With Estimating Equation Constraints.

Tang C; Department of Biomedical Statistics, Graduate School of Medicine, Osaka University, Osaka, Japan., Zhou Y; Department of Biomedical Statistics, Graduate School of Medicine, Osaka University, Osaka, Japan.; Beijing International Center for Mathematical Research, Peking University, Beijing, China., Huang A; Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany., Hattori S; Department of Biomedical Statistics, Graduate School of Medicine, Osaka University, Osaka, Japan.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University, Osaka, Japan.

Journal Article , 2025

Propensity Score Analysis With Baseline and Follow-Up Measurements of the Outcome Variable.

Austin PC; ICES, Toronto, Ontario, Canada.; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.; Sunnybrook Research Institute, Toronto, Ontario, Canada.

Journal Article , 2025

Clinical trial emulation in nephrology.

Zoccali C; Renal Research Institute, New York, NY, USA. carmine.zoccali@tin.it.; Institute of Molecular Biology and Genetics (Biogem), Ariano Irpino, Italy. carmine.zoccali@tin.it.; Associazione Ipertensione Nefrologia Trapianto Renale (IPNET), c/o Nefrologia, Grande Ospedale Metropolitano, 89125, Reggio Calabria, Italy. carmine.zoccali@tin.it., Tripepi G; CNR-IFC, Institute of Clinical Physiology, Research Unit of Clinical Epidemiology, IPNET c/o Nefrologia, Grande Ospedale Metropolitano, 89125, Reggio Calabria, Italy.

Journal Article; Review , 2025

Application of observational research methods to real-world studies for rare disease drugs: A scoping review protocol.

Patel YP; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada., Ghaddar L; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada., Lin Y; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada., Karim N; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada., Chan K; Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, Ontario, Canada.; Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada., Dupuis L; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.; The Hospital for Sick Children (SickKids), Toronto, Ontario, Canada., Tadrous M; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.

Journal Article , 2025

The target trial framework in global health research: barriers and opportunities.

Al-Kassab-Córdova A; Unit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Solna, Stockholm, Sweden.; Centro de Excelencia en Estudios Económicos y Sociales en Salud, Universidad San Ignacio de Loyola, Lima, Peru., Alarcón-Braga EA; Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima, Peru., Parra CO; Unit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Solna, Stockholm, Sweden., Devasenapathy N; George Institute for Global Health, India., Wärnberg MG; Department of Global Public Health, Karolinska Institutet, Solna, Sweden.; Perioperative Medicine and Intensive Care, Karolinska University Hospital, Solna, Sweden., Matthews AA; Unit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Solna, Stockholm, Sweden.

Journal Article; Review , 2025

Validity of the Updated Rx-Risk Index as a Disease Identification and Risk-Adjustment Tool for Use in Observational Health Studies.

Widagdo I; Quality Use of Medicines and Pharmacy Research Centre, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia., Kerr M; Quality Use of Medicines and Pharmacy Research Centre, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia., Kalisch Ellett L; Quality Use of Medicines and Pharmacy Research Centre, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia., Schlegel C; Data and Analytics Branch, Health Economics and Research Division, Department of Health and Aged Care, Canberra, Australian Capital Territory, Australia., Sadeqzadeh E; Data and Analytics Branch, Health Economics and Research Division, Department of Health and Aged Care, Canberra, Australian Capital Territory, Australia., Wang A; Data and Analytics Branch, Health Economics and Research Division, Department of Health and Aged Care, Canberra, Australian Capital Territory, Australia., Clarke AL; Data and Analytics Branch, Health Economics and Research Division, Department of Health and Aged Care, Canberra, Australian Capital Territory, Australia., Pratt N; Quality Use of Medicines and Pharmacy Research Centre, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.

Journal Article; Validation Study , 2025