Sökresultat - "PROTAC"

Fine-Tuning the Epigenetic Landscape: Chemical Modulation of Epigenome Editors

Noviello, Gemma^{Aff4, Aff6}, Gjaltema, Rutger A. F.^Aff5

Jeltsch, Albert^Aff2, Rots, Marianne G.^Aff3, Walker, John M.^Aff1

In Silico Design, Synthesis, and Evaluation of PROTAC Against Hematopoietic Prostaglandin D Synthase

Yokoo, Hidetomo^{Aff3, Aff4}, Shibata, Norihito^Aff5, Demizu, Yosuke^{Aff3, Aff6, Aff7}

Kaczor, Agnieszka A.^Aff2, Walker, John M.^Aff1

Optimizing PROTAC Design: A Novel Approach Using Exposure Scores for Linker Site Selection

Jeong, Yeonju, Choi, Jae-Mun, Kim, Young-Kuk

2025 IEEE International Conference on Big Data and Smart Computing (BigComp)

Targeted Degradation of EGFR Mutations via Self-Delivery Nano-PROTACs for Boosting Tumor Synergistic Immunotherapy

Wang, Xuechun^aff1, Yan, Jie^aff1, Zhao, Yilei^aff1, Li, Songyan^aff1, Ma, Zilin^aff1, Duan, Xiuying^aff1, Wang, Yuelan^aff1, Jiao, Jianwei^aff2, Gu, Changping^aff1, Zhang, Guiqiang^aff1

DEGRADATOR: A Gaming Expedition Into Targeted Protein Degradation Therapies

Szulc, Natalia A.^aff1, Olchowik, Anna^aff1, Jaszczak, Patrycja^aff1, Janiak, Bartosz^aff1, Cup, Mikołaj^aff2, Tomaszewski, Jakub^aff2, Pokrzywa, Wojciech^aff1

Linker-Determined Folding and Hydrophobic Interactions Explain a Major Difference in PROTAC Cell Permeability

Poongavanam, Vasanthanathan, Docent, Peintner, Stefan, 1991, Abeje, Yordanos, Kölling, Florian, Meibom, Daniel, Erdélyi, Máté, 1975, Kihlberg, Jan

electronic

Aptamer Proteolysis-Targeting Chimeras (PROTACs): A Novel Strategy to Combat Drug Resistance in Estrogen Receptor α‑Positive Breast Cancer

Feng, Ying^aff1, Zhang, Zhilin^aff1, Zhang, Haowei^aff1, Guo, Hui^aff1, Tan, Chunyan^aff1, Xu, Naihan^aff2, Tan, Ying^aff1, Jiang, Yuyang^aff1

Development of a Commercial Manufacturing Process for Vepdegestrant, an Orally Bioavailable PROTAC Estrogen Receptor Degrader for the Treatment of Breast Cancer

Avery, Steve^aff1, Buske, Jamie M.^aff1, Chen, Doris^aff2, Chen, Herman^aff2, Chen, Xin^aff2, Davidson, Andrew R.^aff3, Desrosiers, Jean-Nicolas^aff1, Dong, Hanqing^aff2, Fellah, Noalle^aff1, Fernández, David F.^aff1, Grosso, John^aff2, Han, Lu^aff1, Hochdorfer, Teri^aff1, Johnson, Amber M.^aff1, Jones, Brian P.^aff1, Kalinowski, Maciej^aff3, Launer-Felty, Katherine D.^aff3, Lopez, Jorge^aff3, Makowski, Teresa^aff1, Mastriano, Carolyn^aff1, Nguyen, Truong N.^aff1, Patel, Nitinchandra D.^aff2, Peng, Zhihui^aff1, Potter, Tyler^aff1, Pritchard, Robert P.^aff1, Rane, Anil M.^aff1, Reeve, Max^aff2, Richins, Margaret C.^aff1, Salazar, Chase A.^aff1, Salisbury, John J.^aff3, Simpson, Robert^aff2, Tabshey, Liza^aff3, Tweed, Erin J.^aff3, Wahome, Paul G.^aff3, Walsh-Sayles, Nancy^aff3, Willie, Jordan A.^aff1, Wood, Ethan^aff3

Advances in Targeted Therapy for Metastatic Prostate Cancer

Grewal, Kabir, Dorff, Tanya B., Mukhida, Sagar S., Agarwal, Neeraj, Hahn, Andrew W.^{Aff3, IDs11864025013237_cor1}

Targeting Myc through BET-PROTAC elicits potent anti-lymphoma activity in diffuse large B cell lymphoma

Wang, Hui^{Aff1, Aff2}, Wu, Ximei^{Aff1, Aff2}, Gao, Jingjing^{Aff1, Aff2}, Chen, Suchang^{Aff1, Aff2}, Zhou, ZiTao, Zhang, Luyong^{Aff1, Aff3}, Liu, Bing^{Aff2, IDs10637025015356_cor1}, Wei, Min^{Aff1, IDs10637025015356_cor2}

Discovery of potent CRBN-recruiting epidermal growth factor receptor (EGFR) degraders in vitro

Hu, Wenbo, He, Jinmei, Xie, Tianyu, Zhou, Mengjia, Liu, Mingxia, Wang, Xin^{Aff1, Aff2, IDs10637025015392_cor1}

Targeting neurodegenerative disease-associated protein aggregation with proximity-inducing modalities

Ge, Rui-xin, Chen, Miao, Li, Qing-chao, Liu, Min, Zhou, Jun^{Aff1, Aff3, IDs41401025015382_cor1}, Xie, Song-bo^{Aff4, IDs41401025015382_cor2}

Phase 1 study of HP518, a PROTAC AR degrader in patients with mCRPC: results on safety, pharmacokinetics, and anti-tumor activity

Azad, Arun A., Gurney, Howard, Underhill, Craig, Horvath, Lisa, Voskoboynik, Mark, Li, Xinghai, King, Ivan, Shao, Lisa, Dai, Yiyun, Perabo, Frank^{Aff7, IDs10637025015338_cor1}

Non-Markovian Dynamic Models Identify Non-Canonical KRAS-VHL Encounter Complex Conformations for Novel PROTAC Design

Qiu, Yunrui^{aff1, aff2}, Wiewiora, Rafal P.^aff3, Izaguirre, Jesus A.^aff4, Xu, Huafeng^aff4, Sherman, Woody^aff3, Tang, Weiping^aff5, Huang, Xuhui^{aff1, aff2}

Structure-Based Design of CBP/EP300 Degraders: When Cooperativity Overcomes Affinity

Cheng-Sánchez, Iván^aff1, Gosselé, Katherine^{aff1, aff2}, Palaferri, Leonardo^aff1, Laul, Eleen^aff1, Riccabella, Gionata^aff1, Bedi, Rajiv K.^aff2, Li, Yaozong^aff2, Müller, Anna^aff2, Corbeski, Ivan^aff2, Caflisch, Amedeo^aff2, Nevado, Cristina^aff1

Versatile Split-and-Mix Liposome PROTAC Platform for Efficient Degradation of Target Protein In Vivo

Song, Chunli^aff1, Jiao, Zijun^{aff2, aff3}, Hou, Zhanfeng^aff1, Xing, Yun^aff1, Sha, Xinrui^aff2, Wang, Yuechen^aff1, Chen, Jiaxin^aff2, Liu, Susheng^aff2, Li, Zigang^{aff1, aff2}, Yin, Feng^{aff1, aff2}

Evaluating Ligands for Ubiquitin Ligases Using Affinity Beads

Dobrodziej, Jennifer^Aff5, Dong, Hanqing^Aff5, Zimmermann, Kurt^Aff5, Hickey, Christopher M.^Aff6

Cacace, Angela M.^Aff2, Hickey, Christopher M.^Aff3, Békés, Miklós^Aff4, Walker, John M.^Aff1

Modular Development of Enzyme-Activatable Proteolysis Targeting Chimeras for Selective Protein Degradation and Cancer Targeting

Chen, Yanchi^{aff1, aff2}, Zhang, Lina^aff1, Fang, Lincheng^aff1, Chen, Chengjie^aff1, Zhang, Dong^aff1, Peng, Tao^{aff1, aff3}

Design, synthesis, and biological evaluation of RIPK1-targeting PROTACs

Zhang, Hefeng^Aff1, Zhang, Shuonan^{Aff2, Aff4}, Wang, Tianchen^{Aff1, Aff4}, Lan, Yaohan^{Aff1, Aff4}, Dai, Yang, Peng, Xia, An, Yuxiang^{Aff1, Aff4}, Xue, Yi^{Aff1, Aff5}, Ai, Jing^{Aff2, Aff3, Aff4, IDs1103002511166x_cor1}, Duan, Wenhu^{Aff1, Aff3, Aff4, IDs1103002511166x_cor2}

Discovery of the novel celastrol-based PROTACs for the treatment of non-small cell lung cancer

Ma, Chunhui^{Aff1, Aff6}, Wang, Fang^{Aff2, Aff6}, Wang, Yiqing, Wu, Fan, Zhang, Xuguang, Ding, Chuanhua, Zhao, Jifeng, Ma, Ying, Li, Wanzhong^{Aff2, IDs11030025111407_cor1}, Liu, Wenshan^{Aff4, Aff6, IDs11030025111407_cor2}