Search Results - "Pawluczyk, Joseph M."

Efficient and Scalable Diastereoselective Synthesis of ((2R,7aS)‑2-fluorotetrahydro‑1H‑pyrrolizin-7a(5H)‑yl)methanol Hydrochloride

Zhao, Rulin^aff1, Hong, Zhenqiu^aff1, Wang, Bei^aff1, Smith, Daniel^aff1, Pawluczyk, Joseph M.^aff1, Chourey, Shishir^aff1, Nimje, Roshan Y^aff2, Koli, Basavraj^aff2, Chidambaram, Manibalan^aff2, Panchakharla, Ramakrishna^aff2, Gupta, Anuradha^aff3, Shirude, Pravin^aff3, Fink, Brian^aff1, Kempson, James^aff1, Mathur, Arvind^aff1

Route evaluation and development of a practical synthesis of methyl (S)-2-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-7-carboxylate

Pawluczyk, Joseph M., Kempson, James, Mathur, Arvind, Oderinde, Martins S.

Design and Synthesis of a Pro-Drug of Vinblastine Targeted at Treatment of Prostate Cancer with Enhanced Efficacy and Reduced Systemic Toxicity

Brady, Stephen F., Pawluczyk, Joseph M., Lumma, Patricia K., Feng, Dong-Mei, Wai, Jenny M., Jones, Raymond, DeFeo-Jones, Deborah, Wong, Bradley K., Miller-Stein, Cynthia, Lin, Jiunn H., Oliff, Allen, Freidinger, Roger M., Garsky, Victor M.

Development of Orally Active Oxytocin Antagonists: Studies on 1-(1-{4-[1-(2-Methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy]-2- methoxybenzoyl}piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one (L-372,662) and Related Pyridines

Bell, Ian M., Erb, Jill M., Freidinger, Roger M., Gallicchio, Steven N., Guare, James P., Guidotti, Maribeth T., Halpin, Rita A., Hobbs, Doug W., Homnick, Carl F., Kuo, Michelle S., Lis, Edward V., Mathre, David J., Michelson, Stuart R., Pawluczyk, Joseph M., Pettibone, Douglas J., Reiss, Duane R., Vickers, Stanley, Williams, Peter D., Woyden, Carla J.

Nonpeptide oxytocin antagonists: Analogs of L-371,257 with improved potency

Williams, Peter D., Bock, Mark G., Evans, Ben E., Freidinger, Roger M., Gallicchio, Steven N., Guidotti, Maribeth T., Jacobson, Marlene A., Kuo, Michelle S., Levy, Michelle R., Lis, Edward V., Michelson, Stuart R., Pawluczyk, Joseph M., Perlow, Debra S., Pettibone, Douglas J., Quigley, Amy G., Reiss, Duane R., Salvatore, Christopher, Stauffer, Kenneth J., Woyden, Carla J.

Microwave-initiated living free radical polymerization: optimization of the preparative scale synthesis of Rasta resins

Pawluczyk, Joseph M., McClain, Ray T., Denicola, Chris, Mulhearn, James J., Jr., Rudd, Deanne Jackson, Lindsley, Craig W.

Conformationally constrained o-tolylpiperazine camphorsulfonamide oxytocin antagonists. Structural modifications that provide high receptor affinity and suggest a bioactive conformation.

Williams, Peter D., Ball, Richard G., Clineschmidt, Bradley V., Culberson, J.Chris, Erb, Jill M., Freidinger, Roger M., Pawluczyk, Joseph M., Perlow, Debra S., Pettibone, Douglas J., Veber, Daniel F.

Nonpeptide oxytocin antagonists: Potent, orally bioavailable analogs of L-371,257 containing A 1- R-(pyridyl)ethyl ether terminus

Kuo, Michelle S., Bock, Mark G., Freidinger, Roger M., Guidotti, Maribeth T., Lis, Edward V., Pawluczyk, Joseph M., Perlow, Debra S., Pettibone, Douglas J., Quigley, Amy G., Reiss, Duane R., Williams, Peter D., Woyden, Carla J.

A prostate-specific antigen (PSA)-activated vinblastine prodrug selectively kills PSA-secreting cells in vivo.

DeFeo-Jones D, Brady SF, Feng DM, Wong BK, Bolyar T, Haskell K, Kiefer DM, Leander K, McAvoy E, Lumma P, Pawluczyk JM, Wai J, Motzel SL, Keenan K, Van Zwieten M, Lin JH, Garsky VM, Freidinger R, Oliff A, Jones RE

Journal Article , 2002