Search Results - "Peach ML"

Chemoinformatics

Peach, ML, Zakharov, AV, Guasch, L, Nicklaus, MC

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KDM3B inhibitors disrupt the oncogenic activity of PAX3-FOXO1 in fusion-positive rhabdomyosarcoma.

Kim YY; Genetics Branch, NCI, NIH, Bethesda, MD, USA. yong.kim@nih.gov., Gryder BE; Genetics Branch, NCI, NIH, Bethesda, MD, USA.; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA., Sinniah R; Genetics Branch, NCI, NIH, Bethesda, MD, USA., Peach ML; Basic Science Program, Frederick National Laboratory for Cancer Research (FNLCR), Frederick, MD, USA., Shern JF; Pediatric Oncology Branch, NCI, NIH, Bethesda, MD, USA., Abdelmaksoud A; Collaborative Bioinformatics Resource, NCI, NIH, Bethesda, MD, USA., Pomella S; Genetics Branch, NCI, NIH, Bethesda, MD, USA.; Department of Hematology and Oncology, Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Woldemichael GM; Leidos Biomed Res Inc, FNLCR, Basic Sci Program, Frederick, MD, USA.; Molecular Targets Program, NCI, NIH, Frederick, MD, USA., Stanton BZ; Genetics Branch, NCI, NIH, Bethesda, MD, USA.; Nationwide Children's Hospital, Center for Childhood Cancer Research, Columbus, OH, USA.; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA.; Department of Biological Chemistry & Pharmacology, The Ohio State University College of Medicine, Columbus, OH, USA., Milewski D; Genetics Branch, NCI, NIH, Bethesda, MD, USA., Barchi JJ Jr; Chemical Biology Laboratory, NCI, NIH, Frederick, MD, USA., Schneekloth JS Jr; Chemical Biology Laboratory, NCI, NIH, Frederick, MD, USA., Chari R; Genome Modification Core, Laboratory Animal Sciences Program, FNLCR, Frederick, MD, USA., Kowalczyk JT; Genetics Branch, NCI, NIH, Bethesda, MD, USA., Shenoy SR; Leidos Biomed Res Inc, FNLCR, Basic Sci Program, Frederick, MD, USA.; Molecular Targets Program, NCI, NIH, Frederick, MD, USA., Evans JR; Natural Products Branch, NCI, NIH, Frederick, MD, USA., Song YK; Genetics Branch, NCI, NIH, Bethesda, MD, USA., Wang C; Genetics Branch, NCI, NIH, Bethesda, MD, USA., Wen X; Genetics Branch, NCI, NIH, Bethesda, MD, USA., Chou HC; Genetics Branch, NCI, NIH, Bethesda, MD, USA., Gangalapudi V; Genetics Branch, NCI, NIH, Bethesda, MD, USA., Esposito D; Protein Expression Laboratory, FNLCR, NIH, Frederick, MD, USA., Jones J; Protein Expression Laboratory, FNLCR, NIH, Frederick, MD, USA., Procter L; Protein Expression Laboratory, FNLCR, NIH, Frederick, MD, USA., O'Neill M; Protein Characterization Laboratory, FNLCR, NIH, Frederick, MD, USA., Jenkins LM; Laboratory of Cell Biology, NCI, NIH, Bethesda, MD, USA., Tarasova NI; Cancer Innovation Laboratory, NCI, NIH, Bethesda, MD, USA., Wei JS; Genetics Branch, NCI, NIH, Bethesda, MD, USA., McMahon JB; Molecular Targets Program, NCI, NIH, Frederick, MD, USA., O'Keefe BR; Molecular Targets Program, NCI, NIH, Frederick, MD, USA.; Natural Products Branch, NCI, NIH, Frederick, MD, USA., Hawley RG; Genetics Branch, NCI, NIH, Bethesda, MD, USA.; Department of Anatomy and Cell Biology, George Washington University, Washington, DC, USA., Khan J; Genetics Branch, NCI, NIH, Bethesda, MD, USA. khanjav@mail.nih.gov.

Journal Article , 2024

Enigmazole Phosphomacrolides from the Marine Sponge Cinachyrella enigmatica .

Takada K; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States., Oku N; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States., Peach ML; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.; Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702-1201, United States., Ransom TT; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States., Henrich CJ; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.; Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702-1201, United States., Gustafson KR; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.

Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural , 2023

Selective Recognition of Carbohydrate Antigens by Germline Antibodies Isolated from AID Knockout Mice.

DeLaitsch AT; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States., Pridgen JR; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States., Tytla A; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States., Peach ML; Basic Science Program, Chemical Biology Laboratory, Leidos Biomedical Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, United States., Hu R; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States., Farnsworth DW; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States., McMillan AK; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States., Flanagan N; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States., Temme JS; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States., Nicklaus MC; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States., Gildersleeve JC; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States.

Journal Article; Research Support, N.I.H., Intramural , 2022

Design, Synthesis, and Characterization of Novel sn -1 Heterocyclic DAG-Lactones as PKC Activators.

Elhalem E; Departamento de Ingredientes Activos y Biorrefinerías, Instituto Nacional de Tecnología Industrial, Av. General Paz 5445, San Martín, Buenos Aires B1650WAB, Argentina.; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Av. General Paz 5445, San Martín, Buenos Aires B1650WAB, Argentina., Bellomo A; Departamento de Ingredientes Activos y Biorrefinerías, Instituto Nacional de Tecnología Industrial, Av. General Paz 5445, San Martín, Buenos Aires B1650WAB, Argentina.; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Av. General Paz 5445, San Martín, Buenos Aires B1650WAB, Argentina., Cooke M; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.; Department of Medicine, Einstein Medical Center Philadelphia, Philadelphia, Pennsylvania 19141, United States., Scravaglieri A; Departamento de Ingredientes Activos y Biorrefinerías, Instituto Nacional de Tecnología Industrial, Av. General Paz 5445, San Martín, Buenos Aires B1650WAB, Argentina., Pearce LV; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4255, United States., Peach ML; Basic Science Program, Chemical Biology Laboratory, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, Maryland 21702, United States., Gandolfi Donadío L; Departamento de Ingredientes Activos y Biorrefinerías, Instituto Nacional de Tecnología Industrial, Av. General Paz 5445, San Martín, Buenos Aires B1650WAB, Argentina.; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Av. General Paz 5445, San Martín, Buenos Aires B1650WAB, Argentina., Kazanietz MG; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Comin MJ; Departamento de Ingredientes Activos y Biorrefinerías, Instituto Nacional de Tecnología Industrial, Av. General Paz 5445, San Martín, Buenos Aires B1650WAB, Argentina.; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Av. General Paz 5445, San Martín, Buenos Aires B1650WAB, Argentina.

Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't , 2021

Antiangiogenic Activity and in Silico Cereblon Binding Analysis of Novel Thalidomide Analogs.

Peach ML; Basic Science Program, Chemical Biology Laboratory, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD 21701, USA., Beedie SL; Molecular Pharmacology Section, Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.; School of Medicine, Medical Sciences & Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK., Chau CH; Molecular Pharmacology Section, Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Collins MK; Molecular Pharmacology Section, Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Markolovic S; Molecular Pharmacology Section, Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Luo W; Drug Design & Development Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Tweedie D; Drug Design & Development Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Steinebach C; Pharmaceutical Institute, University of Bonn, 53121 Bonn, Germany., Greig NH; Drug Design & Development Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Gütschow M; Pharmaceutical Institute, University of Bonn, 53121 Bonn, Germany., Vargesson N; School of Medicine, Medical Sciences & Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK., Nicklaus MC; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Frederick, MD 21701, USA., Figg WD; Molecular Pharmacology Section, Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

Journal Article , 2020

SAVI, in silico generation of billions of easily synthesizable compounds through expert-system type rules.

Patel H; Computer-Aided Drug Design Group, Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, 21702, USA., Ihlenfeldt WD; Xemistry GmbH, Schwalbenweg 5, D-61479, Glashütten, Germany., Judson PN; Heather Lea, Bland Hill, Norwood, Harrogate, HG3 1TE, England., Moroz YS; Enamine Ltd, 78 Chervonotkatska Street, Suite 1, Kyiv, 02094, Ukraine and Chemspace LLC, 85 Chervonotkatska Street, Suite 1, Kyiv, 02094, Ukraine., Pevzner Y; Computer-Aided Drug Design Group, Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, 21702, USA.; AbbVie, Inc., North Chicago, IL, 60064, USA., Peach ML; Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA., Delannée V; Computer-Aided Drug Design Group, Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, 21702, USA., Tarasova NI; Synthetic Biologics and Drug Discovery Group, Laboratory of Cancer Immunometabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, 21702, USA., Nicklaus MC; Computer-Aided Drug Design Group, Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, 21702, USA. mn1@mail.nih.gov.

Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Intramural , 2020

Epigenetic re-wiring of breast cancer by pharmacological targeting of C-terminal binding protein.

Byun JS; National Institute on Minority Health and Health Disparities, Bethesda, MD, 20892, USA., Park S; Genetics Branch, National Cancer Institute, Bethesda, MD, 20892, USA., Yi DI; Genetics Branch, National Cancer Institute, Bethesda, MD, 20892, USA., Shin JH; Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA., Hernandez SG; Genetics Branch, National Cancer Institute, Bethesda, MD, 20892, USA., Hewitt SM; Laboratory of Pathology, National Cancer Institute, Bethesda, MD, 20892, USA., Nicklaus MC; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, 20892, USA., Peach ML; Basic Science Program, Chemical Biology Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA., Guasch L; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, 20892, USA., Tang B; Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA., Wakefield LM; Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA., Yan T; National Human Genome Institute, Bethesda, MD, 20892, USA., Caban A; National Institute on Minority Health and Health Disparities, Bethesda, MD, 20892, USA., Jones A; National Institute on Minority Health and Health Disparities, Bethesda, MD, 20892, USA., Kabbout M; National Institute on Minority Health and Health Disparities, Bethesda, MD, 20892, USA., Vohra N; Brody School of Medicine at East Carolina University, Greenville, NC, 27834, USA., Nápoles AM; National Institute on Minority Health and Health Disparities, Bethesda, MD, 20892, USA., Singhal S; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, 10032, USA., Yancey R; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, 10032, USA., De Siervi A; Laboratorio de Oncologıa Molecular y Nuevos Blancos Terapeuticos, Instituto de Biologıa y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina., Gardner K; National Institute on Minority Health and Health Disparities, Bethesda, MD, 20892, USA. Klg2160@cumc.columbia.edu.; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, 10032, USA. Klg2160@cumc.columbia.edu.

Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural , 2019