Search Results - "Platelet-derived growth factor"

PDGFRα inhibition reduces myofibroblast expansion in the fibrotic rim and enhances recovery after ischemic stroke.

Protzmann J; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Zeitelhofer M; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Stefanitsch C; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Torrente D; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA., Adzemovic MZ; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Matjunins K; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Randel SJ; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Lewandowski SA; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Muhl L; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Eriksson U; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Nilsson I; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Su EJ; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA., Lawrence DA; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA., Fredriksson L; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

Journal Article , 2025

Deletion of platelet-derived growth factor receptor β suppresses tumorigenesis in metabolic dysfunction-associated steatohepatitis (MASH) mice with diabetes.

Wada T; Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan. twada@pha.u-toyama.ac.jp., Takeda Y; Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan., Okekawa A; Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan., Komatsu G; Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan., Iwasa Y; Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan., Onogi Y; Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.; Research Center for Pre-Disease Science, University of Toyama, 2630 Sugitani, Toyama, Japan., Takasaki I; Department of Pharmacology, Graduate School of Science and Engineering, University of Toyama, 3190, Gofuku, Toyama, Japan., Hamashima T; Department of Pathology, University of Toyama, 2630 Sugitani, Toyama, Japan., Sasahara M; Department of Pathology, University of Toyama, 2630 Sugitani, Toyama, Japan., Tsuneki H; Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.; Department of Integrative Pharmacology, University of Toyama, 2630 Sugitani, Toyama, Japan., Sasaoka T; Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan. tsasaoka@pha.u-toyama.ac.jp.

Journal Article , 2024

Phase II trial of imatinib mesylate in patients with PDGFRA/B-negative hypereosinophilic syndrome.

Kim DH; Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.; Department of Translational Medicine, Seoul National University College of Medicine, Seoul, Korea., Kim S; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea., Park S; Department of Internal Medicine, Inje University Haeundae Paik Hospital, Busan, Korea., Byun JM; Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea., Hong J; Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.; Cancer for Medical Innovation, Seoul National University Hospital, Seoul, Korea., Shin DY; Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.; Cancer for Medical Innovation, Seoul National University Hospital, Seoul, Korea., Kim I; Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea., Bang SM; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea., Lee JO; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea., Lee JY; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea., Kim SA; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea., Kim KH; Department of Internal Medicine, Seoul National University Boramae Hospital, Seoul, Korea., Chung YJ; Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Korea.; Integrated Research Center for Genome Polymorphism, Precision Medicine Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea., Jung SH; Integrated Research Center for Genome Polymorphism, Precision Medicine Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea.; Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, Korea., Koh Y; Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.; Cancer for Medical Innovation, Seoul National University Hospital, Seoul, Korea., Yoon SS; Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.; Cancer for Medical Innovation, Seoul National University Hospital, Seoul, Korea.

Journal Article; Clinical Trial, Phase II , 2024

Imatinib is effective in some PDGFRA/B-negative hypereosinophilic syndromes: A step closer to unveiling underlying mechanisms.

Loscocco GG; Department of Experimental and Clinical Medicine, CRIMM, Center of Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliero-Universitaria Careggi, University of Florence, Florence, Italy., Helbig G; Department of Hematology and Bone Marrow Transplantation, Faculty of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

Journal Article , 2024

Cancer-associated fibroblast activation predicts progression, metastasis, and prognosis of cutaneous squamous cell carcinoma.

Knuutila JS; Department of Dermatology, University of Turku and Turku University Hospital, Turku, Finland.; FICAN West Cancer Research Laboratory, University of Turku and Turku University Hospital, Turku, Finland., Riihilä P; Department of Dermatology, University of Turku and Turku University Hospital, Turku, Finland.; FICAN West Cancer Research Laboratory, University of Turku and Turku University Hospital, Turku, Finland., Nissinen L; Department of Dermatology, University of Turku and Turku University Hospital, Turku, Finland.; FICAN West Cancer Research Laboratory, University of Turku and Turku University Hospital, Turku, Finland., Heiskanen L; Department of Dermatology, University of Turku and Turku University Hospital, Turku, Finland.; FICAN West Cancer Research Laboratory, University of Turku and Turku University Hospital, Turku, Finland., Kallionpää RE; Auria Biobank, Turku University Hospital and University of Turku, Turku, Finland., Pellinen T; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), Helsinki, Finland., Kähäri VM; Department of Dermatology, University of Turku and Turku University Hospital, Turku, Finland.; FICAN West Cancer Research Laboratory, University of Turku and Turku University Hospital, Turku, Finland.

Journal Article , 2024

Effects of pulsed electrical stimulation on α-smooth muscle actin and type I collagen expression in human dermal fibroblasts.

Urabe H; Homer Ion Laboratory Co., Ltd., Tokyo, Japan., Akimoto R; Homer Ion Laboratory Co., Ltd., Tokyo, Japan., Kamiya S; Homer Ion Laboratory Co., Ltd., Tokyo, Japan., Hosoki K; Homer Ion Laboratory Co., Ltd., Tokyo, Japan., Ichikawa H; Homer Ion Laboratory Co., Ltd., Tokyo, Japan., Nishiyama T; Homer Ion Laboratory Co., Ltd., Tokyo, Japan.; Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan.

Journal Article , 2024

PDGF-AA guides cell crosstalk between human dental pulp stem cells in vitro via the PDGFR-α/PI3K/Akt axis.

Xu S; State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China., Wei J; State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China., Liu Y; State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China., Zhang L; State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China., Duan M; State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China., Li J; State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China., Niu Z; State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China., Pu X; State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China., Huang M; State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China., Chen H; State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China., Zhou X; State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China., Xie J; State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.

Journal Article , 2024

Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity.

Okekawa A; Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan., Wada T; Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan. twada@pha.u-toyama.ac.jp., Onogi Y; Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.; Research Center for Pre-Disease Science, University of Toyama, 2630 Sugitani, Toyama, Japan., Takeda Y; Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan., Miyazawa Y; Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan., Sasahara M; Department of Pathology, University of Toyama, 2630 Sugitani, Toyama, Japan., Tsuneki H; Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.; Department of Integrative Pharmacology, University of Toyama, 2630 Sugitani, Toyama, Japan., Sasaoka T; Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan. tsasaoka@pha.u-toyama.ac.jp.

Journal Article , 2024

In the Rat Hippocampus, Pilocarpine-Induced Status Epilepticus Is Associated with Reactive Glia and Concomitant Increased Expression of CD31, PDGFRβ, and Collagen IV in Endothelial Cells and Pericytes of the Blood-Brain Barrier.

Kyriatzis G; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France, Institut de Neurophysiopathologie, Faculté de Médecine, 27 Bd Jean Moulin, 13005 Marseille, France., Bernard A; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France, Institut de Neurophysiopathologie, Faculté de Médecine, 27 Bd Jean Moulin, 13005 Marseille, France., Bôle A; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France, Institut de Neurophysiopathologie, Faculté de Médecine, 27 Bd Jean Moulin, 13005 Marseille, France., Khrestchatisky M; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France, Institut de Neurophysiopathologie, Faculté de Médecine, 27 Bd Jean Moulin, 13005 Marseille, France., Ferhat L; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France, Institut de Neurophysiopathologie, Faculté de Médecine, 27 Bd Jean Moulin, 13005 Marseille, France.

Journal Article , 2024

PDGFRα/β heterodimer activation negatively affects downstream ERK1/2 signaling and cellular proliferation.

Campaña MB; Department of Craniofacial Biology, School of Dental Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Perkins MR; Department of Craniofacial Biology, School of Dental Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., McCabe MC; Department of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Neumann A; Department of Craniofacial Biology, School of Dental Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Larson ED; Department of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA., Fantauzzo KA; Department of Craniofacial Biology, School of Dental Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. katherine.fantauzzo@cuanschutz.edu.

Journal Article , 2025

Effects of a PDGF-stem cell-hydrogel compound on skin wound healing in mice.

Lin J; Department of Endocrinology and Metabolism, The First Affiliated Hospital of Shantou University Medical College, Shantou, China; Shantou University Medical College, Shantou, China., Lin Z; Department of Endocrinology and Metabolism, Shantou Central Hospital, Shantou, China., Huang A; Department of Endocrinology and Metabolism, The First Affiliated Hospital of Shantou University Medical College, Shantou, China; Shantou University Medical College, Shantou, China., Wu X; Department of Endocrinology and Metabolism, The First Affiliated Hospital of Shantou University Medical College, Shantou, China; Shantou University Medical College, Shantou, China., Yan W; Guangdong Provincial Key Laboratory of Marine Biotechnology, Institute of Marine Sciences, Shantou University, Shantou, China., Liu D; Department of Pharmacy, Shantou University Medical College, Shantou, China., Wei C; Guangdong Provincial Key Laboratory of Marine Biotechnology, Institute of Marine Sciences, Shantou University, Shantou, China. Electronic address: chijuwei@stu.edu.cn., Xu W; Department of Endocrinology and Metabolism, The First Affiliated Hospital of Shantou University Medical College, Shantou, China; Shantou University Medical College, Shantou, China. Electronic address: xuwcan@163.com.

Journal Article , 2025

PDGF-Releasing Hydrogels for Enhanced Proliferation of Human Nucleus Pulposus Cells.

Fukunaga T; Musculoskeletal Institute, Emory University School of Medicine, Atlanta, Georgia, USA., Pearson JJ; Coulter Department of Biomedical Engineering, Georgia Tech/Emory University, Atlanta, Georgia, USA., Miller RC; Coulter Department of Biomedical Engineering, Georgia Tech/Emory University, Atlanta, Georgia, USA., Zhang C; Musculoskeletal Institute, Emory University School of Medicine, Atlanta, Georgia, USA.; Atlanta VA Medical Center, Decatur, Georgia, USA., Lakrat M; Musculoskeletal Institute, Emory University School of Medicine, Atlanta, Georgia, USA., Haglund L; Department of Surgery, McGill University, Montreal, Quebec, Canada., Diaz-Hernandez ME; Musculoskeletal Institute, Emory University School of Medicine, Atlanta, Georgia, USA.; Atlanta VA Medical Center, Decatur, Georgia, USA., Temenoff JS; Coulter Department of Biomedical Engineering, Georgia Tech/Emory University, Atlanta, Georgia, USA.; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, USA., Drissi H; Musculoskeletal Institute, Emory University School of Medicine, Atlanta, Georgia, USA.; Atlanta VA Medical Center, Decatur, Georgia, USA.; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, USA.

Journal Article , 2025

Applying Computational Protein Design to Engineer Affibodies for Affinity-controlled Delivery of Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor.

Svendsen JE; Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, Oregon 97403, United States.; Department of Chemistry and Biochemistry, University of Oregon, Eugene, Oregon 97403, United States.; Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403, United States., Ford MR; Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, Oregon 97403, United States.; Department of Human Physiology, University of Oregon, Eugene, Oregon 97403, United States., Asnes CL; Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, Oregon 97403, United States., Oh SC; Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, Oregon 97403, United States.; Department of Biology, University of Oregon, Eugene, Oregon 97403, United States., Dorogin J; Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, Oregon 97403, United States., Fear KM; Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, Oregon 97403, United States., O'Hara-Smith JR; Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403, United States.; Department of Biology, University of Oregon, Eugene, Oregon 97403, United States., Chisholm LO; Department of Chemistry and Biochemistry, University of Oregon, Eugene, Oregon 97403, United States.; Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403, United States., Phillips SR; Department of Chemistry and Biochemistry, University of Oregon, Eugene, Oregon 97403, United States.; Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403, United States., Harms MJ; Department of Chemistry and Biochemistry, University of Oregon, Eugene, Oregon 97403, United States.; Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403, United States., Hosseinzadeh P; Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, Oregon 97403, United States.; Department of Chemistry and Biochemistry, University of Oregon, Eugene, Oregon 97403, United States.; Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403, United States., Hettiaratchi MH; Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, Oregon 97403, United States.; Department of Chemistry and Biochemistry, University of Oregon, Eugene, Oregon 97403, United States.; Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403, United States.

Journal Article , 2025

ECM remodeling by PDGFRβ+ dental pulp stem cells drives angiogenesis and pulp regeneration via integrin signaling.

Di T; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Department of Pediatric Dentistry, School of Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, People's Republic of China.; Department of Stomatology, No. 969 Hospital, Joint Logistics Support Force of the Chinese People's Liberation Army, Hohhot, 010000, Inner Mongolia, People's Republic of China., Wang L; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Department of Pediatric Dentistry, School of Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, People's Republic of China., Feng C; Department of clinical laboratory, No. 969 Hospital, Joint Logistics Support Force of the Chinese People's Liberation Army, Hohhot, 010000, Inner Mongolia, People's Republic of China., Xu J; Department of Stomatology, No. 969 Hospital, Joint Logistics Support Force of the Chinese People's Liberation Army, Hohhot, 010000, Inner Mongolia, People's Republic of China., Shao B; Digital Center of Oral Implantology, Inner Mongolia People's Hospital, Hohhot, 010000, Inner Mongolia, People's Republic of China., Cheng B; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, Department of General Dentistry, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710032, Shaanxi, People's Republic of China., Wang L; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, Department of Orthodontics, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710032, Shaanxi, People's Republic of China., Zhang X; College of Life Sciences, Northwest University, Xi'an, 710069, People's Republic of China. zx443223512@163.com., Zhang L; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Shanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, National Clinical Research Center for Oral Diseases, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, People's Republic of China. lzhang.dent@foxmail.com., Chen Y; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Department of Pediatric Dentistry, School of Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, People's Republic of China. chenyj@fmmu.edu.cn.; Department of Neurobiology and Institute of Neurosciences, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, Shaanxi, People's Republic of China. chenyj@fmmu.edu.cn.

Journal Article , 2025

Pericyte Biomarkers for Ischemic Stroke: Potential and Prospects.

Wang W; Department of Neurology, Second Affiliated Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong 271000, China.; Institute of Brain Science and Brain-inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong Province 250117, China., Han Q; Department of Neurology, Second Affiliated Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong 271000, China.; Institute of Brain Science and Brain-inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong Province 250117, China.; School of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355 Shandong, China., Wang T; Department of Neurology, Second Affiliated Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong 271000, China.; Institute of Brain Science and Brain-inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong Province 250117, China., Liu J; Department of Neurology, Second Affiliated Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong 271000, China.; Institute of Brain Science and Brain-inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong Province 250117, China., Ni Q; The Affiliated Taian City Central Hospital of Qingdao University, Taian, Shandong 271000, China., Sun J; Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China., Wang Y; Department of Neurology, Second Affiliated Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong 271000, China., Sun B; Department of Neurology, Second Affiliated Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong 271000, China.; Institute of Brain Science and Brain-inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong Province 250117, China.; The Affiliated Taian City Central Hospital of Qingdao University, Taian, Shandong 271000, China.

Journal Article , 2025

Edaravone targets PDGFRβ to attenuate VSMC phenotypic transition.

Tang X; Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; Beijing Key Laboratory of Cardiovascular Receptors Research; Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing 100191, China., Estau D; Department of Pharmacy, Peking University Third Hospital, Beijing 100191, China; Department of Pharmaceutical Management and Clinical Pharmacy, College of Pharmacy, Peking University, Beijing, China., Huang X; Department of Pharmacy, Peking University Third Hospital, Beijing 100191, China; Department of Pharmaceutical Management and Clinical Pharmacy, College of Pharmacy, Peking University, Beijing, China., Li Z; Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; Beijing Key Laboratory of Cardiovascular Receptors Research; Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing 100191, China; Department of Pharmacy, Peking University Third Hospital, Beijing 100191, China; Department of Pharmaceutical Management and Clinical Pharmacy, College of Pharmacy, Peking University, Beijing, China. Electronic address: lizijian@bjmu.edu.cn.

Journal Article , 2025

Pdgfrβ marks distinct mesenchymal and pericyte populations within the periosteum with overlapping cellular features.

Wang Z; Department of Pathology, Johns Hopkins University, Baltimore, MD, USA., Qin Q; Department of Pathology, Johns Hopkins University, Baltimore, MD, USA., Thottappillil N; Department of Pathology, Johns Hopkins University, Baltimore, MD, USA., Gomez Salazar M; Department of Pathology, Johns Hopkins University, Baltimore, MD, USA., Cherief M; Department of Pathology, Johns Hopkins University, Baltimore, MD, USA., Archer M; Department of Pathology, Johns Hopkins University, Baltimore, MD, USA., Balaji D; Department of Pathology, Johns Hopkins University, Baltimore, MD, USA., James AW; Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.

Journal Article , 2025

Targeted inhibition of PDGFRA with avapritinib, markedly enhances lenvatinib efficacy in hepatocellular carcinoma in vitro and in vivo: clinical implications.

Zhao B; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, P. R. China.; Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, P. R. China., Zhou Y; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, P. R. China.; Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, P. R. China., Cheng N; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, P. R. China.; Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, P. R. China., Zheng X; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, P. R. China.; Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, P. R. China., Chen G; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, P. R. China.; Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, P. R. China., Qi X; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, P. R. China.; Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, P. R. China., Zhang X; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, P. R. China.; Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, P. R. China., Wang F; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, P. R. China.; Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, P. R. China., Zhuang Q; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, P. R. China.; Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, P. R. China., Assaraf YG; The Fred Wyszkowski Cancer Research Laboratory, Faculty of Biology, Technion-Israel Institute of Technology, Haifa, 3200003, Israel. assaraf@technion.ac.il., Liu X; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, P. R. China. xiaoloong.liu@gmail.com.; Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, P. R. China. xiaoloong.liu@gmail.com., Wang Y; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, P. R. China. yingchaowang@live.com.; Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, P. R. China. yingchaowang@live.com., Zeng Y; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, P. R. China. lamp197311@126.com.; Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, P. R. China. lamp197311@126.com.

Journal Article , 2025

Dual inhibition of TGFβ and PDGF improves RV remodeling and function in response to RV pressure or volume-loading.

Dauz JD; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.; Division of Cardiology, Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada., Yazaki K; Division of Cardiology, Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada., Akazawa Y; Division of Cardiology, Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada., Meister TA; Division of Cardiology, Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada., Kabir G; Li Ka Shing Knowledge Institute, Keenan Research Centre, St. Michael's Hospital, Toronto, Ontario, Canada., Kadowaki S; Division of Cardiology, Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada., Honjo O; Division of Cardiovascular Surgery, The Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada., Heximer SP; Department of Physiology, University of Toronto, Toronto, Ontario, Canada., Wald RM; Division of Cardiology, Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, Toronto, Ontario, Canada., Connelly KA; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.; Li Ka Shing Knowledge Institute, Keenan Research Centre, St. Michael's Hospital, Toronto, Ontario, Canada.; Department of Physiology, University of Toronto, Toronto, Ontario, Canada., Friedberg MK; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.; Division of Cardiology, Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.

Journal Article , 2025

PDGFR-α Mediated the Neuroinflammation and Autophagy via the JAK2/STAT3 Signaling Pathway Contributing to Depression-Like Behaviors in Myofascial Pain Syndrome Rats.

Liu Y; Department of Anesthesiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, No. 107 Wenhua Xi Road, Jinan, 250012, Shandong, China.; Institute of Basic Medical Sciences, Qilu Hospital, Shandong University, Jinan, Shandong, China., Jin F; Department of Anesthesiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, No. 107 Wenhua Xi Road, Jinan, 250012, Shandong, China., Chen Q; Department of Anesthesiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, No. 107 Wenhua Xi Road, Jinan, 250012, Shandong, China.; Institute of Basic Medical Sciences, Qilu Hospital, Shandong University, Jinan, Shandong, China., Liu M; Department of Anesthesiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, No. 107 Wenhua Xi Road, Jinan, 250012, Shandong, China.; Institute of Basic Medical Sciences, Qilu Hospital, Shandong University, Jinan, Shandong, China.; Department of Anesthesiology, Shandong First Medical University Affiliated Binzhou People's Hospital, Binzhou, Shandong, China., Li X; Department of Anesthesiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, No. 107 Wenhua Xi Road, Jinan, 250012, Shandong, China.; Institute of Basic Medical Sciences, Qilu Hospital, Shandong University, Jinan, Shandong, China., Zhou L; Department of Anesthesiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, No. 107 Wenhua Xi Road, Jinan, 250012, Shandong, China.; Institute of Basic Medical Sciences, Qilu Hospital, Shandong University, Jinan, Shandong, China., Li X; Department of Anesthesiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, No. 107 Wenhua Xi Road, Jinan, 250012, Shandong, China.; Institute of Basic Medical Sciences, Qilu Hospital, Shandong University, Jinan, Shandong, China., Yang S; Department of Anesthesiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, No. 107 Wenhua Xi Road, Jinan, 250012, Shandong, China., Qi F; Department of Anesthesiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, No. 107 Wenhua Xi Road, Jinan, 250012, Shandong, China. 198962001111@sdu.edu.cn.

Journal Article , 2025