Search Results - "RNA replication"

Inhibition of early RNA replication in Chikungunya and Dengue virus by lycorine: In vitro and in silico studies.

Agrawal T; Centre for Immunobiology and Immunotherapy, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, 3rd Milestone, Faridabad, 121001, Haryana, India; Centre for Virus Research, Therapeutics and Vaccines, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, 3rd Milestone, Faridabad, 121001, Haryana, India. Electronic address: tanvi@thsti.res.in., Siddqui G; Centre for Virus Research, Therapeutics and Vaccines, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, 3rd Milestone, Faridabad, 121001, Haryana, India., Dahiya R; Computational Biophysics and CADD Group, Computational and Mathematical Biology Centre (CMBC), Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, 3rd Milestone, Faridabad, 121001, Haryana, India., Patidar A; Centre for Immunobiology and Immunotherapy, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, 3rd Milestone, Faridabad, 121001, Haryana, India., Madan U; Centre for Immunobiology and Immunotherapy, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, 3rd Milestone, Faridabad, 121001, Haryana, India., Das S; Centre for Virus Research, Therapeutics and Vaccines, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, 3rd Milestone, Faridabad, 121001, Haryana, India., Asthana S; Computational Biophysics and CADD Group, Computational and Mathematical Biology Centre (CMBC), Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, 3rd Milestone, Faridabad, 121001, Haryana, India., Samal S; Centre for Virus Research, Therapeutics and Vaccines, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, 3rd Milestone, Faridabad, 121001, Haryana, India., Awasthi A; Centre for Immunobiology and Immunotherapy, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, 3rd Milestone, Faridabad, 121001, Haryana, India. Electronic address: aawasthi@thsti.res.in.

Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't , 2024

RNA replication-independent, DNA linearization-dependent expression of reporter genes from a SARS-CoV-2 replicon-encoding DNA in human cells.

Friedhoff R; Department of Medical Biology, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada., Elfayres G; Department of Medical Biology, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada., Mérindol N; Department of Chemistry, Biochemistry and Physics, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada., Desgagné-Penix I; Department of Chemistry, Biochemistry and Physics, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada., Berthoux L; Department of Medical Biology, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada.

Journal Article , 2024

Structural flexibility in the ordered domain of the dengue virus strain 2 capsid protein is critical for chaperoning viral RNA replication.

Sharma KK; Centre for Bioimaging Sciences, National University of Singapore, 14 Science Drive 4, Singapore, 117557, Singapore. dbskks@nus.edu.sg.; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore, 117543, Singapore. dbskks@nus.edu.sg., Raghuvamsi PV; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore, 138671, Republic of Singapore., Aik DYK; Centre for Bioimaging Sciences, National University of Singapore, 14 Science Drive 4, Singapore, 117557, Singapore.; Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Singapore., Marzinek JK; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore, 138671, Republic of Singapore., Bond PJ; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore, 117543, Singapore.; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore, 138671, Republic of Singapore., Wohland T; Centre for Bioimaging Sciences, National University of Singapore, 14 Science Drive 4, Singapore, 117557, Singapore. twohland@nus.edu.sg.; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore, 117543, Singapore. twohland@nus.edu.sg.; Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Singapore. twohland@nus.edu.sg.

Journal Article , 2025

The Phlebovirus Ribonucleoprotein: An Overview

Ferron, François^{Aff3, Aff4}, Lescar, Julien^{Aff5, Aff6}

Lozach, Pierre-Yves^Aff2, Walker, John M.^Aff1

Enhanced RNA replication and pathogenesis in recent SARS-CoV-2 variants harboring the L260F mutation in NSP6.

Taha TY; Gladstone Institutes, San Francisco, California, United States of America.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, United States of America., Ezzatpour S; Department of Microbiology, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, United States of America.; Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, New York, United States of America., Hayashi JM; Gladstone Institutes, San Francisco, California, United States of America., Ye C; Texas Biomedical Research Institute, San Antonio, Texas, United States of America., Zapatero-Belinchón FJ; Gladstone Institutes, San Francisco, California, United States of America., Rosecrans JA; Gladstone Institutes, San Francisco, California, United States of America., Kimmerly GR; Gladstone Institutes, San Francisco, California, United States of America., Chen IP; Gladstone Institutes, San Francisco, California, United States of America.; Department of Medicine, University of California, San Francisco, California, United States of America., Walcott K; Gladstone Institutes, San Francisco, California, United States of America., Kurianowicz A; Gladstone Institutes, San Francisco, California, United States of America., Jorgens DM; Electron Microscope Laboratory, University of California, Berkeley, California, United States of America., Chaplin NR; Electron Microscope Laboratory, University of California, Berkeley, California, United States of America., Choi A; Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, New York, United States of America., Buchholz DW; Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, New York, United States of America., Sahler J; Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, New York, United States of America., Hilt ZT; Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, New York, United States of America., Imbiakha B; Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, New York, United States of America., Vagi-Szmola C; Gladstone Institutes, San Francisco, California, United States of America., Montano M; Gladstone Institutes, San Francisco, California, United States of America., Stevenson E; Gladstone Institutes, San Francisco, California, United States of America.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America.; Quantitative Biosciences Institute (QBI), University of California, San Francisco, California, United States of America.; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America., Gordon M; Gladstone Institutes, San Francisco, California, United States of America.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America.; Quantitative Biosciences Institute (QBI), University of California, San Francisco, California, United States of America.; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America., Swaney DL; Gladstone Institutes, San Francisco, California, United States of America.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America.; Quantitative Biosciences Institute (QBI), University of California, San Francisco, California, United States of America.; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America., Krogan NJ; Gladstone Institutes, San Francisco, California, United States of America.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, United States of America.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America.; Quantitative Biosciences Institute (QBI), University of California, San Francisco, California, United States of America.; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America., Whittaker GR; Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, New York, United States of America., Martinez-Sobrido L; Texas Biomedical Research Institute, San Antonio, Texas, United States of America., Aguilar HC; Department of Microbiology, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, United States of America.; Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, New York, United States of America., Ott M; Gladstone Institutes, San Francisco, California, United States of America.; Department of Medicine, University of California, San Francisco, California, United States of America.; Chan Zuckerberg Biohub - San Francisco, San Francisco, California, United States of America.

Journal Article , 2025

Orthogonal RNA replication enables directed evolution and Darwinian adaptation in mammalian cells.

Ma L; Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.; The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing, China., Lin Y; Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China. yihan.lin@pku.edu.cn.; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China. yihan.lin@pku.edu.cn.; The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing, China. yihan.lin@pku.edu.cn.; Chengdu Academy for Advanced Interdisciplinary Biotechnologies, Peking University, Chengdu, China. yihan.lin@pku.edu.cn.

Journal Article , 2025

Nonenzymatic RNA replication in a mixture of 'spent' nucleotides.

Patki GM; Department of Biology, Indian Institute of Science Education and Research, Pune, Maharashtra, India., Rajamani S; Department of Biology, Indian Institute of Science Education and Research, Pune, Maharashtra, India.

Journal Article; Research Support, Non-U.S. Gov't , 2023

IFITM1 enhances nonenveloped viral RNA replication by facilitating cholesterol transport to the Golgi.

Ishikawa-Sasaki K; Department of Virology, Fujita Health University School of Medicine, Kutsukakecho, Toyoake, Aichi, Japan., Murata T; Department of Virology, Fujita Health University School of Medicine, Kutsukakecho, Toyoake, Aichi, Japan., Sasaki J; Department of Virology, Fujita Health University School of Medicine, Kutsukakecho, Toyoake, Aichi, Japan.

Journal Article; Research Support, Non-U.S. Gov't , 2023

Experimental Tests of the Virtual Circular Genome Model for Nonenzymatic RNA Replication.

Ding D; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, United States., Zhou L; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, United States.; Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Mittal S; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, United States.; Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Szostak JW; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, United States.; Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.; Howard Hughes Medical Institute, Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, United States.

Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. , 2023

cis -Acting Element at the 5' Noncoding Region of Tacaribe Virus S RNA Modulates Genome Replication.

D'Antuono AL; Centro de Virología Humana y Animal, Consejo Nacional de Investigaciones Científicas y Técnicas-Universidad Abierta Interamericana, Buenos Aires, Argentina., Gallo GL; Centro de Virología Humana y Animal, Consejo Nacional de Investigaciones Científicas y Técnicas-Universidad Abierta Interamericana, Buenos Aires, Argentina., Sepulveda C; Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.; Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales, Consejo Nacional de Investigaciones Científicas y Técnicas-Universidad de Buenos Aires, Buenos Aires, Argentina., Fernández J; Centro de Virología Humana y Animal, Consejo Nacional de Investigaciones Científicas y Técnicas-Universidad Abierta Interamericana, Buenos Aires, Argentina., Brignone J; Instituto Nacional de Enfermedades Virales Humanas Dr. Julio I. Maiztegui, ANLIS-Malbran, Ministerio de Salud de la Nación, Pergamino, Buenos Aires, Argentina., Gamboa G; Instituto Nacional de Enfermedades Virales Humanas Dr. Julio I. Maiztegui, ANLIS-Malbran, Ministerio de Salud de la Nación, Pergamino, Buenos Aires, Argentina., Riera L; Instituto Nacional de Enfermedades Virales Humanas Dr. Julio I. Maiztegui, ANLIS-Malbran, Ministerio de Salud de la Nación, Pergamino, Buenos Aires, Argentina., Saavedra MDC; Instituto Nacional de Enfermedades Virales Humanas Dr. Julio I. Maiztegui, ANLIS-Malbran, Ministerio de Salud de la Nación, Pergamino, Buenos Aires, Argentina., López N; Centro de Virología Humana y Animal, Consejo Nacional de Investigaciones Científicas y Técnicas-Universidad Abierta Interamericana, Buenos Aires, Argentina.

Journal Article; Research Support, Non-U.S. Gov't , 2023

Multifunctional Protein A Is the Only Viral Protein Required for Nodavirus RNA Replication Crown Formation.

den Boon JA; John W. and Jeanne M. Rowe Center for Research in Virology, Morgridge Institute for Research, Madison, WI 53715, USA.; Institute for Molecular Virology, University of Wisconsin-Madison, Madison, WI 53706, USA.; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI 53705, USA., Zhan H; John W. and Jeanne M. Rowe Center for Research in Virology, Morgridge Institute for Research, Madison, WI 53715, USA.; Institute for Molecular Virology, University of Wisconsin-Madison, Madison, WI 53706, USA., Unchwaniwala N; John W. and Jeanne M. Rowe Center for Research in Virology, Morgridge Institute for Research, Madison, WI 53715, USA.; Institute for Molecular Virology, University of Wisconsin-Madison, Madison, WI 53706, USA., Horswill M; John W. and Jeanne M. Rowe Center for Research in Virology, Morgridge Institute for Research, Madison, WI 53715, USA.; Institute for Molecular Virology, University of Wisconsin-Madison, Madison, WI 53706, USA.; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI 53705, USA., Slavik K; John W. and Jeanne M. Rowe Center for Research in Virology, Morgridge Institute for Research, Madison, WI 53715, USA.; Institute for Molecular Virology, University of Wisconsin-Madison, Madison, WI 53706, USA., Pennington J; John W. and Jeanne M. Rowe Center for Research in Virology, Morgridge Institute for Research, Madison, WI 53715, USA.; Institute for Molecular Virology, University of Wisconsin-Madison, Madison, WI 53706, USA., Navine A; John W. and Jeanne M. Rowe Center for Research in Virology, Morgridge Institute for Research, Madison, WI 53715, USA.; Institute for Molecular Virology, University of Wisconsin-Madison, Madison, WI 53706, USA., Ahlquist P; John W. and Jeanne M. Rowe Center for Research in Virology, Morgridge Institute for Research, Madison, WI 53715, USA.; Institute for Molecular Virology, University of Wisconsin-Madison, Madison, WI 53706, USA.; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI 53705, USA.

Journal Article; Research Support, Non-U.S. Gov't , 2022

Requirement of the N-terminal region of nonstructural protein 1 in cis for SARS-CoV-2 defective RNA replication.

Terasaki K; Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, USA.; Institute for Human Infection and Immunity, The University of Texas Medical Branch, Galveston, Texas, USA., Makino S; Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, USA.; Institute for Human Infection and Immunity, The University of Texas Medical Branch, Galveston, Texas, USA.; Center for Biodefense and Emerging Infectious Diseases, The University of Texas Medical Branch, Galveston, Texas, USA.; UTMB Center for Tropical Diseases, The University of Texas Medical Branch, Galveston, Texas, USA.; Sealy Center for Vaccine Development, The University of Texas Medical Branch, Galveston, Texas, USA.

Journal Article , 2024

Tanomastat exerts multi-targeted inhibitory effects on viral capsid dissociation and RNA replication in human enteroviruses.

Lim TYM; Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Jaladanki CK; Bioinformatics Institute, Agency for Science, Technology and Research (A∗STAR), 30 Biopolis Street, Matrix #07-01, 138671, Singapore., Wong YH; NUSMed Biosafety Level 3 Core Facility, Yong Loo Lin School of Medicine, National University of Singapore, 14 Medical Drive, 117599, Singapore., Yogarajah T; Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Infectious Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore. Electronic address: micthiy@nus.edu.sg., Fan H; Bioinformatics Institute, Agency for Science, Technology and Research (A∗STAR), 30 Biopolis Street, Matrix #07-01, 138671, Singapore; Synthetic Biology Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Drive, 117597, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, 117596, Singapore; Duke-NUS Medical School, 8 College Rd, 169857, Singapore. Electronic address: fanh@bii.a-star.edu.sg., Chu JJH; Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; NUSMed Biosafety Level 3 Core Facility, Yong Loo Lin School of Medicine, National University of Singapore, 14 Medical Drive, 117599, Singapore; Infectious Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Drive, Proteos #06-05, 138673, Singapore. Electronic address: miccjh@nus.edu.sg.

Journal Article , 2024

MK-0608 inhibits in vitro and in vivo RNA replication of infectious pancreatic necrosis virus.

Li L; University of Shanghai Ocean University, College of Fisheries and Life Sciences, Shanghai, China; Department of Aquatic Animal Diseases and Control, Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences, China., Zhao J; Department of Aquatic Animal Diseases and Control, Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences, China; Key Laboratory of Aquatic Animal Diseases and Immune Technology of Heilongjiang Province, Harbin, China., Shao Y; Department of Aquatic Animal Diseases and Control, Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences, China; Key Laboratory of Aquatic Animal Diseases and Immune Technology of Heilongjiang Province, Harbin, China., Ma J; Department of Fish and Wildlife Sciences, University of Idaho, USA., Lu T; Department of Aquatic Animal Diseases and Control, Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences, China; Key Laboratory of Aquatic Animal Diseases and Immune Technology of Heilongjiang Province, Harbin, China. Electronic address: lutongyan@hrfri.ac.cn., Xu L; Department of Aquatic Animal Diseases and Control, Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences, China; Key Laboratory of Aquatic Animal Diseases and Immune Technology of Heilongjiang Province, Harbin, China. Electronic address: lmxu0917@163.com.

Journal Article , 2024

HCV 5-Methylcytosine Enhances Viral RNA Replication through Interaction with m5C Reader YBX1.

Li ZL; Hubei Province Key Laboratory of Allergy and Immunology, Department of Immunology Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China., Xie Y; Hubei Province Key Laboratory of Allergy and Immunology, Department of Immunology Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China., Xie Y; Hubei Province Key Laboratory of Allergy and Immunology, Department of Immunology Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China., Chen H; Hubei Province Key Laboratory of Allergy and Immunology, Department of Immunology Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China., Zhou X; Department of Chemistry and Molecular Science, Wuhan University, Wuhan 430070, Hubei Province, China., Liu M; Hubei Province Key Laboratory of Allergy and Immunology, Department of Immunology Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China., Zhang XL; Hubei Province Key Laboratory of Allergy and Immunology, Department of Immunology Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China.; State Key Laboratory of Virology, Frontier Science Center for Immunology and Metabolism, Wuhan University School of Medicine, Wuhan 430071, China.

Journal Article; Research Support, Non-U.S. Gov't , 2024

Host caveolin-1 facilitates Zika virus infection by promoting viral RNA replication.

Zhang Q; Unit of Cell Biology and Imaging Study of Pathogen Host Interaction, The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai 200031, China., Zhang Y; Unit of Cell Biology and Imaging Study of Pathogen Host Interaction, The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai 200031, China.; University of Chinese Academy of Sciences, Yuquan Road No. 19(A), Shijingshan District, Beijing 100049, China., Jiu Y; Unit of Cell Biology and Imaging Study of Pathogen Host Interaction, The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai 200031, China.; University of Chinese Academy of Sciences, Yuquan Road No. 19(A), Shijingshan District, Beijing 100049, China.; Key Laboratory of Virology and Biosafety, Chinese Academy of Sciences, Wuhan, 430071, China.

Journal Article; Research Support, Non-U.S. Gov't , 2024

Visualization of Early RNA Replication Kinetics of SARS-CoV-2 by Using Single Molecule RNA-FISH Combined with Immunofluorescence.

Pathak R; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Eliscovich C; Department of Medicine (Hepatology), Albert Einstein College of Medicine, Bronx, NY 10461, USA.; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Mena I; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Cupic A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Rutkowska M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA., García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Singer RH; Departments of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.; Departments of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Kalpana GV; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Journal Article , 2024

Viral RNA Replication Suppression of SARS-CoV-2: Atomistic Insights into Inhibition Mechanisms of RdRp Machinery by ddhCTP.

Ciardullo G; Dipartimento di Chimica E Tecnologie Chimiche, Laboratorio PROMOCS Cubo 14C, Università della Calabria, RENDE (CS) I-87036, Italy., Parise A; Consiglio Nazionale Delle Ricerche (CNR)-IOM C/O International School for Advanced Studies (SISSA/ISAS), Via Bonomea 265, Trieste 34136, Italy., Prejanò M; Dipartimento di Chimica E Tecnologie Chimiche, Laboratorio PROMOCS Cubo 14C, Università della Calabria, RENDE (CS) I-87036, Italy., Marino T; Dipartimento di Chimica E Tecnologie Chimiche, Laboratorio PROMOCS Cubo 14C, Università della Calabria, RENDE (CS) I-87036, Italy.

Journal Article; Research Support, Non-U.S. Gov't , 2024

Identification and Functional Characterization of Viroid Viroids Circular RNAs Circular RNAs (circRNAs)

Daròs, José-Antonio^Aff3

Vaschetto, Luis María^Aff2, Walker, John M.^Aff1

Early enterovirus translation deficits extend viral RNA replication and elicit sustained MDA5-directed innate signaling.

Dobrikov MI; Department of Neurosurgery, Duke University Medical School, Durham, North Carolina, USA., Dobrikova EY; Department of Neurosurgery, Duke University Medical School, Durham, North Carolina, USA., Nardone-White DT; Department of Neurosurgery, Duke University Medical School, Durham, North Carolina, USA.; Department of Molecular Genetics and Microbiology, Duke University Medical School, Durham, North Carolina, USA., McKay ZP; Department of Neurosurgery, Duke University Medical School, Durham, North Carolina, USA., Brown MC; Department of Neurosurgery, Duke University Medical School, Durham, North Carolina, USA., Gromeier M; Department of Neurosurgery, Duke University Medical School, Durham, North Carolina, USA.; Department of Molecular Genetics and Microbiology, Duke University Medical School, Durham, North Carolina, USA.

Journal Article , 2023