Search Results - "Randomized Controlled Trials as Topic"

Integration of non-randomized studies with randomized controlled trials in meta-analyses of clinical studies: a meta-epidemiological study on effect estimation of interventions.

Mei F; Institute of Integrated Traditional Chinese and Western Medicine, Chinese Evidence-Based Medicine Center, Cochrane China and MAGIC China Center, West China Hospital, Sichuan University, Chengdu, China.; NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan, Chengdu, China.; Sichuan Center of Technology Innovation for Real World Data, Chengdu, China., Yao M; Institute of Integrated Traditional Chinese and Western Medicine, Chinese Evidence-Based Medicine Center, Cochrane China and MAGIC China Center, West China Hospital, Sichuan University, Chengdu, China.; NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan, Chengdu, China.; Sichuan Center of Technology Innovation for Real World Data, Chengdu, China., Wang Y; Institute of Integrated Traditional Chinese and Western Medicine, Chinese Evidence-Based Medicine Center, Cochrane China and MAGIC China Center, West China Hospital, Sichuan University, Chengdu, China.; NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan, Chengdu, China.; Sichuan Center of Technology Innovation for Real World Data, Chengdu, China., Huan J; Institute of Integrated Traditional Chinese and Western Medicine, Chinese Evidence-Based Medicine Center, Cochrane China and MAGIC China Center, West China Hospital, Sichuan University, Chengdu, China.; NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan, Chengdu, China.; Sichuan Center of Technology Innovation for Real World Data, Chengdu, China., Ma Y; Institute of Integrated Traditional Chinese and Western Medicine, Chinese Evidence-Based Medicine Center, Cochrane China and MAGIC China Center, West China Hospital, Sichuan University, Chengdu, China.; NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan, Chengdu, China.; Sichuan Center of Technology Innovation for Real World Data, Chengdu, China., Li G; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.; Center for Clinical Epidemiology and Methodology, Guangdong Second Provincial General Hospital, Guangzhou, China.; Biostatistics Unit, Research Institute at St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada., Zou K; Institute of Integrated Traditional Chinese and Western Medicine, Chinese Evidence-Based Medicine Center, Cochrane China and MAGIC China Center, West China Hospital, Sichuan University, Chengdu, China.; NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan, Chengdu, China.; Sichuan Center of Technology Innovation for Real World Data, Chengdu, China., Li L; Institute of Integrated Traditional Chinese and Western Medicine, Chinese Evidence-Based Medicine Center, Cochrane China and MAGIC China Center, West China Hospital, Sichuan University, Chengdu, China. liling@wchscu.cn.; NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan, Chengdu, China. liling@wchscu.cn.; Sichuan Center of Technology Innovation for Real World Data, Chengdu, China. liling@wchscu.cn., Sun X; Institute of Integrated Traditional Chinese and Western Medicine, Chinese Evidence-Based Medicine Center, Cochrane China and MAGIC China Center, West China Hospital, Sichuan University, Chengdu, China. sunxin@wchscu.cn.; NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan, Chengdu, China. sunxin@wchscu.cn.; Sichuan Center of Technology Innovation for Real World Data, Chengdu, China. sunxin@wchscu.cn.; Department of Epidemiology and Biostatistics, School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. sunxin@wchscu.cn.

Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't , 2024

A meta-epidemiological analysis of post-hoc comparisons and primary endpoint interpretability among randomized noncomparative trials in clinical medicine.

Sherry AD; Division of Radiation Oncology, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Msaouel P; Division of Cancer Medicine, Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Division of Pathology/Lab Medicine, Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: PMsaouel@mdanderson.org., Ludmir EB; Division of Radiation Oncology, Department of Gastrointestinal Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: ebludmir@mdanderson.org.

Journal Article , 2024

Treatment Effects in Randomized and Nonrandomized Studies of Pharmacological Interventions: A Meta-Analysis.

Salcher-Konrad M; Department of Health Policy, London School of Economics and Political Science, London, United Kingdom.; World Health Organization Collaborating Centre for Pharmaceutical Pricing and Reimbursement Policies, Pharmacoeconomics Department, Gesundheit Österreich GmbH (GÖG)/Austrian National Public Health Institute, Vienna, Austria., Nguyen M; Department of Health Policy, London School of Economics and Political Science, London, United Kingdom.; Department of Family and Community Medicine, University of California, San Francisco., Savovic J; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.; National Institute for Health and Care Research Applied Research Collaboration West, University Hospitals Bristol and Weston National Health Service Foundation Trust, Bristol, United Kingdom., Higgins JPT; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.; National Institute for Health and Care Research Applied Research Collaboration West, University Hospitals Bristol and Weston National Health Service Foundation Trust, Bristol, United Kingdom., Naci H; Department of Health Policy, London School of Economics and Political Science, London, United Kingdom.

Journal Article; Meta-Analysis , 2024

Problematic meta-analyses: Bayesian and frequentist perspectives on combining randomized controlled trials and non-randomized studies.

Moran JL; The Queen Elizabeth Hospital, Woodville, SA, 5011, Australia. john.moran@adelaide.edu.au., Linden A; Department of Medicine, School of Medicine, University of California, San Francisco, USA.

Journal Article; Research Support, Non-U.S. Gov't , 2024

Single-arm phase 3 designs: An oxymoron?

Hussein A; ECSTRRA, 1, avenue Claude Vellefaux, Paris 75010, France., Levy V; ECSTRRA, 1, avenue Claude Vellefaux, Paris 75010, France; D́epartement de Recherche Clinique, Hôpital Avicenne, Bobigny 93000, France., Chevret S; ECSTRRA, 1, avenue Claude Vellefaux, Paris 75010, France; Institut Universitaire de France, Paris 75, France. Electronic address: sylvie.chevret@u-paris.fr.

Journal Article; Review , 2024

Comprehensive care programmes for children with medical complexity.

Harvey AR; Neurodisability and Rehabilitation, Murdoch Children's Research Institute, Melbourne, Australia., Meehan E; Neurodisability and Rehabilitation, Murdoch Children's Research Institute, Melbourne, Australia., Merrick N; Department of Paediatrics, The University of Melbourne, Melbourne, Australia., D'Aprano AL; Department of Paediatrics, The University of Melbourne, Melbourne, Australia., Cox GR; Neurodevelopment and Disability, Royal Children's Hospital, Melbourne, Australia., Williams K; Department of Paediatrics, Monash University, Melbourne, Australia., Gibb SM; Neurodevelopment and Disability, Royal Children's Hospital, Melbourne, Australia., Mountford NJ; Complex Care Hub, The Royal Children's Hospital, Melbourne, Australia., Connell TG; General Medicine, The Royal Children's Hospital, Melbourne, Australia., Cohen E; Paediatrics and Health Policy, Management & Evaluation, University of Toronto, Toronto, Canada.

Journal Article; Review; Systematic Review , 2024

Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support.

Radford M; McMaster Centre for Transfusion Research, McMaster University, Hamilton, Canada.; Department of Oncology, Hamilton Health Sciences Centre, Hamilton, Canada., Estcourt LJ; Haematology/Transfusion Medicine, NHS Blood and Transplant, Oxford, UK.; Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, UK., Sirotich E; Medicine, Yale School of Medicine, New Haven, Connecticut, USA., Pitre T; Medicine, University of Toronto, Toronto, Canada., Britto J; Oncology, Hamilton Health Sciences Centre, Hamilton, Canada., Watson M; Medicine, University of Toronto, Toronto, Canada., Brunskill SJ; Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, UK.; Systematic Review Initiative, NHS Blood and Transplant, Oxford, UK., Fergusson DA; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada., Dorée C; Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, UK.; Systematic Review Initiative, NHS Blood and Transplant, Oxford, UK., Arnold DM; Division of Hematology and Thromboembolism, Department of Medicine, McMaster University, Ontario, Canada.; McMaster University, Hamilton, Canada.

Journal Article; Systematic Review; Meta-Analysis; Review , 2024

Home versus in-centre haemodialysis for people with kidney failure.

Cheetham MS; Renal Unit, Sunshine Coast University Hospital, Birtinya, Australia.; Faculty of Medicine, The University of Queensland, Herston, Australia., Ethier I; Department of Nephrology, Centre Hospitalier de l'Université de Montréal, Montréal, Canada.; Health Innovation and Evaluation Hub, Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Canada., Krishnasamy R; Renal Unit, Sunshine Coast University Hospital, Birtinya, Australia.; Faculty of Medicine, The University of Queensland, Herston, Australia.; Australasian Kidney Trials Network, Translational Research Institute, Woolloongabba, Australia., Cho Y; Faculty of Medicine, The University of Queensland, Herston, Australia.; Department of Nephrology, Princess Alexandra Hospital, Woolloongabba, Australia.; Australasian Kidney Trials Network, The University of Queensland, Brisbane, Australia., Palmer SC; Department of Medicine, University of Otago Christchurch, Christchurch, New Zealand., Johnson DW; Department of Nephrology, Princess Alexandra Hospital, Woolloongabba, Australia., Craig JC; Cochrane Kidney and Transplant, Centre for Kidney Research, The Children's Hospital at Westmead, Westmead, Australia.; College of Medicine and Public Health, Flinders University, Adelaide, Australia., Stroumza P; Medical Office, Diaverum Marseille, Marseille, France., Frantzen L; Medical Office, Diaverum Marseille, Marseille, France., Hegbrant J; Division of Nephrology, Department of Clinical Sciences, Lund University, Lund, Sweden., Strippoli GF; Cochrane Kidney and Transplant, Centre for Kidney Research, The Children's Hospital at Westmead, Westmead, Australia.; Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.

Meta-Analysis; Systematic Review; Journal Article; Review , 2024

Sharp Variance Estimator and Causal Bootstrap in Stratified Randomized Experiments.

Yu H; Department of Statistics and Data Science, Tsinghua University, Beijing, China., Zhu K; Department of Statistics, North Carolina State University, Raleigh, North Carolina, USA.; Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA., Liu H; Department of Statistics and Data Science, Tsinghua University, Beijing, China.

Journal Article , 2025

International multistakeholder consensus statement on post-publication integrity issues in randomized clinical trials by Cairo Consensus Group.

Khan KS; University of Granada, CIBERESP, Madrid, Spain., Fawzy M; IbnSina (Sohag), Banon (Assiut), Amshaj (Sohag), and Qena (Qena) IVF Centers, Egypt., Chien P; RCSI & UCD Malaysia, Penang, Malaysia., Geary M; Rotunda Hospital, Dublin, Ireland., Bueno-Cavanillas A; University of Granada, CIBERESP, Madrid, Spain., Nunez-Nunez M; San Cecilio University Hospital, Ibs Granada, CIBERESP, Madrid, Spain., Zamora J; Hospital Ramón y Cajal, IRYCIS, CIBERESP, Madrid, Spain.; Birmingham University, Birmingham, UK., Bedaiwy M; University of British Columbia, Vancouver, British Columbia, Canada., Serour G; Al-Azhar University and Egyptian IVF-ET Center, Cairo, Egypt., D'Hooghe T; Global Medical Affairs Fertility, Research and Development, Merck Healthcare KGaA, Darmstadt, Germany., Pacey A; University of Manchester, Manchester, UK., Andrews J; BD Integrated Diagnostic Solutions, Franklin Lakes, NJ, USA., Scott JR; Department of Obstetrics and Gynecology, University of Iowa, Iowa City, Iowa, USA., Ball E; The Royal London Hospital, BartsHealth NHS Trust, London, UK., Mahran A; Assiut University, Assiut, Egypt., Aboulghar M; Cairo University and Egyptian IVF-ET Center, Cairo, Egypt., Wasim T; Services Institute of Medical Sciences, Services Hospital, Lahore, Pakistan., Abdelaleem M; Assiut University, Assiut, Egypt., Maheshwari A; Aberdeen Fertility Center, Aberdeen Maternity Hospital, NHS Grampian, Aberdeen, UK., Odibo A; Washington University in Saint Louis, Saint Louis, Missouri, USA., Sallam H; Alexandria University, Alexandria, Egypt., Grandi G; University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy., Zhang J; Shangai Jiao Tong University School of Medicine, Shangai, China., Fernández-Luna JM; University of Granada, Granada, Spain., Jawid SA; Eastern Mediterranean Association of Medical Editors (EMAME), Karachi, Pakistan., Mignini LE; Hospital Escuela Eva Perón de Granadero Baigorria, Grupo Oroño, Santa Fe, Argentina., Khalaf Y; Guy's & St Thomas' Hospital Foundation Trust, London, UK.

Journal Article; Review , 2025

A new method for dealing with collider bias in the PWP model for recurrent events in randomized controlled trials.

Shi C; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Department of Biostatistics, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China., Wei JW; Novartis Institutes for Biomedical Research Co., Shanghai, China., Zhan ZS; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Department of Biostatistics, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China., Xu XH; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Department of Biostatistics, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China., Yan ZL; School of Biomedical Engineering, School of Information and Communication Engineering, Hainan University, Haikou, 570228, China.; Hainan Institute of Real World Data, Qionghai, 571437, China., Ou CQ; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Department of Biostatistics, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China. ouchunquan@hotmail.com.

Journal Article , 2025

Assessing the replicability of RCTs in RWE emulations.

Köppe J; Institute of Biostatistics and Clinical Research, University of Muenster, Münster, Germany. jeanette.koeppe@ukmuenster.de., Micheloud C; Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zürich, Switzerland., Erdmann S; Institute of Medical Biometry, University of Heidelberg, Heidelberg, Germany., Heyard R; Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zürich, Switzerland., Held L; Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zürich, Switzerland.

Journal Article , 2025

Warnings on the inclusion of cluster randomized trials in meta-analysis: results of a simulation study.

Santos JAR; Department of Business Economics, Health and Social Care (DEASS), University of Applied Sciences and Arts of Southern Switzerland (SUPSI), Manno, Ticino, Switzerland. joseph.santos@supsi.ch.; The George Institute for Global Health, Sydney, Australia. joseph.santos@supsi.ch., Riggi E; Department of Business Economics, Health and Social Care (DEASS), University of Applied Sciences and Arts of Southern Switzerland (SUPSI), Manno, Ticino, Switzerland., Di Tanna GL; Department of Business Economics, Health and Social Care (DEASS), University of Applied Sciences and Arts of Southern Switzerland (SUPSI), Manno, Ticino, Switzerland.

Journal Article , 2025

A review of the statistical analysis of randomised controlled trials conducted within OCTRU.

Ooms A; Oxford Clinical Trials Research Unit, Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. alexander.ooms@csm.ox.ac.uk.; GSK, Stevenage, UK. alexander.ooms@csm.ox.ac.uk., Waldron C; Oxford Clinical Trials Research Unit, Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Kounali D; Oxford Clinical Trials Research Unit, Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Marian IR; Oxford Clinical Trials Research Unit, Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Massa MS; Oxford Clinical Trials Research Unit, Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Peckham N; Oxford Clinical Trials Research Unit, Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Parkes M; Oxford Clinical Trials Research Unit, Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.; Centre for Biostatistics, Division of Population Health, Health Services Research & Primary Care, School of Health Sciences, The University of Manchester, Manchester, UK.; NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre (MAHSC), Manchester, UK., Conroy E; Oxford Clinical Trials Research Unit, Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Cook JA; Oxford Clinical Trials Research Unit, Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

Journal Article; Review , 2025

Guidance for discussants of randomized cancer trials at major meetings.

Eisenhauer EA; Queen's University, Kingston, ON, Canada. Electronic address: eae@queensu.ca., Abdihamid O; Garissa Regional Cancer Center, Garissa, Kenya., Booth CM; Queen's University, Kingston, ON, Canada., Cherny N; Shaare Zedek Medical Center, Jerusalem, Israel., Fojo AT; Columbia University Irving Medical Center, New York, NY, USA., Gyawali B; Queen's University, Kingston, ON, Canada., Marini BL; University of Michigan, Ann Arbor, MI, USA., Mohyuddin GR; University of Utah, Salt Lake City, UT, USA., Pe M; European Organization for Research and Treatment of Cancer, Brussels, Belgium., Pond GR; McMaster University, Hamilton, ON, Canada., Soto-Perez-de-Celis E; University of Colorado, Denver, CO, USA; Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico., Tannock IF; Princess Margaret Cancer Centre and University of Toronto, Toronto, ON, Canada., Trapani D; European Institute of Oncology, Milan, Italy., Tregear M; National Breast Cancer Coalition, Washington, DC, USA., van der Graaf WTA; Netherlands Cancer Institute, Amsterdam, the Netherlands., Wilson BE; Queen's University, Kingston, ON, Canada.

Journal Article , 2025

Why "Minimal Clinically Important Difference" for Interpreting the Magnitude of the Treatment Effect Is Not Useful.

Ganju J; Ganju Clinical Trials, LLC, San Francisco, California, USA.

Journal Article , 2025

Accounting for Inconsistent Use of Covariate Adjustment in Group Sequential Trials.

Bannick MS; Department of Biostatistics, University of Washington, Seattle, Washington, USA., Heltshe SL; Department of Pediatrics, University of Washington, Seattle, Washington, USA., Simon N; Department of Biostatistics, University of Washington, Seattle, Washington, USA.; Cystic Fibrosis Foundation, Therapeutics Development Network Coordinating Center, Seattle Children's Research Institute, Seattle, Washington, USA.

Journal Article , 2025

Inference for Cumulative Incidences and Treatment Effects in Randomized Controlled Trials With Time-to-Event Outcomes Under ICH E9 (R1).

Deng Y; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA., Han S; School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China., Zhou XH; Department of Biostatistics, School of Public Health, Peking University, Beijing, China.; Beijing International Center for Mathematical Research, Peking University, Beijing, China.

Journal Article , 2025

Applying the Principal Stratum Strategy in Equivalence Trials: A Case Study.

Sepin J; Biogen International GmbH, Baar, Switzerland.; University of Lucerne, Lucerne, Switzerland., Debray TPA; Smart Data Analysis and Statistics B.V, Utrecht, the Netherlands.; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Wei W; Biogen International GmbH, Baar, Switzerland., Ebbers HC; Biogen International GmbH, Baar, Switzerland., Fernandez-Mendivil C; Biogen International GmbH, Baar, Switzerland., Mitroiu M; Biogen International GmbH, Baar, Switzerland.

Journal Article , 2025

A Tipping Point Method to Evaluate Sensitivity to Potential Violations in Missing Data Assumptions.

Torres C; Food and Drug Administration, Silver Spring, Maryland, USA., Levin G; Food and Drug Administration, Silver Spring, Maryland, USA., Rubin D; Food and Drug Administration, Silver Spring, Maryland, USA., Koh W; Food and Drug Administration, Silver Spring, Maryland, USA., Chiu R; Food and Drug Administration, Silver Spring, Maryland, USA., Permutt T; retired.

Journal Article , 2025