Sökresultat - "Randomized controlled trials"

Integration of non-randomized studies with randomized controlled trials in meta-analyses of clinical studies: a meta-epidemiological study on effect estimation of interventions.

Mei F; Institute of Integrated Traditional Chinese and Western Medicine, Chinese Evidence-Based Medicine Center, Cochrane China and MAGIC China Center, West China Hospital, Sichuan University, Chengdu, China.; NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan, Chengdu, China.; Sichuan Center of Technology Innovation for Real World Data, Chengdu, China., Yao M; Institute of Integrated Traditional Chinese and Western Medicine, Chinese Evidence-Based Medicine Center, Cochrane China and MAGIC China Center, West China Hospital, Sichuan University, Chengdu, China.; NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan, Chengdu, China.; Sichuan Center of Technology Innovation for Real World Data, Chengdu, China., Wang Y; Institute of Integrated Traditional Chinese and Western Medicine, Chinese Evidence-Based Medicine Center, Cochrane China and MAGIC China Center, West China Hospital, Sichuan University, Chengdu, China.; NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan, Chengdu, China.; Sichuan Center of Technology Innovation for Real World Data, Chengdu, China., Huan J; Institute of Integrated Traditional Chinese and Western Medicine, Chinese Evidence-Based Medicine Center, Cochrane China and MAGIC China Center, West China Hospital, Sichuan University, Chengdu, China.; NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan, Chengdu, China.; Sichuan Center of Technology Innovation for Real World Data, Chengdu, China., Ma Y; Institute of Integrated Traditional Chinese and Western Medicine, Chinese Evidence-Based Medicine Center, Cochrane China and MAGIC China Center, West China Hospital, Sichuan University, Chengdu, China.; NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan, Chengdu, China.; Sichuan Center of Technology Innovation for Real World Data, Chengdu, China., Li G; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.; Center for Clinical Epidemiology and Methodology, Guangdong Second Provincial General Hospital, Guangzhou, China.; Biostatistics Unit, Research Institute at St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada., Zou K; Institute of Integrated Traditional Chinese and Western Medicine, Chinese Evidence-Based Medicine Center, Cochrane China and MAGIC China Center, West China Hospital, Sichuan University, Chengdu, China.; NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan, Chengdu, China.; Sichuan Center of Technology Innovation for Real World Data, Chengdu, China., Li L; Institute of Integrated Traditional Chinese and Western Medicine, Chinese Evidence-Based Medicine Center, Cochrane China and MAGIC China Center, West China Hospital, Sichuan University, Chengdu, China. liling@wchscu.cn.; NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan, Chengdu, China. liling@wchscu.cn.; Sichuan Center of Technology Innovation for Real World Data, Chengdu, China. liling@wchscu.cn., Sun X; Institute of Integrated Traditional Chinese and Western Medicine, Chinese Evidence-Based Medicine Center, Cochrane China and MAGIC China Center, West China Hospital, Sichuan University, Chengdu, China. sunxin@wchscu.cn.; NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan, Chengdu, China. sunxin@wchscu.cn.; Sichuan Center of Technology Innovation for Real World Data, Chengdu, China. sunxin@wchscu.cn.; Department of Epidemiology and Biostatistics, School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. sunxin@wchscu.cn.

Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't , 2024

A meta-epidemiological analysis of post-hoc comparisons and primary endpoint interpretability among randomized noncomparative trials in clinical medicine.

Sherry AD; Division of Radiation Oncology, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Msaouel P; Division of Cancer Medicine, Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Division of Pathology/Lab Medicine, Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: PMsaouel@mdanderson.org., Ludmir EB; Division of Radiation Oncology, Department of Gastrointestinal Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: ebludmir@mdanderson.org.

Journal Article , 2024

Treatment Effects in Randomized and Nonrandomized Studies of Pharmacological Interventions: A Meta-Analysis.

Salcher-Konrad M; Department of Health Policy, London School of Economics and Political Science, London, United Kingdom.; World Health Organization Collaborating Centre for Pharmaceutical Pricing and Reimbursement Policies, Pharmacoeconomics Department, Gesundheit Österreich GmbH (GÖG)/Austrian National Public Health Institute, Vienna, Austria., Nguyen M; Department of Health Policy, London School of Economics and Political Science, London, United Kingdom.; Department of Family and Community Medicine, University of California, San Francisco., Savovic J; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.; National Institute for Health and Care Research Applied Research Collaboration West, University Hospitals Bristol and Weston National Health Service Foundation Trust, Bristol, United Kingdom., Higgins JPT; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.; National Institute for Health and Care Research Applied Research Collaboration West, University Hospitals Bristol and Weston National Health Service Foundation Trust, Bristol, United Kingdom., Naci H; Department of Health Policy, London School of Economics and Political Science, London, United Kingdom.

Journal Article; Meta-Analysis , 2024

Problematic meta-analyses: Bayesian and frequentist perspectives on combining randomized controlled trials and non-randomized studies.

Moran JL; The Queen Elizabeth Hospital, Woodville, SA, 5011, Australia. john.moran@adelaide.edu.au., Linden A; Department of Medicine, School of Medicine, University of California, San Francisco, USA.

Journal Article; Research Support, Non-U.S. Gov't , 2024

Single-arm phase 3 designs: An oxymoron?

Hussein A; ECSTRRA, 1, avenue Claude Vellefaux, Paris 75010, France., Levy V; ECSTRRA, 1, avenue Claude Vellefaux, Paris 75010, France; D́epartement de Recherche Clinique, Hôpital Avicenne, Bobigny 93000, France., Chevret S; ECSTRRA, 1, avenue Claude Vellefaux, Paris 75010, France; Institut Universitaire de France, Paris 75, France. Electronic address: sylvie.chevret@u-paris.fr.

Journal Article; Review , 2024

Comprehensive care programmes for children with medical complexity.

Harvey AR; Neurodisability and Rehabilitation, Murdoch Children's Research Institute, Melbourne, Australia., Meehan E; Neurodisability and Rehabilitation, Murdoch Children's Research Institute, Melbourne, Australia., Merrick N; Department of Paediatrics, The University of Melbourne, Melbourne, Australia., D'Aprano AL; Department of Paediatrics, The University of Melbourne, Melbourne, Australia., Cox GR; Neurodevelopment and Disability, Royal Children's Hospital, Melbourne, Australia., Williams K; Department of Paediatrics, Monash University, Melbourne, Australia., Gibb SM; Neurodevelopment and Disability, Royal Children's Hospital, Melbourne, Australia., Mountford NJ; Complex Care Hub, The Royal Children's Hospital, Melbourne, Australia., Connell TG; General Medicine, The Royal Children's Hospital, Melbourne, Australia., Cohen E; Paediatrics and Health Policy, Management & Evaluation, University of Toronto, Toronto, Canada.

Journal Article; Review; Systematic Review , 2024

Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support.

Radford M; McMaster Centre for Transfusion Research, McMaster University, Hamilton, Canada.; Department of Oncology, Hamilton Health Sciences Centre, Hamilton, Canada., Estcourt LJ; Haematology/Transfusion Medicine, NHS Blood and Transplant, Oxford, UK.; Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, UK., Sirotich E; Medicine, Yale School of Medicine, New Haven, Connecticut, USA., Pitre T; Medicine, University of Toronto, Toronto, Canada., Britto J; Oncology, Hamilton Health Sciences Centre, Hamilton, Canada., Watson M; Medicine, University of Toronto, Toronto, Canada., Brunskill SJ; Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, UK.; Systematic Review Initiative, NHS Blood and Transplant, Oxford, UK., Fergusson DA; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada., Dorée C; Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, UK.; Systematic Review Initiative, NHS Blood and Transplant, Oxford, UK., Arnold DM; Division of Hematology and Thromboembolism, Department of Medicine, McMaster University, Ontario, Canada.; McMaster University, Hamilton, Canada.

Journal Article; Systematic Review; Meta-Analysis; Review , 2024

Home versus in-centre haemodialysis for people with kidney failure.

Cheetham MS; Renal Unit, Sunshine Coast University Hospital, Birtinya, Australia.; Faculty of Medicine, The University of Queensland, Herston, Australia., Ethier I; Department of Nephrology, Centre Hospitalier de l'Université de Montréal, Montréal, Canada.; Health Innovation and Evaluation Hub, Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Canada., Krishnasamy R; Renal Unit, Sunshine Coast University Hospital, Birtinya, Australia.; Faculty of Medicine, The University of Queensland, Herston, Australia.; Australasian Kidney Trials Network, Translational Research Institute, Woolloongabba, Australia., Cho Y; Faculty of Medicine, The University of Queensland, Herston, Australia.; Department of Nephrology, Princess Alexandra Hospital, Woolloongabba, Australia.; Australasian Kidney Trials Network, The University of Queensland, Brisbane, Australia., Palmer SC; Department of Medicine, University of Otago Christchurch, Christchurch, New Zealand., Johnson DW; Department of Nephrology, Princess Alexandra Hospital, Woolloongabba, Australia., Craig JC; Cochrane Kidney and Transplant, Centre for Kidney Research, The Children's Hospital at Westmead, Westmead, Australia.; College of Medicine and Public Health, Flinders University, Adelaide, Australia., Stroumza P; Medical Office, Diaverum Marseille, Marseille, France., Frantzen L; Medical Office, Diaverum Marseille, Marseille, France., Hegbrant J; Division of Nephrology, Department of Clinical Sciences, Lund University, Lund, Sweden., Strippoli GF; Cochrane Kidney and Transplant, Centre for Kidney Research, The Children's Hospital at Westmead, Westmead, Australia.; Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.

Meta-Analysis; Systematic Review; Journal Article; Review , 2024

Semiparametric Estimation of Relative Causal Effects in Randomized Controlled Trials With Noncompliance.

Liu W; KLATASDS-MOE, School of Statistics, East China Normal University, Shanghai, China., Qin J; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Liu Y; KLATASDS-MOE, School of Statistics, East China Normal University, Shanghai, China.

Journal Article , 2025

A new method for dealing with collider bias in the PWP model for recurrent events in randomized controlled trials.

Shi C; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Department of Biostatistics, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China., Wei JW; Novartis Institutes for Biomedical Research Co., Shanghai, China., Zhan ZS; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Department of Biostatistics, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China., Xu XH; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Department of Biostatistics, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China., Yan ZL; School of Biomedical Engineering, School of Information and Communication Engineering, Hainan University, Haikou, 570228, China.; Hainan Institute of Real World Data, Qionghai, 571437, China., Ou CQ; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Department of Biostatistics, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China. ouchunquan@hotmail.com.

Journal Article , 2025

Shortcomings in reporting country-level participation in multicenter randomized controlled trials involving Ireland as a collaborating partner: a metaresearch study.

Larkin J; Department of General Practice, RCSI University of Medicine and Health Sciences, Dublin, Ireland; School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin, Ireland. Electronic address: Larkinja@tcd.ie., Alanza U; Department of General Practice, RCSI University of Medicine and Health Sciences, Dublin, Ireland., Raj Nagarajan V; Department of General Practice, RCSI University of Medicine and Health Sciences, Dublin, Ireland., Collins M; Department of General Practice, RCSI University of Medicine and Health Sciences, Dublin, Ireland., Termanini S; Department of General Practice, RCSI University of Medicine and Health Sciences, Dublin, Ireland., Farrington E; School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin, Ireland., Clyne B; Department of General Practice, RCSI University of Medicine and Health Sciences, Dublin, Ireland; Department of Public Health and Epidemiology, School of Population Health, RCSI University of Medicine and Health Sciences, Dublin, Ireland., Fahey T; Department of General Practice, RCSI University of Medicine and Health Sciences, Dublin, Ireland., Moriarty F; School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin, Ireland.

Journal Article , 2025

Detecting irregularities in randomized controlled trials using machine learning.

Nelson W; Centre for Data Science and Digital Health, Hamilton Health Sciences, Hamilton, ON, Canada.; Department of Statistical Sciences, University of Toronto, Toronto, ON, Canada., Petch J; Centre for Data Science and Digital Health, Hamilton Health Sciences, Hamilton, ON, Canada.; Population Health Research Institute, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada., Ranisau J; Centre for Data Science and Digital Health, Hamilton Health Sciences, Hamilton, ON, Canada., Zhao R; Population Health Research Institute, Hamilton, ON, Canada., Balasubramanian K; Population Health Research Institute, Hamilton, ON, Canada., Bangdiwala SI; Population Health Research Institute, Hamilton, ON, Canada.; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.

Journal Article , 2025

Sample Size Assessment and Interim Analysis Strategies for Survival Trial Designs With Covariate-Adaptive Randomization.

Su PF; Department of Statistics, National Cheng Kung University, Tainan, Taiwan., Wu CC; Department of Statistics, National Cheng Kung University, Tainan, Taiwan.

Journal Article , 2025

BEAM: Bayesian Hybrid Design With Adaptive Sample Size Through Multisource Exchangeability Modeling.

Tian F; University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Liu M; Takeda Pharmaceuticals, Cambridge, Massachusetts, USA., Zhao Y; Takeda Pharmaceuticals, Cambridge, Massachusetts, USA., Lin J; Takeda Pharmaceuticals, Cambridge, Massachusetts, USA., Liu R; Takeda Pharmaceuticals, Cambridge, Massachusetts, USA.

Journal Article , 2025

A Two-Stage Method for Extending Inferences From a Collection of Trials.

Schnitzler N; Ohio Colleges of Medicine Government Resource Center, The Ohio State University, Columbus, Ohio, USA., Kaizar E; Department of Statistics, The Ohio State University, Columbus, Ohio, USA.

Journal Article , 2025

Definitions of validity terms for use in discussions of randomized controlled trials.

Yazdani Y; Department of Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada; Centre for Studies in Family Medicine, Department of Family Medicine, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada. Electronic address: yyazdan3@uwo.ca., Taljaard M; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; School of Epidemiology & Public Health, University of Ottawa, Ottawa, Ontario, Canada., Zwarenstein M; Department of Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada; Centre for Studies in Family Medicine, Department of Family Medicine, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada; ICES, Toronto, Ontario, Canada. Electronic address: mzwarens@uwo.ca.

Journal Article; Review , 2025

Sharp Variance Estimator and Causal Bootstrap in Stratified Randomized Experiments.

Yu H; Department of Statistics and Data Science, Tsinghua University, Beijing, China., Zhu K; Department of Statistics, North Carolina State University, Raleigh, North Carolina, USA.; Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA., Liu H; Department of Statistics and Data Science, Tsinghua University, Beijing, China.

Journal Article , 2025

Reporting Compliance and Factors Influencing Timeliness of Stroke-Related Trial Results on ClinicalTrials.gov.

Cwajna M; Saba University School of Medicine, The Bottom, Saba, Dutch Caribbean, Netherlands. m.cwajna@saba.edu., Hamouda AM; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, 55905, USA. Hamouda.Abdelrahman@mayo.edu., Kendall N; The University of South Dakota Sanford School of Medicine, Vermillion, SD, 57069, USA., Ghozy S; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Radiology, Mayo Clinic, Rochester, MN, 55905, USA., Elder BD; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, 55905, USA., Kallmes DF; Department of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.

Journal Article; Observational Study , 2025

International multistakeholder consensus statement on post-publication integrity issues in randomized clinical trials by Cairo Consensus Group.

Khan KS; University of Granada, CIBERESP, Madrid, Spain., Fawzy M; IbnSina (Sohag), Banon (Assiut), Amshaj (Sohag), and Qena (Qena) IVF Centers, Egypt., Chien P; RCSI & UCD Malaysia, Penang, Malaysia., Geary M; Rotunda Hospital, Dublin, Ireland., Bueno-Cavanillas A; University of Granada, CIBERESP, Madrid, Spain., Nunez-Nunez M; San Cecilio University Hospital, Ibs Granada, CIBERESP, Madrid, Spain., Zamora J; Hospital Ramón y Cajal, IRYCIS, CIBERESP, Madrid, Spain.; Birmingham University, Birmingham, UK., Bedaiwy M; University of British Columbia, Vancouver, British Columbia, Canada., Serour G; Al-Azhar University and Egyptian IVF-ET Center, Cairo, Egypt., D'Hooghe T; Global Medical Affairs Fertility, Research and Development, Merck Healthcare KGaA, Darmstadt, Germany., Pacey A; University of Manchester, Manchester, UK., Andrews J; BD Integrated Diagnostic Solutions, Franklin Lakes, NJ, USA., Scott JR; Department of Obstetrics and Gynecology, University of Iowa, Iowa City, Iowa, USA., Ball E; The Royal London Hospital, BartsHealth NHS Trust, London, UK., Mahran A; Assiut University, Assiut, Egypt., Aboulghar M; Cairo University and Egyptian IVF-ET Center, Cairo, Egypt., Wasim T; Services Institute of Medical Sciences, Services Hospital, Lahore, Pakistan., Abdelaleem M; Assiut University, Assiut, Egypt., Maheshwari A; Aberdeen Fertility Center, Aberdeen Maternity Hospital, NHS Grampian, Aberdeen, UK., Odibo A; Washington University in Saint Louis, Saint Louis, Missouri, USA., Sallam H; Alexandria University, Alexandria, Egypt., Grandi G; University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy., Zhang J; Shangai Jiao Tong University School of Medicine, Shangai, China., Fernández-Luna JM; University of Granada, Granada, Spain., Jawid SA; Eastern Mediterranean Association of Medical Editors (EMAME), Karachi, Pakistan., Mignini LE; Hospital Escuela Eva Perón de Granadero Baigorria, Grupo Oroño, Santa Fe, Argentina., Khalaf Y; Guy's & St Thomas' Hospital Foundation Trust, London, UK.

Journal Article; Review , 2025

Assessing the replicability of RCTs in RWE emulations.

Köppe J; Institute of Biostatistics and Clinical Research, University of Muenster, Münster, Germany. jeanette.koeppe@ukmuenster.de., Micheloud C; Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zürich, Switzerland., Erdmann S; Institute of Medical Biometry, University of Heidelberg, Heidelberg, Germany., Heyard R; Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zürich, Switzerland., Held L; Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zürich, Switzerland.

Journal Article , 2025