Search Results - "Schuringa, Jan Jacob"

Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation

Dembitz, Vilma^{Aff1, Aff2}, Lawson, Hannah^{Aff1, Aff3}, Burt, Richard^{Aff4, Aff5}, Natani, Sirisha, Philippe, Céline^{Aff1, Aff6}, James, Sophie C., Atkinson, Samantha^{Aff4, Aff5}, Durko, Jozef, Wang, Lydia M.^{Aff1, Aff3}, Campos, Joana^{Aff1, Aff3}, Magee, Aoife M. S., Woodley, Keith, Austin, Michael J., Rio-Machin, Ana^{Aff1, Aff7}, Casado, Pedro, Bewicke-Copley, Findlay^{Aff1, Aff8}, Rodriguez Blanco, Giovanny, Pereira-Martins, Diego, Oudejans, Lieve, Boet, Emeline^{Aff11, Aff12}, von Kriegsheim, Alex, Schwaller, Juerg, Finch, Andrew J., Patel, Bela, Sarry, Jean-Emmanuel^{Aff11, Aff12}, Tamburini, Jerome, Schuringa, Jan Jacob, Hazlehurst, Lori, Copland III, John A., Yuneva, Mariia, Peck, Barrie, Cutillas, Pedro, Fitzgibbon, Jude, Rouault-Pierre, Kevin, Kranc, Kamil^{Aff1, Aff3}, Gallipoli, Paolo^{Aff1, IDs41375024023909_cor36}

VISTA drives macrophages towards a pro-tumoral phenotype that promotes cancer cell phagocytosis yet down-regulates T cell responses

Lin, Yusheng, Choukrani, Ghizlane, Dubbel, Lena, Rockstein, Lena, Freile, Jimena Alvarez, Qi, Yuzhu, Wiersma, Valerie, Zhang, Hao, Koch, Karl-Wilhelm, Ammatuna, Emanuele, Schuringa, Jan Jacob, van Meerten, Tom, Huls, Gerwin, Bremer, Edwin^{Aff1, IDs4016402400501x_cor14}

K12-ligand-based CAR T cell therapy for CD7-positive T cell malignancies

Visser, Nienke ^{1, 2}, González-Corrales, Macarena ^{1, 2}, Álvarez-Freile, Jimena ¹, Pruis, Maurien G. ¹, Rockstein, Lena ¹, Lourens, Harm Jan ¹, Schuringa, Jan Jacob ¹, van Meerten, Tom ¹, Huls, Gerwin ¹, Bremer, Edwin ^{1, ∗}

Elastic properties of leukemic cells linked to maturation stage and integrin activation

Richards, Ceri J. ¹, Wierenga, Albertus T.J. ², Brouwers-Vos, Annet Z. ², Kyrloglou, Emmanouil ², Dillingh, Laura S. ^{1, 2, 3}, Mulder, Patty P.M.F.A. ⁴, Palasantzas, Georgios ³, Schuringa, Jan Jacob ^{2, ∗}, Roos, Wouter H. ^{1, 5, ∗∗}

Menin inhibitors in the treatment of acute myeloid leukemia

Huls, Gerwin ^∗, Woolthuis, Carolien M., Schuringa, Jan Jacob

Ex Vivo Assays to Study Self-Renewal, Long-Term Expansion, and Leukemic Transformation of Genetically Modified Human Hematopoietic and Patient-Derived Leukemic Stem Cells

Sontakke, Pallavi^Aff4, Carretta, Marco^Aff4, Capala, Marta^Aff4, Schepers, Hein^Aff4, Schuringa, Jan Jacob^Aff4

Bunting, Kevin D.^Aff2, Qu, Cheng-Kui^Aff3, Walker, John M.^Aff1

Ex Vivo Assays to Study Self-Renewal and Long-Term Expansion of Genetically Modified Primary Human Acute Myeloid Leukemia Stem Cells

Schuringa, Jan Jacob^Aff1_14, Schepers, Hein

Eric So, Chi Wai^Aff1

Preclinical efficacy of the potent, selective menin-KMT2A inhibitor JNJ-75276617 (bleximenib) in KMT2A- and NPM1-altered leukemias

Kwon, Min Chul, Thuring, Jan Willem, Querolle, Olivier, Dai, Xuedong, Verhulst, Tinne, Pande, Vineet, Marien, Ann, Goffin, Dries, Wenge, Daniela V., Yue, Hong, Cutler, Jevon A., Jin, Cyrus, Perner, Florian, Hogeling, Shanna M., Shaffer, Paul L., Jacobs, Frank, Vinken, Petra, Cai, Wei, Keersmaekers, Vikki, Eyassu, Filmon, Bhogal, Balpreet, Verstraeten, Karin, El Ashkar, Sara, Perry, Jennifer A., Jayaguru, Prathiba, Barreyro, Laura, Kuchnio, Anna, Darville, Nicolas, Krosky, Daniel, Urbanietz, Gregor, Verbist, Bie, Edwards, James P., Cowley, Glenn S., Kirkpatrick, Robert, Steele, Ruth, Ferrante, Lucille, Guttke, Christina, Daskalakis, Nikki, Pietsch, E. Christine, Wilson, David M., Attar, Ricardo, Elsayed, Yusri, Fischer, Eric S., Schuringa, Jan Jacob, Armstrong, Scott A., Packman, Kathryn, Philippar, Ulrike

Potency and efficacy of pharmacological PIP4K2 inhibitors in acute lymphoblastic leukemia

Lima, Keli, Nogueira, Frederico Lisboa, Cipelli, Marcella, Carvalho, Maria Fernanda Lopes, Pereira-Martins, Diego Antonio, da Silva, Wellington Fernandes, Cavaglieri, Rita de Cássia, Nardinelli, Luciana, Leal, Aline de Medeiros, Velloso, Elvira Deolinda Rodrigues Pereira, Bendit, Israel, Câmara, Niels Olsen Saraiva, Schuringa, Jan Jacob, Machado-Neto, João Agostinho, Rego, Eduardo Magalhães

Skin autofluorescence, a measure for accumulation of advanced glycation end products, positively associates with blood neutrophil and monocyte counts in the general population, and particularly in men with prediabetes

Groenen, Anouk G., Halmos, Benedek, van Zeventer, Isabelle A., Salzbrunn, Jonas B., Mayer, Marianne L., La Rose, Nikita D., Nolte, Ilja M., Schuringa, Jan Jacob, Huls, Gerwin, Westerterp, Marit

Automated cell type annotation and exploration of single-cell signaling dynamics using mass cytometry

Kleftogiannis, Dimitrios ^{1, 2, 6, 7, ∗}, Gavasso, Sonia ⁶, Tislevoll, Benedicte Sjo ², van der Meer, Nisha ⁵, Motzfeldt, Inga K.F. ³, Hellesøy, Monica ³, Gullaksen, Stein-Erik ³, Griessinger, Emmanuel ⁵, Fagerholt, Oda ², Lenartova, Andrea ⁴, Fløisand, Yngvar ⁴, Schuringa, Jan Jacob ⁵, Gjertsen, Bjørn Tore ^{2, 3}, Jonassen, Inge ^{1, 2}

PDP1 is a key metabolic gatekeeper and modulator of drug resistance in FLT3-ITD-positive acute myeloid leukemia

Alshamleh, Islam^{Aff1, Aff2, Aff3, Aff4}, Kurrle, Nina^{Aff2, Aff3, Aff4}, Makowka, Philipp, Bhayadia, Raj^{Aff2, Aff4, Aff5}, Kumar, Rahul, Süsser, Sebastian, Seibert, Marcel^{Aff2, Aff3, Aff4}, Ludig, Damian, Wolf, Sebastian^{Aff3, Aff4}, Koschade, Sebastian E., Stoschek, Karoline, Kreitz, Johanna^{Aff3, Aff4}, Fuhrmann, Dominik C., Toenges, Rosa, Notaro, Marco, Comoglio, Federico, Schuringa, Jan Jacob, Berg, Tobias^{Aff3, Aff10}, Brüne, Bernhard^{Aff4, Aff7, Aff11}, Krause, Daniela S.^{Aff4, Aff6, Aff12}, Klusmann, Jan-Henning^{Aff2, Aff4, Aff5}, Oellerich, Thomas^{Aff2, Aff3, Aff4}, Schnütgen, Frank^{Aff2, Aff3, Aff4, IDs41375023020415_cor23}, Schwalbe, Harald^{Aff1, Aff2, Aff4, IDs41375023020415_cor24}, Serve, Hubert^{Aff2, Aff3, Aff4, IDs41375023020415_cor25}

Lactate dehydrogenase A-coupled NAD⁺ regeneration is critical for acute myeloid leukemia cell survival

Erdem, Ayşegül, Kaye, Séléna, Caligiore, Francesco, Johanns, Manuel, Leguay, Fleur, Schuringa, Jan Jacob, Ito, Keisuke^{Aff5, Aff6, Aff7}, Bommer, Guido, van Gastel, Nick^{Aff1, Aff8, IDs40170025003924_cor1}

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Fluorescence lifetime imaging microscopy of flexible and rigid dyes probes the biophysical properties of synthetic and biological membranes

Lira, Rafael B. ^{1, ∗}, Dillingh, Laura S. ^{1, 2}, Schuringa, Jan-Jacob ², Yahioglu, Gokhan ³, Suhling, Klaus ^{4, ∗∗}, Roos, Wouter H. ¹

The nonessential amino acid cysteine is required to prevent ferroptosis in acute myeloid leukemia

Cunningham, Alan, Oudejans, Lieve L., Geugien, Marjan, Pereira-Martins, Diego Antonio, Wierenga, Albertus T. J., Erdem, Ayşegül, Sternadt, Dominique, Huls, Gerwin, Schuringa, Jan Jacob

The european hematology association roadmap for european hematology research: A consensus document

Engert, Andreas, Balduini, Carlo, Brand, Anneke, Coiffier, Bertrand, Cordonnier, Catherine, Döhner, Hartmut, De Wit, Thom Duyvené, Eichinger, Sabine, Fibbe, Willem, Green, Tony, De Haas, Fleur, Iolascon, Achille, Jaffredo, Thierry, Rodeghiero, Francesco, Sall Es, Gilles, Schuringa, Jan Jacob, André, Marc, Andre-Schmutz, Isabelle, Bacigalupo, Andrea, Bochud, Pierre Yves, Den Boer, Monique, Bonini, Chiara, Camaschella, Clara, Cant, Andrew, Cappellini, Maria Domenica, Cazzola, Mario, Celso, Cristina Lo, Dimopoulos, Meletios, Douay, Luc, Dzierzak, Elaine, Einsele, Hermann, Ferreri, Andrés, De Franceschi, Lucia, Gaulard, Philippe, Gottgens, Berthold, Greinacher, Andreas, Gresele, Paolo, Gribben, John, De Haan, Gerald, Hansen, John Bjarne, Hochhaus, Andreas, Kadir, Rezan, Kaveri, Srini, Kouskoff, Valerie, Kühne, Thomas, Kyrle, Paul, Ljungman, Per, Maschmeyer, Georg, Méndez-Ferrer, Simón, Milsom, Michael, Mummery, Christine, Ossenkoppele, Gert, Pecci, Alessandro, Peyvandi, Flora, Philipsen, Sjaak, Reitsma, Pieter, Ribera, José Maria, Risitano, Antonio, Rivella, Stefano, Ruf, Wolfram, Schroeder, Timm, Scully, Marie, Socie, Gerard, Staal, Frank, Stanworth, Simon, Stauder, Reinhard, Stilgenbauer, Stephan, Tamary, Hannah, Theilgaard-Mönch, Kim, Thein, Swee Lay, Tilly, Hervé, Trneny, Marek, Vainchenker, William, Vannucchi, Alessandro Maria, Viscoli, Claudio, Vrielink, Hans, Zaaijer, Hans, Zanella, Alberto, Zolla, Lello, Zwaginga, Jaap Jan, Martinez, Patricia Aguilar, Van Den Akker, Emile, Allard, Shubha, Anagnou, Nicholas, Andolfo, Immacolata, Andrau, Jean Christophe, Angelucci, Emanuele, Anstee, David, Aurer, Igor, Avet-Loiseau, Hervé, Aydinok, Yesim, Bakchoul, Tamam, Balduini, Alessandra, Barcellini, Wilma, Baruch, Dominique, Baruchel, André, Bayry, Jagadeesh, Bento, Celeste, Van Den Berg, Anke, Bernardi, Rosa, Bianchi, Paola, Bigas, Anna, Biondi, Andrea, Bohonek, Milos, Bonnet, Dominique, Borchmann, Peter, Borregaard, Niels, Brækkan, Sigrid, Van Den Brink, Marcel, Brodin, Ellen, Bullinger, Lars, Buske, Christian, Butzeck, Barbara, Cammenga, Jörg, Campo, Elias, Carbone, Antonino, Cervantes, Francisco, Cesaro, Simone, Charbord, Pierre, Claas, Frans, Cohen, Hannah, Conard, Jacqueline, Coppo, Paul, Vives Corron, Joan Lluis, Da Costa, Lydie, Davi, Frederic, Delwel, Ruud, Dianzani, Irma, Domanović, Dragoslav, Donnelly, Peter, Drnovšek, Tadeja Dovč, Dreyling, Martin, Du, Ming Qing, Dufour, Carlo, Durand, Charles, Efremov, Dimitar, Eleftheriou, Androulla, Elion, Jacques, Emonts, Marieke, Engelhardt, Monika, Ezine, Sophie, Falkenburg, Fred, Favier, Remi, Federico, Massimo, Fenaux, Pierre, Fitzgibbon, Jude, Flygare, Johan, Foà, Robin, Forrester, Lesley, Galacteros, Frederic, Garagiola, Isabella, Gardiner, Chris, Garraud, Olivier, Van Geet, Christel, Geiger, Hartmut, Geissler, Jan, Germing, Ulrich, Ghevaert, Cedric, Girelli, Domenico, Godeau, Bertrand, Gökbuget, Nicola, Goldschmidt, Hartmut, Goodeve, Anne, Graf, Thomas, Graziadei, Giovanna, Griesshammer, Martin, Gruel, Yves, Guilhot, Francois, Von Gunten, Stephan, Gyssens, Inge, Halter, Jörg, Harrison, Claire, Harteveld, Cornelis, Hellström-Lindberg, Eva, Hermine, Olivier, Higgs, Douglas, Hillmen, Peter, Hirsch, Hans, Hoskin, Peter, Huls, Gerwin, Inati, Adlette, Johnson, Peter, Kattamis, Antonis, Kiefel, Volker, Kleanthous, Marina, Klump, Hannes, Krause, Daniela, Hovinga, Johanna Kremer, Lacaud, Georges, Lacroix-Desmazes, Sébastien, Landman-Parker, Judith, Legouill, Steven, Lenz, Georg, Von Lilienfeld-Toal, Marie, Von Lindern, Marieke, Lopez-Guillermo, Armando, Lopriore, Enrico, Lozano, Miguel, Macintyre, Elizabeth, Makris, Michael, Mannhalter, Christine, Martens, Joost, Mathas, Stephan, Matzdorff, Axel, Medvinsky, Alexander, Menendez, Pablo, Migliaccio, Anna Rita, Miharada, Kenichi, Mikulska, Malgorzata, Minard, Véronique, Montalbán, Carlos, De Montalembert, Mariane, Montserrat, Emili, Morange, Pierre Emmanuel, Mountford, Joanne, Muckenthaler, Martina, Müller-Tidow, Carsten, Mumford, Andrew, Nadel, Bertrand, Navarro, Jose Tomas, El Nemer, Wassim, Noizat-Pirenne, France, O’Mahony, Brian, Oldenburg, Johannes, Olsson, Martin, Oostendorp, Robert, Palumbo, Antonio, Passamonti, Francesco, Patient, Roger, De Latour, Regis Peffault, Pflumio, Francoise, Pierelli, Luca, Piga, Antonio, Pollard, Debra, Raaijmakers, Marc, Radford, John, Rambach, Ralf, Koneti Rao, A., Raslova, Hana, Rebulla, Paolo, Rees, David, Ribrag, Vincent, Rijneveld, Anita, Rinalducci, Sara, Robak, Tadeusz, Roberts, Irene, Rodrigues, Charlene, Rosendaal, Frits, Rosenwald, Andreas, Rule, Simon, Russo, Roberta, Saglio, Guiseppe, Sanchez, Mayka, Scharf, Rüdiger E., Schlenke, Peter, Semple, John, Sierra, Jorge, So-Osman, Cynthia, Soria, José Manuel, Stamatopoulos, Kostas, Stegmayr, Bernd, Stunnenberg, Henk, Swinkels, Dorine, Barata, João Pedro Taborda, Taghon, Tom, Taher, Ali, Terpos, Evangelos, Thachil, Jecko, Tissot, Jean Daniel, Touw, Ivo, Toye, Ash, Trappe, Ralf, Traverse-Glehen, Alexandra, Unal, Sule, Vaulont, Sophie, Viprakasit, Vip, Vitolo, Umberto, Van Wijk, Richard, Wójtowicz, Agnieszka, Zeerleder, Sacha, Zieger, Barbara

Lund University, Faculty of Medicine, Department of Laboratory Medicine, Division of Molecular Medicine and Gene Therapy, Lunds universitet, Medicinska fakulteten, Institutionen för laboratoriemedicin, Avdelningen för molekylärmedicin och genterapi, Originator, Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), StemTherapy: National Initiative on Stem Cells for Regenerative Therapy, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), StemTherapy: National Initiative on Stem Cells for Regenerative Therapy, Originator, Lund University, Faculty of Medicine, Lunds universitet, Medicinska fakulteten, Originator, Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), EpiHealth: Epidemiology for Health, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), EpiHealth: Epidemiology for Health, Originator, Lund University, Faculty of Medicine, Department of Laboratory Medicine, Division of Transfusion Medicine, Transfusion Medicine, Lunds universitet, Medicinska fakulteten, Institutionen för laboratoriemedicin, Avdelningen för transfusionsmedicin, Transfusionsmedicin, Originator, Lund University, Faculty of Medicine, Department of Laboratory Medicine, Division of Hematology and Clinical Immunology, Lunds universitet, Medicinska fakulteten, Institutionen för laboratoriemedicin, Avdelningen för hematologi och klinisk immunologi, Originator, Lund University, Faculty of Medicine, Department of Laboratory Medicine, Lunds universitet, Medicinska fakulteten, Institutionen för laboratoriemedicin, Originator

Evolutionary landscape of clonal hematopoiesis in 3,359 individuals from the general population

van Zeventer, Isabelle A., de Graaf, Aniek O., Salzbrunn, Jonas B., Nolte, Ilja M., Kamphuis, Priscilla, Dinmohamed, Avinash, van der Reijden, Bert A., Schuringa, Jan Jacob, Jansen, Joop H., Huls, Gerwin

Clonal hematopoiesis in patients with stem cell mobilization failure: a nested case-control study

Hazenberg, Carin L. E., de Graaf, Aniek O., Mulder, René, Bungener, Laura B., van Bergen, Maaike G. J. M., Mulder, André B., Choi, Goda, Schuringa, Jan Jacob, de Groot, Marco R., Vellenga, Edo, Jansen, Joop H., Huls, Gerwin, van Zeventer, Isabelle A.

Dietary methionine starvation impairs acute myeloid leukemia progression

Cunningham, Alan ¹, Erdem, Ayşegül ¹, Alshamleh, Islam ², Geugien, Marjan ¹, Pruis, Maurien ¹, Pereira-Martins, Diego Antonio ^{1, 3}, van den Heuvel, Fiona A. J. ¹, Wierenga, Albertus T. J. ¹, ten Berge, Hilde ¹, Dennebos, Robin ¹, van den Boom, Vincent ¹, Hogeling, Shanna M. ¹, Weinhäuser, Isabel ^{1, 3}, Knops, Ruth ⁴, de Blaauw, Pim ⁵, Heiner-Fokkema, M. Rebecca ⁵, Woolthuis, Carolien ¹, Günther, Ulrich L. ⁶, Rego, Eduardo M. ³, Martens, Joost H. A. ⁷, Jansen, Joop H. ⁴, Schwalbe, Harald ², Huls, Gerwin ¹, Schuringa, Jan Jacob ^{1, ∗}