Sökresultat - "Souers, Andrew J."

Enabling, Decagram-Scale Synthesis of Macrocyclic MCL‑1 Inhibitor ABBV-467

Brady, Patrick B.^aff1, Sorensen, Bryan K.^aff1, Risi, Roberto M.^aff1, Curtin, Michael L.^aff1, Mantei, Robert A.^aff1, Florjancic, Alan S.^aff1, Mastracchio, Anthony^aff2, Ji, Cheng^aff2, Kunzer, Aaron R.^aff2, Lai, Chunqiu^aff1, Storer, Gregory E.^aff3, Chan, Vincent S.^aff3, Henry, Rodger F.^aff4, Souers, Andrew J.^aff5, Michaelides, Michael R.^aff5, Judd, Andrew S.^aff2, Hansen, T. Matthew^aff1

Pharmaceutical Development Challenges in a Beyond Rule of Five Prodrug: Case Study of ABBV-167, Phosphate Prodrug of Venetoclax

Hong, Richard, Nie, Haichen, Henry, Rodger F., Garner, Sean M., Catron, Nathaniel D., Hertzler, Russell L., Souers, Andrew J., Sheikh, Ahmad Y., Chen, Shuang

Integrated molecular and functional characterization of the intrinsic apoptotic machinery identifies therapeutic vulnerabilities in glioma

Fernandez, Elizabeth G, Mai, Wilson X, Song, Kai, Bayley, Nicholas A, Kim, Jiyoon, Zhu, Henan, Pioso, Marissa, Young, Pauline, Andrasz, Cassidy L, Cadet, Dimitri, Liau, Linda M, Li, Gang, Yong, William H, Rodriguez, Fausto J, Dixon, Scott J, Souers, Andrew J, Li, Jingyi Jessica, Graeber, Thomas G, Cloughesy, Timothy F, Nathanson, David A

application/pdf

Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients

Yuda, Junichiro, Will, Christine, Phillips, Darren C., Abraham, Linu, Alvey, Cory, Avigdor, Abraham^{Aff3, Aff4}, Buck, Wayne, Besenhofer, Lauren, Boghaert, Erwin^{Aff2, Aff6}, Cheng, Dong, Cojocari, Dan, Doyle, Kelly, Hansen, T. Matthew, Huang, Kevin, Johnson, Eric F., Judd, Andrew S., Judge, Russell A., Kalvass, John C., Kunzer, Aaron, Lam, Lloyd T., Li, Rachel, Martin, Ruth L., Mastracchio, Anthony, Mitten, Mike^{Aff2, Aff7}, Petrich, Adam^{Aff2, Aff5, Aff8}, Wang, Jin, Ward, James E.^{Aff2, Aff9}, Zhang, Haichao, Wang, Xilu, Wolff, Johannes E.^{Aff2, Aff10}, Bell-McGuinn, Katherine M.^{Aff2, Aff11}, Souers, Andrew J.^{Aff2, IDs4385602300380z_cor32}

Denna resultat visas inte till gäster.
Logga in för full Login for full tillgång.

Senolytic-Mediated Elimination of Head and Neck Tumor Cells Induced Into Senescence by Cisplatin

Ahmadinejad, Fereshteh ¹, Bos, Tasia ¹, Hu, Bin, Britt, Erin, Koblinski, Jennifer, Souers, Andrew J., Leverson, Joel D., Faber, Anthony C., Gewirtz, David A. ^*, Harada, Hisashi ^*

Structure-Guided Design of a Series of MCL‑1 Inhibitors with High Affinity and Selectivity

Bruncko, Milan, Wang, Le, Sheppard, George S., Phillips, Darren C., Tahir, Stephen K., Xue, John, Erickson, Scott, Fidanze, Steve, Fry, Elizabeth, Hasvold, Lisa, Jenkins, Gary J., Jin, Sha, Judge, Russell A., Kovar, Peter J., Madar, David, Nimmer, Paul, Park, Chang, Petros, Andrew M., Rosenberg, Saul H., Smith, Morey L., Song, Xiaohong, Sun, Chaohong, Tao, Zhi-Fu, Wang, Xilu, Xiao, Yu, Zhang, Haichao, Tse, Chris, Leverson, Joel D., Elmore, Steven W., Souers, Andrew J.

Identification and Preliminary Characterization of a Potent, Safe, and Orally Efficacious Inhibitor of Acyl-CoA:Diacylglycerol Acyltransferase 1

Yeh, Vince S. C., Beno, David W. A., Brodjian, Sevan, Brune, Michael E., Cullen, Steven C., Dayton, Brian D., Dhaon, Madhup K., Falls, Hugh D., Gao, Ju, Grihalde, Nelson, Hajduk, Philip, Hansen, T. Matthew, Judd, Andrew S., King, Andrew J., Klix, Russel C., Larson, Kelly J., Lau, Yau Y., Marsh, Kennan C., Mittelstadt, Scott W., Plata, Dan, Rozema, Michael J., Segreti, Jason A., Stoner, Eric J., Voorbach, Martin J., Wang, Xiaojun, Xin, Xili, Zhao, Gang, Collins, Christine A., Cox, Bryan F., Reilly, Regina M., Kym, Philip R., Souers, Andrew J.

Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity

Sleebs, Brad E.^{aff1, aff2}, Czabotar, Peter E.^{aff1, aff2}, Fairbrother, Wayne J.^aff3, Fairlie, W. Douglas^{aff1, aff2}, Flygare, John A.^aff3, Huang, David C. S.^{aff1, aff2}, Kersten, Wilhelmus J. A.^{aff1, aff2}, Koehler, Michael F. T.^aff3, Lessene, Guillaume^{aff1, aff2}, Lowes, Kym^{aff1, aff2}, Parisot, John P.^{aff1, aff2}, Smith, Brian J.^{aff1, aff2}, Smith, Morey L.^aff4, Souers, Andrew J.^aff4, Street, Ian P.^{aff1, aff2}, Yang, Hong^{aff1, aff2}, Baell, Jonathan B.^{aff1, aff2}

Balancing Properties with Carboxylates: A Lead Optimization Campaign for Selective and Orally Active CDK9 Inhibitors

Tong, Yunsong^aff1, Florjancic, Alan S.^aff2, Clark, Rick F.^aff2, Lai, Chunqiu^aff2, Mastracchio, Anthony^aff2, Zhu, Gui-dong^aff2, Smith, Morey L.^aff2, Kovar, Peter J.^aff8, Shaw, Bailin^aff2, Albert, Daniel H.^aff2, Qiu, Wei^aff11, Longenecker, Kenton L.^aff11, Liu, Xiaoqin^aff13, Olson, Amanda M.^aff13, Osterling, Donald J.^aff13, Tahir, Stephen K.^aff2, Phillips, Darren C.^aff2, Leverson, Joel D.^aff2, Souers, Andrew J.^aff2, Penning, Thomas D.^aff2

Structure-Based Design of A‑1293102, a Potent and Selective BCL‑XL Inhibitor

Tao, Zhi-Fu, Wang, Xilu, Chen, Jun, Ingram, Justin P., Jin, Sha, Judge, Russell A., Kovar, Peter J., Park, Chang, Sun, Chaohong, Wakefield, Brian D., Zhou, Li, Zhang, Haichao, Elmore, Steven W., Phillips, Darren C., Judd, Andrew S., Leverson, Joel D., Souers, Andrew J.

Screening for Cardiovascular Safety: A Structure−Activity Approach for Guiding Lead Selection of Melanin Concentrating Hormone Receptor 1 Antagonists

Kym, Philip R., Souers, Andrew J., Campbell, Thomas J., Lynch, John K., Judd, Andrew S., Iyengar, Rajesh, Vasudevan, Anil, Gao, Ju, Freeman, Jennifer C., Wodka, Dariusz, Mulhern, Mathew, Zhao, Gang, Wagaw, Seble H., Napier, James J., Brodjian, Sevan, Dayton, Brian D., Reilly, Regina M., Segreti, Jason A., Fryer, Ryan M., Preusser, Lee C., Reinhart, Glenn A., Hernandez, Lisa, Marsh, Kennan C., Sham, Hing L., Collins, Christine A., Polakowski, James S.

MCL1 nuclear translocation induces chemoresistance in colorectal carcinoma

Fu, Dechen, Pfannenstiel, Luke, Demelash, Abeba, Phoon, Yee Peng^{Aff1, IDs4141902104334y_cor4}, Mayell, Cameron, Cabrera, Claudia, Liu, Caini, Zhao, Junjie, Dermawan, Josephine, Patil, Deepa, DeVecchio, Jennifer, Kalady, Matthew, Souers, Andrew J., Phillips, Darren C., Li, Xiaoxia, Gastman, Brian^{Aff1, IDs4141902104334y_cor16}

The Preparation and Utility of Bis(sulfinyl)imidoamidine Ligands for the Copper-Catalyzed Diels−Alder Reaction

Owens, Timothy D., Souers, Andrew J., Ellman, Jonathan A.

Identification of a Potent Heterocyclic Ligand To Somatostatin Receptor Subtype 5 by the Synthesis and Screening of β-Turn Mimetic Libraries

Souers, Andrew J., Virgilio, Alex A., Rosenquist, Åsa, Fenuik, Wasyl, Ellman, Jonathan A.

A novel CDK9 inhibitor increases the efficacy of venetoclax (ABT-199) in multiple models of hematologic malignancies

Phillips, Darren C.^Aff1, Jin, Sha, Gregory, Gareth P.^{Aff2, Aff3}, Zhang, Qi, Xue, John, Zhao, Xiaoxian, Chen, Jun, Tong, Yunsong, Zhang, Haichao, Smith, Morey, Tahir, Stephen K., Clark, Rick F., Penning, Thomas D., Devlin, Jennifer R.^{Aff2, Aff7}, Shortt, Jake, Hsi, Eric D., Albert, Daniel H., Konopleva, Marina, Johnstone, Ricky W.^{Aff2, Aff7}, Leverson, Joel D., Souers, Andrew J.

Coamplification of miR-4728 protects HER2 -amplified breast cancers from targeted therapy

Floros, Konstantinos V., Lochmann, Timothy L., Hu, Bin, Monterrubio, Carles, Hughes, Mark T., Wells, Jason D., Morales, Cristina Bernadó, Ghotra, Maninderjit S., Costa, Carlotta, Souers, Andrew J., Boikos, Sosipatros A., Leverson, Joel D., Tan, Ming, Serra, Violeta, Koblinski, Jennifer E., Arribas, Joaquin, Prat, Aleix, Paré, Laia, Miller, Todd W., Dozmorov, Mikhail G., Harada, Hisashi, Windle, Brad E., Scaltriti, Maurizio, Faber, Anthony C.

Denna resultat visas inte till gäster.
Logga in för full Login for full tillgång.

Denna resultat visas inte till gäster.
Logga in för full Login for full tillgång.

Synthesis and Crystal Structure of a Unique and Homochiral N,S-Bonded N,N ‘-Bis(tert-butanesulfinyl)amidinate Rhodium(I) Complex

Souers, Andrew J., Owens, Timothy D., Oliver, Allen G., Hollander, Frederick J., Ellman, Jonathan A.