Sökresultat - "Sphingosine-1-phosphate"

Sphingosine-1-phosphate affects myocardial vascular homeostasis by regulating the balance of sphingosine-1-phosphate receptors in the hearts of diabetic mice.

Jin G; Department of Cardiology, Wuhan Fourth Hospital, China., Zhao H; Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China., Li L; Department of Cardiology, Wuhan Fourth Hospital, China., Cao Q; Department of Cardiology, Wuhan Fourth Hospital, China., Yan H; Department of Cardiology, Wuhan Fourth Hospital, China.

Journal Article , 2025

S1PR3 inhibition impairs cell cycle checkpoint via the AKT/WEE1 pathway in oral squamous cell carcinoma.

Zhou X; Department of Clinical Immunology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China., Liu J; Department of Clinical Immunology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China., Chen X; Department of Clinical Immunology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China., Zhou X; Department of Oral and Maxillofacial-Head and Neck Oncology, College of Stomatology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China., Xu B; Department of Clinical Immunology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China., Gan G; Department of Clinical Immunology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China. agan1992@126.com., Chen F; Department of Clinical Immunology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China. chenfx@sjtu.edu.cn.; College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. chenfx@sjtu.edu.cn.

Journal Article , 2025

Neuroprotective mechanisms of A-971432: Targeting S1PR5 to modulate PI3K/Akt and MAPK pathways in cerebral ischemia/reperfusion injury.

Guo X; Department of Neurology, Xiangyang No.1 People's Hospital, Hubei University of Medicine, 441100 Xiangyang, China., Wang Y; Yangtze River Shipping General Hospital/Wuhan Brain Hospital, 430015 Wuhan, China., Tao W; Department of Critical Care Medicine, Department of Emergency Medicine, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, No. 136, Jingzhou Street, Xiangcheng District, Xiangyang 441021, Hubei, China., Wu G; Department of Neurology, Xiangyang No.1 People's Hospital, Hubei University of Medicine, 441100 Xiangyang, China., Li X; Department of Neurology, Xiangyang No.1 People's Hospital, Hubei University of Medicine, 441100 Xiangyang, China., Wang J; Department of Neurology, Xiangyang No.1 People's Hospital, Hubei University of Medicine, 441100 Xiangyang, China., Zhang S; Department of Neurology, Xiangyang No.1 People's Hospital, Hubei University of Medicine, 441100 Xiangyang, China., Ren Z; Department of Neurology, Xiangyang No.1 People's Hospital, Hubei University of Medicine, 441100 Xiangyang, China. Electronic address: renzijing8@126.com., Zhou P; Department of Neurology, Xiangyang No.1 People's Hospital, Hubei University of Medicine, 441100 Xiangyang, China. Electronic address: 13597491119@126.com.

Journal Article , 2025

ATP11B triggers the infiltration of T cells into GBM and intensifies anti-GBM immunity by upregulating and externalizing S1PR1.

Qiu H; Cancer Institute, Xuzhou Medical University, Jiangsu, Xuzhou, 221000, China.; Department of Radiation Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, Jiangsu, China., Chen Z; Cancer Institute, Xuzhou Medical University, Jiangsu, Xuzhou, 221000, China.; Department of Radiation Oncology, Affiliated Huai'an Hospital of Yangzhou University, Huai'an Fifth People's Hospital, Huai'an, 223300, Jiangsu, China., Chen J; Cancer Institute, Xuzhou Medical University, Jiangsu, Xuzhou, 221000, China.; Department of Radiation Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, Jiangsu, China., Yu H; Department of Radiation Oncology, Affiliated Huai'an Hospital of Yangzhou University, Huai'an Fifth People's Hospital, Huai'an, 223300, Jiangsu, China., Wen X; Cancer Institute, Xuzhou Medical University, Jiangsu, Xuzhou, 221000, China.; Department of Radiation Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, Jiangsu, China., Xu C; Cancer Institute, Xuzhou Medical University, Jiangsu, Xuzhou, 221000, China., Liu G; Cancer Institute, Xuzhou Medical University, Jiangsu, Xuzhou, 221000, China., Chai L; Cancer Institute, Xuzhou Medical University, Jiangsu, Xuzhou, 221000, China., Zhang L; Cancer Institute, Xuzhou Medical University, Jiangsu, Xuzhou, 221000, China.; Department of Radiation Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, Jiangsu, China., Guo Y; Cancer Institute, Xuzhou Medical University, Jiangsu, Xuzhou, 221000, China. guoyilong888@163.com.; Department of Radiation Oncology, Affiliated Pizhou Hospital of Xuzhou Medical University, Xuzhou, 221300, Jiangsu, China. guoyilong888@163.com., Ding X; Cancer Institute, Xuzhou Medical University, Jiangsu, Xuzhou, 221000, China. dingxin81@163.com.; Department of Radiation Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, Jiangsu, China. dingxin81@163.com.

Journal Article , 2025

Conjugated bile acids promote metabolic dysfunction-associated steatotic liver disease through inducing nuclear translocation of sphingosine-1-phosphate receptor 2 to disrupt peroxisome proliferator-activated receptor alpha.

Miao RR; Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.; Department of Pharmacy, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, 410007, China., Tan MY; Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, 100069, China., Shao HB; Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, 100069, China., Sun ZM; Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China., Zhan S; Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China., Liang WS; Department of Orthopedic Surgery, Beijing Chaoyang Hospital, Joint Laboratory for Research & Treatment of Spinal Cord Injury in Spinal Deformity, Capital Medical University, Beijing, 100020, China., Liu XH; Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China., Li KQ; Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China., Cheng YY; Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, 100069, China., Wu XF; Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China., Xu R; Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China., Cui SX; Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, 100069, China., Hai Y; Department of Orthopedic Surgery, Beijing Chaoyang Hospital, Joint Laboratory for Research & Treatment of Spinal Cord Injury in Spinal Deformity, Capital Medical University, Beijing, 100020, China. yong.hai@ccmu.edu.cn.; Beijing Chaoyang Hospital, Capital Medical University, Beijing, China. yong.hai@ccmu.edu.cn., Qu XJ; Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China. qxj@ccmu.edu.cn.; School of Basic Medical Sciences, Capital Medical University, Beijing, China. qxj@ccmu.edu.cn.

Journal Article , 2025

Hedgehog pathway inhibitor HhAntag suppresses virus infection via the GLI-S1PR axis.

Zhang J; Jiangsu Key Laboratory of Infection and Immunity, Children's Hospital of Soochow University, Institute of Biology and Medical Sciences, Suzhou Medical College of Soochow University, Suzhou 215123, China; Central Laboratory, The Fourth Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China., Dong C; Jiangsu Key Laboratory of Infection and Immunity, Children's Hospital of Soochow University, Institute of Biology and Medical Sciences, Suzhou Medical College of Soochow University, Suzhou 215123, China., Chen Z; Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China., Hua R; Jiangsu Key Laboratory of Infection and Immunity, Children's Hospital of Soochow University, Institute of Biology and Medical Sciences, Suzhou Medical College of Soochow University, Suzhou 215123, China., Li Z; School of Life Science and Technology, Shandong Second Medical University, Weifang 261053, China., Lin Y; The Second Clinical Medical School of Nanjing Medical University, Nanjing 211166, China., Wang Y; Department of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou 215000, China. Electronic address: wang_yu_qing@126.com., Feng T; Central Laboratory, The Fourth Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. Electronic address: ttfeng@njmu.edu.cn., Dai J; Jiangsu Key Laboratory of Infection and Immunity, Children's Hospital of Soochow University, Institute of Biology and Medical Sciences, Suzhou Medical College of Soochow University, Suzhou 215123, China; MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou 215123, China. Electronic address: daijianfeng@suda.edu.cn.

Journal Article , 2025

Sphingosine-1-phosphate receptor 3 activation promotes sociability and regulates transcripts important for anxiolytic-like behavior.

Castro-Vildosola J; Department of Biology, Rutgers University, Camden, NJ, USA., Bryan CA; Department of Biology, Rutgers University, Camden, NJ, USA; Center for Computational and Integrative Biology, Rutgers University, Camden, NJ, USA., Tajamal N; Department of Biology, Rutgers University, Camden, NJ, USA., Jonnalagadda SA; Department of Biology, Rutgers University, Camden, NJ, USA., Kasturi A; Department of Biology, Rutgers University, Camden, NJ, USA., Tilly J; Department of Biology, Rutgers University, Camden, NJ, USA., Garcia I; Department of Biology, Rutgers University, Camden, NJ, USA., Kumar R; Center for Computational and Integrative Biology, Rutgers University, Camden, NJ, USA., Fried NT; Department of Biology, Rutgers University, Camden, NJ, USA; Center for Computational and Integrative Biology, Rutgers University, Camden, NJ, USA., Hala T; Department of Biology, Rutgers University, Camden, NJ, USA., Corbett BF; Department of Biology, Rutgers University, Camden, NJ, USA; Center for Computational and Integrative Biology, Rutgers University, Camden, NJ, USA. Electronic address: brian.corbett@rutgers.edu.

Journal Article , 2025

The sphingosine-1-phosphate signaling pathway (sphingosine-1-phosphate and its receptor, sphingosine kinase) and epilepsy.

Wang L; Department of Neurology, Affiliated Hospital of Jining Medical University, Jining City, China.; Epilepsy Center, Affiliated Hospital of Jining Medical University, Jining City, China.; The Chinese University of Hong Kong, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Central Ave, Hong Kong, Hong Kong., Kong Q; Department of Neurology, Affiliated Hospital of Jining Medical University, Jining City, China.; Epilepsy Center, Affiliated Hospital of Jining Medical University, Jining City, China., Leng X; The Chinese University of Hong Kong, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Central Ave, Hong Kong, Hong Kong., Leung H; Division of Neurology, Department of Medicine and Therapeutics, Prince of Wales Hospital, 7/F Clinical Science Building, Prince of Wales Hospital, Hong Kong, Hong Kong., Li Y; Department of Oncology, Affiliated Hospital of Jining Medical University, Jining City, China.

Journal Article; Review , 2025

Identification of the potential role of S1PR1 in adult moyamoya disease based on multiple bioinformatics analysis and experimental verification.

Zhou J; Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.; Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China., Lei Y; Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China., Zhang S; Naval Aviation University of Chinese People's Liberation Army, Yantai, People's Republic of China., Qin R; The Third People's Hospital of Yichang, The Third People's Hospital of China Three Gorges University, Yichang, People's Republic of China., Liu Y; Department of Gastroenterology, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Wuhan, People's Republic of China., Yi D; Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

Journal Article , 2025

Transcriptional signature of rapidly responding NK cells reveals S1P5 and CXCR4 as anti-tumor response disruptors.

Puig-Gámez M; Department of Cancer Immunology and Immune Modulation, Boehringer Ingelheim Pharma GmbH & Co. KG, 88387, Biberach an der Riss, Germany., Van Attekum M; Department of Global Computational Biology and Digital Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, 88387, Biberach an der Riss, Germany., Theis T; Department of Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, 88387, Biberach an der Riss, Germany., Dick A; Department of Global Computational Biology and Digital Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, 88387, Biberach an der Riss, Germany., Park JE; Department of Cancer Immunology and Immune Modulation, Boehringer Ingelheim Pharma GmbH & Co. KG, 88387, Biberach an der Riss, Germany. john.park@boehringer-ingelheim.com.

Journal Article , 2025

S1PR3 in hippocampal neurons improves synaptic plasticity and decreases depressive behavior via downregulation of RhoA/ROCK1.

Liu H; Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, China; Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, China., Chen S; Department of Biochemistry, School of Life Sciences of Central South University, Changsha, China., Xiang H; Center for Experimental Medicine, The Third Xiangya Hospital of Central South University, Changsha, China., Xiao J; Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, China; Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, China., Zhao S; Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, China; Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, China., Zhang X; Department of Biochemistry, School of Life Sciences of Central South University, Changsha, China., Shu Z; Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, China; Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, China., Zhang J; Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, China; Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, China., Ouyang J; Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, China; Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, China., Liu Q; Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, China; Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, China., Quan Q; Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, China; Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, China., Fan J; Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, China; Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, China., Gao P; Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, China; Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, China., Zheng X; Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, China; Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, China., Chen AF; Center for Experimental Medicine, The Third Xiangya Hospital of Central South University, Changsha, China; Institute for Cardiovascular Development and Regenerative Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China., Lu H; Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, China; Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, China. Electronic address: hongweilu@csu.edu.cn.

Journal Article , 2025

Duhuo Jisheng Mixture attenuates neuropathic pain by inhibiting S1PR1/P2Y 1 R pathway after Chronic Constriction Injury in mice.

Li R; Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Changle West Street 15, Xi'an, Shaanxi, 710032, China., Zhang W; Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Changle West Street 15, Xi'an, Shaanxi, 710032, China., Bai X; Department of Pharmacy, Tangdu Hospital, Fourth Military Medical University, Xinsi Street 1, Xi'an, Shaanxi, 710038, China., Wang F; Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Changle West Street 15, Xi'an, Shaanxi, 710032, China., Yao M; Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Changle West Street 15, Xi'an, Shaanxi, 710032, China., Zhao C; Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Changle West Street 15, Xi'an, Shaanxi, 710032, China. Electronic address: zhaochao7god@163.com., Wang J; Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Changle West Street 15, Xi'an, Shaanxi, 710032, China. Electronic address: wangjingwen8021@163.com.

Journal Article , 2025

S1PR1-biased activation drives the resolution of endothelial dysfunction-associated inflammatory diseases by maintaining endothelial integrity.

Zheng H; Department of Respiratory and Critical Care Medicine, Center for High Altitude Medicine, Institutes for Systems Genetics, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China., Yu J; Department of Respiratory and Critical Care Medicine, Center for High Altitude Medicine, Institutes for Systems Genetics, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.; Division of Nephrology and Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, China., Gao L; Department of Respiratory and Critical Care Medicine, Center for High Altitude Medicine, Institutes for Systems Genetics, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China., Wang K; Department of Respiratory and Critical Care Medicine, Center for High Altitude Medicine, Institutes for Systems Genetics, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.; Division of Nephrology and Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, China., Xu Z; Department of Respiratory and Critical Care Medicine, Center for High Altitude Medicine, Institutes for Systems Genetics, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China., Zeng Z; Department of Gastroenterology, Lab of Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, China., Zheng K; Department of Respiratory and Critical Care Medicine, Center for High Altitude Medicine, Institutes for Systems Genetics, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China., Tang X; Department of Respiratory and Critical Care Medicine, Center for High Altitude Medicine, Institutes for Systems Genetics, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China., Tian X; Department of Respiratory and Critical Care Medicine, Center for High Altitude Medicine, Institutes for Systems Genetics, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.; Division of Nephrology and Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, China., Zhao Q; Department of Respiratory and Critical Care Medicine, Center for High Altitude Medicine, Institutes for Systems Genetics, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China., Zhao J; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu, China., Wan H; Department of Respiratory and Critical Care Medicine, Center for High Altitude Medicine, Institutes for Systems Genetics, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China., Cao Z; Department of Respiratory and Critical Care Medicine, Center for High Altitude Medicine, Institutes for Systems Genetics, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China., Zhang K; Center for Biomedicine and Innovations, Faculty of Medicine, Macau University of Science and Technology and University Hospital, Macau, China., Cheng J; Department of Respiratory and Critical Care Medicine, Center for High Altitude Medicine, Institutes for Systems Genetics, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China., Brosius J; Department of Respiratory and Critical Care Medicine, Center for High Altitude Medicine, Institutes for Systems Genetics, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China., Zhang H; Department of Gastroenterology, Lab of Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, China., Li W; Department of Dermatology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China., Yan W; Department of Respiratory and Critical Care Medicine, Center for High Altitude Medicine, Institutes for Systems Genetics, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China. weiyan2018@scu.edu.cn.; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu, China. weiyan2018@scu.edu.cn., Shao Z; Department of Respiratory and Critical Care Medicine, Center for High Altitude Medicine, Institutes for Systems Genetics, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China. zhenhuashao@scu.edu.cn.; Division of Nephrology and Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, China. zhenhuashao@scu.edu.cn.; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu, China. zhenhuashao@scu.edu.cn., Luo F; Department of Respiratory and Critical Care Medicine, Center for High Altitude Medicine, Institutes for Systems Genetics, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China. luofengming@wchscu.cn., Deng C; Department of Respiratory and Critical Care Medicine, Center for High Altitude Medicine, Institutes for Systems Genetics, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China. dengcheng@wchscu.cn.

Journal Article , 2025

A guide to selecting high-performing antibodies for S1PR1 (UniProt ID: P21453) for use in western blot, immunoprecipitation, and immunofluorescence.

Ayoubi R; Department of Neurology and Neurosurgery, Structural Genomics Consortium, The Montreal Neurological Institute, McGill University, Montreal, Québec, H3A 2B4, Canada., Fotouhi M; Department of Neurology and Neurosurgery, Structural Genomics Consortium, The Montreal Neurological Institute, McGill University, Montreal, Québec, H3A 2B4, Canada., Alende C; Department of Neurology and Neurosurgery, Structural Genomics Consortium, The Montreal Neurological Institute, McGill University, Montreal, Québec, H3A 2B4, Canada., González Bolívar S; Department of Neurology and Neurosurgery, Structural Genomics Consortium, The Montreal Neurological Institute, McGill University, Montreal, Québec, H3A 2B4, Canada., Southern K; Department of Neurology and Neurosurgery, Structural Genomics Consortium, The Montreal Neurological Institute, McGill University, Montreal, Québec, H3A 2B4, Canada., Laflamme C; Department of Neurology and Neurosurgery, Structural Genomics Consortium, The Montreal Neurological Institute, McGill University, Montreal, Québec, H3A 2B4, Canada.

NeuroSGC/YCharOS/EDDU collaborative group, ABIF consortium

Journal Article , 2025

Cardiomyocyte S1PR1 promotes cardiac regeneration via AKT/mTORC1 signaling pathway.

Liu X; State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China., Yue J; State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China., Zhou C; State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China., Duan Y; State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China., Chen X; State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China., Liu J; State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China., Zhuang S; Department of Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.; Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China., Luo Y; Department of Cardiology, Zigong Fourth People's Hospital, Sichuan, 643099, China., Wu J; Department of Cardiology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Zhang Y; State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China., Zhang L; State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.; Clinical Center for Heart Disease Research, School of Medicine, Tongji University, Shanghai, China.

Journal Article , 2025

Targeting SphK1/S1PR3 axis ameliorates sepsis-induced multiple organ injury via orchestration of macrophage polarization and glycolysis.

Wang D; Surgical Anesthesia Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China; Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China., Bi X; Surgical Anesthesia Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China; Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China., Zhao L; Surgical Anesthesia Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China; Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China., Xiang S; Department of Pharmacy, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China; Shenzhen Key Laboratory of Chinese Medicine Active Substance Screening and Translational Research, Shenzhen, China., Xi W; Surgical Anesthesia Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China., Yang S; Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China., Wu W; Surgical Anesthesia Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China., Chen T; Department of Gastrointestinal Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Zheng L; Surgical Anesthesia Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China. Electronic address: zhenglei3@mail.sysu.edu.cn., Chi X; Surgical Anesthesia Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China. Electronic address: chixj@mail.sysu.edu.cn., Kang Y; Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China. Electronic address: kangy26@mail.sysu.edu.cn.

Journal Article , 2025

Ex Vivo Overactivation of Lymphocyte Subsets in Fibrotic Hypersensitivity Pneumonitis Is Blunted by a Sphingosine-1-Phosphate Receptor Ligand.

Courtemanche O; Centre de recherche de l'Institut Universitaire de cardiologie et de pneumologie de Québec, 2725 Chemin Sainte-Foy, Quebec City, QC G1V 4G5, Canada., Huppé CA; Centre de recherche de l'Institut Universitaire de cardiologie et de pneumologie de Québec, 2725 Chemin Sainte-Foy, Quebec City, QC G1V 4G5, Canada., Blais-Lecours P; Centre de recherche de l'Institut Universitaire de cardiologie et de pneumologie de Québec, 2725 Chemin Sainte-Foy, Quebec City, QC G1V 4G5, Canada., Maranda C; Centre de recherche de l'Institut Universitaire de cardiologie et de pneumologie de Québec, 2725 Chemin Sainte-Foy, Quebec City, QC G1V 4G5, Canada., Morissette MC; Centre de recherche de l'Institut Universitaire de cardiologie et de pneumologie de Québec, 2725 Chemin Sainte-Foy, Quebec City, QC G1V 4G5, Canada.; Department of Medicine, Faculty of Medicine, Université Laval, Quebec City, QC G1V 0A6, Canada., Blanchet MR; Centre de recherche de l'Institut Universitaire de cardiologie et de pneumologie de Québec, 2725 Chemin Sainte-Foy, Quebec City, QC G1V 4G5, Canada.; Department of Medicine, Faculty of Medicine, Université Laval, Quebec City, QC G1V 0A6, Canada., Dion G; Centre de recherche de l'Institut Universitaire de cardiologie et de pneumologie de Québec, 2725 Chemin Sainte-Foy, Quebec City, QC G1V 4G5, Canada., Marsolais D; Centre de recherche de l'Institut Universitaire de cardiologie et de pneumologie de Québec, 2725 Chemin Sainte-Foy, Quebec City, QC G1V 4G5, Canada.; Department of Medicine, Faculty of Medicine, Université Laval, Quebec City, QC G1V 0A6, Canada.

Journal Article , 2025

Compression force regulates cementoblast mineralization via S1PR1/mitophagy axis.

Wang H; Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Laboratory of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.; Institute of Stomatology & Research Center of Dental and Craniofacial Implants, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.; Department of Orthodontics, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China., Cai J; Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Laboratory of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.; Institute of Stomatology & Research Center of Dental and Craniofacial Implants, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.; Department of Orthodontics, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China., Chen L; Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Laboratory of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.; Institute of Stomatology & Research Center of Dental and Craniofacial Implants, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.; Department of Orthodontics, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China., Chen S; Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Laboratory of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.; Institute of Stomatology & Research Center of Dental and Craniofacial Implants, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.; Department of Orthodontics, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China., Yang X; Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Laboratory of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.; Institute of Stomatology & Research Center of Dental and Craniofacial Implants, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.; Department of Orthodontics, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China., Chen Z; Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Laboratory of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.; Institute of Stomatology & Research Center of Dental and Craniofacial Implants, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.; Department of Orthodontics, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China., Xu L; Department of Orthodontics, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.

Journal Article , 2025

S1P/S1PRs-TRPV4 axis is a novel therapeutic target for persistent pain and itch in chronic dermatitis.

Zhang X; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing, China.; Key Laboratory for Chinese Medicine of Prevention and Treatment in Neurological Diseases, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, China., Zhou Y; Key Laboratory for Chinese Medicine of Prevention and Treatment in Neurological Diseases, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, China., Wang C; Key Laboratory for Chinese Medicine of Prevention and Treatment in Neurological Diseases, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, China., Ren J; Key Laboratory for Chinese Medicine of Prevention and Treatment in Neurological Diseases, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, China., Wang Y; Key Laboratory for Chinese Medicine of Prevention and Treatment in Neurological Diseases, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, China., Liu P; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing, China., Feng W; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing, China., Li X; Key Laboratory for Chinese Medicine of Prevention and Treatment in Neurological Diseases, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, China., Qi M; Key Laboratory for Chinese Medicine of Prevention and Treatment in Neurological Diseases, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, China., Yang Y; Key Laboratory for Chinese Medicine of Prevention and Treatment in Neurological Diseases, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, China., Zhu C; Key Laboratory for Chinese Medicine of Prevention and Treatment in Neurological Diseases, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, China., Wang F; Department of Dermatology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China., Ma Y; School of Life Science, China Pharmaceutical University, Nanjing, China., Tang Z; Key Laboratory for Chinese Medicine of Prevention and Treatment in Neurological Diseases, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, China., Yu G; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing, China.; Key Laboratory for Chinese Medicine of Prevention and Treatment in Neurological Diseases, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, China.

Journal Article , 2025

PET Imaging of Sphingosine-1-Phosphate Receptor 1 with [ ¹⁸ F]TZ4877 in Nonhuman Primates.

Gu J; Yale PET Center, Yale School of Medicine, New Haven, USA.; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, USA., Zheng MQ; Yale PET Center, Yale School of Medicine, New Haven, USA.; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, USA., Holden D; Yale PET Center, Yale School of Medicine, New Haven, USA.; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, USA., Fowles K; Yale PET Center, Yale School of Medicine, New Haven, USA.; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, USA., Qiu L; Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, USA., Felchner Z; Yale PET Center, Yale School of Medicine, New Haven, USA.; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, USA., Zhang L; Yale PET Center, Yale School of Medicine, New Haven, USA.; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, USA., Ropchan J; Yale PET Center, Yale School of Medicine, New Haven, USA.; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, USA., Gropler RJ; Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, USA., Carson RE; Yale PET Center, Yale School of Medicine, New Haven, USA.; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, USA., Tu Z; Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, USA., Huang Y; Yale PET Center, Yale School of Medicine, New Haven, USA.; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, USA., Hillmer AT; Yale PET Center, Yale School of Medicine, New Haven, USA. hillmera@med.umich.edu.; Department of Psychiatry, Yale School of Medicine, New Haven, USA. hillmera@med.umich.edu.; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, USA. hillmera@med.umich.edu.

Journal Article , 2025