Search Results - "Tertiary lymphoid structures"

Tertiary lymphoid structures: exploring opportunities to improve immunotherapy in ovarian cancer.

Varghese A; Department of Gynecologic Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.; Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, NY, United States., Hess SM; Department of Gynecologic Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States., Chilakapati S; Department of Gynecologic Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.; Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, United States., Conejo-Garcia JR; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, NC, United States., McGray AJR; Department of Gynecologic Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States., Zsiros E; Department of Gynecologic Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.

Journal Article; Review , 2025

Identification and characterization of tertiary lymphoid structures in brain metastases.

Mughal SS; Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. s.mughal@dkfz-heidelberg.de.; German Cancer Consortium (DKTK), Core Center Heidelberg, 69120, Heidelberg, Germany. s.mughal@dkfz-heidelberg.de., Reiss Y; Institute of Neurology (Edinger-Institute), University Hospital, Goethe University, Heinrich-Hoffmann-Strasse 7, 60590, Frankfurt, Germany.; Frankfurt Cancer Institute (FCI), Paul-Ehrlich-Straße 42-44, 60596, Frankfurt, Germany.; German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz and German Cancer Research Center (DKFZ), Heidelberg, Germany., Felsberg J; Institute of Neuropathology, Medical Faculty, Heinrich Heine University and University Hospital Düsseldorf, Moorenstrasse 5, Düsseldorf, Germany., Meyer L; Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Macas J; Institute of Neurology (Edinger-Institute), University Hospital, Goethe University, Heinrich-Hoffmann-Strasse 7, 60590, Frankfurt, Germany.; Frankfurt Cancer Institute (FCI), Paul-Ehrlich-Straße 42-44, 60596, Frankfurt, Germany., Schlue S; Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, 69120, Heidelberg, Germany., Starzetz T; Institute of Neurology (Edinger-Institute), University Hospital, Goethe University, Heinrich-Hoffmann-Strasse 7, 60590, Frankfurt, Germany., Köhrer K; Center for Biological and Medical Research (BMFZ), Genomics and Transcriptomics Laboratory (GTL), Heinrich Heine University, Universitätsstrasse 1, Düsseldorf, Germany., Fehm T; Department of Gynecology and Obstetrics, Center of Integrated Oncology ABCD, Medical Faculty, Heinrich Heine University and University Hospital Düsseldorf, Moorenstrasse 5, Düsseldorf, Germany., Müller V; Department of Gynecology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany., Lamszus K; Laboratory for Brain Tumor Biology, Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany., Schadendorf D; Department of Dermatology, University Hospital Essen, University Duisburg-Essen, Hufelandstrasse 50, 45147, Essen, Germany.; German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf and German Cancer Research Center (DKFZ), Heidelberg, Germany., Helfrich I; Department of Dermatology, University Hospital Essen, University Duisburg-Essen, Hufelandstrasse 50, 45147, Essen, Germany.; Department of Dermatology and Allergy, University Hospital of Munich, Ludwig-Maximilian-University (LMU), Frauenlobstrasse 9-11, 80337, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich and German Cancer Research Center (DKFZ), Heidelberg, Germany., Wikman H; Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany., Berghoff A; Department of Internal Medicine 1, Clinical Division of Oncology, Medical University Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria., Brors B; Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.; Medical Faculty and Faculty of Biosciences, Heidelberg University, 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.; German Cancer Consortium (DKTK), Core Center Heidelberg, 69120, Heidelberg, Germany., Plate KH; Institute of Neurology (Edinger-Institute), University Hospital, Goethe University, Heinrich-Hoffmann-Strasse 7, 60590, Frankfurt, Germany.; Frankfurt Cancer Institute (FCI), Paul-Ehrlich-Straße 42-44, 60596, Frankfurt, Germany.; German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz and German Cancer Research Center (DKFZ), Heidelberg, Germany., Reifenberger G; Institute of Neuropathology, Medical Faculty, Heinrich Heine University and University Hospital Düsseldorf, Moorenstrasse 5, Düsseldorf, Germany.; German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf and German Cancer Research Center (DKFZ), Heidelberg, Germany.

Journal Article , 2025

Tertiary Lymphoid Structures as Independent Predictors of Favorable Prognosis in Muscle-Invasive Bladder Cancer.

Teng X; Department of Pathology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Chen Z; Department of Pathology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Bai Y; Department of Pathology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Cao H; Department of Pathology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Zhang J; Department of Pathology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Xu L; Department of Pathology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Liu K; Nanjing Geneseeq Technology Inc., Nanjing, Jiangsu, China., Shi Y; Nanjing Geneseeq Technology Inc., Nanjing, Jiangsu, China., Shao Y; Nanjing Geneseeq Technology Inc., Nanjing, Jiangsu, China.

Journal Article , 2025

A Tertiary lymphoid structures-based pathological score predicts survival and recurrence in colorectal Cancer patients.

Le Rochais M; LBAI, UMR1227, Univ Brest, Inserm, Brest, France,. Electronic address: marion.lerochais@chu-brest.fr., Morvan M; Registre des Tumeurs Digestives du Finistère, Brest, France; EA7479 SPURBO, Université de Bretagne Occidentale, Brest, France., Bouzeloc S; Registre des Tumeurs Digestives du Finistère, Brest, France; EA7479 SPURBO, Université de Bretagne Occidentale, Brest, France. Electronic address: servane.bouzeloc@chu-brest.fr., Nousbaum JB; Registre des Tumeurs Digestives du Finistère, Brest, France; CHU Brest, Hepato-gastroenterology Department, Brest, France; EA7479 SPURBO, Université de Bretagne Occidentale, Brest, France. Electronic address: jean-baptiste.nousbaum@chu-brest.fr., Guillard M; CHU Brest, Pathology Department, Brest, France. Electronic address: matthieu.guillard@chu-brest.fr., Le Noac'h P; CHU Brest, Oncology Department, Brest, France. Electronic address: pierre.lenoach@chu-brest.fr., Garaud S; LBAI, UMR1227, Univ Brest, Inserm, Brest, France,. Electronic address: Soizic.Garaud@univ-brest.fr., Uguen A; LBAI, UMR1227, Univ Brest, Inserm, Brest, France,; CHU Brest, Pathology Department, Brest, France. Electronic address: arnaud.uguen@chu-brest.fr.

Journal Article , 2025

Genomic Characteristics Related to Histology-Based Immune Features in Breast Cancer.

Cha YJ; Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., O'Connell CE; Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Calhoun BC; Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Felsheim BM; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Bioinformatics and Computational Biology Curriculum, Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Fernandez-Martinez A; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Drug Development Department (DITEP), Gustave Roussy Cancer Campus, Villejuif, France; Inserm, Gustave Roussy Cancer Campus, UMR981, Villejuif, France., Fan C; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Brueffer C; Division of Oncology, Department of Clinical Sciences, Lund University, Sweden; Lund University Cancer Center, Lund University, Sweden; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden., Larsson C; Lund University Cancer Center, Lund University, Sweden; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden; Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University, Sweden., Borg Å; Division of Oncology, Department of Clinical Sciences, Lund University, Sweden; Lund University Cancer Center, Lund University, Sweden; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden., Saal LH; Division of Oncology, Department of Clinical Sciences, Lund University, Sweden; Lund University Cancer Center, Lund University, Sweden; Skåne University Hospital Comprehensive Cancer Center, Lund, Sweden., Perou CM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Electronic address: cperou@med.unc.edu.

Journal Article , 2025

Correlation analysis of tertiary lymphoid structure parameters with the prognosis of patients with locally advanced rectal cancer after neoadjuvant chemotherapy: a retrospective study.

Jiang Y; Department of Colorectal Surgery, Harbin Medical University Cancer Hospital, No.150 Haping Road, Harbin City, 150081, Heilongjiang Province, China., Zhang C; Department of Colorectal Surgery, Harbin Medical University Cancer Hospital, No.150 Haping Road, Harbin City, 150081, Heilongjiang Province, China., Hou Y; School of Nursing, Harbin Medical University, Harbin, 150081, Heilongjiang Province, China., Zhao B; Fourth Ward of General Surgery, The First Affiliated Hospital of Jiamusi University, No. 348 Dexiang Street, Jiamusi City, 154002, Heilongjiang Province, China. 15604549026@163.com., Cui B; Department of Colorectal Surgery, Harbin Medical University Cancer Hospital, No.150 Haping Road, Harbin City, 150081, Heilongjiang Province, China. binbincui@hrbmu.edu.cn.

Journal Article , 2025

Characterisation and Clinical Relevance of Tertiary Lymphoid Structures in Primary Biliary Cholangitis.

Chu H; Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.; Tianjin Institute of Digestive Diseases, Tianjin, China.; Tianjin Key Laboratory of Digestive Diseases, Tianjin, China., Li Y; Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.; Tianjin Institute of Digestive Diseases, Tianjin, China.; Tianjin Key Laboratory of Digestive Diseases, Tianjin, China., Yang H; Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.; Tianjin Institute of Digestive Diseases, Tianjin, China.; Tianjin Key Laboratory of Digestive Diseases, Tianjin, China., Liu Y; Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.; Tianjin Institute of Digestive Diseases, Tianjin, China.; Tianjin Key Laboratory of Digestive Diseases, Tianjin, China., Zheng R; Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.; Tianjin Institute of Digestive Diseases, Tianjin, China.; Tianjin Key Laboratory of Digestive Diseases, Tianjin, China., Zhang X; Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.; Tianjin Institute of Digestive Diseases, Tianjin, China.; Tianjin Key Laboratory of Digestive Diseases, Tianjin, China., Wang X; Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.; Tianjin Institute of Digestive Diseases, Tianjin, China.; Tianjin Key Laboratory of Digestive Diseases, Tianjin, China., Zhao J; Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.; Tianjin Institute of Digestive Diseases, Tianjin, China.; Tianjin Key Laboratory of Digestive Diseases, Tianjin, China., Zhang Y; Department of Pathology, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China., Wang Q; Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China., Ran Y; Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.; Tianjin Institute of Digestive Diseases, Tianjin, China.; Tianjin Key Laboratory of Digestive Diseases, Tianjin, China., Guo L; Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.; Tianjin Institute of Digestive Diseases, Tianjin, China.; Tianjin Key Laboratory of Digestive Diseases, Tianjin, China., Zhou S; Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.; Tianjin Institute of Digestive Diseases, Tianjin, China.; Tianjin Key Laboratory of Digestive Diseases, Tianjin, China., Liu M; Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.; Tianjin Institute of Digestive Diseases, Tianjin, China.; Tianjin Key Laboratory of Digestive Diseases, Tianjin, China., Song W; Department of Pathology, General Hospital, Tianjin Medical University, Tianjin, China., Wang B; Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.; Tianjin Institute of Digestive Diseases, Tianjin, China.; Tianjin Key Laboratory of Digestive Diseases, Tianjin, China., Li L; Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China., Zhou L; Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.; Tianjin Institute of Digestive Diseases, Tianjin, China.; Tianjin Key Laboratory of Digestive Diseases, Tianjin, China.

Journal Article , 2025

Tertiary lymphoid structures in pulmonary granulomas of cattle experimentally infected with aerosolized Mycobacterium bovis.

Palmer MV; United States Department of Agriculture, Infectious Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, 1920 Dayton Ave, Ames, IA, 50010, USA. mitchell.palmer@usda.gov., Jones DE; Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, 1600 S 16 th St., Ames, IA, 50011, USA., Bockenstedt NJ; Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, 1600 S 16 th St., Ames, IA, 50011, USA., Boggiatto PM; United States Department of Agriculture, Infectious Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, 1920 Dayton Ave, Ames, IA, 50010, USA.

Journal Article , 2025

Spatial distribution of tertiary lymphoid structures in the molecular and clinical context of non-small cell lung cancer.

Elfving H; Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, 751 85, Sweden. hedvig.elfving@igp.uu.se., Yu H; Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, 751 85, Sweden., Fessehatsion KK; Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, 751 85, Sweden., Brunnström H; Division of Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden., Botling J; Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, 751 85, Sweden., Gulyas M; Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, 751 85, Sweden., Backman M; Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, 751 85, Sweden., Lindberg A; Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, 751 85, Sweden., Strell C; Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, 751 85, Sweden.; Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, University of Bergen, Bergen, Norway., Micke P; Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, 751 85, Sweden.

Journal Article , 2025

A novel hybrid model for predicting tertiary lymphoid structures and targeted immunotherapy outcomes in hepatocellular carcinoma: a multicenter retrospective study.

Li Y; 7T Magnetic Resonance Translational Medicine Research Center, Department of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China., Li X; Department of Radiology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China., Xiao X; Department of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China., Cheng J; 7T Magnetic Resonance Translational Medicine Research Center, Department of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China., Li Q; Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China., Liu C; 7T Magnetic Resonance Translational Medicine Research Center, Department of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China., Cai P; 7T Magnetic Resonance Translational Medicine Research Center, Department of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China. caiping@tmmu.edu.cn., Chen W; 7T Magnetic Resonance Translational Medicine Research Center, Department of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China. landcw@tmmu.edu.cn., Zhang H; Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China. 13677653886@163.com., Li X; 7T Magnetic Resonance Translational Medicine Research Center, Department of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China. lxm359261069@tmmu.edu.cn.

Journal Article; Multicenter Study , 2025

RORc-expressing immune cells negatively regulate tertiary lymphoid structure formation and support their pro-tumorigenic functions.

Cinnamon E; The Concern Foundation Laboratories at The Lautenberg Center for Immunology and Cancer Research, Israel-Canada Medical Research Institute, Faculty of Medicine, The Hebrew University, Jerusalem, Israel., Stein I; The Concern Foundation Laboratories at The Lautenberg Center for Immunology and Cancer Research, Israel-Canada Medical Research Institute, Faculty of Medicine, The Hebrew University, Jerusalem, Israel; Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel., Zino E; The Concern Foundation Laboratories at The Lautenberg Center for Immunology and Cancer Research, Israel-Canada Medical Research Institute, Faculty of Medicine, The Hebrew University, Jerusalem, Israel., Rabinovich S; The Concern Foundation Laboratories at The Lautenberg Center for Immunology and Cancer Research, Israel-Canada Medical Research Institute, Faculty of Medicine, The Hebrew University, Jerusalem, Israel., Shovman Y; The Concern Foundation Laboratories at The Lautenberg Center for Immunology and Cancer Research, Israel-Canada Medical Research Institute, Faculty of Medicine, The Hebrew University, Jerusalem, Israel; Department of Neurology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel., Schlesinger Y; The Concern Foundation Laboratories at The Lautenberg Center for Immunology and Cancer Research, Israel-Canada Medical Research Institute, Faculty of Medicine, The Hebrew University, Jerusalem, Israel., Salame TM; Flow Cytometry Unit, Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel., Reich-Zeliger S; Department of System Immunology, Weizmann Institute of Science, Rehovot, Israel., Albrecht T; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany., Roessler S; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany., Schirmacher P; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany., Lotem M; Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel., Ben-Neriah Y; The Concern Foundation Laboratories at The Lautenberg Center for Immunology and Cancer Research, Israel-Canada Medical Research Institute, Faculty of Medicine, The Hebrew University, Jerusalem, Israel., Parnas O; The Concern Foundation Laboratories at The Lautenberg Center for Immunology and Cancer Research, Israel-Canada Medical Research Institute, Faculty of Medicine, The Hebrew University, Jerusalem, Israel., Pikarsky E; The Concern Foundation Laboratories at The Lautenberg Center for Immunology and Cancer Research, Israel-Canada Medical Research Institute, Faculty of Medicine, The Hebrew University, Jerusalem, Israel; Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Electronic address: peli@hadassah.org.il.

Journal Article , 2025

Artery tertiary lymphoid organs in atherosclerosis: A review.

Li Y; School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, Shanghai 201203, China; School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, Shanghai 201203, China., Gong S; School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, Shanghai 201203, China; School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, Shanghai 201203, China., Yan K; School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, Shanghai 201203, China; School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, Shanghai 201203, China., Shi Z; School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, Shanghai 201203, China; School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, Shanghai 201203, China., Bao Y; School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, Shanghai 201203, China; School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, Shanghai 201203, China. Electronic address: yiminbao@163.com., Ning K; School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, Shanghai 201203, China; School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, Shanghai 201203, China; Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, 2220 Pierce Ave, Preston Research Building, Room 359, Nashville, TN 37232, United States. Electronic address: ke.ning@vumc.org.

Journal Article; Review , 2025

Tertiary lymphoid structures in gliomas: impact on tumour immunity and progression.

Chen J; Shanghai Medical College, Fudan University, Shanghai, China., Yang Y; Department of Neurosurgery, Fudan University Shanghai Cancer Center, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China., Luan S; Maternity & Child Care Center Of DeZhou, Shanghai, Shandong, China., Xu W; Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China. xwhao0407@163.com.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. xwhao0407@163.com., Gao Y; Department of Neurosurgery, Fudan University Shanghai Cancer Center, Shanghai, China. dryanggao@126.com.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. dryanggao@126.com.

Journal Article; Review , 2025

Mature tertiary lymphoid structures evoke intra-tumoral T and B cell responses via progenitor exhausted CD4 ⁺ T cells in head and neck cancer.

Li H; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China.; Department of Oral Maxillofacial-Head Neck Oncology, School & Hospital of Stomatology, Wuhan University, Wuhan, China., Zhang MJ; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China., Zhang B; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China., Lin WP; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China., Li SJ; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China., Xiong D; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China., Wang Q; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China., Wang WD; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China., Yang QC; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China., Huang CF; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China., Deng WW; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China. dww@whu.edu.cn.; Department of Oral Maxillofacial-Head Neck Oncology, School & Hospital of Stomatology, Wuhan University, Wuhan, China. dww@whu.edu.cn., Sun ZJ; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China. sunzj@whu.edu.cn.; Department of Oral Maxillofacial-Head Neck Oncology, School & Hospital of Stomatology, Wuhan University, Wuhan, China. sunzj@whu.edu.cn.

Journal Article , 2025

Retrospective study on the correlation between CXCL13, immune infiltration, and tertiary lymphoid structures in cutaneous squamous cell carcinoma.

Chen Y; Department of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.; Skin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China., Wu Y; Department of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.; Skin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China., Zhao Z; Department of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.; Skin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China., Wen L; Department of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.; Skin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China., Wu M; Department of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.; Skin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China., Song D; Department of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.; Skin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China., Zeng Q; Department of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.; Skin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China., Liu Y; Department of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.; Skin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China., Yan G; Department of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.; Skin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China., Zhang G; Department of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.; Skin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.

Journal Article , 2025

Tertiary Lymphoid Structures Are Associated with Enhanced Macrophage Activation and Immune Checkpoint Expression and Predict Outcome in Cervical Cancer.

Gorvel L; Immunity and Cancer Team, Cancer Research Center of Marseille, CRCM, INSERM U1068, CNRS UMR7258, Aix-Marseille University U105, Marseille, France.; Immunomonitoring Platform, Cancer Research Center of Marseille, CRCM, INSERM U1068, CNRS UMR7258, Aix-Marseille University U105, Marseille, France., Panouillot M; UMRS1135 Sorbonne University, INSERM U1135, Centre of Immunology and Microbial Infections (Cimi), Immune Microenvironment and Immunotherapy Team, Paris, France., Rouvière MS; Immunity and Cancer Team, Cancer Research Center of Marseille, CRCM, INSERM U1068, CNRS UMR7258, Aix-Marseille University U105, Marseille, France.; Immunomonitoring Platform, Cancer Research Center of Marseille, CRCM, INSERM U1068, CNRS UMR7258, Aix-Marseille University U105, Marseille, France., Billon E; Immunomonitoring Platform, Cancer Research Center of Marseille, CRCM, INSERM U1068, CNRS UMR7258, Aix-Marseille University U105, Marseille, France., Fattori S; Immunity and Cancer Team, Cancer Research Center of Marseille, CRCM, INSERM U1068, CNRS UMR7258, Aix-Marseille University U105, Marseille, France., Sonongbua J; Immunity and Cancer Team, Cancer Research Center of Marseille, CRCM, INSERM U1068, CNRS UMR7258, Aix-Marseille University U105, Marseille, France., Boucherit N; Immunity and Cancer Team, Cancer Research Center of Marseille, CRCM, INSERM U1068, CNRS UMR7258, Aix-Marseille University U105, Marseille, France.; Immunomonitoring Platform, Cancer Research Center of Marseille, CRCM, INSERM U1068, CNRS UMR7258, Aix-Marseille University U105, Marseille, France., Ben Amara A; Immunity and Cancer Team, Cancer Research Center of Marseille, CRCM, INSERM U1068, CNRS UMR7258, Aix-Marseille University U105, Marseille, France.; Immunomonitoring Platform, Cancer Research Center of Marseille, CRCM, INSERM U1068, CNRS UMR7258, Aix-Marseille University U105, Marseille, France., Quilichini O; Department of Surgical Oncology, Institut Paoli-Calmettes, Marseille, France., Granjeaud S; CRCM Integrative Bioinformatics Platform, Cancer Research Center of Marseille, CRCM, INSERM U1068, CNRS UMR7258, Aix-Marseille University U105, Marseille, France., Degos C; Immunity and Cancer Team, Cancer Research Center of Marseille, CRCM, INSERM U1068, CNRS UMR7258, Aix-Marseille University U105, Marseille, France., Nunès JA; Immunity and Cancer Team, Cancer Research Center of Marseille, CRCM, INSERM U1068, CNRS UMR7258, Aix-Marseille University U105, Marseille, France., Carcopino X; Department of Obstetrics and Gynecology, Hôpital Nord, APHM, Aix-Marseille University (AMU), CNRS, IRD, IMBE UMR 7263, 13397, Marseille, France., Lambaudie E; Department of Surgical Oncology, Institut Paoli-Calmettes, Marseille, France., Chrétien AS; Immunomonitoring Platform, Cancer Research Center of Marseille, CRCM, INSERM U1068, CNRS UMR7258, Aix-Marseille University U105, Marseille, France., Sabatier R; Predictive Oncology Laboratory, Cancer Research Center of Marseille, CRCM, INSERM U1068, CNRS UMR7258, Aix-Marseille University U105, Marseille, France.; Department of Medical Oncology, Institut Paoli-Calmettes, Marseille, France., Dieu-Nosjean MC; UMRS1135 Sorbonne University, INSERM U1135, Centre of Immunology and Microbial Infections (Cimi), Immune Microenvironment and Immunotherapy Team, Paris, France., Olive D; Immunity and Cancer Team, Cancer Research Center of Marseille, CRCM, INSERM U1068, CNRS UMR7258, Aix-Marseille University U105, Marseille, France.; Immunomonitoring Platform, Cancer Research Center of Marseille, CRCM, INSERM U1068, CNRS UMR7258, Aix-Marseille University U105, Marseille, France.

Journal Article , 2025

Presence of Tertiary Lymphoid Structures and Exhausted Tissue-Resident T Cells Determines Clinical Response to PD-1 Blockade in Renal Cell Carcinoma.

Hugaboom MB; Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut., Wirth LV; Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut., Street K; Division of Biostatistics, Keck School of Medicine of USC, Los Angeles, California., Ruthen N; Weill Cornell Graduate School of Medical Sciences, New York, New York., Jegede OA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Schindler NR; Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut., Shah V; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Zaemes JP; Georgetown Lombardi Comprehensive Cancer Center, Washington, District of Columbia., El Ahmar N; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts., Matar S; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts., Savla V; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts., Choueiri TK; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Denize T; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts., West DJ; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts., McDermott DF; Division of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts., Plimack ER; Fox Chase Cancer Center, Temple Health, Philadelphia, Pennsylvania., Sosman JA; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois., Haas NB; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania., Stein MN; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York., Alter R; Hackensack University Medical Center, Hackensack, New Jersey., Bilen MA; Winship Cancer Institute, Emory University, Atlanta, Georgia., Hurwitz ME; Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut., Hammers H; Division of Hematology and Oncology, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas., Signoretti S; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts., Atkins MB; Georgetown Lombardi Comprehensive Cancer Center, Washington, District of Columbia., Wu CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Braun DA; Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut.

Journal Article , 2025

CXCL9 and CXCL13 shape endometrial cancer immune-activated microenvironment via tertiary lymphoid structure formation.

Nagase Y; Department of Pathology, Tokyo Yamate Medical Center, Tokyo, Japan., Kodama M; Department of Pathology, Tokyo Yamate Medical Center, Tokyo, Japan.; Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.; Genomics Unit, Keio Cancer Center, Keio University School of Medicine, Tokyo, Japan., Aimono E; Genomics Unit, Keio Cancer Center, Keio University School of Medicine, Tokyo, Japan., Nakamura K; Genomics Unit, Keio Cancer Center, Keio University School of Medicine, Tokyo, Japan., Takamatsu R; Genomics Unit, Keio Cancer Center, Keio University School of Medicine, Tokyo, Japan., Abe K; Department of Pathology, Tokyo Yamate Medical Center, Tokyo, Japan., Yoshimura T; Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan., Chiyoda T; Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan., Yamagami W; Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan., Nishihara H; Genomics Unit, Keio Cancer Center, Keio University School of Medicine, Tokyo, Japan.

Journal Article , 2025

Impact of Tertiary Lymphoid Structure on Prognosis and Tumor Microenvironment in Undifferentiated Pleomorphic Sarcoma.

Sonoda H; Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.; Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Iwasaki T; Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Ishihara S; Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.; Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.; Department of Pathology and Laboratory Medicine, Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, British Columbia, Canada., Mori T; Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Nakashima Y; Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Oda Y; Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Journal Article , 2025

Tertiary lymphoid structures and clinicopathological characteristics in pT1b Esophageal squamous cell carcinoma.

Jiang D; Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China., Liu Y; Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China., Deng M; Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China., Xiao Y; Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China., Song Q; Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China., Luan L; Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China., Huang J; Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China., Su J; Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China., Xu C; Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China. Electronic address: xu.chen@zs-hospital.sh.cn., Hou Y; Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China. Electronic address: houyingyong@aliyun.com.

Journal Article , 2025