Sökresultat - "Tree TI"

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Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling.

Ogishi M; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA; The David Rockefeller Graduate Program, Rockefeller University, New York, NY 10065, USA. Electronic address: oogishi-tky@umin.ac.jp., Kitaoka K; Department of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Kyoto University Graduate School of Medicine, Kyoto 606-8303, Japan., Good-Jacobson KL; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia; Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Rinchai D; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA., Zhang B; Department of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Kyoto University Graduate School of Medicine, Kyoto 606-8303, Japan; Laboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Yokohama 230-0045, Japan., Wang J; Department of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Kyoto University Graduate School of Medicine, Kyoto 606-8303, Japan., Gies V; Department of Clinical Immunology and Internal Medicine, Strasbourg University Hospital, INSERM UMR-S1109, 67000 Strasbourg, France., Rao G; Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia., Nguyen T; Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW 2052, Australia., Avery DT; Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia., Khan T; Department of Human Immunology, Research Branch, Sidra Medicine, Doha, Qatar., Smithmyer ME; Center for Interventional Immunology, Diabetes Clinical Research Program, Benaroya Research Institute, Seattle, WA 98101, USA., Mackie J; Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW 2052, Australia., Yang R; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA., Arias AA; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA; Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia; School of Microbiology, University of Antioquia UdeA, Medellin, Colombia., Asano T; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA., Ponsin K; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA., Chaldebas M; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA., Zhang P; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA., Peel JN; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA., Bohlen J; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France; Paris Cité University, Imagine Institute, Paris, France., Lévy R; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France; Paris Cité University, Imagine Institute, Paris, France., Pelham SJ; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA., Lei WT; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA., Han JE; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA., Fagniez I; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA., Chrabieh M; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France; Paris Cité University, Imagine Institute, Paris, France., Laine C; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France; Paris Cité University, Imagine Institute, Paris, France., Langlais D; McGill University Genome Center, Montreal, QC, Canada; McGill Research Centre on Complex Traits, Dahdaleh Institute of Genomic Medicine, Montreal, QC H3A 0G1, Canada; Department of Human Genetics, McGill University, Montreal, QC H3A 0G1, Canada., Gruber C; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Al Ali F; Department of Human Immunology, Research Branch, Sidra Medicine, Doha, Qatar., Rahman M; Department of Human Immunology, Research Branch, Sidra Medicine, Doha, Qatar., Aytekin C; Department of Pediatric Immunology, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey., Benson B; Center for Systems Immunology, Benaroya Research Institute, Seattle, WA 98101, USA., Dufort MJ; Center for Systems Immunology, Benaroya Research Institute, Seattle, WA 98101, USA., Domingo-Vila C; Department of Immunobiology, School of Immunobiology & Microbial Sciences, Kings' College London, London WC2R 2LS, UK., Moriya K; Department of Pediatrics, Tohoku University Graduate School of Medicine, Sendai 980-0872, Japan., Shlomchik M; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Uzel G; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Gray PE; Department of Immunology and Infectious Diseases, Sydney Children's Hospital, High Street, Randwick, NSW 2031, Australia; School of Women's and Children's Health, University of New South Wales, Sydney, NSW 2052, Australia; Clinical Immunogenomics Research Consortium Australasia (CIRCA), Darlinghurst, NSW 2010, Australia., Suan D; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia; Clinical Immunogenomics Research Consortium Australasia (CIRCA), Darlinghurst, NSW 2010, Australia; Westmead Clinical School, The University of Sydney, Westmead, NSW 2145, Australia., Preece K; John Hunter Children's Hospital, Newcastle, NSW 2305, Australia., Chua I; Canterbury Health Laboratories, Christchurch 8140, New Zealand., Okada S; Department of Pediatrics, Hiroshima University Hospital, Hiroshima 734-0037, Japan., Chikuma S; Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo 160-0016, Japan., Kiyonari H; Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research, Kobe, Hyogo 650-0047, Japan., Tree TI; Department of Immunobiology, School of Immunobiology & Microbial Sciences, Kings' College London, London WC2R 2LS, UK., Bogunovic D; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Gros P; McGill Research Centre on Complex Traits, Dahdaleh Institute of Genomic Medicine, Montreal, QC H3A 0G1, Canada; Department of Biochemistry, McGill University, Montreal, QC H3A 0G1, Canada., Marr N; Department of Human Immunology, Research Branch, Sidra Medicine, Doha, Qatar; College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar., Speake C; Center for Interventional Immunology, Diabetes Clinical Research Program, Benaroya Research Institute, Seattle, WA 98101, USA; Diabetes Clinical Research Program, Benaroya Research Institute, Seattle, WA 98101, USA., Oram RA; Clinical and Biomedical Science, Faculty of Health and Life Sciences, University of Exeter, Exeter EX1 2ED, UK., Béziat V; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France; Paris Cité University, Imagine Institute, Paris, France., Bustamante J; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France; Paris Cité University, Imagine Institute, Paris, France; Center for the Study of Primary Immunodeficiencies, Necker Hospital for Sick Children Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France., Abel L; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France; Paris Cité University, Imagine Institute, Paris, France., Boisson B; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France; Paris Cité University, Imagine Institute, Paris, France., Korganow AS; Department of Clinical Immunology and Internal Medicine, Strasbourg University Hospital, INSERM UMR-S1109, 67000 Strasbourg, France., Ma CS; Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW 2052, Australia; Clinical Immunogenomics Research Consortium Australasia (CIRCA), Darlinghurst, NSW 2010, Australia., Johnson MB; Clinical and Biomedical Science, Faculty of Health and Life Sciences, University of Exeter, Exeter EX1 2ED, UK., Chamoto K; Department of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Kyoto University Graduate School of Medicine, Kyoto 606-8303, Japan; Department of Immuno-Oncology PDT, Kyoto University Graduate School of Medicine, Kyoto 606-8303, Japan., Boisson-Dupuis S; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France; Paris Cité University, Imagine Institute, Paris, France., Honjo T; Department of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Kyoto University Graduate School of Medicine, Kyoto 606-8303, Japan., Casanova JL; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France; Paris Cité University, Imagine Institute, Paris, France; Department of Pediatrics, Necker Hospital for Sick Children, 75015 Paris, France; Howard Hughes Medical Institute, New York, NY 10065, USA., Tangye SG; Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW 2052, Australia; Clinical Immunogenomics Research Consortium Australasia (CIRCA), Darlinghurst, NSW 2010, Australia. Electronic address: s.tangye@garvan.org.au.

Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't , 2024

Human inherited PD-L1 deficiency is clinically and immunologically less severe than PD-1 deficiency.

Johnson MB; Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter , Exeter, UK., Ogishi M; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University , New York, NY, USA., Domingo-Vila C; Department of Immunobiology, School of Immunology and Microbial Sciences, Kings College London, London, UK., De Franco E; Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter , Exeter, UK., Wakeling MN; Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter , Exeter, UK., Imane Z; Faculty of Medicine and Pharmacy, Mohammed 5 University of Rabat , Rabat, Morocco., Resnick B; National Institute for Health and Care Research Exeter Clinical Research Facility, Royal Devon University Healthcare NHS Foundation Trust , Exeter, UK., Williams E; Department of Immunobiology, School of Immunology and Microbial Sciences, Kings College London, London, UK., Galão RP; Department of Infectious Diseases, School of Immunobiology and Microbial Sciences, Kings College London, London, UK., Caswell R; Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter , Exeter, UK., Russ-Silsby J; Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter , Exeter, UK., Seeleuthner Y; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163 , Paris, France.; Imagine Institute, Paris Cité University , Paris, France., Rinchai D; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University , New York, NY, USA., Fagniez I; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University , New York, NY, USA., Benson B; Center for Systems Immunology, Benaroya Research Institute , Seattle, WA, USA., Dufort MJ; Center for Systems Immunology, Benaroya Research Institute , Seattle, WA, USA., Speake C; Center for Interventional Immunology, Benaroya Research Institute , Seattle, WA, USA., Smithmyer ME; Center for Interventional Immunology, Benaroya Research Institute , Seattle, WA, USA., Hudson M; Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter , Exeter, UK.; National Institute for Health and Care Research Exeter Clinical Research Facility, Royal Devon University Healthcare NHS Foundation Trust , Exeter, UK., Dobbs R; Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter , Exeter, UK.; National Institute for Health and Care Research Exeter Clinical Research Facility, Royal Devon University Healthcare NHS Foundation Trust , Exeter, UK., Quandt Z; Endocrine Division, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.; Diabetes Center, University of California San Francisco , San Francisco, CA, USA., Hattersley AT; Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter , Exeter, UK., Zhang P; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University , New York, NY, USA., Boisson-Dupuis S; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University , New York, NY, USA.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163 , Paris, France.; Imagine Institute, Paris Cité University , Paris, France., Anderson MS; Endocrine Division, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.; Diabetes Center, University of California San Francisco , San Francisco, CA, USA., Casanova JL; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University , New York, NY, USA.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163 , Paris, France.; Imagine Institute, Paris Cité University , Paris, France.; Department of Pediatrics, Necker Hospital for Sick Children, Paris, France.; Howard Hughes Medical Institute , New York, NY, USA., Tree TI; Department of Immunobiology, School of Immunology and Microbial Sciences, Kings College London, London, UK., Oram RA; Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter , Exeter, UK.

EXE-T1D consortium

Journal Article , 2024

Identifying the 'Achilles heel' of type 1 diabetes.

Battaglia M; San Raffaele Diabetes Research Institute, IRCCS San Raffaele Hospital, Milan, Italy., Buckner JH; Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA., Levings MK; BC Children's Hospital Research Institute, Vancouver, BC, Canada., Richardson SJ; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK., Wong FS; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK., Tree TI; Department of Immunobiology, School of Immunology and Microbial Sciences (SIMS), King's College London, London, UK.; NIHR Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK.

Journal Article; Review , 2021

Historical and new insights into pathogenesis of type 1 diabetes (2).

Wong FS; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK., Tree TI; Programme of Infection and Immunity, Department of Immunobiology, Faculty of Life Sciences and Medicine, King's College London, Borough Wing, Guy's Hospital, London, UK.

Editorial , 2021

Historical and new insights into pathogenesis of type 1 diabetes.

Wong FS; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK., Tree TI; Programme of Infection and Immunity, Department of Immunobiology, Faculty of Life Sciences and Medicine, King's College London, Borough Wing, Guy's Hospital, London, UK.

Editorial; Introductory Journal Article , 2019

Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp ⁶²⁰ Risk Allele Drive the Expansion of FOXP3 ⁺ Regulatory T Cells and PD-1 Expression.

Ferreira RC; JDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom., Castro Dopico X; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom., Oliveira JJ; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom., Rainbow DB; JDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom., Yang JH; Department of Immunobiology, NIHR Biomedical Research Centre, King's College London, London, United Kingdom., Trzupek D; JDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom., Todd SA; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom., McNeill M; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom., Steri M; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Rome, Italy., Orrù V; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Rome, Italy., Fiorillo E; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Rome, Italy., Crouch DJM; JDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom., Pekalski ML; JDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom., Cucca F; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Rome, Italy.; Dipartimento di Scienze Biomediche, Università degli Studi di Sassari, Sassari, Italy., Tree TI; Department of Immunobiology, NIHR Biomedical Research Centre, King's College London, London, United Kingdom., Vyse TJ; Department of Medical & Molecular Genetics, King's College London, Guy's Hospital, London, United Kingdom., Wicker LS; JDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom., Todd JA; JDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.

Journal Article; Research Support, Non-U.S. Gov't , 2019

Persistent C-peptide is associated with reduced hypoglycaemia but not HbA 1c in adults with longstanding Type 1 diabetes: evidence for lack of intensive treatment in UK clinical practice?

Marren SM; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, Exeter, UK., Hammersley S; NIHR Exeter Clinical Research Facility, University of Exeter Medical School, Exeter, UK., McDonald TJ; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, Exeter, UK.; NIHR Exeter Clinical Research Facility, University of Exeter Medical School, Exeter, UK.; Blood Sciences, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK., Shields BM; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, Exeter, UK.; NIHR Exeter Clinical Research Facility, University of Exeter Medical School, Exeter, UK., Knight BA; NIHR Exeter Clinical Research Facility, University of Exeter Medical School, Exeter, UK., Hill A; NIHR Exeter Clinical Research Facility, University of Exeter Medical School, Exeter, UK., Bolt R; NIHR Exeter Clinical Research Facility, University of Exeter Medical School, Exeter, UK., Tree TI; Department of Immunobiology, School of Immunobiology & Microbial Sciences, Kings College London, London, UK.; NIHR Biomedical Research Centre Guys and St Thomas' NHS Foundation Trust and Kings College London, London, UK., Roep BO; Department of Diabetes Immunology, Diabetes & Metabolism Research Institute at the City of Hope National Medical Center, Duarte, CA, USA.; Department of Immunohaematology & Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands., Hattersley AT; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, Exeter, UK.; NIHR Exeter Clinical Research Facility, University of Exeter Medical School, Exeter, UK., Jones AG; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, Exeter, UK.; NIHR Exeter Clinical Research Facility, University of Exeter Medical School, Exeter, UK., Oram RA; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, Exeter, UK.; NIHR Exeter Clinical Research Facility, University of Exeter Medical School, Exeter, UK.

TIGI consortium

Journal Article; Research Support, Non-U.S. Gov't , 2019

Generation of human islet-specific regulatory T cells by TCR gene transfer.

Hull CM; Department of Immunobiology, Faculty of Life Sciences & Medicine, King's College London, London SE1 9RT, UK; NIHR Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust and King's College London, London SE1 9RT, UK. Electronic address: caroline.hull@kcl.ac.uk., Nickolay LE; Department of Immunobiology, Faculty of Life Sciences & Medicine, King's College London, London SE1 9RT, UK; NIHR Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust and King's College London, London SE1 9RT, UK., Estorninho M; Department of Immunobiology, Faculty of Life Sciences & Medicine, King's College London, London SE1 9RT, UK; NIHR Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust and King's College London, London SE1 9RT, UK., Richardson MW; Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA., Riley JL; Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA., Peakman M; Department of Immunobiology, Faculty of Life Sciences & Medicine, King's College London, London SE1 9RT, UK; Peak Therapeutics, London SE24 9LG, UK; Division of Diabetes and Nutrition, King's College London, SE1 1UL, UK; NIHR Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust and King's College London, London SE1 9RT, UK., Maher J; NIHR Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust and King's College London, London SE1 9RT, UK; CAR Mechanics Group, Division of Cancer Studies, Guy's Hospital Campus, King's College London School of Medicine, London SE1 1UL, UK; Department of Allergy and Immunology, King's College Hospital National Health Service Foundation Trust, London SE5 9RS, UK., Tree TI; Department of Immunobiology, Faculty of Life Sciences & Medicine, King's College London, London SE1 9RT, UK; NIHR Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust and King's College London, London SE1 9RT, UK. Electronic address: timothy.tree@kcl.ac.uk.

Journal Article , 2017

A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding.

Douthwaite J; MedImmune, Cambridge CB21 6GH, United Kingdom., Moisan J; MedImmune, Gaithersburg, MD 20878., Privezentzev C; MedImmune, Cambridge CB21 6GH, United Kingdom., Soskic B; Royal Free Campus, Institute of Immunity and Transplantation, University College London, London NW3 2PF, United Kingdom., Sabbah S; Department of Immunobiology, King's College London, London SE1 9RT, United Kingdom.; Faculty of Life Sciences and Medicine, King's College London, London SE1 9RT, United Kingdom.; National Institutes of Health Research Biomedical Research Centre at Guy's and St. Thomas' National Health Service Foundation Trust, London SE1 9RT, United Kingdom; and., Cohen S; MedImmune, Cambridge CB21 6GH, United Kingdom., Collinson A; MedImmune, Cambridge CB21 6GH, United Kingdom., England E; MedImmune, Cambridge CB21 6GH, United Kingdom., Huntington C; MedImmune, Cambridge CB21 6GH, United Kingdom., Kemp B; MedImmune, Cambridge CB21 6GH, United Kingdom., Zhuang L; MedImmune, Gaithersburg, MD 20878., Hudak S; MedImmune, Gaithersburg, MD 20878., Rees DG; MedImmune, Cambridge CB21 6GH, United Kingdom., Goldberg D; MedImmune, Gaithersburg, MD 20878., Barton C; MedImmune, Gaithersburg, MD 20878., Chang L; MedImmune, Mountain View, CA 94043., Vainshtein I; MedImmune, Mountain View, CA 94043., Liang M; MedImmune, Mountain View, CA 94043., Iciek L; MedImmune, Gaithersburg, MD 20878., Ambery P; MedImmune, Cambridge CB21 6GH, United Kingdom., Peakman M; Department of Immunobiology, King's College London, London SE1 9RT, United Kingdom.; Faculty of Life Sciences and Medicine, King's College London, London SE1 9RT, United Kingdom.; National Institutes of Health Research Biomedical Research Centre at Guy's and St. Thomas' National Health Service Foundation Trust, London SE1 9RT, United Kingdom; and., Vaughan TJ; MedImmune, Cambridge CB21 6GH, United Kingdom., Tree TI; Department of Immunobiology, King's College London, London SE1 9RT, United Kingdom.; Faculty of Life Sciences and Medicine, King's College London, London SE1 9RT, United Kingdom.; National Institutes of Health Research Biomedical Research Centre at Guy's and St. Thomas' National Health Service Foundation Trust, London SE1 9RT, United Kingdom; and., Sansom DM; Royal Free Campus, Institute of Immunity and Transplantation, University College London, London NW3 2PF, United Kingdom., Bowen MA; MedImmune, Gaithersburg, MD 20878., Minter RR; MedImmune, Cambridge CB21 6GH, United Kingdom., Jermutus L; MedImmune, Cambridge CB21 6GH, United Kingdom; jermutusl@medimmune.com.

Journal Article , 2017

Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial.

Todd JA; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Evangelou M; Department of Mathematics, Imperial College London, London, United Kingdom., Cutler AJ; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Pekalski ML; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Walker NM; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Stevens HE; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Porter L; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Smyth DJ; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Rainbow DB; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Ferreira RC; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Esposito L; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Hunter KM; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Loudon K; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Irons K; National Institute for Health Research Cambridge Clinical Trials Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge, United Kingdom., Yang JH; Department of Immunobiology, Faculty of Life Sciences & Medicine, King's College London, National Institute of Health Research Biomedical Research Centre, Guy's and St Thomas' National Health Service Foundation Trust and King's College London, London, United Kingdom., Bell CJ; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Schuilenburg H; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Heywood J; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Challis B; Wellcome Trust/MRC Institute of Metabolic Science, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, United Kingdom., Neupane S; Wellcome Trust/MRC Institute of Metabolic Science, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, United Kingdom., Clarke P; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Coleman G; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Dawson S; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Goymer D; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Anselmiova K; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Kennet J; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Brown J; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Caddy SL; Division of Virology, Department of Pathology, Addenbrooke's Hospital, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Lu J; Division of Virology, Department of Pathology, Addenbrooke's Hospital, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Greatorex J; Public Health England, Clinical Microbiology and Public Health Laboratory, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge, United Kingdom., Goodfellow I; Division of Virology, Department of Pathology, Addenbrooke's Hospital, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Wallace C; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom.; MRC Biostatistics Unit Hub for Trials Methodology Research, Cambridge Institute of Public Health, Cambridge Biomedical Campus, Cambridge, United Kingdom., Tree TI; Department of Immunobiology, Faculty of Life Sciences & Medicine, King's College London, National Institute of Health Research Biomedical Research Centre, Guy's and St Thomas' National Health Service Foundation Trust and King's College London, London, United Kingdom., Evans M; Wellcome Trust/MRC Institute of Metabolic Science, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, United Kingdom., Mander AP; 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Journal Article; Randomized Controlled Trial , 2016

Natural Variation in Interleukin-2 Sensitivity Influences Regulatory T-Cell Frequency and Function in Individuals With Long-standing Type 1 Diabetes.

Yang JH; Department of Immunobiology, Faculty of Life Sciences & Medicine, King's College London, London, U.K. National Institute of Health Research Biomedical Research Centre at Guy's and St Thomas' National Health Service Foundation Trust and King's College London, London, U.K. timothy.tree@kcl.ac.uk jennie.yang@kcl.ac.uk., Cutler AJ; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, U.K., Ferreira RC; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, U.K., Reading JL; Department of Immunobiology, Faculty of Life Sciences & Medicine, King's College London, London, U.K. National Institute of Health Research Biomedical Research Centre at Guy's and St Thomas' National Health Service Foundation Trust and King's College London, London, U.K., Cooper NJ; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, U.K., Wallace C; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, U.K., Clarke P; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, U.K., Smyth DJ; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, U.K., Boyce CS; BD Biosciences, Cell Analysis, San Diego, CA., Gao GJ; BD Biosciences, Cell Analysis, San Diego, CA., Todd JA; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, U.K., Wicker LS; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, U.K., Tree TI; Department of Immunobiology, Faculty of Life Sciences & Medicine, King's College London, London, U.K. National Institute of Health Research Biomedical Research Centre at Guy's and St Thomas' National Health Service Foundation Trust and King's College London, London, U.K. timothy.tree@kcl.ac.uk jennie.yang@kcl.ac.uk.

Journal Article; Research Support, Non-U.S. Gov't , 2015

Phenotypic Complexity of the Human Regulatory T Cell Compartment Revealed by Mass Cytometry.

Mason GM; Department of Immunobiology, King's College London, London SE1 9RT, United Kingdom;, Lowe K; MRC Centre for Transplantation, King's College London, London SE1 9RT, United Kingdom; and., Melchiotti R; NIHR Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust and King's College London, London SE1 9RT, United Kingdom., Ellis R; NIHR Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust and King's College London, London SE1 9RT, United Kingdom., de Rinaldis E; NIHR Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust and King's College London, London SE1 9RT, United Kingdom., Peakman M; Department of Immunobiology, King's College London, London SE1 9RT, United Kingdom;, Heck S; NIHR Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust and King's College London, London SE1 9RT, United Kingdom., Lombardi G; MRC Centre for Transplantation, King's College London, London SE1 9RT, United Kingdom; and., Tree TI; Department of Immunobiology, King's College London, London SE1 9RT, United Kingdom; timothy.tree@kcl.ac.uk.

Journal Article; Research Support, Non-U.S. Gov't , 2015

Immune modulation in humans: implications for type 1 diabetes mellitus.

Roep BO; Leiden University Medical Center, Department of Immunohaematology & Blood Transfusion, P. O. Box 9600, NL-2300 RC Leiden, Netherlands., Tree TI; Department of Immunobiology, King's College London, School of Medicine, London SE1 9RT, UK.

Journal Article; Review , 2014

Clinical-grade multipotent adult progenitor cells durably control pathogenic T cell responses in human models of transplantation and autoimmunity.

Reading JL; Department of Immunobiology, King's College London, Guy's Hospital, London SE1 9RT, United Kingdom., Yang JH, Sabbah S, Skowera A, Knight RR, Pinxteren J, Vaes B, Allsopp T, Ting AE, Busch S, Raber A, Deans R, Tree TI

Journal Article , 2013

Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors.

Pekalski ML; Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom., Ferreira RC, Coulson RM, Cutler AJ, Guo H, Smyth DJ, Downes K, Dendrou CA, Castro Dopico X, Esposito L, Coleman G, Stevens HE, Nutland S, Walker NM, Guy C, Dunger DB, Wallace C, Tree TI, Todd JA, Wicker LS

Journal Article; Research Support, Non-U.S. Gov't , 2013

Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function.

Garg G; Department of Immunobiology, School of Medicine, King's College London, London SE1 9RT, United Kingdom., Tyler JR, Yang JH, Cutler AJ, Downes K, Pekalski M, Bell GL, Nutland S, Peakman M, Todd JA, Wicker LS, Tree TI

Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't , 2012

Current approaches to measuring human islet-antigen specific T cell function in type 1 diabetes.

Mannering SI; St Vincent's Institute, The University of Melbourne, Department of Medicine, St Vincent's Hospital, Fitzroy, Vic, Australia. smannering@svi.edu.au, Wong FS, Durinovic-Belló I, Brooks-Worrell B, Tree TI, Cilio CM, Schloot NC, Mallone R

Immunology of Diabetes Society T-Cell Workshop Committee

Journal Article; Research Support, Non-U.S. Gov't; Review , 2010