Sökresultat - "Tumor microenvironment"

Dissecting the tumor microenvironment in primary breast angiosarcoma: insights from single-cell RNA sequencing.

Ding P; Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China., Pei S; Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China., Zhai Y; Department of Oncology, Zibo Central Hospital, Zibo, Shandong, 255036, China., Qu Z; Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China., Yang Y; Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China., Feng X; Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China., Liu Q; Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.; Department of Nutrition, Harvard T.H. Chan School of Public Health, 655 Huntington Avenue, Boston, MA, 02115, USA., Wang X; Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China., Zhang W; Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China., Wang Z; Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China., Kong X; Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. kongxiangyi@pumc.edu.cn., Wang J; Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. wangjing@cicams.ac.cn., Fang Y; Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. fangyi@cicams.ac.cn.

Journal Article , 2025

PDE3B and HBB are key prognostic biomarkers driving cell proliferation and regulating immune microenvironment in breast cancer.

Yin B; The Central Hospital of Shaoyang, Shaoyang Hunan, 422400, China., Luo X; The Central Hospital of Shaoyang, Shaoyang Hunan, 422400, China., Yan X; The Central Hospital of Shaoyang, Shaoyang Hunan, 422400, China., Shen H; The Central Hospital of Shaoyang, Shaoyang Hunan, 422400, China., Jiang J; The Central Hospital of Shaoyang, Shaoyang Hunan, 422400, China. jiangjianping1101@163.com.

Journal Article , 2025

Precision nanomedicine: navigating the tumor microenvironment for enhanced cancer immunotherapy and targeted drug delivery.

Sabit H; Department of Medical Biotechnology, College of Biotechnology, Misr University for Science and Technology, P.O. Box 77, Giza, Egypt. hussein.sabit@must.edu.eg., Pawlik TM; Department of Surgery, The Ohio State University, Wexner Medical Center, Columbus, OH, 43210, USA. tim.pawlik@osumc.edu., Radwan F; Center for Coastal Environmental Health and Biomolecular Research, NCCOS/NOS/NOAA, Charleston, SC, 29412, USA., Abdel-Hakeem M; Department of Pharmaceutical Biotechnology, College of Biotechnology, Misr University for Science and Technology, P.O. Box 77, Giza, Egypt., Abdel-Ghany S; Department of Environmental Biotechnology, College of Biotechnology, Misr University for Science and Technology, P.O. Box 77, Giza, Egypt., Wadan AS; Oral Biology Department, Faculty of Dentistry, Galala Plateau, Galala University, Suez Governorate, Attaka, 15888, Egypt., Elzawahri M; Department of Medical Biotechnology, College of Biotechnology, Misr University for Science and Technology, P.O. Box 77, Giza, Egypt., El-Hashash A; Elizabeth City State Campus of the University of North Carolina (UNC), Elizabeth, USA., Arneth B; Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Hospital of the Universities of Giessen and Marburg (UKGM), Philipps University Marburg, Baldingerstr. 1, 35043, Marburg, Germany.

Journal Article; Review , 2025

Study of the Role of the Tumor Microenvironment in Ovarian Cancer (MICO): A Prospective Monocentric Trial.

Arcieri M; Clinic of Obstetrics and Gynecology, 'Santa Maria Della Misericordia' University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy., Capezzali E; Department of Medicine (DMED), University of Udine, Udine, Italy., Restaino S; Clinic of Obstetrics and Gynecology, 'Santa Maria Della Misericordia' University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy.; Department of Obstetrics and Gynecology, University of Sassari, Sassari, Italy., Pregnolato S; Department of Medicine (DMED), University of Udine, Udine, Italy., Mariuzzi L; Department of Medicine (DMED), University of Udine, Udine, Italy.; Institute of Pathology, Academic Hospital, Udine, Italy., Mangogna A; Department of Medicine (DMED), University of Udine, Udine, Italy.; Institute of Pathology, Academic Hospital, Udine, Italy., Orsaria M; Institute of Pathology, Academic Hospital, Udine, Italy., Tulisso A; Institute of Pathology, Academic Hospital, Udine, Italy., Tonon S; Department of Medicine (DMED), University of Udine, Udine, Italy., De Martino M; Department of Medicine (DMED), University of Udine, Udine, Italy., Isola M; Department of Medicine (DMED), University of Udine, Udine, Italy., Driul L; Clinic of Obstetrics and Gynecology, 'Santa Maria Della Misericordia' University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy.; Department of Medicine (DMED), University of Udine, Udine, Italy., Pucillo C; Department of Medicine (DMED), University of Udine, Udine, Italy., Scambia G; Gynecologic Oncology Unit, Fondazione 'Policlinico Universitario A. Gemelli IRCCS,' Catholic University of the Sacred Heart, Rome, Italy.; Institute of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Rome, Italy., Frossi B; Department of Medicine (DMED), University of Udine, Udine, Italy., Vizzielli G; Clinic of Obstetrics and Gynecology, 'Santa Maria Della Misericordia' University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy.; Department of Medicine (DMED), University of Udine, Udine, Italy.

Journal Article; Observational Study; Clinical Trial Protocol , 2025

GABRP Mediates GABA-A Receptor to Shape Tumor Immunosuppressive Microenvironment and Promote Tumor Immune Escape and Corresponding Targeted Therapy.

Cen W; Xingyi People's Hospital Affiliated to Guizhou Medical University, Xingyi, Guizhou Province, China.; The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China., Fu G; The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China., Wang X; The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China., Wei R; The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China., Zhou X; The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China., Teng W; The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China., Ling Y; The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China., Tang J; The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China., Wang Z; Xingyi People's Hospital Affiliated to Guizhou Medical University, Xingyi, Guizhou Province, China., Chu L; The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China.

Journal Article , 2025

Interactions between radiotherapy resistance mechanisms and the tumor microenvironment.

Li D; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China., Wang J; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China., Li X; Department of Rehabilitation, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China., Wang Z; Department of Urology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China., Yu Q; Department of Pathology, Ningbo Clinical Pathology Diagnosis Center, Ningbo, Zhejiang 315211, China., Koh SB; Faculty of Health and Life Sciences, University of Bristol, Bristol, BS8 1TD, UK., Wu R; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China., Ye L; Department of Public Research Platform, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China., Guo Y; Department of Public Research Platform, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China., Okoli U; Division of Surgery & Interventional Science, University College London, London, UK; Basic and Translational Cancer Research Group, Department of Pharmacology and Therapeutics, College of Medicine, University of Nigeria, Eastern part of Nigeria, Nsukka, Enugu, Nigeria., Pati-Alam A; Division of Surgery & Interventional Science, University College London, London, UK., Mota E; Division of Surgery & Interventional Science, University College London, London, UK., Wei W; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China., Yoo KH; Department of Urology, Kyung Hee University, South Korea., Cho WC; Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong Special Administrative Region of China. Electronic address: williamcscho@gmail.com., Feng D; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China; Division of Surgery & Interventional Science, University College London, London, UK. Electronic address: dechao.feng@ucl.ac.uk., Heavey S; Division of Surgery & Interventional Science, University College London, London, UK. Electronic address: s.heavey@ucl.ac.uk.

Journal Article; Review , 2025

Systemic inflammation in response to radiation drives the genesis of an immunosuppressed tumor microenvironment.

Ma L; Department of Stomatology, Shenzhen University General Hospital, Shenzhen University, Shenzhen, 518055, China., Mao JH; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Barcellos-Hoff MH; Department of Radiation Oncology, School of Medicine, Helen Diller Comprehensive Cancer Center, University of California, San Francisco, CA 94143 USA. Electronic address: maryhelen.barcellos-hoff@ucsf.edu.

Journal Article; Review , 2025

Single-cell transcriptomics reveal the effects of chemoimmunotherapy on hypopharyngeal cancer and its tumor microenvironment.

Zhu X; Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China., Xu H; GrandOmics Biosciences, Beijing, China; Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China., Zhao Y; School of Life Science, East China Normal University, Shanghai, China., Diao W; Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China., Yan F; Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China., Zhu Y; Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China., Zhao T; School of Life Science, East China Normal University, Shanghai, China., Chen X; Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. Electronic address: xingming.chen@hotmail.com.

Journal Article , 2025

Immunocompetent tumor-on-a-chip: A translational tool for drug screening and cancer therapy.

Liang A; Department of Cardiothoracic Surgery, Jiangyin People's Hospital Affiliated to Nantong University, Jiangyin, China; The Second Affiliated Hospital, Guangdong Medical University, Zhanjiang, China., Tao T; Department of Gastroenterology, Zibo Central Hospital, Zibo, China., Chen J; The Second Affiliated Hospital, Guangdong Medical University, Zhanjiang, China., Yang Y; The Second Affiliated Hospital, Guangdong Medical University, Zhanjiang, China., Zhou X; Department of Immunology, School of Medicine, Nantong University, Nantong, China., Zhu X; The Second Affiliated Hospital, Guangdong Medical University, Zhanjiang, China; The Marine Biomedical Research Institute of Guangdong Zhanjiang, School of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang, China. Electronic address: xzhu@gdmu.edu.cn., Yu G; Department of Cardiothoracic Surgery, Jiangyin People's Hospital Affiliated to Nantong University, Jiangyin, China. Electronic address: xiaoyuer97103@163.com.

Journal Article; Review , 2025

Development of a cuproptosis-related prognostic signature to reveal heterogeneity of the immune microenvironment and drug sensitivity in acute lymphoblastic leukemia.

Zhang B; Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China., Zhu S; Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China., Zheng D; Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China., Zhang X; Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China., Xie W; Department of Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China., Zhou S; Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China., Zheng S; Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China., Wang Q; Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China., Lin Z; Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China., Zheng Z; Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China., Chen Z; Department of Hepatobiliary Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China., Lan E; Department of Hepatobiliary Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China., Cui L; Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China., Ying H; Department of Hepatobiliary Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China., Zhang Y; Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China., Lin X; Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China., Zhuang Q; Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China., Qian H; Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China., Hu X; Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China., Zhuang Y; Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China., Zhang Q; Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China., Jin Z; Department of Hepatobiliary Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China. wzjinzx@163.com., Jiang S; Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China. jiangsongfu@189.cn., Ma Y; Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China. mayy@wmu.edu.cn.; Zhejiang Engineering Research Center for Hospital Emergency and Process Digitization, Wenzhou, 325000, Zhejiang, China. mayy@wmu.edu.cn.

Journal Article , 2025

The impact of breast radiotherapy on the tumor genome and immune ecosystem.

Schalck A; Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate School of Biological Sciences, University of Texas, Houston, TX 770303, USA., Tran T; Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Li J; Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Sei E; Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Bai S; Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Hu M; Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Lin J; Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Bright SJ; Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Reddick S; Department of Breast Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Yang F; Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Janssen China Research & Development, Johnson&Johnson, Shanghai 201210, China., Batra H; Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Contreras A; Department of Anatomical Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Raso MG; Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Stauder MC; Department of Breast Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Hoffman KE; Department of Breast Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Reddy JP; Department of Breast Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Nead KT; Department of Breast Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Smith BD; Department of Breast Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Sawakuchi GO; Graduate School of Biological Sciences, University of Texas, Houston, TX 770303, USA; Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Woodward WA; Department of Breast Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Watowich SS; Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Litton JK; Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Bedrosian I; Department of Breast Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Mittendorf EA; Department of Breast Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115, USA; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA., Le-Petross H; Department of Breast Imaging, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Navin NE; Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate School of Biological Sciences, University of Texas, Houston, TX 770303, USA; Department of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: nnavin@mdanderson.org., Shaitelman SF; Department of Breast Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: sfshaitelman@mdanderson.org.

Journal Article , 2025

Machine learning and single-cell analysis uncover distinctive characteristics of CD300LG within the TNBC immune microenvironment: experimental validation.

Zhu B; Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.; Department of Breast Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.; Department of Thyroid and Breast Surgery, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, China., Wan H; Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.; Department of Breast Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China., Ling Z; Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.; Department of Breast Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China., Jiang H; Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.; Department of Breast Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China., Pei J; Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. peijing@ahmu.edu.cn.; Department of Breast Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. peijing@ahmu.edu.cn.

Journal Article , 2025

Integrated multi-omics profiling to establish an IGFBP-based prognostic score for pancreatic ductal adenocarcinoma: unraveling prognostic biomarkers, immune microenvironment crosstalk, and therapeutic implications.

Guan X; State Key Lab of Molecular Oncology and Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Mu Y; State Key Lab of Molecular Oncology and Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Jin X; State Key Lab of Molecular Oncology and Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Wang C; State Key Lab of Molecular Oncology and Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Journal Article , 2025

Conserved spatial subtypes and cellular neighborhoods of cancer-associated fibroblasts revealed by single-cell spatial multi-omics.

Liu Y; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Sinjab A; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Min J; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Sheikh Ahmed Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Han G; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Paradiso F; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Zhang Y; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Wang R; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Pei G; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Dai Y; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences (GSBS), Houston, TX 77030, USA., Liu Y; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Cho KS; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Dai E; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Basi A; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Burks JK; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Rajapakshe KI; Sheikh Ahmed Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Chu Y; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Jiang J; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Zhang D; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Yan X; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Guerrero PA; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Serrano A; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Li M; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Hwang TH; Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, 37232, USA., Futreal A; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Ajani JA; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Solis Soto LM; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Jazaeri AA; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Kadara H; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences (GSBS), Houston, TX 77030, USA. Electronic address: hkadara@mdanderson.org., Maitra A; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Sheikh Ahmed Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: amaitra@mdanderson.org., Wang L; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences (GSBS), Houston, TX 77030, USA; The James P. Allison Institute, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Institute for Data Science in Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: lwang22@mdanderson.org.

Journal Article , 2025

Single-Cell and Spatial Transcriptomics Explore Purine Metabolism-Related Prognostic Risk Model and Tumor Immune Microenvironment Modulation in Ovarian Cancer.

Liu Y; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Nantong University (First People's Hospital of Nantong City), Nantong, China., Geng R; Suzhou Center for Disease Control and Prevention, Suzhou, China., Zhao S; Department of Neurosurgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China., Yang J; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Nantong University (First People's Hospital of Nantong City), Nantong, China.; Medical School of Nantong University, Nantong, China., Liu J; Department of Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Zheng Y; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Nantong University (First People's Hospital of Nantong City), Nantong, China., Tang W; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Nantong University (First People's Hospital of Nantong City), Nantong, China.

Journal Article , 2025

Role of the tumor microenvironment in cancer therapy: unveiling new targets to overcome drug resistance.

Garemilla SSS; The George Washington University, Washington, DC, USA., Gampa SC; Department of Life Sciences, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh, 530045, India., Garimella S; Department of Life Sciences, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh, 530045, India. sgarimel@gitam.edu.

Journal Article; Review , 2025

Integrative single-cell and spatial transcriptomics analysis reveals MDK-NCL pathway's role in shaping the immunosuppressive environment of lung adenocarcinoma.

Fu Y; Department of Thoracic Surgery, Shengjing Hospital of China Medical University, Shenyang, China., Li S; Department of Thoracic Surgery, Shengjing Hospital of China Medical University, Shenyang, China., Zhao Y; Department of Thoracic Surgery, Shengjing Hospital of China Medical University, Shenyang, China., Zhang X; Department of Thoracic Surgery, Shengjing Hospital of China Medical University, Shenyang, China., Mao X; Department of Thoracic Surgery, Shengjing Hospital of China Medical University, Shenyang, China., Xu R; Department of Thoracic Surgery, Shengjing Hospital of China Medical University, Shenyang, China.

Journal Article , 2025

Whole-body CT scanning radiation improves the immune microenvironment of tumor tissues to enhance the antitumor effect of ICI.

Dong J; Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300000, China.; Qingdao People's Hospital Group (Jiaozhou), Jiaozhou Central Hospital of Qingdao, Qingdao, China., Qi Y; Qingdao People's Hospital Group (Jiaozhou), Jiaozhou Central Hospital of Qingdao, Qingdao, China., Sha S; Qingdao People's Hospital Group (Jiaozhou), Jiaozhou Central Hospital of Qingdao, Qingdao, China., Fu C; Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300000, China.; Department of Radiotherapy, Shandong Cancer Hospital, Jinan, 250000, China., Xu X; Qingdao People's Hospital Group (Jiaozhou), Jiaozhou Central Hospital of Qingdao, Qingdao, China. 2020021032@qdu.edu.cn., Li B; Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300000, China. baoshli1963@163.com.; Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin, China. baoshli1963@163.com.; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Department of Radiation Oncology, Tianjin, China. baoshli1963@163.com.; Medical University; Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong, Jinan, China. baoshli1963@163.com.; Academy of Medical Sciences, No. 440 Jiyan Road, Jinan, 250017, China. baoshli1963@163.com.

Journal Article , 2025

Tumor microenvironment as niche constructed by cancer stem cells: Breaking the ecosystem to combat cancer.

Zhong H; State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China; Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, China; Haihe Laboratory of Modern Chinese Medicine, Tianjin, China., Zhou S; State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China; Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, China; Haihe Laboratory of Modern Chinese Medicine, Tianjin, China., Yin S; State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China; Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, China; Haihe Laboratory of Modern Chinese Medicine, Tianjin, China., Qiu Y; School of Pharmacy, Tianjin Medical University, Tianjin, China. Electronic address: qiuyuling@tmu.edu.cn., Liu B; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, China. Electronic address: liubo2400@scu.edu.cn., Yu H; State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China; Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, China; Haihe Laboratory of Modern Chinese Medicine, Tianjin, China. Electronic address: hyyu@tjutcm.edu.cn.

Journal Article; Review , 2025

Novel CHI3L1-Associated Angiogenic Phenotypes Define Glioma Microenvironments: Insights From Multi-Omics Integration.

Zhao YH; Brain Glioma Center & Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, China., Cai YX; Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, China., Pan ZY; Brain Glioma Center & Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, China., Tang F; Brain Glioma Center & Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, China., Ma C; Brain Glioma Center & Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, China., Wang ZF; Department of Physiology, Wuhan University School of Basic Medical Sciences, Wuhan, China., Li G; Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, China., Chang H; Berkeley Biomedical Data Science Center, Lawrence Berkeley National Laboratory, Berkeley, California, USA., Tian SF; Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, China., Li ZQ; Brain Glioma Center & Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, China.; Hubei International Science and Technology Cooperation Base for Research and Clinical Techniques for Brain Glioma Diagnosis and Treatment, Hubei, China.

Journal Article , 2025