Search Results - "VA Million Veteran Program"

Rare genetic variation in PTPRB is associated with central serous chorioretinopathy, varicose veins and glaucoma

Joel T. Rämö, Bryan R. Gorman, Lu-Chen Weng, Sean J. Jurgens, Panisa Singhanetr, Marisa G. Tieger, Elon HC van Dijk, Christopher W. Halladay, Xin Wang, Blake M. Hauser, Soo Hyun Kim, Joost Brinks, Seung Hoan Choi, Yuyang Luo, FinnGen, VA Million Veteran Program, Saiju Pyarajan, Cari L. Nealon, Michael B. Gorin, Wen-Chih Wu, Scott A. Anthony, David P. Roncone, Lucia Sobrin, Kai Kaarniranta, Suzanne Yzer, Aarno Palotie, Neal S. Peachey, Joni A. Turunen, Camiel JF Boon, Patrick T. Ellinor, Sudha K. Iyengar, Mark J. Daly, Elizabeth J. Rossin

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Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk

Bryan R. Gorman, Sun-Gou Ji, Michael Francis, Anoop K. Sendamarai, Yunling Shi, Poornima Devineni, Uma Saxena, Elizabeth Partan, Andrea K. DeVito, Jinyoung Byun, Younghun Han, Xiangjun Xiao, Don D. Sin, Wim Timens, Jennifer Moser, Sumitra Muralidhar, Rachel Ramoni, Rayjean J. Hung, James D. McKay, Yohan Bossé, Ryan Sun, Christopher I. Amos, VA Million Veteran Program, Saiju Pyarajan

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Analyses of GWAS signal using GRIN identify additional genes contributing to suicidal behavior

Kyle A. Sullivan, Matthew Lane, Mikaela Cashman, J. Izaak Miller, Mirko Pavicic, Angelica M. Walker, Ashley Cliff, Jonathon Romero, Xuejun Qin, Niamh Mullins, Anna Docherty, Hilary Coon, Douglas M. Ruderfer, International Suicide Genetics Consortium, VA Million Veteran Program, MVP Suicide Exemplar Workgroup, Michael R. Garvin, John P. Pestian, Allison E. Ashley-Koch, Jean C. Beckham, Benjamin McMahon, David W. Oslin, Nathan A. Kimbrel, Daniel A. Jacobson, David Kainer

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Heterogeneous associations between interleukin-6 receptor variants and phenotypes across ancestries and implications for therapy

Xuan Wang, Molei Liu, Isabelle-Emmanuella Nogues, Tony Chen, Xin Xiong, Clara-Lea Bonzel, Harrison Zhang, Chuan Hong, Yin Xia, Kumar Dahal, Lauren Costa, Jing Cui, VA Million Veteran Program, J. Michael Gaziano, Seoyoung C. Kim, Yuk-Lam Ho, Kelly Cho, Tianxi Cai, Katherine P. Liao

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A multi-ancestry GWAS of Fuchs corneal dystrophy highlights the contributions of laminins, collagen, and endothelial cell regulation

Bryan R. Gorman, Michael Francis, Cari L. Nealon, Christopher W. Halladay, Nalvi Duro, Kyriacos Markianos, Giulio Genovese, Pirro G. Hysi, Hélène Choquet, Natalie A. Afshari, Yi-Ju Li, VA Million Veteran Program, J. Michael Gaziano, Adriana M. Hung, Wen-Chih Wu, Paul B. Greenberg, Saiju Pyarajan, Jonathan H. Lass, Neal S. Peachey, Sudha K. Iyengar

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Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure

Danielle Rasooly, Gina M. Peloso, Alexandre C. Pereira, Hesam Dashti, Claudia Giambartolomei, Eleanor Wheeler, Nay Aung, Brian R. Ferolito, Maik Pietzner, Eric H. Farber-Eger, Quinn Stanton Wells, Nicole M. Kosik, Liam Gaziano, Daniel C. Posner, A. Patrícia Bento, Qin Hui, Chang Liu, Krishna Aragam, Zeyuan Wang, Brian Charest, Jennifer E. Huffman, Peter W. F. Wilson, Lawrence S. Phillips, John Whittaker, Patricia B. Munroe, Steffen E. Petersen, Kelly Cho, Andrew R. Leach, María Paula Magariños, John Michael Gaziano, VA Million Veteran Program, Claudia Langenberg, Yan V. Sun, Jacob Joseph, Juan P. Casas

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Modeling the longitudinal changes of ancestry diversity in the Million Veteran Program

Frank R. Wendt, Gita A. Pathak, Jacqueline Vahey, Xuejun Qin, Dora Koller, Brenda Cabrera-Mendoza, Angela Haeny, Kelly M. Harrington, Nallakkandi Rajeevan, Linh M. Duong, Daniel F. Levey, Flavio De Angelis, Antonella De Lillo, Tim B. Bigdeli, Saiju Pyarajan, VA Million Veteran Program, John Michael Gaziano, Joel Gelernter, Mihaela Aslan, Dawn Provenzale, Drew A. Helmer, Elizabeth R. Hauser, Renato Polimanti, Department of Veteran Affairs Cooperative Study Program (#2006)

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Genetic architecture of heart failure with preserved versus reduced ejection fraction

Jacob Joseph, Chang Liu, Qin Hui, Krishna Aragam, Zeyuan Wang, Brian Charest, Jennifer E. Huffman, Jacob M. Keaton, Todd L. Edwards, Serkalem Demissie, Luc Djousse, Juan P. Casas, J. Michael Gaziano, Kelly Cho, Peter W. F. Wilson, Lawrence S. Phillips, VA Million Veteran Program, Christopher J. O’Donnell, Yan V. Sun

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Genomics and phenomics of body mass index reveals a complex disease network

Jie Huang, Jennifer E. Huffman, Yunfeng Huang, Ítalo Do Valle, Themistocles L. Assimes, Sridharan Raghavan, Benjamin F. Voight, Chang Liu, Albert-László Barabási, Rose D. L. Huang, Qin Hui, Xuan-Mai T. Nguyen, Yuk-Lam Ho, Luc Djousse, Julie A. Lynch, Marijana Vujkovic, Catherine Tcheandjieu, Hua Tang, Scott M. Damrauer, Peter D. Reaven, Donald Miller, Lawrence S. Phillips, Maggie C. Y. Ng, Mariaelisa Graff, Christopher A. Haiman, Ruth J. F. Loos, Kari E. North, Loic Yengo, George Davey Smith, Danish Saleheen, J. Michael Gaziano, Daniel J. Rader, Philip S. Tsao, Kelly Cho, Kyong-Mi Chang, Peter W. F. Wilson, VA Million Veteran Program, Yan V. Sun, Christopher J. O’Donnell

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A translational genomics approach identifies IL10RB as the top candidate gene target for COVID-19 susceptibility

Georgios Voloudakis, James M. Vicari, Sanan Venkatesh, Gabriel E. Hoffman, Kristina Dobrindt, Wen Zhang, Noam D. Beckmann, Christina A. Higgins, Stathis Argyriou, Shan Jiang, Daisy Hoagland, Lina Gao, André Corvelo, Kelly Cho, Kyung Min Lee, Jiantao Bian, Jennifer S. Lee, Sudha K. Iyengar, Shiuh-Wen Luoh, Schahram Akbarian, Robert Striker, Themistocles L. Assimes, Eric E. Schadt, Julie A. Lynch, Miriam Merad, Benjamin R. tenOever, Alexander W. Charney, Mount Sinai COVID-19 Biobank, VA Million Veteran Program COVID-19 Science Initiative, Kristen J. Brennand, John F. Fullard, Panos Roussos

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Identifying intragenic functional modules of genomic variations associated with cancer phenotypes by learning representation of association networks

Minsu Kim, Jennifer E. Huffman, Amy Justice, Ian Goethert, Greeshma Agasthya, VA Million Veteran Program, Ioana Danciu

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Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

Thomas W. Winkler, Humaira Rasheed, Alexander Teumer, Mathias Gorski, Bryce X. Rowan, Kira J. Stanzick, Laurent F. Thomas, Adrienne Tin, Anselm Hoppmann, Audrey Y. Chu, Bamidele Tayo, Chris H. L. Thio, Daniele Cusi, Jin-Fang Chai, Karsten B. Sieber, Katrin Horn, Man Li, Markus Scholz, Massimiliano Cocca, Matthias Wuttke, Peter J. van der Most, Qiong Yang, Sahar Ghasemi, Teresa Nutile, Yong Li, Giulia Pontali, Felix Günther, Abbas Dehghan, Adolfo Correa, Afshin Parsa, Agnese Feresin, Aiko P. J. de Vries, Alan B. Zonderman, Albert V. Smith, Albertine J. Oldehinkel, Alessandro De Grandi, Alexander R. Rosenkranz, Andre Franke, Andrej Teren, Andres Metspalu, Andrew A. Hicks, Andrew P. Morris, Anke Tönjes, Anna Morgan, Anna I. Podgornaia, Annette Peters, Antje Körner, Anubha Mahajan, Archie Campbell, Barry I. Freedman, Beatrice Spedicati, Belen Ponte, Ben Schöttker, Ben Brumpton, Bernhard Banas, Bernhard K. Krämer, Bettina Jung, Bjørn Olav Åsvold, Blair H. Smith, Boting Ning, Brenda W. J. H. Penninx, Brett R. Vanderwerff, Bruce M. Psaty, Candace M. Kammerer, Carl D. Langefeld, Caroline Hayward, Cassandra N. Spracklen, Cassianne Robinson-Cohen, Catharina A. Hartman, Cecilia M. Lindgren, Chaolong Wang, Charumathi Sabanayagam, Chew-Kiat Heng, Chiara Lanzani, Chiea-Chuen Khor, Ching-Yu Cheng, Christian Fuchsberger, Christian Gieger, Christian M. Shaffer, Christina-Alexandra Schulz, Cristen J. Willer, Daniel I. Chasman, Daniel F. Gudbjartsson, Daniela Ruggiero, Daniela Toniolo, Darina Czamara, David J. Porteous, Dawn M. Waterworth, Deborah Mascalzoni, Dennis O. Mook-Kanamori, Dermot F. Reilly, E. Warwick Daw, Edith Hofer, Eric Boerwinkle, Erika Salvi, Erwin P. Bottinger, E-Shyong Tai, Eulalia Catamo, Federica Rizzi, Feng Guo, Fernando Rivadeneira, Franco Guilianini, Gardar Sveinbjornsson, Georg Ehret, Gerard Waeber, Ginevra Biino, Giorgia Girotto, Giorgio Pistis, Girish N. Nadkarni, Graciela E. Delgado, Grant W. Montgomery, Harold Snieder, Harry Campbell, Harvey D. White, He Gao, Heather M. Stringham, Helena Schmidt, Hengtong Li, Hermann Brenner, Hilma Holm, Holgen Kirsten, Holly Kramer, Igor Rudan, Ilja M. Nolte, Ioanna Tzoulaki, Isleifur Olafsson, Jade Martins, James P. Cook, James F. Wilson, Jan Halbritter, Janine F. Felix, Jasmin Divers, Jaspal S. Kooner, Jeannette Jen-Mai Lee, Jeffrey O’Connell, Jerome I. Rotter, Jianjun Liu, Jie Xu, Joachim Thiery, Johan Ärnlöv, Johanna Kuusisto, Johanna Jakobsdottir, Johanne Tremblay, John C. Chambers, John B. Whitfield, John M. Gaziano, Jonathan Marten, Josef Coresh, Jost B. Jonas, Josyf C. Mychaleckyj, Kaare Christensen, Kai-Uwe Eckardt, Karen L. Mohlke, Karlhans Endlich, Katalin Dittrich, Kathleen A. Ryan, Kenneth M. Rice, Kent D. Taylor, Kevin Ho, Kjell Nikus, Koichi Matsuda, Konstantin Strauch, Kozeta Miliku, Kristian Hveem, Lars Lind, Lars Wallentin, Laura M. Yerges-Armstrong, Laura M. Raffield, Lawrence S. Phillips, Lenore J. Launer, Leo-Pekka Lyytikäinen, Leslie A. Lange, Lorena Citterio, Lucija Klaric, M. Arfan Ikram, Marcus Ising, Marcus E. Kleber, Margherita Francescatto, Maria Pina Concas, Marina Ciullo, Mario Piratsu, Marju Orho-Melander, Markku Laakso, Markus Loeffler, Markus Perola, Martin H. de Borst, Martin Gögele, Martina La Bianca, Mary Ann Lukas, Mary F. Feitosa, Mary L. Biggs, Mary K. Wojczynski, Maryam Kavousi, Masahiro Kanai, Masato Akiyama, Masayuki Yasuda, Matthias Nauck, Melanie Waldenberger, Miao-Li Chee, Miao-Ling Chee, Michael Boehnke, Michael H. Preuss, Michael Stumvoll, Michael A. Province, Michele K. Evans, Michelle L. O’Donoghue, Michiaki Kubo, Mika Kähönen, Mika Kastarinen, Mike A. Nalls, Mikko Kuokkanen, Mohsen Ghanbari, Murielle Bochud, Navya Shilpa Josyula, Nicholas G. Martin, Nicholas Y. Q. Tan, Nicholette D. Palmer, Nicola Pirastu, Nicole Schupf, Niek Verweij, Nina Hutri-Kähönen, Nina Mononen, Nisha Bansal, Olivier Devuyst, Olle Melander, Olli T. Raitakari, Ozren Polasek, Paolo Manunta, Paolo Gasparini, Pashupati P. Mishra, Patrick Sulem, Patrik K. E. Magnusson, Paul Elliott, Paul M. Ridker, Pavel Hamet, Per O. Svensson, Peter K. Joshi, Peter Kovacs, Peter P. Pramstaller, Peter Rossing, Peter Vollenweider, Pim van der Harst, Rajkumar Dorajoo, Ralene Z. H. Sim, Ralph Burkhardt, Ran Tao, Raymond Noordam, Reedik Mägi, Reinhold Schmidt, Renée de Mutsert, Rico Rueedi, Rob M. van Dam, Robert J. Carroll, Ron T. Gansevoort, Ruth J. F. Loos, Sala Cinzia Felicita, Sanaz Sedaghat, Sandosh Padmanabhan, Sandra Freitag-Wolf, Sarah A. Pendergrass, Sarah E. Graham, Scott D. Gordon, Shih-Jen Hwang, Shona M. Kerr, Simona Vaccargiu, Snehal B. Patil, Stein Hallan, Stephan J. L. Bakker, Su-Chi Lim, Susanne Lucae, Suzanne Vogelezang, Sven Bergmann, Tanguy Corre, Tarunveer S. Ahluwalia, Terho Lehtimäki, Thibaud S. Boutin, Thomas Meitinger, Tien-Yin Wong, Tobias Bergler, Ton J. Rabelink, Tõnu Esko, Toomas Haller, Unnur Thorsteinsdottir, Uwe Völker, Valencia Hui Xian Foo, Veikko Salomaa, Veronique Vitart, Vilmantas Giedraitis, Vilmundur Gudnason, Vincent W. V. Jaddoe, Wei Huang, Weihua Zhang, Wen Bin Wei, Wieland Kiess, Winfried März, Wolfgang Koenig, Wolfgang Lieb, Xin Gao, Xueling Sim, Ya Xing Wang, Yechiel Friedlander, Yih-Chung Tham, Yoichiro Kamatani, Yukinori Okada, Yuri Milaneschi, Zhi Yu, Lifelines cohort study, DiscovEHR/MyCode study, VA Million Veteran Program, Klaus J. Stark, Kari Stefansson, Carsten A. Böger, Adriana M. Hung, Florian Kronenberg, Anna Köttgen, Cristian Pattaro, Iris M. Heid

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Genome-wide association study identifies four pan-ancestry loci for suicidal ideation in the Million Veteran Program.

Allison E Ashley-Koch, Nathan A Kimbrel, Xue J Qin, Jennifer H Lindquist, Melanie E Garrett, Michelle F Dennis, Lauren P Hair, Jennifer E Huffman, Daniel A Jacobson, Ravi K Madduri, Hilary Coon, Anna R Docherty, Jooeun Kang, Niamh Mullins, Douglas M Ruderfer, VA Million Veteran Program (MVP), MVP Suicide Exemplar Workgroup, International Suicide Genetics Consortium, Philip D Harvey, Benjamin H McMahon, David W Oslin, Elizabeth R Hauser, Michael A Hauser, Jean C Beckham

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Clinical knowledge extraction via sparse embedding regression (KESER) with multi-center large scale electronic health record data

Chuan Hong, Everett Rush, Molei Liu, Doudou Zhou, Jiehuan Sun, Aaron Sonabend, Victor M. Castro, Petra Schubert, Vidul A. Panickan, Tianrun Cai, Lauren Costa, Zeling He, Nicholas Link, Ronald Hauser, J. Michael Gaziano, Shawn N. Murphy, George Ostrouchov, Yuk-Lam Ho, Edmon Begoli, Junwei Lu, Kelly Cho, Katherine P. Liao, Tianxi Cai, VA Million Veteran Program

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Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals

Kira J. Stanzick, Yong Li, Pascal Schlosser, Mathias Gorski, Matthias Wuttke, Laurent F. Thomas, Humaira Rasheed, Bryce X. Rowan, Sarah E. Graham, Brett R. Vanderweff, Snehal B. Patil, VA Million Veteran Program, Cassiane Robinson-Cohen, John M. Gaziano, Christopher J. O’Donnell, Cristen J. Willer, Stein Hallan, Bjørn Olav Åsvold, Andre Gessner, Adriana M. Hung, Cristian Pattaro, Anna Köttgen, Klaus J. Stark, Iris M. Heid, Thomas W. Winkler

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Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals

Ke Xu, Boyang Li, Kathleen A. McGinnis, Rachel Vickers-Smith, Cecilia Dao, Ning Sun, Rachel L. Kember, Hang Zhou, William C. Becker, Joel Gelernter, Henry R. Kranzler, Hongyu Zhao, Amy C. Justice, VA Million Veteran Program

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A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program.

Sridharan Raghavan, Jie Huang, Catherine Tcheandjieu, Jennifer E Huffman, Elizabeth Litkowski, Chang Liu, Yuk-Lam A Ho, Haley Hunter-Zinck, Hongyu Zhao, Eirini Marouli, Kari E North, VA Million Veteran Program, Ethan Lange, Leslie A Lange, Benjamin F Voight, J Michael Gaziano, Saiju Pyarajan, Elizabeth R Hauser, Philip S Tsao, Peter W F Wilson, Kyong-Mi Chang, Kelly Cho, Christopher J O'Donnell, Yan V Sun, Themistocles L Assimes

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A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program.

Anurag Verma, Noah L Tsao, Lauren O Thomann, Yuk-Lam Ho, Sudha K Iyengar, Shiuh-Wen Luoh, Rotonya Carr, Dana C Crawford, Jimmy T Efird, Jennifer E Huffman, Adriana Hung, Kerry L Ivey, Michael G Levin, Julie Lynch, Pradeep Natarajan, Saiju Pyarajan, Alexander G Bick, Lauren Costa, Giulio Genovese, Richard Hauger, Ravi Madduri, Gita A Pathak, Renato Polimanti, Benjamin Voight, Marijana Vujkovic, Seyedeh Maryam Zekavat, Hongyu Zhao, Marylyn D Ritchie, VA Million Veteran Program COVID-19 Science Initiative, Kyong-Mi Chang, Kelly Cho, Juan P Casas, Philip S Tsao, J Michael Gaziano, Christopher O'Donnell, Scott M Damrauer, Katherine P Liao

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Genetic Loci Associated With COVID-19 Positivity and Hospitalization in White, Black, and Hispanic Veterans of the VA Million Veteran Program

Gina M. Peloso, Catherine Tcheandjieu, John E. McGeary, Daniel C. Posner, Yuk-Lam Ho, Jin J. Zhou, Austin T. Hilliard, Jacob Joseph, Christopher J. O’Donnell, Jimmy T. Efird, Dana C. Crawford, Wen-Chih Wu, Mehrdad Arjomandi, VA Million Veteran Program COVID-19 Science Initiative, Yan V. Sun, Themistocles L Assimes, Jennifer E. Huffman

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Phenome-wide association of 1809 phenotypes and COVID-19 disease progression in the Veterans Health Administration Million Veteran Program.

Rebecca J Song, Yuk-Lam Ho, Petra Schubert, Yojin Park, Daniel Posner, Emily M Lord, Lauren Costa, Hanna Gerlovin, Katherine E Kurgansky, Tori Anglin-Foote, Scott DuVall, Jennifer E Huffman, Saiju Pyarajan, Jean C Beckham, Kyong-Mi Chang, Katherine P Liao, Luc Djousse, David R Gagnon, Stacey B Whitbourne, Rachel Ramoni, Sumitra Muralidhar, Philip S Tsao, Christopher J O'Donnell, John Michael Gaziano, Juan P Casas, Kelly Cho, VA Million Veteran Program COVID-19 Science Initiative

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