Search Results - "Volgraf, Matthew"

Discovery and Optimization of Selective Brain-Penetrant EBP Inhibitors that Enhance Oligodendrocyte Formation

Dorel, Ruth^aff1, Sun, Dawei^aff1, Carruthers, Nicholas^aff2, Castanedo, Georgette M.^aff1, Ung, Peter M.-U.^aff1, Factor, Daniel C.^aff2, Li, Tianbo^aff1, Baumann, Hannah^aff2, Janota, Danielle^aff2, Pang, Jodie^aff1, Salphati, Laurent^aff1, Meklemburg, Robert^aff2, Korman, Allison J.^aff2, Harper, Halie E.^aff2, Stubblefield, Samantha^aff2, Payandeh, Jian^aff1, McHugh, Daniel^aff2, Lang, Bradley T.^aff2, Tesar, Paul J.^aff2, Dere, Edward^aff1, Masureel, Matthieu^aff1, Adams, Drew J.^aff2, Volgraf, Matthew^aff1, Braun, Marie-Gabrielle^aff1

Discovery of TRPA1 Antagonist GDC-6599: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease

Terrett, Jack A.^aff1d1, Ly, Justin Q.^aff1d2, Katavolos, Paula^aff1d3, Hasselgren, Catrin^aff1d3, Laing, Steven^aff1d3, Zhong, Fiona^aff1d3, Villemure, Elisia^aff1d1, Déry, Martin^aff2, Larouche-Gauthier, Robin^aff2, Chen, Huifen^aff1d1, Shore, Daniel G.^aff1d1, Lee, Wyne P.^aff1d4, Suto, Eric^aff1d4, Johnson, Kevin^aff1d2, Brooks, Marjory^aff4, Stablein, Alyssa^aff4, Beaumier, Francis^aff2, Constantineau-Forget, Léa^aff2, Grand-Maître, Chantal^aff2, Lépissier, Luce^aff2, Ciblat, Stéphane^aff2, Sturino, Claudio^aff2, Chen, Yong^aff3, Hu, Baihua^aff3, Elstrott, Justin^aff1d5, Gandham, Vineela^aff1d5, Joseph, Victory^aff1d5, Booler, Helen^aff1d3, Cain, Gary^aff1d3, Chou, Carolina^aff1d3, Fullerton, Aaron^aff1d3, Lepherd, Michelle^aff1d3, Stainton, Shannon^aff1d3, Torres, Elizabeth^aff1d3, Urban, Konnie^aff1d3, Yu, Lanlan^aff1d3, Zhong, Yu^aff1d3, Bao, Linda^aff1d6, Chou, Kang-Jye^aff1d6, Lin, Jessica^aff1d6, Zhang, Wei^aff1d6, La, Hank^aff1d2, Liu, Liling^aff1d2, Mulder, Teresa^aff1d2, Chen, Jun^aff1d7, Chernov-Rogan, Tania^aff1d7, Johnson, Adam R.^aff1d7, Hackos, David H.^aff1d8, Leahey, Rebecca^aff1d8, Shields, Shannon D.^aff1d8, Balestrini, Alessia^aff1d9, Riol-Blanco, Lorena^aff1d9, Safina, Brian S.^aff1d1, Volgraf, Matthew^aff1d1, Magnuson, Steven^aff1d1, Kakiuchi-Kiyota, Satoko^aff1d3

Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy

Terrett, Jack A.^aff1, Chen, Huifen^aff1, Shore, Daniel G.^aff1, Villemure, Elisia^aff1, Larouche-Gauthier, Robin^aff9, Déry, Martin^aff9, Beaumier, Francis^aff9, Constantineau-Forget, Léa^aff9, Grand-Maître, Chantal^aff9, Lépissier, Luce^aff9, Ciblat, Stéphane^aff9, Sturino, Claudio^aff9, Chen, Yong^aff10, Hu, Baihua^aff10, Lu, Aijun^aff10, Wang, Yunli^aff10, Cridland, Andrew P.^aff11, Ward, Stuart I.^aff11, Hackos, David H.^aff2, Reese, Rebecca M.^aff2, Shields, Shannon D.^aff2, Chen, Jun^aff3, Balestrini, Alessia^aff4, Riol-Blanco, Lorena^aff4, Lee, Wyne P.^aff5, Liu, John^aff5, Suto, Eric^aff5, Wu, Xiumin^aff5, Zhang, Juan^aff5, Ly, Justin Q.^aff6, La, Hank^aff6, Johnson, Kevin^aff6, Baumgardner, Matt^aff6, Chou, Kang-Jye^aff7, Rohou, Alexis^aff8, Rougé, Lionel^aff8, Safina, Brian S.^aff1, Magnuson, Steven^aff1, Volgraf, Matthew^aff1

A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel

Liu, Chang, Reese, Rebecca, Vu, Simon, Rougé, Lionel, Shields, Shannon D, Kakiuchi-Kiyota, Satoko, Chen, Huifen, Johnson, Kevin, Shi, Yu Patrick, Chernov-Rogan, Tania, Greiner, Demi Maria Zabala, Kohli, Pawan Bir, Hackos, David, Brillantes, Bobby, Tam, Christine, Li, Tianbo, Wang, Jianyong, Safina, Brian, Magnuson, Steve, Volgraf, Matthew, Payandeh, Jian, Zheng, Jie, Rohou, Alexis, Chen, Jun

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Discovery of a Potent (4R,5S)‑4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling

Chen, Huifen^aff1d1, Volgraf, Matthew^aff1d1, Do, Steven^aff1d1, Kolesnikov, Aleksandr^aff1d1, Shore, Daniel G.^aff1d1, Verma, Vishal A.^aff1d1, Villemure, Elisia^aff1d1, Wang, Lan^aff1d1, Chen, Yong^aff2, Hu, Baihua^aff2, Lu, Ai-Jun^aff2, Wu, Guosheng^aff2, Xu, Xiaofeng^aff2, Yuen, Po-wai^aff2, Zhang, Yamin^aff2, Erickson, Shawn D.^aff3, Dahl, Martin^aff3, Brotherton-Pleiss, Christine^aff3, Tay, Suzanne^aff1d4, Ly, Justin Q.^aff1d4, Murray, Lesley J.^aff1d4, Chen, Jun^aff1d3, Amm, Desiree^aff4, Lange, Wienke^aff4, Hackos, David H.^aff1d2, Reese, Rebecca M.^aff1d2, Shields, Shannon D.^aff1d2, Lyssikatos, Joseph P.^aff1d1, Safina, Brian S.^aff1d1, Estrada, Anthony A.^aff1d1

GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer's Disease Models.

Hanson, Jesse E, Ma, Keran, Elstrott, Justin, Weber, Martin, Saillet, Sandrine, Khan, Abdullah S, Simms, Jeffrey, Liu, Benjamin, Kim, Thomas A, Yu, Gui-Qiu, Chen, Yelin, Wang, Tzu-Ming, Jiang, Zhiyu, Liederer, Bianca M, Deshmukh, Gauri, Solanoy, Hilda, Chan, Connie, Sellers, Benjamin D, Volgraf, Matthew, Schwarz, Jacob B, Hackos, David H, Weimer, Robby M, Sheng, Morgan, Gill, T Michael, Scearce-Levie, Kimberly, Palop, Jorge J

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Discovery of 5‑Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability

Wang, Xiaojing^aff1, Kolesnikov, Aleksandr^aff1, Tay, Suzanne^aff1, Chan, Grace^aff1, Chao, Qi^aff2, Do, Steven^aff1, Drummond, Jason^aff1, Ebens, Allen J.^aff1, Liu, Ning^aff1, Ly, Justin^aff1, Harstad, Eric^aff1, Hu, Huiyong^aff1, Moffat, John^aff1, Munugalavadla, Veerendra^aff1, Murray, Jeremy^aff1, Slaga, Dionysos^aff1, Tsui, Vickie^aff1, Volgraf, Matthew^aff1, Wallweber, Heidi^aff1, Chang, Jae H.^aff1

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design

Volgraf, Matthew^aff1d1, Sellers, Benjamin D.^aff1d1, Jiang, Yu^aff2, Wu, Guosheng^aff2, Ly, Cuong Q.^aff1d1, Villemure, Elisia^aff1d1, Pastor, Richard M.^aff1d1, Yuen, Po-wai^aff2, Lu, Aijun^aff2, Luo, Xifeng^aff2, Liu, Mingcui^aff2, Zhang, Shun^aff2, Sun, Liang^aff2, Fu, Yuhong^aff2, Lupardus, Patrick J.^aff1d5, Wallweber, Heidi J.A.^aff1d5, Liederer, Bianca M.^aff1d4, Deshmukh, Gauri^aff1d4, Plise, Emile^aff1d4, Tay, Suzanne^aff1d4, Reynen, Paul^aff1d3, Herrington, James^aff1d3, Gustafson, Amy^aff1d3, Liu, Yichin^aff1d3, Dirksen, Akim^aff3, Dietz, Matthias G. A.^aff3, Liu, Yanzhou^aff1d1, Wang, Tzu-Ming^aff1d2, Hanson, Jesse E.^aff1d2, Hackos, David^aff1d2, Scearce-Levie, Kimberly^aff1d2, Schwarz, Jacob B.^aff1d1

Discovery of 7‑Tetrahydropyran-2-yl Chromans: β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors That Reduce Amyloid β‑Protein (Aβ) in the Central Nervous System

Thomas, Allen A.^aff1, Hunt, Kevin W.^aff1, Volgraf, Matthew^aff2, Watts, Ryan J.^aff2, Liu, Xingrong^aff2, Vigers, Guy^aff1, Smith, Darin^aff1, Sammond, Douglas^aff1, Tang, Tony P.^aff1, Rhodes, Susan P.^aff1, Metcalf, Andrew T.^aff1, Brown, Karin D.^aff1, Otten, Jennifer N.^aff1, Burkard, Michael^aff1, Cox, April A.^aff1, Do, Mary K. Geck^aff1, Dutcher, Darrin^aff1, Rana, Sumeet^aff1, DeLisle, Robert K.^aff1, Regal, Kelly^aff1, Wright, Albion D.^aff1, Groneberg, Robert^aff1, Scearce-Levie, Kimberly^aff2, Siu, Michael^aff2, Purkey, Hans E.^aff2, Lyssikatos, Joseph P.^aff2, Gunawardana, Indrani W.^aff1

A Retrospective Look at the Impact of Binding Site Environment on the Optimization of TRPA1 Antagonists

Villemure, Elisia^aff1, Terrett, Jack A.^aff1, Larouche-Gauthier, Robin^aff2, Déry, Martin^aff2, Chen, Huifen^aff1, Reese, Rebecca M.^aff1a, Shields, Shannon D.^aff1a, Chen, Jun^aff1b, Magnuson, Steven^aff1, Volgraf, Matthew^aff1

Ligand binding at the protein–lipid interface: strategic considerations for drug design

Payandeh, Jian, Volgraf, Matthew^{Aff2, IDs41573021002402_cor2}

TRPA1 modulation by piperidine carboxamides suggests an evolutionarily conserved binding site and gating mechanism

Chernov-Rogan, Tania, Gianti, Eleonora, Liu, Chang, Villemure, Elisia, Cridland, Andrew P., Hu, Xiaoyu, Ballini, Elisa, Lange, Wienke, Deisemann, Heike, Li, Tianbo, Ward, Stuart I., Hackos, David H., Magnuson, Steven, Safina, Brian, Klein, Michael L., Volgraf, Matthew, Carnevale, Vincenzo, Chena, Jun

A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain

Wang, Tzu-Ming, Brown, Brandon M., Deng, Lunbin, Sellers, Benjamin D., Lupardus, Patrick J., Wallweber, Heidi J.A., Gustafson, Amy, Wong, Evera, Volgraf, Matthew, Schwarz, Jacob B., Hackos, David H., Hanson, Jesse E.

Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function

Hackos, David H., Lupardus, Patrick J., Grand, Teddy, Chen, Yelin, Wang, Tzu-Ming, Reynen, Paul, Gustafson, Amy, Wallweber, Heidi J.A., Volgraf, Matthew, Sellers, Benjamin D., Schwarz, Jacob B., Paoletti, Pierre, Sheng, Morgan, Zhou, Qiang, Hanson, Jesse E.

GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile

Villemure, Elisia^aff1d1, Volgraf, Matthew^aff1d1, Jiang, Yu^aff2, Wu, Guosheng^aff2, Ly, Cuong Q.^aff1d1, Yuen, Po-wai^aff2, Lu, Aijun^aff2, Luo, Xifeng^aff2, Liu, Mingcui^aff2, Zhang, Shun^aff2, Lupardus, Patrick J.^aff1d5, Wallweber, Heidi J. A.^aff1d5, Liederer, Bianca M.^aff1d4, Deshmukh, Gauri^aff1d4, Plise, Emile^aff1d4, Tay, Suzanne^aff1d4, Wang, Tzu-Ming^aff1d2, Hanson, Jesse E.^aff1d2, Hackos, David H.^aff1d2, Scearce-Levie, Kimberly^aff1d2, Schwarz, Jacob B.^aff1d1, Sellers, Benjamin D.^aff1d1

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Engineering Light-Gated Ion Channels †

Banghart, Matthew R., Volgraf, Matthew, Trauner, Dirk