Sökresultat - "Ware, Joseph"

Absorption, Metabolism, and Excretion of Taselisib (GDC-0032), a Potent β-Sparing PI3K Inhibitor in Rats, Dogs, and Humans

Ma, Shuguang ^{1, 2}, Cho, Sungjoon ¹, Sahasranaman, Srikumar ³, Zhao, Weiping, Pang, Jodie, Ding, Xiao, Dean, Brian, Wang, Bin ⁴, Hsu, Jerry Y. ⁵, Ware, Joseph ⁶, Salphati, Laurent ^*

Impact of Food and the Proton Pump Inhibitor Rabeprazole on the Pharmacokinetics of GDC-0941 in Healthy Volunteers: Bench to Bedside Investigation of pH-Dependent Solubility

Ware, Joseph A.^aff1d1, Dalziel, Gena^aff1d2, Jin, Jin Y.^aff1d1, Pellett, Jackson D.^aff1d2, Smelick, Gillian S.^aff1d1, West, David A.^aff1d1, Salphati, Laurent^aff1d3, Ding, Xiao^aff1d3, Sutton, Rebecca^aff1d4, Fridyland, Jane^aff1d5, Dresser, Mark J.^aff1d1, Morrisson, Glenn^aff1d5, Holden, Scott N.^aff1d5

Prevalence of Acid-Reducing Agents (ARA) in Cancer Populations and ARA Drug–Drug Interaction Potential for Molecular Targeted Agents in Clinical Development

Smelick, Gillian S.^aff1, Heffron, Timothy P.^aff2, Chu, Laura^aff3, Dean, Brian^aff4, West, David A.^aff1, DuVall, Scott L.^aff5, Lum, Bert L.^aff1, Budha, Nageshwar^aff1, Holden, Scott N.^aff6, Benet, Leslie Z.^aff7, Frymoyer, Adam^aff8, Dresser, Mark J.^aff1, Ware, Joseph A.^aff1

Gastric Reacidification with Betaine HCl in Healthy Volunteers with Rabeprazole-Induced Hypochlorhydria

Yago, Marc R.^aff1, Frymoyer, Adam R.^aff2, Smelick, Gillian S.^aff3, Frassetto, Lynda A.^aff4, Budha, Nageshwar R.^aff3, Dresser, Mark J.^aff3, Ware, Joseph A.^aff3, Benet, Leslie Z.^aff1

Pharmacokinetics and Absorption of the Anticancer Agents Dasatinib and GDC-0941 under Various Gastric Conditions in Dogs – Reversing the Effect of Elevated Gastric pH with Betaine HCl

Pang, Jodie^aff1d1, Dalziel, Gena^aff1d2, Dean, Brian^aff1d1, Ware, Joseph A.^aff1d3, Salphati, Laurent^aff1d1

Mechanistic physiology-based pharmacokinetic modeling to elucidate vincristine-induced peripheral neuropathy following treatment with novel kinase inhibitors

Pilla Reddy , Venkatesh^{Aff1, Aff2}, Fretland, Adrian J., Zhou, Diansong, Sharma, Shringi, Chen, Buyun, Vishwanathan, Karthick, McGinnity, Dermot F., Xu, Yan, Ware, Joseph A.

Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

Flygare, John A.^aff1d1, Beresini, Maureen^aff1d2, Budha, Nageshwar^aff1d3, Chan, Helen^aff1d4, Chan, Iris T.^aff1d5, Cheeti, Sravanthi^aff1d3, Cohen, Frederick^aff1d1, Deshayes, Kurt^aff1d6, Doerner, Karl^aff1d7, Eckhardt, S. Gail^aff2, Elliott, Linda O.^aff1d2, Feng, Bainian^aff1d1, Franklin, Matthew C.^aff1d6, Reisner, Stacy Frankovitz^aff1d2, Gazzard, Lewis^aff1d1, Halladay, Jason^aff1d4, Hymowitz, Sarah G.^aff1d8, La, Hank^aff1d4, LoRusso, Patricia^aff3, Maurer, Brigitte^aff1d8, Murray, Lesley^aff1d7, Plise, Emile^aff1d4, Quan, Clifford^aff1d6, Stephan, Jean-Philippe^aff1d2, Young, Shin G.^aff1d4, Tom, Jeffrey^aff1d6, Tsui, Vickie^aff1d1, Um, Joanne^aff1d1, Varfolomeev, Eugene^aff1d6, Vucic, Domagoj^aff1d6, Wagner, Andrew J.^aff4, Wallweber, Heidi J. A.^aff1d8, Wang, Lan^aff1d1, Ware, Joseph^aff1d3, Wen, Zhaoyang^aff1d1, Wong, Harvey^aff1d4, Wong, Jonathan M.^aff1d1, Wong, Melisa^aff1d1, Wong, Susan^aff1d4, Yu, Ron^aff1d9, Zobel, Kerry^aff1d6, Fairbrother, Wayne J.^aff1d6

Breast Cancer Resistance Protein (Bcrp/abcg2) Is a Major Determinant of Sulfasalazine Absorption and Elimination in the Mouse

Zaher, Hani, Khan, Anis A., Palandra, Joe, Brayman, Timothy G., Yu, Linning, Ware, Joseph A.

Modulation of Cell Adhesion Molecules in Various Epithelial Cell Lines after Treatment with PP2 †

Calcagno, Anna Maria, Fostel, Jennifer M., Orchekowski, Randal P., Alston, James T., Mattes, William B., Siahaan, Teruna J., Ware, Joseph A.

Mechanistic Studies on the Bioactivation of Diclofenac: Identification of Diclofenac-S-acyl-glutathione in Vitro in Incubations with Rat and Human Hepatocytes †

Grillo, Mark P., Hua, Fengmei, Knutson, Charles G., Ware, Joseph A., Li, Chunze

The Use of Betaine HCl to Enhance Dasatinib Absorption in Healthy Volunteers with Rabeprazole-Induced Hypochlorhydria

Yago, Marc R, Frymoyer, Adam, Benet, Leslie Z, Smelick, Gillian S, Frassetto, Lynda A, Ding, Xiao, Dean, Brian, Salphati, Laurent, Budha, Nageshwar, Jin, Jin Y, Dresser, Mark J, Ware, Joseph A

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Immunochemical Detection and Identification of Protein Adducts of Diclofenac in the Small Intestine of Rats: Possible Role in Allergic Reactions

Ware, Joseph A., Graf, Mary Louise M., Martin, Brian M., Lustberg, Lisa R., Pohl, Lance R.

A phase IB dose-escalation study of the safety and pharmacokinetics of pictilisib in combination with either paclitaxel and carboplatin (with or without bevacizumab) or pemetrexed and cisplatin (with or without bevacizumab) in patients with advanced non–small cell lung cancer

Soria, Jean-Charles, Adjei, Alex A., Bahleda, Rastilav, Besse, Benjamin, Ferte, Charles, Planchard, David, Zhou, Jing, Ware, Joseph, Morrissey, Kari, Shankar, Geetha, Lin, Wei, Schutzman, Jennifer L., Dy, Grace K., Groen, Harry J.M.

Pharmacogenomics in the age of personalized medicine

Dickmann, Leslie J., Ware, Joseph A.

Simultaneous determination of itraconazole, hydroxy itraconazole, keto itraconazole and N-desalkyl itraconazole concentration in human plasma using liquid chromatography with tandem mass spectrometry

Liang, Xiaorong, Van Parys, Michael, Ding, Xiao, Zeng, Ning, Bi, Luke, Dorshort, Drew, McKnight, Janine, Milanowski, Dennis, Mao, Jialin, Chen, Yuan, Ware, Joseph A, Dean, Brian, Hop, Cornelis E.C.A., Deng, Yuzhong

Breast Cancer Resistance Protein (ABCG2) in Clinical Pharmacokinetics and Drug Interactions: Practical Recommendations for Clinical Victim and Perpetrator Drug-Drug Interaction Study Design

Lee, Caroline A ¹, O’Connor, Meeghan A, Ritchie, Tasha K, Galetin, Aleksandra, Cook, Jack A, Ragueneau-Majlessi, Isabelle, Ellens, Harma, Feng, Bo, Taub, Mitchell E, Paine, Mary F, Polli, Joseph W, Ware, Joseph A, Zamek-Gliszczynski, Maciej J ^*

Evaluation of Metabolism and Disposition of GDC-0152 in Rats Using 14C Labeling Strategy at Two Different Positions: A Novel Formation of Hippuric Acid from 4-Phenyl-5-Amino-1,2,3-Thiadiazole

Yue, Qin ¹, Mulder, Teresa, Rudewicz, Patrick J. ¹, Solon, Eric, Budha, Nageshwar, Ware, Joseph A, Lyssikatos, Joseph, Hop, Cornelis E.C.A., Wong, Harvey, Khojasteh, S. Cyrus ^*

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Identification, Expression, and Functional Characterization of Full-Length and Splice Variants of Murine Organic Anion Transporting Polypeptide 1b2
Functional Characterization of Murine Oatp1b2

Meyer zu Schwabedissen, Henriette E., Ware, Joseph A., Tirona, Rommel G., Kim, Richard B.

γ-Glutamyltranspeptidase-Mediated Degradation of Diclofenac-S-acyl-glutathione in Vitro and in Vivo in Rat
γ-GT Degradation of Diclofenac-S-acyl-glutathione

Grillo, Mark P., Hua, Fengmei, March, Kristi L., Benet, Leslie Z., Knutson, Charles G., Ware, Joseph A.