Search Results - "Yuen, Po-wai"

Discovery of a Potent (4R,5S)‑4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling

Chen, Huifen^aff1d1, Volgraf, Matthew^aff1d1, Do, Steven^aff1d1, Kolesnikov, Aleksandr^aff1d1, Shore, Daniel G.^aff1d1, Verma, Vishal A.^aff1d1, Villemure, Elisia^aff1d1, Wang, Lan^aff1d1, Chen, Yong^aff2, Hu, Baihua^aff2, Lu, Ai-Jun^aff2, Wu, Guosheng^aff2, Xu, Xiaofeng^aff2, Yuen, Po-wai^aff2, Zhang, Yamin^aff2, Erickson, Shawn D.^aff3, Dahl, Martin^aff3, Brotherton-Pleiss, Christine^aff3, Tay, Suzanne^aff1d4, Ly, Justin Q.^aff1d4, Murray, Lesley J.^aff1d4, Chen, Jun^aff1d3, Amm, Desiree^aff4, Lange, Wienke^aff4, Hackos, David H.^aff1d2, Reese, Rebecca M.^aff1d2, Shields, Shannon D.^aff1d2, Lyssikatos, Joseph P.^aff1d1, Safina, Brian S.^aff1d1, Estrada, Anthony A.^aff1d1

Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors

Zak, Mark^aff1, Yuen, Po-wai^aff3, Liu, Xiongcai^aff3, Patel, Snahel^aff1, Sampath, Deepak^aff1, Oeh, Jason^aff1, Liederer, Bianca M.^aff1, Wang, Weiru^aff1, O’Brien, Thomas^aff1, Xiao, Yang^aff1, Skelton, Nicholas^aff1, Hua, Rongbao^aff3, Sodhi, Jasleen^aff1, Wang, Yunli^aff3, Zhang, Lei^aff3, Zhao, Guiling^aff1, Zheng, Xiaozhang^aff2, Ho, Yen-Ching^aff2, Bair, Kenneth W.^aff2, Dragovich, Peter S.^aff1

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design

Volgraf, Matthew^aff1d1, Sellers, Benjamin D.^aff1d1, Jiang, Yu^aff2, Wu, Guosheng^aff2, Ly, Cuong Q.^aff1d1, Villemure, Elisia^aff1d1, Pastor, Richard M.^aff1d1, Yuen, Po-wai^aff2, Lu, Aijun^aff2, Luo, Xifeng^aff2, Liu, Mingcui^aff2, Zhang, Shun^aff2, Sun, Liang^aff2, Fu, Yuhong^aff2, Lupardus, Patrick J.^aff1d5, Wallweber, Heidi J.A.^aff1d5, Liederer, Bianca M.^aff1d4, Deshmukh, Gauri^aff1d4, Plise, Emile^aff1d4, Tay, Suzanne^aff1d4, Reynen, Paul^aff1d3, Herrington, James^aff1d3, Gustafson, Amy^aff1d3, Liu, Yichin^aff1d3, Dirksen, Akim^aff3, Dietz, Matthias G. A.^aff3, Liu, Yanzhou^aff1d1, Wang, Tzu-Ming^aff1d2, Hanson, Jesse E.^aff1d2, Hackos, David^aff1d2, Scearce-Levie, Kimberly^aff1d2, Schwarz, Jacob B.^aff1d1

Tetrahydroindazoles as Interleukin‑2 Inducible T‑Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo

Burch, Jason D.^aff1, Barrett, Kathy^aff1, Chen, Yuan^aff1, DeVoss, Jason^aff1, Eigenbrot, Charles^aff1, Goldsmith, Richard^aff1, Ismaili, M. Hicham A.^aff1, Lau, Kevin^aff1, Lin, Zhonghua^aff1, Ortwine, Daniel F.^aff1, Zarrin, Ali A.^aff1, McEwan, Paul A.^aff2, Barker, John J.^aff2, Ellebrandt, Claire^aff3, Kordt, Daniel^aff3, Stein, Daniel B.^aff3, Wang, Xiaolu^aff3, Chen, Yong^aff4, Hu, Baihua^aff4, Xu, Xiaofeng^aff4, Yuen, Po-Wai^aff4, Zhang, Yamin^aff4, Pei, Zhonghua^aff1

Property- and Structure-Guided Discovery of a Tetrahydroindazole Series of Interleukin‑2 Inducible T‑Cell Kinase Inhibitors

Burch, Jason D.^aff1, Lau, Kevin^aff1, Barker, John J.^aff2, Brookfield, Fred^aff2, Chen, Yong^aff4, Chen, Yuan^aff1, Eigenbrot, Charles^aff1, Ellebrandt, Claire^aff3, Ismaili, M. Hicham A.^aff1, Johnson, Adam^aff1, Kordt, Daniel^aff3, MacKinnon, Colin H.^aff2, McEwan, Paul A.^aff2, Ortwine, Daniel F.^aff1, Stein, Daniel B.^aff3, Wang, Xiaolu^aff3, Winkler, Dirk^aff3, Yuen, Po-Wai^aff4, Zhang, Yamin^aff4, Zarrin, Ali A.^aff1, Pei, Zhonghua^aff1

Fragment-Based Identification of Amides Derived from trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)

Giannetti, Anthony M.^aff1, Zheng, Xiaozhang^aff2, Skelton, Nicholas J.^aff1, Wang, Weiru^aff1, Bravo, Brandon J.^aff1, Bair, Kenneth W.^aff2, Baumeister, Timm^aff2, Cheng, Eric^aff1, Crocker, Lisa^aff1, Feng, Yezhen^aff3, Gunzner-Toste, Janet^aff1, Ho, Yen-Ching^aff2, Hua, Rongbao^aff3, Liederer, Bianca M.^aff1, Liu, Yongbo^aff3, Ma, Xiaolei^aff1, O’Brien, Thomas^aff1, Oeh, Jason^aff1, Sampath, Deepak^aff1, Shen, Youming^aff3, Wang, Chengcheng^aff4, Wang, Leslie^aff1, Wu, Hongxing^aff3, Xiao, Yang^aff1, Yuen, Po-wai^aff3, Zak, Mark^aff1, Zhao, Guiling^aff1, Zhao, Qiang^aff4, Dragovich, Peter S.^aff1

Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

Zheng, Xiaozhang^aff1, Bauer, Paul^aff1, Baumeister, Timm^aff1, Buckmelter, Alexandre J.^aff1, Caligiuri, Maureen^aff1, Clodfelter, Karl H.^aff1, Han, Bingsong^aff1, Ho, Yen-Ching^aff1, Kley, Nikolai^aff1, Lin, Jian^aff1, Reynolds, Dominic J.^aff1, Sharma, Geeta^aff1, Smith, Chase C.^aff1, Wang, Zhongguo^aff1, Dragovich, Peter S.^aff2, Gunzner-Toste, Janet^aff2, Liederer, Bianca M.^aff2, Ly, Justin^aff2, O’Brien, Thomas^aff2, Oh, Angela^aff2, Wang, Leslie^aff2, Wang, Weiru^aff2, Xiao, Yang^aff2, Zak, Mark^aff2, Zhao, Guiling^aff2, Yuen, Po-wai^aff3, Bair, Kenneth W.^aff1

Structure-Based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

Zheng, Xiaozhang^aff1, Bauer, Paul^aff1, Baumeister, Timm^aff1, Buckmelter, Alexandre J.^aff1, Caligiuri, Maureen^aff1, Clodfelter, Karl H.^aff1, Han, Bingsong^aff1, Ho, Yen-Ching^aff1, Kley, Nikolai^aff1, Lin, Jian^aff1, Reynolds, Dominic J.^aff1, Sharma, Geeta^aff1, Smith, Chase C.^aff1, Wang, Zhongguo^aff1, Dragovich, Peter S.^aff2, Oh, Angela^aff2, Wang, Weiru^aff2, Zak, Mark^aff2, Gunzner-Toste, Janet^aff2, Zhao, Guiling^aff2, Yuen, Po-wai^aff3, Bair, Kenneth W.^aff1

Chemistry and Behavioral Studies Identify Chiral Cyclopropanes as Selective α4β2-Nicotinic Acetylcholine Receptor Partial Agonists Exhibiting an Antidepressant Profile

Zhang, Hankun^aff1, Tückmantel, Werner^aff3, Eaton, J. Brek^aff2, Yuen, Po-wai^aff3, Yu, Li-Fang^aff1, Bajjuri, Krishna Mohan^aff1, Fedolak, Allison^aff3, Wang, Daguang^aff3, Ghavami, Afshin^aff3, Caldarone, Barbara^aff3, Paterson, Neil E.^aff3, Lowe, David A.^aff3, Brunner, Daniela^aff3, Lukas, Ronald J.^aff2, Kozikowski, Alan P.^aff1

Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors

Parr, Brendan T.^aff1, Pastor, Richard^aff1, Sellers, Benjamin D.^aff1, Pei, Zhonghua^aff1, Jaipuri, Firoz A.^aff2, Castanedo, Georgette M.^aff1, Gazzard, Lewis^aff1, Kumar, Sanjeev^aff2, Li, Xiaokai^aff2, Liu, Wen^aff1, Mendonca, Rohan^aff1, Pavana, Roheeth K.^aff2, Potturi, Hima^aff2, Shao, Cheng^aff3, Velvadapu, Venkata^aff2, Waldo, Jesse P.^aff2, Wu, Guosheng^aff3, Yuen, Po-wai^aff3, Zhang, Zuhui^aff2, Zhang, Yamin^aff3, Harris, Seth F.^aff1, Oh, Angela J.^aff1, DiPasquale, Antonio^aff1, Dement, Kevin^aff1, La, Hank^aff1, Goon, Leanne^aff1, Gustafson, Amy^aff1, VanderPorten, Erica C.^aff1, Mautino, Mario R.^aff2, Liu, Yichin^aff1

Structure−Activity Relationship of N-(Phenylalkyl)cinnamides as Novel NR2B Subtype-Selective NMDA Receptor Antagonists

Tamiz, Amir P., Cai, Sui Xiong, Zhou, Zhang-Lin, Yuen, Po-Wai, Schelkun, Robert M., Whittemore, Edward R., Weber, Eckard, Woodward, Richard M., Keana, John F. W.

Novel Use of Substituted 1,4-Dihydrobenz[d][1,3]oxazin-2-ones in the Synthesis of Important Aminomethyl o-Nitroanilines

Nikam, Sham S., Yuen, Po-Wai, Kornberg, Brian E., Tobias, Brian, Rafferty, Michael F.

Aminoisoxazoles as Potent Inhibitors of Tryptophan 2,3-Dioxygenase 2 (TDO2)

Pei, Zhonghua^aff1d1, Mendonca, Rohan^aff1d1, Gazzard, Lewis^aff1d1, Pastor, Richard^aff1d1, Goon, Leanne^aff1d3, Gustafson, Amy^aff1d3, VanderPorten, Erica^aff1d3, Hatzivassiliou, Georgia^aff1d5, Dement, Kevin^aff1d4, Cass, Robert^aff1d4, Yuen, Po-wai^aff2, Zhang, Yamin^aff2, Wu, Guosheng^aff2, Lin, Xingyu^aff2, Liu, Yichin^aff1d3, Sellers, Benjamin D.^aff1d1

An Alpha-Mercaptoacrylic Acid Derivative is a Selective Nonpeptide Cell-Permeable Calpain Inhibitor and is Neuroprotective

Nath, Rathna, Posner, Avigail, Raser, Kadee J., Buroker-Kilgore, Michelle, Hajimohammadreza, Iradj, Probert, Albert W., Marcoux, Frank W., Ye, Qizhuang, Takano, Emiko, Hatanaka, Masakazu, Maki, Masatoshi, Caner, Hakan, Collins, Jennifer L., Fergus, Andrea, Lee, Kevin S., Lunney, Elizabeth A., Hays, Sheryl J., Yuen, Po-Wai

GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile

Villemure, Elisia^aff1d1, Volgraf, Matthew^aff1d1, Jiang, Yu^aff2, Wu, Guosheng^aff2, Ly, Cuong Q.^aff1d1, Yuen, Po-wai^aff2, Lu, Aijun^aff2, Luo, Xifeng^aff2, Liu, Mingcui^aff2, Zhang, Shun^aff2, Lupardus, Patrick J.^aff1d5, Wallweber, Heidi J. A.^aff1d5, Liederer, Bianca M.^aff1d4, Deshmukh, Gauri^aff1d4, Plise, Emile^aff1d4, Tay, Suzanne^aff1d4, Wang, Tzu-Ming^aff1d2, Hanson, Jesse E.^aff1d2, Hackos, David H.^aff1d2, Scearce-Levie, Kimberly^aff1d2, Schwarz, Jacob B.^aff1d1, Sellers, Benjamin D.^aff1d1

Post-injury administration of NAAG peptidase inhibitor prodrug, PGI-02776, in experimental TBI

Feng, Jun-Feng, Van, Ken C., Gurkoff, Gene G., Kopriva, Christina, Olszewski, Rafal T., Song, Minsoo, Sun, Shifeng, Xu, Man, Neale, Joseph H., Yuen, Po-Wai, Lowe, David A., Zhou, Jia, Lyeth, Bruce G.

Structure−Activity Relationship Study and Drug Profile of N-(4-Fluorophenylsulfonyl)-l-valyl-l-leucinal (SJA6017) as a Potent Calpain Inhibitor

Inoue, Jun, Nakamura, Masayuki, Cui, Ying-She, Sakai, Yusuke, Sakai, Osamu, Hill, Jeanette R., Wang, Kevin K. W., Yuen, Po-Wai

Subtype-Selective N-Methyl-d-aspartate Receptor Antagonists: Benzimidazalone and Hydantoin as Phenol Replacements

Schelkun, Robert M., Yuen, Po-wai, Serpa, Kevin, Meltzer, Leonard T., Wise, Lawrence D., Whittemore, Edward R., Woodward, Richard M.

Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling

Zak, Mark, Hanan, Emily J., Lupardus, Patrick, Brown, David G., Robinson, Colin, Siu, Michael, Lyssikatos, Joseph P., Romero, F. Anthony, Zhao, Guiling, Kellar, Terry, Mendonca, Rohan, Ray, Nicholas C., Goodacre, Simon C., Crackett, Peter H., McLean, Neville, Hurley, Christopher A., Yuen, Po-wai, Cheng, Yun-Xing, Liu, Xiongcai, Liimatta, Marya, Kohli, Pawan Bir, Nonomiya, Jim, Salmon, Gary, Buckley, Gerry, Lloyd, Julia, Gibbons, Paul, Ghilardi, Nico, Kenny, Jane R., Johnson, Adam

Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers

Schelkun, Robert M., Yuen, Po-wai, Malone, Thomas C., Rock, David M., Stoehr, Sally, Szoke, Balazs, Tarczy-Hornoch, Katalin