Sökresultat - "adaptive"

Value-adaptive clinical trial designs for efficient delivery of publicly funded trials - a discussion of methods, case studies, opportunities and challenges.

Flight L; Sheffield Centre for Health and Related Research (SCHARR), School of Medicine and Population Health, University of Sheffield, Regent Court, 30 Regent Street, Sheffield, S1 4DA, UK., Brennan A; Sheffield Centre for Health and Related Research (SCHARR), School of Medicine and Population Health, University of Sheffield, Regent Court, 30 Regent Street, Sheffield, S1 4DA, UK. a.brennan@sheffield.ac.uk., Chick SE; INSEAD, Technology and Operations Management Area, Fontainebleau, France., Forster M; Department of Statistical Sciences 'Paolo Fortunati', University of Bologna, Bologna, Italy., Julious S; Sheffield Centre for Health and Related Research (SCHARR), School of Medicine and Population Health, University of Sheffield, Regent Court, 30 Regent Street, Sheffield, S1 4DA, UK., Tharmanathan P; York Trials Unit, Department of Health Sciences, University of York, York, UK.

Journal Article , 2025

The Quest for Antibodies and Other Acquired Immune Receptors: A Historical Perspective.

De Lerma Barbaro A; Department of Biotechnology and Life Sciences, Laboratory of Comparative Physiopathology, University of Insubria, Varese, Italy., Balkhi S; Department of Biotechnology and Life Sciences, Immunology and General Pathology Laboratory, University of Insubria, Varese, Italy., Giovannardi S; Department of Biotechnology and Life Sciences, Laboratory of Comparative Physiopathology, University of Insubria, Varese, Italy.; Centre for Neuroscience, University of Insubria, Varese, Italy., Vianelli A; Department of Human Sciences and Sciences of the Innovation for the Territory, University of Insubria, Varese, Italy., Ribatti D; Department of Translational Biomedicine and Neurosciences, University of Bari Medical School, Bari, Italy., Mortara L; Department of Biotechnology and Life Sciences, Immunology and General Pathology Laboratory, University of Insubria, Varese, Italy.

Journal Article; Review; Historical Article , 2025

Using Bayesian pre-trial simulations to optimize the design of adaptive clinical trials in childhood nephrotic syndrome.

Robinson CH; Division of Nephrology, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Paediatrics, The University of Toronto, Toronto, Ontario, Canada; Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address: cal.robinson@sickkids.ca., Parekh RS; Division of Nephrology, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Paediatrics, The University of Toronto, Toronto, Ontario, Canada; Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Medicine, Women's College Hospital, Toronto, Ontario, Canada., Cuthbertson B; Interdepartmental Division of Critical Care Medicine, The University of Toronto, Ontario, Canada; Sunnybrook Health Sciences Centre Research Institute, Toronto, Ontario, Canada; Department of Critical Care Medicine, Sunnybrook Health Sciences Centres, Toronto, Canada., Fan E; Interdepartmental Division of Critical Care Medicine, The University of Toronto, Ontario, Canada., Ouyang Y; Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada; Division of Biostatistics, Dalla Lana School of Public Health, The University of Toronto, Toronto, Ontario, Canada., Heath A; Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada; Division of Biostatistics, Dalla Lana School of Public Health, The University of Toronto, Toronto, Ontario, Canada; Department of Statistical Science, University College London, London, UK.

Journal Article , 2025

The role of the adaptive immune system in the initiation and persistence of multiple sclerosis.

Afzali AM; Institute for Experimental Neuroimmunology, Technical University of Munich School of Medicine and Health, Ismaninger Str. 22, Munich 81675, Germany; Department of Neurology, Technical University of Munich School of Medicine and Health, Ismaninger Str. 22, Munich 81675, Germany., Korn T; Institute for Experimental Neuroimmunology, Technical University of Munich School of Medicine and Health, Ismaninger Str. 22, Munich 81675, Germany; Department of Neurology, Technical University of Munich School of Medicine and Health, Ismaninger Str. 22, Munich 81675, Germany; Munich Cluster for Systems Neurology, Feodor-Lynen-Str. 17, Munich 81377, Germany. Electronic address: thomas.korn@tum.de.

Journal Article; Review , 2025

Methods integrating innate and adaptive immune responses in human in vitro immunization assays.

Bowley TY; Physical Chemistry and Applied Spectroscopy, Chemistry Division, Los Alamos National Laboratory, Los Alamos, NM, United States., Lenz KD; Physical Chemistry and Applied Spectroscopy, Chemistry Division, Los Alamos National Laboratory, Los Alamos, NM, United States., Shanker A; Physical Chemistry and Applied Spectroscopy, Chemistry Division, Los Alamos National Laboratory, Los Alamos, NM, United States., Kubicek-Sutherland JZ; Physical Chemistry and Applied Spectroscopy, Chemistry Division, Los Alamos National Laboratory, Los Alamos, NM, United States.

Journal Article; Review , 2025

Astragalus Extract Mixture HT042 Reverses Cyclophosphamide-Induced Immunosuppression Through Dual Modulation of Innate and Adaptive Immunity.

Kim SY; Korea Institute of Science and Technology for Eastern Medicine (KISTEM) NeuMed Inc., 88 Imun-ro, Dongdaemun-gu, Seoul 02440, Republic of Korea., Son J; Department of Herbal Pharmacology, College of Korean Medicine, Gachon University, 1342 Seongnamdae-ro, Sujeong-gu, Seongnam-si 13120, Republic of Korea., Kim M; Korea Institute of Science and Technology for Eastern Medicine (KISTEM) NeuMed Inc., 88 Imun-ro, Dongdaemun-gu, Seoul 02440, Republic of Korea., Baek CY; Department of Herbal Pharmacology, College of Korean Medicine, Gachon University, 1342 Seongnamdae-ro, Sujeong-gu, Seongnam-si 13120, Republic of Korea., Kim MY; Korea Institute of Science and Technology for Eastern Medicine (KISTEM) NeuMed Inc., 88 Imun-ro, Dongdaemun-gu, Seoul 02440, Republic of Korea., Shin A; Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea., Lee D; Department of Herbal Pharmacology, College of Korean Medicine, Gachon University, 1342 Seongnamdae-ro, Sujeong-gu, Seongnam-si 13120, Republic of Korea., Kim H; Korea Institute of Science and Technology for Eastern Medicine (KISTEM) NeuMed Inc., 88 Imun-ro, Dongdaemun-gu, Seoul 02440, Republic of Korea.; Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.

Journal Article , 2025

CD47-amyloid-β-CD74 signaling triggers adaptive immunosuppression in sepsis.

Feng Z; Institute of Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China., Wang L; Institute of Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China., Li Y; Institute of Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China., Wei Y; Department of Liver Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China., Zhou Y; Frontier Medical Center, Xin Chuan Road, Zhong He Street, 610212, Chengdu, Sichuan, China., Wang S; Institute of Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China., Zhang X; Department of Orthodontics, State Key laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China., Jiang C; Department of Anesthesiology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China., Liao X; Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China., Kang Y; Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China. kangyan@scu.edu.cn., Xiao F; Department of Intensive Care Unit of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. icuxiaofei@scu.edu.cn., Zhang W; Institute of Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China. zhangwei197610@wchscu.edu.cn.

Journal Article , 2025

Modulation of lipid nanoparticle-formulated plasmid DNA drives innate immune activation promoting adaptive immunity.

Tursi NJ; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Tiwari S; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Bedanova N; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Kannan T; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Parzych E; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Okba N; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Liaw K; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Sárközy A; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Livingston C; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Trullen MI; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Gary EN; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Vadovics M; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Laenger N; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA; Biology Department, Saint Joseph's University, Philadelphia, PA 19131, USA., Londregan J; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Khan MS; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Omo-Lamai S; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Muramatsu H; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Blatney K; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Hojecki C; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Machado V; Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA., Maricic I; Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA., Smith TRF; Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA., Humeau LM; Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA., Patel A; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Kossenkov A; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Brenner JS; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Allman D; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Ignaz Semmelweis Institute, Interuniversity Institute for Infection Research, Medical University of Vienna, Vienna, Austria., Pardi N; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: pnorbert@pennmedicine.upenn.edu., Weiner DB; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA. Electronic address: dweiner@wistar.org.

Journal Article , 2025

Heart-brain axis in health and disease: role of innate and adaptive immunity.

Simats A; Department of Neuroscience and Experimental Therapeutics, Institute of Biomedical Research of Barcelona (IIBB), Spanish National Research Council (CSIC), c/Rosselló 161, 08036 Barcelona, Spain., Sager HB; DZHK (German Center for Cardiovascular Research), Partner site Munich Heart Alliance, Munich, Germany.; Department of Cardiology, German Heart Centre Munich, Technical University of Munich, Munich, Germany., Liesz A; Institute for Stroke and Dementia Research (ISD), University Medical Center Munich, Feodor-Lynen-Straße 17, 81377 Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Feodor-Lynen-Str. 17, 81377 Munich, Germany.

Journal Article; Review , 2025

Development and evaluation of an ovarian cancer prognostic model based on adaptive immune-related genes.

Shi H; Department of Obstetrics and Gynaecology, People's Hospital of Shangcheng District, Hangzhou, China., Li L; Health Management Center, Longquan People's Hospital, Longquan, Zhejiang, China., Zhou L; Department of Obstetrics and Gynaecology, Longquan People's Hospital, Longquan, Zhejiang, China., Hong C; Department of Obstetrics and Gynaecology, People's Hospital of Shangcheng District, Hangzhou, China.

Journal Article , 2025

Photodynamic priming with red light triggers adaptive immune responses in a pancreatic cancer mouse model.

De Silva P; Wellman Center for Photomedicine, Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA., Saad MA; Wellman Center for Photomedicine, Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA., Swain JWR; Wellman Center for Photomedicine, Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA., Mai Z; Wellman Center for Photomedicine, Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA., Kidd MD; Wellman Center for Photomedicine, Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA; Harvard University, Cambridge, MA, USA., Choe JJ; Wellman Center for Photomedicine, Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA; Boston College, Chestnut Hill, MA, USA., Camargo AP; Wellman Center for Photomedicine, Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA; Bunker Hill Community College, Boston, MA, USA., Anand S; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Chandrasekhara V; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA., Pogue BW; Thayer School of Engineering, Dartmouth College, Hanover, NH, USA., Wang KK; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA., Spring BQ; Department of Physics, College of Science, Northeastern University, Boston, USA., Maytin EV; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Hasan T; Wellman Center for Photomedicine, Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA; Division of Health Sciences and Technology, Harvard University and Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address: thasan@mgh.harvard.edu.

Journal Article , 2025

Mycobacterium tuberculosis Antigen Rv1471 Induces Innate Immune Memory and Adaptive Immunity Against Infection.

Huang X; Shanghai Public Health Clinical Center & Shanghai Institute of Infectious Diseases and Biosecurity, Fudan University, Shanghai, China., Wu J; Shanghai Public Health Clinical Center & Shanghai Institute of Infectious Diseases and Biosecurity, Fudan University, Shanghai, China., Xu J; Shanghai Public Health Clinical Center & Shanghai Institute of Infectious Diseases and Biosecurity, Fudan University, Shanghai, China., Wang H; Shanghai Public Health Clinical Center & Shanghai Institute of Infectious Diseases and Biosecurity, Fudan University, Shanghai, China., Chen Z; Shanghai Public Health Clinical Center & Shanghai Institute of Infectious Diseases and Biosecurity, Fudan University, Shanghai, China., Fan XY; Shanghai Public Health Clinical Center & Shanghai Institute of Infectious Diseases and Biosecurity, Fudan University, Shanghai, China., Hu Z; Shanghai Public Health Clinical Center & Shanghai Institute of Infectious Diseases and Biosecurity, Fudan University, Shanghai, China.

Journal Article , 2025

Current anti-inflammatory strategies for treatment of heart failure: From innate to adaptive immunity.

Taylor EB; Department of Physiology and Biophysics and Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, MS 39216, United States., Hall JE; Department of Physiology and Biophysics and Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, MS 39216, United States., Mouton AJ; Department of Physiology and Biophysics and Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, MS 39216, United States. Electronic address: amouton@umc.edu.

Journal Article; Review , 2025

The kinetics of gene expression related to innate and adaptive immunity in the lung and spleen following Newcastle disease virus (NDV) infection in vaccinated broiler chickens employing different vaccination regimes.

Hassanin O; Department of Avian and Rabbit Medicine, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt. Electronic address: olafalcon2001@yahoo.com., Abdallah F; Department of Virology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt., Mohamed MH; Department of Avian and Rabbit Medicine, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt; Department of Clinical Studies, Collage of Veterinary Medicine, King Faisal University, 31982, Saudi Arabia., Ahmed MS; Department of Clinical Studies, Collage of Veterinary Medicine, King Faisal University, 31982, Saudi Arabia; Department of Poultry Diseases, Faculty of Veterinary Medicine, South Valley University, Egypt., Al-Rasheed M; Department of Clinical Studies, Collage of Veterinary Medicine, King Faisal University, 31982, Saudi Arabia., Rashad EM; Animal Health Research Institute (Domietta Branch), Agriculture Research Centre, Egypt.

Journal Article , 2025

Albumin-based synergistic chemiexcited photodynamic biomimetic nanoreactor overcoming adaptive immune resistance for enhanced cancer immunotherapy.

Li K; School of Basic Medicine, Qingdao University, Qingdao, China., Su Y; School of Basic Medicine, Qingdao University, Qingdao, China., Zhao W; Puyang People's Hospital, Puyang, China., An H; School of Pharmacy, Qingdao University, Qingdao, China., Qin H; School of Basic Medicine, Qingdao University, Qingdao, China., Shen J; Puyang People's Hospital, Puyang, China., Su M; School of Pharmacy, Qingdao University, Qingdao, China., Chen W; School of Pharmacy, Qingdao University, Qingdao, China., Gao R; Qilu Institute of Technology, Jinan, China., Han Y; School of Basic Medicine, Qingdao University, Qingdao, China., Han C; Qingdao Women and Children's Hospital, Qingdao University, Qingdao, China. Electronic address: happy.hcs@163.com., Chen X; School of Basic Medicine, Qingdao University, Qingdao, China. Electronic address: chenxuehong@qdu.edu.cn.

Journal Article , 2025

Prior SARS-CoV-2 infection affects adaptive immune responses to Omicron BA.4/BA.5 mRNA booster.

Wachter BT; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md., Xu Q; Laboratory of Immune System Biology, NIAID, NIH, Bethesda, Md., Shi L; Laboratory of Immune System Biology, NIAID, NIH, Bethesda, Md., Burbelo PD; Adeno-Associated Virus Biology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Md., Myint-Hpu K; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md., Schwartzberg PL; Laboratory of Immune System Biology, NIAID, NIH, Bethesda, Md., Rehman MT; Virus Isolation and Serology Laboratory, Frederick National Laboratory, Frederick, Md., Dewar RL; Virus Isolation and Serology Laboratory, Frederick National Laboratory, Frederick, Md., Boswell KL; Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Md., Koup RA; Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Md., Oguz C; Integrated Data Sciences Section, Research Technologies Branch, NIAID, NIH, Bethesda, Md., Imberti L; Spedali Civili di Brescia, Universita' Degli Studi di Brescia, Brescia, Italy., Bellusci L; Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Md., Pourhashemi S; Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Md., Khurana S; Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Md., Manthiram K; Laboratory of Immune System Biology, NIAID, NIH, Bethesda, Md., Notarangelo LD; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md. Electronic address: luigi.notarangelo2@nih.gov., Delmonte OM; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md. Electronic address: ottavia.delmonte@nih.gov.

Journal Article , 2025

The immune system in cardiovascular diseases: from basic mechanisms to therapeutic implications.

Wang X; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China. xyzaheart@163.com.; State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China. xyzaheart@163.com., Chen L; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.; State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China., Wei J; Central Diagnostics Laboratory, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Zheng H; Jiangsu Provincial Key Laboratory of Critical Care Medicine and Department of Critical Care Medicine, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, China., Zhou N; Department of Cardiovascular Medicine, Anzhen Hospital Affiliated to Capital Medical University, Beijing, China., Xu X; State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Deng X; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.; State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China., Liu T; Jiangsu Provincial Key Laboratory of Critical Care Medicine and Department of Critical Care Medicine, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, China. liut47@126.com.; Department of Biochemistry and Molecular Biology, School of Medicine, Southeast University, Jiangsu, Nanjing, China. liut47@126.com.; State Key Laboratory of Respiratory Disease, Joint International Research Laboratory of Respiratory Health, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. liut47@126.com., Zou Y; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China. zou.yunzeng@zs-hospital.sh.cn.; State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China. zou.yunzeng@zs-hospital.sh.cn.; Institutes of Advanced Medical Sciences and Huaihe Hospital, Henan University, Kaifeng, Henan, China. zou.yunzeng@zs-hospital.sh.cn.

Journal Article; Review , 2025

Association between transcriptomic metrics of exogenous antigen presentation and adaptive immunity with locoregional recurrence in localized estrogen receptor negative breast cancer: retrospective review of multi-institutional datasets.

Robinson TJ; Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, USA., Liveringhouse CL; Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Wilson C; Biostatistics and Bioinformatics Shared Resource, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Friedman S; Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, USA., Nakashima J; Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, USA., Mills MN; Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Purcell JD; Michigan State University College of Human Medicine, East Lansing, MI, USA., Figura NB; Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Dongliang D; Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Thapa R; Biostatistics and Bioinformatics Shared Resource, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Welsh E; Biostatistics and Bioinformatics Shared Resource, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Ahmed KA; Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Grass GD; Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Fridley BL; Biostatistics and Bioinformatics Shared Resource, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Diaz R; Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. Roberto.Diaz@Moffitt.Org.

Journal Article; Multicenter Study , 2025

Histocompatibility in Botryllus schlosseri and the origins of adaptive immunity.

De Tomaso AW; Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA, 93106, USA. awdeto@ucsb.edu., Rodriguez-Valbuena H; Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA, 93106, USA.

Journal Article; Review , 2025

The REFRACT trial: implementation of Bayesian power priors in a randomised, sequential phase II adaptive platform trial.

Gaskell C; Cancer Research UK Clinical Trials Unit, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. c.gaskell@bham.ac.uk., Linton K; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, M20 4BX, UK.; Division of Cancer Sciences, The Manchester Cancer Research Centre, University of Manchester, Manchester, M20 4GJ, UK., Bishton M; Translational Medical Sciences, University of Nottingham, Nottingham, NG7 2RD, UK.; Department of Haematology, Nottingham University Hospitals NHS Trust, Nottingham, UK., McIlroy G; Cancer Research UK Clinical Trials Unit, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Lax S; Cancer Research UK Clinical Trials Unit, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Fox S; Cancer Research UK Clinical Trials Unit, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Hopkins L; Cancer Research UK Clinical Trials Unit, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Collings R; Cancer Research UK Clinical Trials Unit, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Rhodes M; Patient advocate, National Cancer Research Institute, London, UK., Seale T; Division of Cancer Sciences, Wolfson Molecular Imaging Centre, The University of Manchester, 27 Palantine Road, Withington, Manchester, M20 3LJ, UK., Jackson A; Cancer Research UK Clinical Trials Unit, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

Clinical Trial Protocol; Journal Article , 2025