Sökresultat - "fibroblasts"

Fibroblast hierarchy dynamics during mammary gland morphogenesis and tumorigenesis.

Pascual R; ACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia., Cheng J; ACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia.; Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia., De Smet AH; ACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia., Capaldo BD; ACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia., Tsai M; ACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia., Kordafshari S; ACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia., Vaillant F; ACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia., Song X; ACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia., Giner G; Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia., Milevskiy MJG; ACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia., Jackling FC; ACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia., Pal B; Translational Breast Cancer Program, Olivia Newton-John Cancer Research Institute and School for Cancer Medicine La Trobe University, Heidelberg, VIC, 3084, Australia., Dite T; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia.; Advanced Technology and Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia., Yousef J; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia.; Advanced Technology and Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia., Dagley LF; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia.; Advanced Technology and Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia., Smyth GK; Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; School of Mathematics and Statistics, The University of Melbourne, Parkville, VIC, 3010, Australia., Fu N; ACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia., Lindeman GJ; ACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, 3010, Australia.; Parkville Familial Cancer Centre and Department of Medical Oncology, The Royal Melbourne Hospital and Peter MacCallum Cancer Centre, Parkville, VIC, 3050, Australia., Chen Y; ACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia.; Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia., Visvader JE; ACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia. visvader@wehi.edu.au.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia. visvader@wehi.edu.au.

Journal Article , 2025

CD105 ⁺ fibroblasts support an immunosuppressive niche in women at high risk of breast cancer initiation.

Carlson EG; Department of Population Sciences, City of Hope, Duarte, CA, USA., Lopez JC; Department of Population Sciences, City of Hope, Duarte, CA, USA., Yamaguchi Y; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA., Gibson J; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA., Priceman SJ; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA.; Department of Medicine, University of Southern California, Los Angeles, United States., LaBarge MA; Department of Population Sciences, City of Hope, Duarte, CA, USA. mlabarge@coh.org.

Journal Article , 2025

Periductal fibroblasts participate in liver homeostasis, fibrosis, and tumorigenesis.

Wang SS; Department of Hepatic Oncology, Liver Cancer Institute, Zhongshan Hospital, Fudan University and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, China., Yuan J; Department of Hepatic Oncology, Liver Cancer Institute, Zhongshan Hospital, Fudan University and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, China., Tang XT; Key Laboratory of Multi-Cell System, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences , Beijing, China., Yin X; Key Laboratory of Multi-Cell System, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China., Fang K; Key Laboratory of Multi-Cell System, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China., Chen LV; Key Laboratory of Multi-Cell System, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences , Beijing, China., Ren Z; Department of Hepatic Oncology, Liver Cancer Institute, Zhongshan Hospital, Fudan University and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, China., Zhou BO; Key Laboratory of Multi-Cell System, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences , Beijing, China.; State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.

Journal Article , 2025

SCGB3A1-Epi and KLK10-Epi Crosstalk With Fibroblasts Promotes Liver Metastasis of Breast Cancer and Pancreatic Ductal Adenocarcinoma.

Xuan Z; Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.; Department of Pharmacy, Zhejiang Provincial People's Hospital Bijie Hospital, Bijie, Guizhou, China., Wu Z; Department of Pharmacy, Zhejiang Provincial People's Hospital Bijie Hospital, Bijie, Guizhou, China., Cheng L; Department of Pharmacy, Zhejiang Provincial People's Hospital Bijie Hospital, Bijie, Guizhou, China., Jiang J; Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.; Department of Pharmacy, Zhejiang Provincial People's Hospital Bijie Hospital, Bijie, Guizhou, China., Zhang Y; Department of Pharmacy, Zhejiang Provincial People's Hospital Bijie Hospital, Bijie, Guizhou, China., Xia Y; Outpatient Department, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.

Journal Article , 2025

Spatial dissection of tumour microenvironments in gastric cancers reveals the immunosuppressive crosstalk between CCL2+ fibroblasts and STAT3 -activated macrophages.

Lee SH; Department of Hospital Pathology, Seoul St. Mary's Hostpital, Collage of Medicine, The Catholic University of Korea, Seoul, The Republic of Korea., Lee D; Department of Surgery, Ajou University School of Medicine, Suwon, The Republic of Korea., Choi J; Department of Surgery, Ajou University School of Medicine, Suwon, The Republic of Korea.; Cancer Biology Graduate Program, Ajou University School of Medicine, Suwon, The Republic of Korea., Oh HJ; Department of Surgery, Ajou University School of Medicine, Suwon, The Republic of Korea., Ham IH; Department of Surgery, Ajou University School of Medicine, Suwon, The Republic of Korea.; Inflamm-Aging Translational Research Center, Ajou University School of Medicine, Suwon, The Republic of Korea., Ryu D; Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, The Republic of Korea., Lee SY; Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, The Republic of Korea.; Department of Biomedicine & Health Sciences, Graduate School, The Catholic University of Korea, Seoul, The Republic of Korea., Han DJ; Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, The Republic of Korea.; Department of Biomedicine & Health Sciences, Graduate School, The Catholic University of Korea, Seoul, The Republic of Korea., Kim S; Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, The Republic of Korea.; Department of Biomedicine & Health Sciences, Graduate School, The Catholic University of Korea, Seoul, The Republic of Korea., Moon Y; Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, The Republic of Korea.; Department of Biomedicine & Health Sciences, Graduate School, The Catholic University of Korea, Seoul, The Republic of Korea., Song IH; Department of Pathology, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, The Republic of Korea., Song KY; Division of Gastrointestinal Surgery, Department of Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, The Republic of Korea., Lee H; Department of Hospital Pathology, Seoul St. Mary's Hostpital, Collage of Medicine, The Catholic University of Korea, Seoul, The Republic of Korea., Lee S; Department of Surgery, Yonsei University, Seoul, The Republic of Korea., Hur H; Department of Surgery, Ajou University School of Medicine, Suwon, The Republic of Korea tmkim@catholic.ac.kr hhcmc75@ajou.ac.kr.; Cancer Biology Graduate Program, Ajou University School of Medicine, Suwon, The Republic of Korea.; Inflamm-Aging Translational Research Center, Ajou University School of Medicine, Suwon, The Republic of Korea., Kim TM; Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, The Republic of Korea tmkim@catholic.ac.kr hhcmc75@ajou.ac.kr.; Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, The Republic of Korea.; CMC Institute for Basic Medical Science, the Catholic Medical Center of The Catholic University of Korea, Seoul, The Republic of Korea.

Journal Article , 2025

Integration of single-cell and spatial transcriptomics reveals fibroblast subtypes in hepatocellular carcinoma: spatial distribution, differentiation trajectories, and therapeutic potential.

Liu Y; School of Medicine, Nankai University, Tianjin, 300071, China.; Department of Ultrasound, Fifth Medical Center of Chinese, PLA General Hospital, Beijing, 100853, China.; Department of Interventional Ultrasound, First Medical Center of Chinese, PLA General Hospital, Beijing, 100853, China., Dong G; Department of Ultrasound, Fifth Medical Center of Chinese, PLA General Hospital, Beijing, 100853, China.; Department of Interventional Ultrasound, First Medical Center of Chinese, PLA General Hospital, Beijing, 100853, China., Yu J; Department of Ultrasound, Fifth Medical Center of Chinese, PLA General Hospital, Beijing, 100853, China.; Department of Interventional Ultrasound, First Medical Center of Chinese, PLA General Hospital, Beijing, 100853, China., Liang P; School of Medicine, Nankai University, Tianjin, 300071, China. liangping301@126.com.; Department of Ultrasound, Fifth Medical Center of Chinese, PLA General Hospital, Beijing, 100853, China. liangping301@126.com.; Department of Interventional Ultrasound, First Medical Center of Chinese, PLA General Hospital, Beijing, 100853, China. liangping301@126.com.

Journal Article , 2025

Substrate stiffness-dependent activation of Hippo pathway in cancer associated fibroblasts.

Rubí-Sans G; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain; CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain., Nyga A; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain. Electronic address: anyga@mrc-lmb.cam.ac.uk., Mateos-Timoneda MA; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain., Engel E; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain; CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain; IMEM-BRT group, Department of Materials Science, EEBE, Technical University of Catalonia (UPC), Barcelona, Spain. Electronic address: eengel@ibecbarcelona.eu.

Journal Article , 2025

TGF-β-mediated activation of fibroblasts in cervical cancer: implications for tumor microenvironment and prognosis.

Qu H; Obstetrics and Gynecology Department, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, China., Zhao J; Obstetrics and Gynecology Department, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, China., Zuo X; Obstetrics and Gynecology Department, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, China., He H; Obstetrics and Gynecology Department, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, China., Wang X; Obstetrics and Gynecology Department, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, China., Li H; Obstetrics and Gynecology Department, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, China., Zhang K; Obstetrics and Gynecology Department, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, China.

Journal Article , 2025

Single-cell and spatial transcriptome profiling reveal CTHRC1+ fibroblasts promote EMT through WNT5A signaling in colorectal cancer.

Lu Y; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; The First College of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu, China., Chen Y; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; The First College of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu, China., Wang Z; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; The First College of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu, China., Shen H; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; The First College of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu, China., Xu L; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; The First College of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu, China., Huang C; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; The First College of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu, China., Tong Y; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; The First College of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu, China., Shao Y; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; The First College of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu, China., Zhang H; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; The First College of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu, China., Fu Z; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. fuzan1971@njmu.edu.cn.; The First College of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu, China. fuzan1971@njmu.edu.cn.

Journal Article , 2025

The extracellular matrix protein type I collagen and fibronectin are regulated by β-arrestin-1/endothelin axis in human ovarian fibroblasts.

Masi I; Institute of Molecular Biology and Pathology (IBPM), National Research Council (CNR), Rome, Italy., Ottavi F; Institute of Molecular Biology and Pathology (IBPM), National Research Council (CNR), Rome, Italy., Caprara V; Unit of Preclinical Models and New Therapeutic Agents, IRCCS, Regina Elena National Cancer Institute, Rome, Italy., Rio DD; Institute of Molecular Biology and Pathology (IBPM), National Research Council (CNR), Rome, Italy., Kunkl M; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University, Rome, Italy.; Neuroimmunology Unit, IRCCS Santa Lucia Foundation, Rome, Italy., Spadaro F; Confocal Microscopy Unit, Core Facilities, Istituto Superiore di Sanità, Rome, Italy., Licursi V; Institute of Molecular Biology and Pathology (IBPM), National Research Council (CNR), Rome, Italy., Tuosto L; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University, Rome, Italy., Bagnato A; Unit of Preclinical Models and New Therapeutic Agents, IRCCS, Regina Elena National Cancer Institute, Rome, Italy., Rosano' L; Institute of Molecular Biology and Pathology (IBPM), National Research Council (CNR), Rome, Italy. laura.rosano@cnr.it.

Journal Article , 2025

E2F1 activates breast stromal fibroblasts and promotes their paracrine pro-carcinogenic effects.

Al-Kharashi LA; Department of Molecular Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, 11211, Kingdom of Saudi Arabia.; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Kingdom of Saudi Arabia., Al-Mohanna FH; Department of Comparative Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, 11211, Kingdom of Saudi Arabia., Aboussekhra A; Department of Molecular Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, 11211, Kingdom of Saudi Arabia. aboussekhra@kfshrc.edu.sa., Abousekhra A; Department of Molecular Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, 11211, Kingdom of Saudi Arabia.

Journal Article , 2025

Targeting fibroblast-endothelial cell interactions in LAM pathogenesis using 3D spheroid models and spatial transcriptomics.

Koc-Gunel S; Hastings Center for Pulmonary Research; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine; and.; Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.; Department of Internal Medicine II, Infectious Diseases, and.; Institute for Medical Virology, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main, Germany., Liu EC; Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA., Gautam LK; Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA., Calvert BA; Hastings Center for Pulmonary Research; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine; and.; Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.; Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA., Murthy S; Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA., Harriott NC; Hastings Center for Pulmonary Research; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine; and.; Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.; Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA., Nawroth JC; Hastings Center for Pulmonary Research; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine; and.; Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.; Helmholtz Pioneer Campus and Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany., Zhou B; Hastings Center for Pulmonary Research; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine; and., Krymskaya VP; Division of Pulmonary and Critical Care Medicine, Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania (UPenn), Philadelphia, Pennsylvania, USA., Ryan AL; Hastings Center for Pulmonary Research; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine; and.; Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.; Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.

Journal Article , 2025

Botox-A induced apoptosis and suppressed cell proliferation in fibroblasts pre-treated with breast cancer exosomes.

Sayaf H; Department of Biotechnology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran., Salimian N; Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Department of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran., Mohammadi M; Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Department of Biology, Faculty of Basic Sciences, Islamshahr Branch, Islamic Azad University, Islamshar, Tehran, Iran., Ahmadi P; Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran., Gholamzad A; Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Department of Laboratory Medicine, Faculty of Paramedical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran., Babashah S; Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran., Entezari M; Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. Electronic address: mentezari@iautmu.ac.ir., Farahani N; Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. Electronic address: Najmafarahani@gmail.com., Montazeri M; Department of Biotechnology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. Electronic address: mmontazeri@iautmu.ac.ir., Hashemi M; Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. Electronic address: drmehashemi@iautmu.ac.ir.

Journal Article , 2025

Single cell and spatial analysis of immune-hot and immune-cold tumours identifies fibroblast subtypes associated with distinct immunological niches and positive immunotherapy response.

Jenkins BH; School of Cancer Sciences, University of Southampton, Southampton, UK.; NIHR Experimental Cancer Medicine Centre, University of Southampton, Southampton, UK., Tracy I; School of Cancer Sciences, University of Southampton, Southampton, UK.; NIHR Experimental Cancer Medicine Centre, University of Southampton, Southampton, UK., Rodrigues MFSD; School of Cancer Sciences, University of Southampton, Southampton, UK.; NIHR Experimental Cancer Medicine Centre, University of Southampton, Southampton, UK.; Postgraduate Program in Medicine-Biophotonics, Nove de Julho University, São Paulo, Brazil., Smith MJL; School of Cancer Sciences, University of Southampton, Southampton, UK.; NIHR Experimental Cancer Medicine Centre, University of Southampton, Southampton, UK., Martinez BR; School of Cancer Sciences, University of Southampton, Southampton, UK.; NIHR Experimental Cancer Medicine Centre, University of Southampton, Southampton, UK., Edmond M; School of Cancer Sciences, University of Southampton, Southampton, UK.; Dorset Cancer Centre, Poole Hospital NHS Foundation Trust, Poole, UK., Mahadevan S; Gilead Sciences Inc., Foster City, CA, US., Rao A; Gilead Sciences Inc., Foster City, CA, US., Zong H; Gilead Sciences Inc., Foster City, CA, US., Liu K; Gilead Sciences Inc., Foster City, CA, US., Aggarwal A; Gilead Sciences Inc., Foster City, CA, US., Li L; Gilead Sciences Inc., Foster City, CA, US., Diehl L; Gilead Sciences Inc., Foster City, CA, US., King EV; School of Cancer Sciences, University of Southampton, Southampton, UK.; Dorset Cancer Centre, Poole Hospital NHS Foundation Trust, Poole, UK., Bates JG; Gilead Sciences Inc., Foster City, CA, US., Hanley CJ; School of Cancer Sciences, University of Southampton, Southampton, UK.; NIHR Experimental Cancer Medicine Centre, University of Southampton, Southampton, UK., Thomas GJ; School of Cancer Sciences, University of Southampton, Southampton, UK. g.thomas@soton.ac.uk.; NIHR Experimental Cancer Medicine Centre, University of Southampton, Southampton, UK. g.thomas@soton.ac.uk.

Journal Article , 2025

Patient-derived tumor organoid and fibroblast assembloid models for interrogation of the tumor microenvironment in esophageal adenocarcinoma.

Sharpe BP; School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK., Nazlamova LA; School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK; Early Cancer Institute, University of Cambridge, Department of Oncology, Box 197 Cambridge Biomedical Campus, Hills Road, Cambridge SB2 0XZ, UK., Tse C; School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK., Johnston DA; Biomedical Imaging Unit, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK., Thomas J; Bio-R Bioinformatics Research Facility, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK., Blyth R; School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK., Pickering OJ; School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK; University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK., Grace B; School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK; Southampton Clinical Trials Unit, University of Southampton, Southampton, UK., Harrington J; School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK., Rajak R; University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK., Rose-Zerilli M; School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK., Walters ZS; School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK., Underwood TJ; School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK; Bio-R Bioinformatics Research Facility, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK. Electronic address: tju@soton.ac.uk.

Journal Article , 2024

Enhanced RHO-ROCK signaling is associated with CRELD2 production and fibroblast recruitment in cutaneous squamous cell carcinoma.

Pittar A; Centre for Cancer Biology, an Alliance between SA Pathology and the University of South Australia, Adelaide, Australia., Buckley EJ; Centre for Cancer Biology, an Alliance between SA Pathology and the University of South Australia, Adelaide, Australia., Boyle ST; Centre for Cancer Biology, an Alliance between SA Pathology and the University of South Australia, Adelaide, Australia., Ibbetson SJ; Division of Surgical Pathology, SA Pathology, Adelaide, Australia., Samuel MS; Centre for Cancer Biology, an Alliance between SA Pathology and the University of South Australia, Adelaide, Australia.; Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia.; Basil Hetzel Institute for Translational Health Research, Woodville South, Adelaide, Australia.

Journal Article , 2024

Reprogramming of normal fibroblasts into ovarian cancer-associated fibroblasts via non-vesicular paracrine signaling induces an activated fibroblast phenotype.

Axemaker H; Cancer Biology and Immunotherapies Group, Sanford Research, Sioux Falls, SD 57104, USA., Plesselova S; Cancer Biology and Immunotherapies Group, Sanford Research, Sioux Falls, SD 57104, USA., Calar K; Cancer Biology and Immunotherapies Group, Sanford Research, Sioux Falls, SD 57104, USA., Jorgensen M; Cancer Biology and Immunotherapies Group, Sanford Research, Sioux Falls, SD 57104, USA., Wollman J; Flow Cytometry Core, Sanford Research, Sioux Falls, SD 57104, USA., de la Puente P; Cancer Biology and Immunotherapies Group, Sanford Research, Sioux Falls, SD 57104, USA; Flow Cytometry Core, Sanford Research, Sioux Falls, SD 57104, USA; Department of Obstetrics and Gynecology, University of South Dakota Sanford School of Medicine, Sioux Falls, SD 57105, USA; Department of Surgery, University of South Dakota Sanford School of Medicine, Sioux Falls, SD 57105, USA. Electronic address: pilar.puente@sanfordhealth.org.

Journal Article , 2024

Mindin regulates fibroblast subpopulations through distinct Src family kinases during fibrogenesis.

Kataria S; IFOM-inStem Joint Research Laboratory, Centre for Inflammation and Tissue Homeostasis, Institute for Stem Cell Science and Regenerative Medicine (inStem), Bangalore, Karnataka, India.; Department of Life Sciences, Shiv Nadar Institution of Eminence, Gautam Buddha Nagar, India.; National Centre for Biological Sciences, Gandhi Krishi Vigyan Kendra Post, Bangalore, Karnataka, India., Rana I; IFOM-inStem Joint Research Laboratory, Centre for Inflammation and Tissue Homeostasis, Institute for Stem Cell Science and Regenerative Medicine (inStem), Bangalore, Karnataka, India.; Shanmugha Arts, Science, Technology and Research Academy (SASTRA) University, Thanjavur, Tamil Nadu, India., Badarinath K; IFOM-inStem Joint Research Laboratory, Centre for Inflammation and Tissue Homeostasis, Institute for Stem Cell Science and Regenerative Medicine (inStem), Bangalore, Karnataka, India.; National Centre for Biological Sciences, Gandhi Krishi Vigyan Kendra Post, Bangalore, Karnataka, India., Zaarour RF; IFOM-inStem Joint Research Laboratory, Centre for Inflammation and Tissue Homeostasis, Institute for Stem Cell Science and Regenerative Medicine (inStem), Bangalore, Karnataka, India., Kansagara G; IFOM-inStem Joint Research Laboratory, Centre for Inflammation and Tissue Homeostasis, Institute for Stem Cell Science and Regenerative Medicine (inStem), Bangalore, Karnataka, India.; Manipal Academy of Higher Education, Manipal, India., Ahmed S; IFOM-inStem Joint Research Laboratory, Centre for Inflammation and Tissue Homeostasis, Institute for Stem Cell Science and Regenerative Medicine (inStem), Bangalore, Karnataka, India., Rizvi A; IFOM-inStem Joint Research Laboratory, Centre for Inflammation and Tissue Homeostasis, Institute for Stem Cell Science and Regenerative Medicine (inStem), Bangalore, Karnataka, India., Saha D; IFOM-inStem Joint Research Laboratory, Centre for Inflammation and Tissue Homeostasis, Institute for Stem Cell Science and Regenerative Medicine (inStem), Bangalore, Karnataka, India.; Manipal Academy of Higher Education, Manipal, India., Dam B; IFOM-inStem Joint Research Laboratory, Centre for Inflammation and Tissue Homeostasis, Institute for Stem Cell Science and Regenerative Medicine (inStem), Bangalore, Karnataka, India.; Manipal Academy of Higher Education, Manipal, India., Dutta A; IFOM-inStem Joint Research Laboratory, Centre for Inflammation and Tissue Homeostasis, Institute for Stem Cell Science and Regenerative Medicine (inStem), Bangalore, Karnataka, India.; Shanmugha Arts, Science, Technology and Research Academy (SASTRA) University, Thanjavur, Tamil Nadu, India., Zirmire RK; IFOM-inStem Joint Research Laboratory, Centre for Inflammation and Tissue Homeostasis, Institute for Stem Cell Science and Regenerative Medicine (inStem), Bangalore, Karnataka, India.; Shanmugha Arts, Science, Technology and Research Academy (SASTRA) University, Thanjavur, Tamil Nadu, India., Hajam EY; IFOM-inStem Joint Research Laboratory, Centre for Inflammation and Tissue Homeostasis, Institute for Stem Cell Science and Regenerative Medicine (inStem), Bangalore, Karnataka, India.; Shanmugha Arts, Science, Technology and Research Academy (SASTRA) University, Thanjavur, Tamil Nadu, India., Kumar P; IFOM-inStem Joint Research Laboratory, Centre for Inflammation and Tissue Homeostasis, Institute for Stem Cell Science and Regenerative Medicine (inStem), Bangalore, Karnataka, India., Gulyani A; Integrative Chemical Biology, inStem, Bangalore, Karnataka, India., Jamora C; IFOM-inStem Joint Research Laboratory, Centre for Inflammation and Tissue Homeostasis, Institute for Stem Cell Science and Regenerative Medicine (inStem), Bangalore, Karnataka, India.; Department of Life Sciences, Shiv Nadar Institution of Eminence, Gautam Buddha Nagar, India.

Journal Article , 2024

Evidence that CRISPR-Cas9 Y537S-mutant expressing breast cancer cells activate Yes-associated protein 1 to driving the conversion of normal fibroblasts into cancer-associated fibroblasts.

Gelsomino L; Department of Pharmacy and Health and Nutritional Sciences, University of Calabria, Arcavacata Di Rende (CS), Cosenza, Italy.; Health Center, University of Calabria, Arcavacata Di Rende (CS), Cosenza, Italy., Caruso A; Department of Pharmacy and Health and Nutritional Sciences, University of Calabria, Arcavacata Di Rende (CS), Cosenza, Italy., Tasan E; Department of Pharmacy and Health and Nutritional Sciences, University of Calabria, Arcavacata Di Rende (CS), Cosenza, Italy., Leonetti AE; Department of Pharmacy and Health and Nutritional Sciences, University of Calabria, Arcavacata Di Rende (CS), Cosenza, Italy., Malivindi R; Department of Pharmacy and Health and Nutritional Sciences, University of Calabria, Arcavacata Di Rende (CS), Cosenza, Italy.; Clinical Laboratory Unit, A.O. 'Annunziata', Cosenza, Italy., Naimo GD; Department of Pharmacy and Health and Nutritional Sciences, University of Calabria, Arcavacata Di Rende (CS), Cosenza, Italy., Giordano F; Department of Pharmacy and Health and Nutritional Sciences, University of Calabria, Arcavacata Di Rende (CS), Cosenza, Italy., Panza S; Department of Experimental and Clinical Medicine, 'Magna Graecia', University of Catanzaro, Catanzaro, Italy., Gu G; Lester & Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA., Perrone B; Department of Pharmacy and Health and Nutritional Sciences, University of Calabria, Arcavacata Di Rende (CS), Cosenza, Italy.; Health Center, University of Calabria, Arcavacata Di Rende (CS), Cosenza, Italy., Giordano C; Department of Pharmacy and Health and Nutritional Sciences, University of Calabria, Arcavacata Di Rende (CS), Cosenza, Italy.; Health Center, University of Calabria, Arcavacata Di Rende (CS), Cosenza, Italy.; Clinical Laboratory Unit, A.O. 'Annunziata', Cosenza, Italy., Mauro L; Department of Pharmacy and Health and Nutritional Sciences, University of Calabria, Arcavacata Di Rende (CS), Cosenza, Italy., Nardo B; Department of Pharmacy and Health and Nutritional Sciences, University of Calabria, Arcavacata Di Rende (CS), Cosenza, Italy.; Department of Surgery, General Surgery Unit, Annunziata Hospital, Cosenza, Italy., Filippelli G; San Francesco Hospital, Paola (CS), Italy., Bonofiglio D; Department of Pharmacy and Health and Nutritional Sciences, University of Calabria, Arcavacata Di Rende (CS), Cosenza, Italy.; Health Center, University of Calabria, Arcavacata Di Rende (CS), Cosenza, Italy., Barone I; Department of Pharmacy and Health and Nutritional Sciences, University of Calabria, Arcavacata Di Rende (CS), Cosenza, Italy.; Health Center, University of Calabria, Arcavacata Di Rende (CS), Cosenza, Italy., Fuqua SAW; Lester & Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA., Catalano S; Department of Pharmacy and Health and Nutritional Sciences, University of Calabria, Arcavacata Di Rende (CS), Cosenza, Italy.; Health Center, University of Calabria, Arcavacata Di Rende (CS), Cosenza, Italy.; Clinical Laboratory Unit, A.O. 'Annunziata', Cosenza, Italy., Andò S; Department of Pharmacy and Health and Nutritional Sciences, University of Calabria, Arcavacata Di Rende (CS), Cosenza, Italy. sebastiano.ando@unical.it.; Health Center, University of Calabria, Arcavacata Di Rende (CS), Cosenza, Italy. sebastiano.ando@unical.it.

Journal Article , 2024

Preexisting senescent fibroblasts in the aged bladder create a tumor-permissive niche through CXCL12 secretion.

Meguro S; Division of Cancer Cell Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.; Department of Urology, Fukushima Medical University School of Medicine, Fukushima, Japan., Johmura Y; Division of Cancer Cell Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan. johmuray@staff.kanazawa-u.ac.jp.; Division of Cancer and Senescence Biology, Cancer Research Institute, Institute for Frontier Science Initiative, Kanazawa University, Kanazawa, Japan. johmuray@staff.kanazawa-u.ac.jp., Wang TW; Division of Cancer Cell Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan., Kawakami S; Division of Cancer Cell Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan., Tanimoto S; Division of Cancer Cell Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan., Omori S; Division of Cancer Cell Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Okamura YT; Division of Cancer Cell Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan., Hoshi S; Department of Urology, Fukushima Medical University School of Medicine, Fukushima, Japan., Kayama E; Department of Urology, Fukushima Medical University School of Medicine, Fukushima, Japan., Yamaguchi K; Division of Clinical Genome Research, Institute of Medical Science, University of Tokyo, Tokyo, Japan., Hatakeyama S; Division of Clinical Genome Research, Institute of Medical Science, University of Tokyo, Tokyo, Japan., Yamazaki S; Division of Stem Cell Biology, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan.; Laboratory of Stem Cell Therapy, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan., Shimizu E; Division of Health Medical Intelligence, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan., Imoto S; Division of Health Medical Intelligence, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan., Furukawa Y; Division of Clinical Genome Research, Institute of Medical Science, University of Tokyo, Tokyo, Japan., Kojima Y; Department of Urology, Fukushima Medical University School of Medicine, Fukushima, Japan. ykojima@fmu.ac.jp., Nakanishi M; Division of Cancer Cell Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan. mkt-naka@g.ecc.u-tokyo.ac.jp.

Journal Article , 2024