Search Results - "molecular glue"

Single-Molecule-Based, Label-Free Monitoring of Molecular Glue Efficacies for Promoting Protein–Protein Interactions Using YaxAB Nanopores

Ryu, Minju^{aff1, aff2}, Oh, Sohee^aff1, Jeong, Ki-Baek^{aff1, aff3}, Hwang, Sungbo^aff1, Kim, Jin-Sik^{aff1, aff3}, Chung, Minji^{aff1, aff2}, Chi, Seung-Wook^{aff1, aff2, aff4}

Evaluation of anti-leukemic activity and underlying mechanisms of the novel GSPT1 degrader AB138 in acute myeloid leukemia

Wang, Liqiang, Cai, Xin, Kong, Yang, Wu, Qingchun, Hu, Wei^{Aff2, IDs10637025015418_cor1}, Wang, Yongsheng^{Aff4, IDs10637025015418_cor2}

DDB1 engagement defines the selectivity of S656 analogs for cyclin K degradation over CDK inhibition

Moison, Céline^Aff1, Mendoza-Sanchez, Rodrigo^Aff1, Gracias, Deanne^Aff1, Schuetz, Doris A, Spinella, Jean-François, Girard, Simon, Thavonekham, Bounkham, Chagraoui, Jalila, Durand, Aurélie, Fortier, Simon, MacRae, Tara, Bonneil, Eric, Rose, Yannick, Mayotte, Nadine, Boivin, Isabel, Thibault, Pierre^{Aff1, Aff2}, Hébert, Josée^{Aff1, Aff3, Aff4, Aff5}, Ruel, Réjean, Marinier, Anne^{Aff1, Aff2, IDs4431902500448y_cor1}, Sauvageau, Guy^{Aff1, Aff3, Aff4, Aff5, IDs4431902500448y_cor2}

Targeting MYC for the treatment of breast cancer: use of the novel MYC-GSPT1 degrader, GT19630

Tang, Minhong, Crown, John, Duffy, Michael J.^{Aff1, Aff3, IDs10637024015045_cor1}

Visible-Light-Switchable molecular glues for reversible control of protein function

Zhang, Jun, Herzog, Laura K., Li, Shuang, Chen, Xi, Wu, Yao-Wen, Professor

electronic

Modular photoswitchable molecular glues for chemo-optogenetic control of protein function in living cells

Zhang, Jun, Herzog, Laura K., Corkery, Dale P., Lin, Tzu-Chen, Klewer, Laura, Chen, Xi, Xin, Xiaoyi, Li, Yaozong, Wu, Yao-Wen, Professor

electronic

Development of a NanoBRET assay for evaluation of 14-3-3σ molecular glues.

Vickery, Holly, Virta, Johanna, Konstantinidou, Markella, Arkin, Michelle

application/pdf

Molecular glue meets antibody: next-generation antibody–drug conjugates

Tao, Yiran ^{1, 4}, Lu, Ying ^{1, 4}, Yu, Bin ^{2, ⁎}, Wang, Yuxi ^{1, 3, ⁎}

Cullin-RING ligase BioE3 reveals molecular-glue-induced neosubstrates and rewiring of the endogenous Cereblon ubiquitome

Laura Merino-Cacho, Orhi Barroso-Gomila, Mónica Pozo-Rodríguez, Veronica Muratore, Claudia Guinea-Pérez, Álvaro Serrano, Coralia Pérez, Sandra Cano-López, Ainhoa Urcullu, Mikel Azkargorta, Ibon Iloro, Carles Galdeano, Jordi Juárez-Jiménez, Ugo Mayor, Felix Elortza, Rosa Barrio, James D. Sutherland

electronic resource

View item

Meisoindigo Acts as a Molecular Glue to Target PKMYT1 for Degradation in Chronic Myeloid Leukemia Therapy

Zhao‐Xin Zhang, Shu‐Ying Li, Fang‐Fei Li, Qin‐Yan Shi, Cheng‐Yong Tan, Xiao‐Jing Wang, Mi Li, Yun‐Bao Liu, Jing Jin, Yong Li, Shi‐Shan Yu

electronic resource

View item

Heteroaryl Glutarimides and Dihydrouracils as Cereblon Ligand Scaffolds for Molecular Glue Degrader Discovery

Zhou, Yuebiao^aff1, Garrigues, Star L.^aff1, Villemure, Elisia^aff1, Ishisoko, Noriko^aff1, Nguyen, Huy Q.^aff1, Hamidi, Nikkia K.^aff1, Vogt, Rebecca^aff1, Wang, Yong^aff1, Blake, Robert A.^aff1, Rudolph, Joachim^aff1, Nilewski, Christian^aff1

Polyphenol-Mediated Synthesis of Mesoporous Au–In2O3 Nanospheres for Room-Temperature Detection of Triethylamine

Feng, Bingxi^aff1, Wu, Yue^aff1, Chen, Yiqing^aff1, Yuan, Kaiping^aff2, Yue, Qin^aff3, Deng, Yonghui^aff4, Wei, Jing^aff1

Novel potent molecular glue degraders against broad range of hematological cancer cell lines via multiple neosubstrates degradation

Li, Pengyun^{Aff1, Aff2}, Hu, Xiaotong^{Aff1, Aff2}, Fan, Zhiya, Sun, Shiyang^{Aff1, Aff2}, Ran, Qijie^{Aff4, Aff5}, Wei, Ting^{Aff1, Aff2}, Wei, Pengli^{Aff1, Aff2}, Jiang, Qiyu, Yan, Jian^{Aff1, Aff2}, Yang, Ning^{Aff1, Aff2}, Jia, Changkai^{Aff1, Aff2}, Yang, Tingting, Mao, Yaqiu^{Aff1, Aff2}, Cai, Xu^{Aff1, Aff2}, Xu, Tingting^{Aff1, Aff2}, Zhao, Zhiyuan^{Aff1, Aff2}, Qian, Xiaohong, Qin, Weijie, Zhuang, Xiaomei^{Aff2, IDs1304502401592z_cor19}, Fan, Feng^{Aff4, IDs1304502401592z_cor20}, Xiao, Junhai^{Aff1, Aff2, IDs1304502401592z_cor21}, Zheng, Zhibing^{Aff1, Aff2, IDs1304502401592z_cor22}, Li, Song^{Aff1, Aff2}

Targeted protein degradation in hematologic malignancies: clinical progression towards novel therapeutics

Feng, Yupiao, Hu, Xinting^{Aff1, Aff2, IDs40364024006381_cor2}, Wang, Xin^{Aff1, Aff2, Aff3, IDs40364024006381_cor3}

In-vivo-targeted gene delivery using adenovirus-antibody site-specific covalent conjugates

Rice-Boucher, Paul J. ^{1, 2}, Kashentseva, Elena A. ¹, Dmitriev, Igor P. ¹, Guo, Hongjie ³, Tremblay, Jacqueline M. ⁴, Shoemaker, Charles B. ⁴, Curiel, David T. ^{1, 2}, Lu, Zhi Hong ^{1, ∗}

Molecular glue binding behavior of phosphoantigens to alpaca butyrophilins

Liu, Chang ¹, Yi, Simin ¹, Zhang, Mengting ¹, Chen, Chun-Chi ^{1, 2}, Liu, Yingle ³, Zhang, Zhen ⁴, Guo, Rey-Ting ^{1, 2, ∗}, Yang, Yunyun ^{1, ∗}

Interfacial molecular anchor for ambient all-bladed perovskite solar modules

Zhu, Xuejie ^{1, 10}, Yu, Dongqi ^{2, 10}, Zhou, Xin ³, Wang, Nan ¹, Liu, Hong ⁴, Liang, Zihui ^{5, 6}, Wu, Congcong ⁴, Wang, Kai ^{6, ∗}, Jin, Dayong ^{7, 8, ∗∗}, Liu, Shengzhong ^{1, 9, ∗∗∗}, Yang, Dong ^{1, 9, 11, ∗∗∗∗}

The dual role of the TSC complex in cancer

Hartung, Josephine ¹, Müller, Christine ¹, Calkhoven, Cornelis F. ^{1, ⁎}

Molecular glue-augmented E2-ubiquitin recognition from a computational approach

Muhammad, Danial ^{a, b, c, 1}, Xia, Wei ^{d, e, 1}, Wang, Musheng ^{a, b, c}, Sun, Zhaoxi ^{a, b, ⁎}, Zhang, John Z.H. ^{a, b, c, d, e, ⁎}

Temperature-driven CsgA-enhanced mutant enable distinct self-assembly

Chen, Yao ^{a, b, 1}, Yang, Li ^{a, 1}, Xu, Zijian ^{a, 1}, Liu, Minghui ^c, Shi, Yi ^{a, b}, Ming, Dengming ^b, Jiang, Ling ^{a, ⁎}