Sökresultat - "synthetic lethality"

Assessing Drug Sensitivity in Fission Yeast Using Half-Maximal Inhibitory Concentration (IC50) Assays

Chhipa, Mohammed Ayan^Aff3, Sanayhie, Samantha A.^Aff4, Sabatinos, Sarah A.^{Aff3, Aff4}

Petreaca, Ruben C.^Aff2, Walker, John M.^Aff1

TARSL: Triple-Attention Cross-Network Representation Learning to Predict Synthetic Lethality for Anti-Cancer Drug Discovery

Li, J., Lu, X., Jiang, K., Tang, D., Ning, B., Sun, F.

SLInterpreter: An Exploratory and Iterative Human-AI Collaborative System for GNN-Based Synthetic Lethal Prediction

Jiang, H., Shi, S., Zhang, S., Zheng, J., Li, Q.

Dead-Seq : Discovering Synthetic Lethal Interactions from Dead Cells Genomics

Blanco-Fernandez, Joan^Aff4, Jourdain, Alexis A.^Aff4

Barrientos, Antoni^Aff2, Fontanesi, Flavia^Aff3, Walker, John M.^Aff1

DSESL: A Deep Stacking Ensemble Model for Synthetic Lethality Prediction

Li, Zhuang, Wang, Xiaowen, Li, Yulong, Zhu, Hongming, Liu, Qin

2024 IEEE International Conference on Systems, Man, and Cybernetics (SMC)

A CRISPR Platform for Targeted In Vivo Screens

Maranda, Vincent^Aff3, Zhang, Yue^Aff3, Vizeacoumar, Frederick S.^Aff4, Freywald, Andrew^Aff4, Vizeacoumar, Franco J.^{Aff3, Aff5}

Ursini-Siegel, Josie^Aff2, Walker, John M.^Aff1

Combined inhibition of de novo glutathione and nucleotide biosynthesis is synthetically lethal in glioblastoma

Udutha, Suresh, Taglang, Céline, Batsios, Georgios, Gillespie, Anne Marie, Tran, Meryssa, Hoeve, Johanna Ten, Graeber, Thomas G, Viswanath, Pavithra

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Multiple Heterogeneous Networks Representation With Latent Space for Synthetic Lethality Prediction

Hu, X., Yi, H., Cheng, H., Zhao, Y., Zhang, D., Li, J., Ruan, J., Zhang, J., Lu, X.

Using Synthetic Genetic Interactions in Candida glabrata as a Novel Method to Detect Genes with Roles in Antifungal Drug Resistance

Usher, Jane^Aff3

Calderone, Richard^Aff2, Walker, John M.^Aff1

A Methodological Workflow to Analyze Synthetic Lethality Drug Synthetic Lethality and Drug Synergism Drug Synergism in Cancer Cells

Gout, Johann^Aff3, Roger, Elodie^Aff3, Kleger, Alexander^Aff3, Perkhofer, Lukas^Aff3

Baiocchi, Marta^Aff2, Walker, John M.^Aff1

Proteomic compensation by paralogs preserves protein interaction networks after gene loss in cancer

Venkatesh, Anjan^{Aff1, Aff2, Aff3}, Quinn, Niall^{Aff2, Aff3}, Upadhya, Swathi Ramachandra^{Aff1, Aff3}, De Kegel, Barbara^{Aff2, Aff3}, Bolado Carrancio, Alfonso, Lefeivre, Thomas^{Aff1, Aff2, Aff3}, Dennler, Olivier^{Aff1, Aff3}, Wynne, Kieran^{Aff1, Aff2, Aff5}, von Kriegsheim, Alexander, Ryan, Colm J^{Aff1, Aff2, Aff3, Aff5, IDs44320025001224_cor1}

PARP Inhibitors in the Neoadjuvant Setting; A Comprehensive Overview of the Rationale for their Use, Past and Ongoing Clinical Trials

Habaka, Minatoullah^{Aff1, IDs1191202501669z_cor1}, Daly, Gordon R.^{Aff1, Aff2}, Shinyanbola, Deborah, Alabdulrahman, Mohammad, McGrath, Jason, Dowling, Gavin P.^{Aff1, Aff2}, Hehir, Cian^{Aff1, Aff2}, Huang, Helen Ye Rim, Hill, Arnold D. K.^{Aff1, Aff2, Aff4}, Varešlija, Damir^{Aff3, Aff4}, Young, Leonie S.^{Aff1, Aff4}

A Recent Overview of Molecular Pathways in Synthetic Lethality as a Proposed Valid Target in Oncology: Current Insights and Future Directions

Raja, Sangeetha, Rahangan, Akash, Prabath, Indumathi^{Aff1, IDs13193024020885_cor1}, Rani, Jamuna

Computational Prediction of Chemical Tools for Identification and Validation of Synthetic Lethal Interaction Networks

Bhanumathy, Kalpana K.^Aff4, Abuhussein, Omar^Aff5, Vizeacoumar, Frederick S.^{Aff6, Aff7}, Freywald, Andrew^Aff7, Vizeacoumar, Franco J.^{Aff4, Aff8}, Phenix, Christopher P.^Aff9, Price, Eric W.^Aff9, Cao, Ran^Aff4

Vizeacoumar, Franco Joseph^Aff2, Freywald, Andrew^Aff3, Walker, John M.^Aff1

CDK12 loss drives prostate cancer progression, transcription-replication conflicts, and synthetic lethality with paralog CDK13.

Tien, Jean, Luo, Jie, Chang, Yu, Zhang, Yuping, Cheng, Yunhui, Wang, Xiaoju, Yang, Jianzhang, Mannan, Rahul, Mahapatra, Somnath, Shah, Palak, Wang, Xiao-Ming, Todd, Abigail, Eyunni, Sanjana, Cheng, Caleb, Rebernick, Ryan, Xiao, Lanbo, Bao, Yi, Neiswender, James, Brough, Rachel, Pettitt, Stephen, Cao, Xuhong, Miner, Stephanie, Zhou, Licheng, Wu, Yi-Mi, Labanca, Estefania, Wang, Yuzhuo, Parolia, Abhijit, Cieslik, Marcin, Robinson, Dan, Wang, Zhen, Feng, Felix, Chou, Jonathan, Lord, Christopher, Ding, Ke, Chinnaiyan, Arul

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Multi-omics Sampling-based Graph Transformer for Synthetic Lethality Prediction

Zhao, Xusheng, Liu, Hao, Dai, Qiong, Peng, Hao, Bai, Xu, Peng, Huailiang

2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

Latent space feature representation on multiple biological network for synthetic lethality interaction prediction

Li, Jinxin, Lu, Xinguo, Jiang, Kaibao, Tang, Daoxu, Sun, Fengxu, Ruan, Jingjing

2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

Meta Learning for Low-Data Prediction of Cancer-Specific Synthetic Lethality as Drug Targets

Liu, Xin, Tao, Siyu, Zheng, Jie

2023 IEEE International Conference on Knowledge Graph (ICKG)

ASTER: A Method to Predict Clinically Relevant Synthetic Lethal Genetic Interactions

Liany, H., Jayagopal, A., Huang, D., Lim, J.Q., NBH, N.I., Jeyasekharan, A., Ong, C.K., Rajan, V.

A Phase 1b study of the OxPhos inhibitor ME-344 with bevacizumab in refractory metastatic colorectal cancer

Boland, Patrick M.^{Aff1, Aff11, IDs10637024014891_cor1}, Lenz, Heinz-Josef^Aff2, Ciombor, Kristen K., Florou, Vaia, Pishvaian, Michael J., Cusnir, Michael, Cohen, Deirdre, Guo, Jessie Y., Tang, Min, Rajagopalan, Prabhu, Wiley, Sandra E., Ghalie, Richard G., Hochster, Howard S.